| Chain sequence(s) |
A: GSLPTNPEPELKSTSEFVTPTDLLYIAETDLLTEEGNPEKDIIVDGKVLVPRVSAYQFKVFLLKLPDPNKLPLPSENFVDFSTEILIWRLLAFKIHVGGPLGKGSYGHPNFNRLGDVDNPTTYQQETADDKVNYSFTPKRLQQYVIGDRPPLGKYTTIAAPEPGLPAGAAPPLTTVTTTIEHGDMADIGFGAKDYAALLPRKDDVPDIILDTATKVLDYDGMKADPWGDRMFTHDSLSSSYNSDTLVRSGPDLFPLPSAPPPSLLYTPPPPSSPFWKLPSTDIFNIPNAGEITEEDLLFNKPVFLTKTSGLNDGILWGNRLYITVLDNSRAEIATNRTRISTPPINVFDPSNYVTSKTYKREYRLSLIVQLCKIPLTPETLDLIRRRDPSILVNANLPFIPPVERPDPLAGKKFHEIDLTDKLSTNLEKYELGRLYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.1688 | |
| 2 | S | A | 0.2266 | |
| 3 | L | A | 1.0009 | |
| 4 | P | A | -0.0441 | |
| 5 | T | A | -0.7573 | |
| 6 | N | A | -1.7925 | |
| 7 | P | A | -2.1688 | |
| 8 | E | A | -2.7758 | |
| 9 | P | A | -2.1094 | |
| 10 | E | A | -2.2000 | |
| 11 | L | A | -0.6553 | |
| 12 | K | A | -0.9436 | |
| 13 | S | A | -0.7515 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -1.3355 | |
| 16 | E | A | -1.9468 | |
| 17 | F | A | -1.1197 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.5725 | |
| 20 | P | A | -0.7160 | |
| 21 | T | A | -0.8992 | |
| 22 | D | A | -1.6345 | |
| 23 | L | A | -0.4905 | |
| 24 | L | A | -0.2115 | |
| 25 | Y | A | -0.1109 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.1812 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.6075 | |
| 31 | L | A | -0.2325 | |
| 32 | L | A | -0.2731 | |
| 33 | T | A | -1.0039 | |
| 34 | E | A | -1.7056 | |
| 35 | E | A | -2.6356 | |
| 36 | G | A | 0.0000 | |
| 37 | N | A | -1.4711 | |
| 38 | P | A | 0.0000 | |
| 39 | E | A | -1.7025 | |
| 40 | K | A | -2.1191 | |
| 41 | D | A | -0.3468 | |
| 42 | I | A | 1.7286 | |
| 43 | I | A | 2.6280 | |
| 44 | V | A | 1.7016 | |
| 45 | D | A | -0.9715 | |
| 46 | G | A | -0.5316 | |
| 47 | K | A | -0.1172 | |
| 48 | V | A | 2.1319 | |
| 49 | L | A | 2.7602 | |
| 50 | V | A | 1.4634 | |
| 51 | P | A | -0.0699 | |
| 52 | R | A | -1.2323 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0459 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | -1.5143 | |
| 67 | D | A | -1.3482 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2726 | |
| 70 | K | A | -1.8932 | |
| 71 | L | A | -0.8171 | |
| 72 | P | A | -0.6541 | |
| 73 | L | A | -0.5872 | |
| 74 | P | A | -0.6237 | |
| 75 | S | A | -1.3849 | |
| 76 | E | A | -2.6484 | |
| 77 | N | A | -2.3086 | |
| 78 | F | A | -1.1797 | |
| 79 | V | A | 0.0000 | |
| 80 | D | A | -1.8837 | |
| 81 | F | A | -0.1593 | |
| 82 | S | A | -0.3877 | |
| 83 | T | A | -0.5344 | |
| 84 | E | A | -0.7149 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3544 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | 0.1170 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | -1.0449 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -1.1213 | |
| 97 | V | A | 0.0000 | |
| 98 | G | A | -0.6902 | |
| 99 | G | A | -0.9947 | |
| 100 | P | A | -0.6297 | |
| 101 | L | A | -0.5379 | |
| 102 | G | A | -1.1487 | |
| 103 | K | A | -1.6198 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.6817 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.8642 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -1.5554 | |
| 110 | N | A | -2.5329 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | R | A | -1.1281 | |
| 114 | L | A | -0.9828 | |
| 115 | G | A | -0.7985 | |
| 116 | D | A | -1.2223 | |
| 117 | V | A | -0.9186 | |
| 118 | D | A | -2.6331 | |
| 119 | N | A | -2.3417 | |
| 120 | P | A | -1.3402 | |
| 121 | T | A | -0.6943 | |
| 122 | T | A | -0.3543 | |
| 123 | Y | A | 0.1835 | |
| 124 | Q | A | -0.7768 | |
| 125 | Q | A | -1.6577 | |
| 126 | E | A | -1.9363 | |
| 127 | T | A | -1.4611 | |
| 128 | A | A | -1.1765 | |
| 129 | D | A | -2.4124 | |
| 130 | D | A | -2.0386 | |
| 131 | K | A | -2.1521 | |
| 132 | V | A | -1.3947 | |
| 133 | N | A | -1.7649 | |
| 134 | Y | A | -0.9660 | |
| 135 | S | A | -0.5404 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.4803 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | -0.3777 | |
| 140 | R | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | Q | A | -0.3582 | |
| 144 | Y | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | R | A | -0.6313 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.2082 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.2596 | |
| 155 | Y | A | -0.2526 | |
| 156 | T | A | 0.2081 | |
| 157 | T | A | 0.6709 | |
| 158 | I | A | 1.3521 | |
| 159 | A | A | 0.6724 | |
| 160 | A | A | -0.1296 | |
| 161 | P | A | -0.8095 | |
| 162 | E | A | -1.9883 | |
| 163 | P | A | -1.2354 | |
| 164 | G | A | -0.7367 | |
| 165 | L | A | -0.1300 | |
| 166 | P | A | -0.0825 | |
| 167 | A | A | -0.1419 | |
| 168 | G | A | -0.0998 | |
| 169 | A | A | 0.1733 | |
| 170 | A | A | 0.5654 | |
| 171 | P | A | 0.2706 | |
| 172 | P | A | 0.6179 | |
| 173 | L | A | 1.7824 | |
| 174 | T | A | 0.9829 | |
| 175 | T | A | 0.3831 | |
| 176 | V | A | 0.4482 | |
| 177 | T | A | 0.0545 | |
| 178 | T | A | -0.0306 | |
| 179 | T | A | -0.4729 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.2270 | |
| 182 | H | A | -1.2479 | |
| 183 | G | A | -0.7211 | |
| 184 | D | A | -0.6309 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.3824 | |
| 190 | F | A | -0.1813 | |
| 191 | G | A | -0.2434 | |
| 192 | A | A | -0.4114 | |
| 193 | K | A | -0.5162 | |
| 194 | D | A | -0.6582 | |
| 195 | Y | A | 0.0000 | |
| 196 | A | A | -1.1796 | |
| 197 | A | A | -0.2300 | |
| 198 | L | A | -0.0489 | |
| 199 | L | A | -0.9183 | |
| 200 | P | A | -1.2518 | |
| 201 | R | A | -1.9118 | |
| 202 | K | A | -2.7410 | |
| 203 | D | A | 0.0000 | |
| 204 | D | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.7583 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.5592 | |
| 211 | D | A | -2.2591 | |
| 212 | T | A | -1.1634 | |
| 213 | A | A | -0.8154 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.2793 | |
| 217 | L | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | Y | A | -1.2153 | |
| 220 | D | A | -2.3319 | |
| 221 | G | A | -1.5849 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.4728 | |
| 224 | A | A | -1.4237 | |
| 225 | D | A | -1.0645 | |
| 226 | P | A | -0.3195 | |
| 227 | W | A | -0.0926 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | R | A | -0.7212 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.6575 | |
| 234 | H | A | -0.7877 | |
| 235 | D | A | -0.9425 | |
| 236 | S | A | -0.4349 | |
| 237 | L | A | -0.1402 | |
| 238 | S | A | -0.1688 | |
| 239 | S | A | -0.2405 | |
| 240 | S | A | -0.3737 | |
| 241 | Y | A | 0.1764 | |
| 242 | N | A | -1.2262 | |
| 243 | S | A | -1.1029 | |
| 244 | D | A | -1.6620 | |
| 245 | T | A | -1.1562 | |
| 246 | L | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.6333 | |
| 249 | S | A | -1.2299 | |
| 250 | G | A | -0.7363 | |
| 251 | P | A | -0.1584 | |
| 252 | D | A | 0.5479 | |
| 253 | L | A | 1.9893 | |
| 254 | F | A | 2.4702 | |
| 255 | P | A | 1.1155 | |
| 256 | L | A | 0.9673 | |
| 257 | P | A | 0.2107 | |
| 258 | S | A | -0.3281 | |
| 259 | A | A | -0.1010 | |
| 260 | P | A | 0.1261 | |
| 261 | P | A | -0.2770 | |
| 262 | P | A | 0.1995 | |
| 263 | S | A | 0.9699 | |
| 264 | L | A | 2.2465 | |
| 265 | L | A | 2.4404 | |
| 266 | Y | A | 1.4053 | |
| 267 | T | A | 0.4648 | |
| 268 | P | A | 0.1625 | |
| 269 | P | A | 0.0886 | |
| 270 | P | A | -0.1404 | |
| 271 | P | A | -0.3364 | |
| 272 | S | A | -0.2893 | |
| 273 | S | A | 0.0589 | |
| 274 | P | A | 0.0924 | |
| 275 | F | A | 0.9623 | |
| 276 | W | A | 0.4386 | |
| 277 | K | A | -1.0229 | |
| 278 | L | A | -0.0900 | |
| 279 | P | A | -0.6002 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | 0.1890 | |
| 282 | D | A | -0.2382 | |
| 283 | I | A | 1.2520 | |
| 284 | F | A | 0.1836 | |
| 285 | N | A | -0.8613 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | N | A | -0.8760 | |
| 289 | A | A | 0.0000 | |
| 290 | G | A | -1.0547 | |
| 291 | E | A | -1.9017 | |
| 292 | I | A | -1.6636 | |
| 293 | T | A | -2.2176 | |
| 294 | E | A | -3.0683 | |
| 295 | E | A | -3.4424 | |
| 296 | D | A | -2.9136 | |
| 297 | L | A | 0.0000 | |
| 298 | L | A | -1.1785 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.4251 | |
| 301 | K | A | -1.7419 | |
| 302 | P | A | -0.8188 | |
| 303 | V | A | 0.1052 | |
| 304 | F | A | 0.1590 | |
| 305 | L | A | -0.1288 | |
| 306 | T | A | -0.6780 | |
| 307 | K | A | -1.7174 | |
| 308 | T | A | 0.0000 | |
| 309 | S | A | -0.9694 | |
| 310 | G | A | -0.7388 | |
| 311 | L | A | -0.1829 | |
| 312 | N | A | 0.0000 | |
| 313 | D | A | -0.8514 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | G | A | -0.9862 | |
| 319 | N | A | -1.1445 | |
| 320 | R | A | -1.6003 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.2259 | |
| 333 | I | A | -1.3120 | |
| 334 | A | A | -1.1814 | |
| 335 | T | A | -1.3386 | |
| 336 | N | A | -1.5225 | |
| 337 | R | A | -1.6149 | |
| 338 | T | A | -0.2388 | |
| 339 | R | A | 0.4876 | |
| 340 | I | A | 1.9117 | |
| 341 | S | A | 0.5711 | |
| 342 | T | A | -0.0003 | |
| 343 | P | A | -0.4482 | |
| 344 | P | A | -0.2642 | |
| 345 | I | A | 0.6315 | |
| 346 | N | A | 0.1555 | |
| 347 | V | A | 2.0611 | |
| 348 | F | A | 2.2212 | |
| 349 | D | A | 0.4135 | |
| 350 | P | A | 0.0325 | |
| 351 | S | A | 0.3027 | |
| 352 | N | A | 0.6077 | |
| 353 | Y | A | 0.9539 | |
| 354 | V | A | 1.4606 | |
| 355 | T | A | -0.4019 | |
| 356 | S | A | -0.8956 | |
| 357 | K | A | -1.4453 | |
| 358 | T | A | -1.5627 | |
| 359 | Y | A | 0.0000 | |
| 360 | K | A | -2.6894 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -1.0406 | |
| 363 | Y | A | 0.0000 | |
| 364 | R | A | -1.2437 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.3786 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.5447 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.5353 | |
| 376 | L | A | -0.3639 | |
| 377 | T | A | -0.8647 | |
| 378 | P | A | -1.3552 | |
| 379 | E | A | -2.3820 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -1.5461 | |
| 382 | D | A | -2.4618 | |
| 383 | L | A | -1.8735 | |
| 384 | I | A | 0.0000 | |
| 385 | R | A | -2.7383 | |
| 386 | R | A | -1.8394 | |
| 387 | R | A | 0.0000 | |
| 388 | D | A | -1.0937 | |
| 389 | P | A | -1.5624 | |
| 390 | S | A | -1.3498 | |
| 391 | I | A | -0.8910 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.0462 | |
| 394 | N | A | -1.8214 | |
| 395 | A | A | -1.3138 | |
| 396 | N | A | -1.3101 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.3891 | |
| 399 | F | A | 1.5289 | |
| 400 | I | A | 0.7710 | |
| 401 | P | A | 0.2053 | |
| 402 | P | A | -0.4848 | |
| 403 | V | A | -0.2442 | |
| 404 | E | A | -2.3117 | |
| 405 | R | A | -2.7038 | |
| 406 | P | A | -1.8560 | |
| 407 | D | A | -1.9902 | |
| 408 | P | A | -1.1075 | |
| 409 | L | A | -0.8634 | |
| 410 | A | A | -1.0192 | |
| 411 | G | A | -1.3482 | |
| 412 | K | A | -1.9737 | |
| 413 | K | A | -2.5648 | |
| 414 | F | A | -1.6506 | |
| 415 | H | A | -1.6353 | |
| 416 | E | A | -2.7269 | |
| 417 | I | A | 0.0000 | |
| 418 | D | A | -2.9474 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.7904 | |
| 421 | D | A | -2.2985 | |
| 422 | K | A | -1.8530 | |
| 423 | L | A | -0.7228 | |
| 424 | S | A | -0.8988 | |
| 425 | T | A | -0.9170 | |
| 426 | N | A | -2.4190 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.5702 | |
| 429 | K | A | -3.5524 | |
| 430 | Y | A | -2.6222 | |
| 431 | E | A | -2.6955 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -3.0428 | |
| 435 | L | A | -1.1709 | |
| 436 | Y | A | -0.6598 | |
| 437 | L | A | -0.4723 | |
| 438 | N | A | -1.6975 | |
| 439 | R | A | -1.9924 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine