Project name: 30627af6862c715

Chain sequence(s)	H: EVQLLESGGGLVQPGGSMRLSCAASGFTFSNYWMNWVRQAPGKGLEWVAQIRLKSDNYATHYADSVKGRFTISRDDSKNTVYLQMNSLRAEDTGVYYCNDGPPSGSWGQGTLLTVSS; L: DIQMTQSPSSLSASVGDRVTITCRISENIYSYLAWYQQKPGKAPKLLVYNAKILVEGVPSRFSGSGSGTDFTLTISSLQPEDFGTYYCQHHYTVPWTFGQGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:09)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:10)

• Minimal score value: -2.953
• Maximal score value: 1.6362
• Average score: -0.6166
• Total score value: -138.1186

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.7282
2	V	H	-0.5367
3	Q	H	-0.8310
4	L	H	0.0000
5	L	H	0.6565
6	E	H	0.0000
7	S	H	-0.2541
8	G	H	-0.6410
9	G	H	0.2019
11	G	H	0.8327
12	L	H	1.3462
13	V	H	0.0000
14	Q	H	-1.4154
15	P	H	-1.4393
16	G	H	-1.4551
17	G	H	-1.1797
18	S	H	-1.0855
19	M	H	-0.9150
20	R	H	-1.6870
21	L	H	0.0000
22	S	H	-0.3455
23	C	H	0.0000
24	A	H	-0.2452
25	A	H	0.0000
26	S	H	-0.7957
27	G	H	-0.9476
28	F	H	-0.4206
29	T	H	-0.4146
30	F	H	0.0000
35	S	H	-1.3576
36	N	H	-1.3106
37	Y	H	-0.1764
38	W	H	0.2556
39	M	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.5963
45	A	H	-0.9911
46	P	H	-0.7991
47	G	H	-1.4557
48	K	H	-2.3639
49	G	H	-1.5802
50	L	H	0.0000
51	E	H	-1.0189
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	Q	H	0.0000
56	I	H	0.0000
57	R	H	-0.8228
58	L	H	-1.3410
59	K	H	-2.4629
60	S	H	-1.7547
61	D	H	-1.6874
62	N	H	-2.0057
63	Y	H	-1.0787
64	A	H	-0.7444
65	T	H	-0.2627
66	H	H	-0.5396
67	Y	H	-0.9595
68	A	H	-1.3725
69	D	H	-2.5291
70	S	H	-1.7866
71	V	H	0.0000
72	K	H	-2.6425
74	G	H	-1.7087
75	R	H	-1.4320
76	F	H	0.0000
77	T	H	-0.8156
78	I	H	0.0000
79	S	H	-0.2735
80	R	H	-0.9659
81	D	H	-1.3928
82	D	H	-1.8904
83	S	H	-1.5354
84	K	H	-2.3900
85	N	H	-1.8484
86	T	H	-1.0178
87	V	H	0.0000
88	Y	H	-0.4288
89	L	H	0.0000
90	Q	H	-1.1066
91	M	H	0.0000
92	N	H	-1.3227
93	S	H	-1.2446
94	L	H	0.0000
95	R	H	-2.3098
96	A	H	-1.7204
97	E	H	-2.2254
98	D	H	0.0000
99	T	H	-0.3499
100	G	H	0.0000
101	V	H	0.8586
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	N	H	0.0000
106	D	H	0.0000
107	G	H	-0.0310
108	P	H	-0.2503
114	P	H	-0.2516
115	S	H	-0.6900
116	G	H	-0.2960
117	S	H	-0.3169
118	W	H	-0.4600
119	G	H	0.0000
120	Q	H	-1.2558
121	G	H	-0.2765
122	T	H	0.5784
123	L	H	1.6362
124	L	H	0.0000
125	T	H	0.3581
126	V	H	0.0000
127	S	H	-0.5729
128	S	H	-0.5704
1	D	L	-2.2136
2	I	L	0.0000
3	Q	L	-2.2505
4	M	L	0.0000
5	T	L	-1.3742
6	Q	L	0.0000
7	S	L	-0.7029
8	P	L	-0.5691
9	S	L	-0.8108
10	S	L	-0.9943
11	L	L	-0.7809
12	S	L	-1.1200
13	A	L	0.0000
14	S	L	-0.7230
15	V	L	0.2757
16	G	L	-0.7029
17	D	L	-1.7401
18	R	L	-2.2355
19	V	L	0.0000
20	T	L	-0.6118
21	I	L	0.0000
22	T	L	-0.7865
23	C	L	0.0000
24	R	L	-2.8776
25	I	L	0.0000
26	S	L	-2.4360
27	E	L	-2.9530
28	N	L	-1.6194
29	I	L	0.0000
36	Y	L	0.7664
37	S	L	0.2508
38	Y	L	0.8153
39	L	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.7537
44	Q	L	0.0000
45	K	L	-1.5203
46	P	L	-1.1032
47	G	L	-1.6167
48	K	L	-2.5666
49	A	L	-1.6023
50	P	L	0.0000
51	K	L	-1.3795
52	L	L	0.0000
53	L	L	0.0000
54	V	L	0.0000
55	Y	L	0.0969
56	N	L	-0.0230
57	A	L	0.0000
65	K	L	-1.2817
66	I	L	-0.0163
67	L	L	-0.0178
68	V	L	-0.7499
69	E	L	-1.7938
70	G	L	-1.2779
71	V	L	0.0000
72	P	L	-0.5777
74	S	L	-0.5729
75	R	L	-0.7133
76	F	L	0.0000
77	S	L	-0.5128
78	G	L	0.0000
79	S	L	-1.0203
80	G	L	-1.1277
83	S	L	-0.7425
84	G	L	-0.8461
85	T	L	-1.8174
86	D	L	-2.0669
87	F	L	0.0000
88	T	L	-0.9031
89	L	L	0.0000
90	T	L	0.0000
91	I	L	0.0000
92	S	L	-1.2783
93	S	L	-1.1535
94	L	L	0.0000
95	Q	L	-0.6345
96	P	L	-0.6635
97	E	L	-1.6036
98	D	L	0.0000
99	F	L	-0.1287
100	G	L	0.0000
101	T	L	-0.8791
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	H	L	0.0000
107	H	L	0.4641
108	Y	L	1.1031
109	T	L	0.3947
114	V	L	0.3349
115	P	L	-0.3426
116	W	L	-0.0828
117	T	L	-0.5814
118	F	L	-0.4568
119	G	L	0.0000
120	Q	L	-1.5501
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.4874
124	L	L	0.0000
125	E	L	-1.5435
126	I	L	-0.4323
127	K	L	-1.4939