| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIIKNGKVVVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGRGTVGHPLFNKLGDTENPTAPVHCGADDRVAFSYDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRCGPDGVPLPSAPPPSPLYVPPPPSSPYAVLPPTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPAENVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9494 | |
| 2 | L | A | 1.9730 | |
| 3 | P | A | 0.6523 | |
| 4 | P | A | 0.3478 | |
| 5 | T | A | 0.1153 | |
| 6 | T | A | 0.1423 | |
| 7 | P | A | 0.2016 | |
| 8 | V | A | 1.2137 | |
| 9 | A | A | 0.0426 | |
| 10 | K | A | -1.1338 | |
| 11 | V | A | -0.3802 | |
| 12 | Q | A | -1.5085 | |
| 13 | S | A | -1.5990 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4331 | |
| 16 | E | A | -2.4430 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4605 | |
| 20 | P | A | 0.1080 | |
| 21 | T | A | 0.1179 | |
| 22 | S | A | -0.1686 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.0996 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2686 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8741 | |
| 31 | R | A | -2.6908 | |
| 32 | L | A | -0.8344 | |
| 33 | L | A | 1.1091 | |
| 34 | T | A | 1.3815 | |
| 35 | V | A | 1.9390 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.1943 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.5740 | |
| 40 | K | A | -1.5073 | |
| 41 | D | A | -0.6708 | |
| 42 | I | A | 1.0079 | |
| 43 | I | A | 1.2698 | |
| 44 | K | A | -1.0625 | |
| 45 | N | A | -1.8756 | |
| 46 | G | A | -1.1764 | |
| 47 | K | A | -0.8608 | |
| 48 | V | A | 1.6074 | |
| 49 | V | A | 2.1450 | |
| 50 | V | A | 1.4056 | |
| 51 | P | A | 0.6051 | |
| 52 | K | A | -0.5290 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1469 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4773 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2755 | |
| 70 | K | A | -1.8181 | |
| 71 | F | A | -0.6682 | |
| 72 | A | A | -0.5774 | |
| 73 | L | A | -0.8660 | |
| 74 | P | A | -1.2616 | |
| 75 | Q | A | -2.4769 | |
| 76 | K | A | -3.0952 | |
| 77 | D | A | -2.9914 | |
| 78 | F | A | -1.6449 | |
| 79 | Y | A | -1.9222 | |
| 80 | D | A | -2.7636 | |
| 81 | P | A | -2.3526 | |
| 82 | E | A | -3.0713 | |
| 83 | K | A | -3.4403 | |
| 84 | E | A | -2.5012 | |
| 85 | R | A | -1.3161 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6484 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9708 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.4093 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7981 | |
| 99 | G | A | -0.6176 | |
| 100 | P | A | -0.5293 | |
| 101 | L | A | -0.1998 | |
| 102 | G | A | -0.7334 | |
| 103 | R | A | -1.6772 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.6666 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1500 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4026 | |
| 110 | L | A | 0.2462 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.0985 | |
| 113 | K | A | -0.2684 | |
| 114 | L | A | -0.7250 | |
| 115 | G | A | -0.7672 | |
| 116 | D | A | -1.4805 | |
| 117 | T | A | -1.2740 | |
| 118 | E | A | -2.5805 | |
| 119 | N | A | -2.4445 | |
| 120 | P | A | -1.5599 | |
| 121 | T | A | -0.7631 | |
| 122 | A | A | -0.3203 | |
| 123 | P | A | 0.3577 | |
| 124 | V | A | 0.4307 | |
| 125 | H | A | -0.0849 | |
| 126 | C | A | -0.6382 | |
| 127 | G | A | -1.1956 | |
| 128 | A | A | -1.2646 | |
| 129 | D | A | -2.1617 | |
| 130 | D | A | -1.7413 | |
| 131 | R | A | -1.1652 | |
| 132 | V | A | 0.1901 | |
| 133 | A | A | 0.4275 | |
| 134 | F | A | 0.2766 | |
| 135 | S | A | -0.0689 | |
| 136 | Y | A | 0.0000 | |
| 137 | D | A | -0.8727 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | -0.2799 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5650 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2502 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1320 | |
| 157 | D | A | 0.3299 | |
| 158 | L | A | 0.8223 | |
| 159 | A | A | 0.1672 | |
| 160 | E | A | -1.4443 | |
| 161 | P | A | -0.2040 | |
| 162 | C | A | 0.1932 | |
| 163 | P | A | -0.1556 | |
| 164 | G | A | -0.0576 | |
| 165 | L | A | 0.6238 | |
| 166 | P | A | -0.0951 | |
| 167 | P | A | -0.3316 | |
| 168 | G | A | -0.4165 | |
| 169 | A | A | 0.3023 | |
| 170 | C | A | 1.0182 | |
| 171 | P | A | 0.5339 | |
| 172 | P | A | 0.8376 | |
| 173 | I | A | 1.9554 | |
| 174 | Q | A | 0.8223 | |
| 175 | L | A | 1.4685 | |
| 176 | V | A | 0.8343 | |
| 177 | N | A | -0.3628 | |
| 178 | S | A | -0.0106 | |
| 179 | V | A | 0.3574 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3573 | |
| 182 | D | A | 0.0653 | |
| 183 | G | A | -0.1621 | |
| 184 | D | A | -0.5568 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1519 | |
| 190 | F | A | 0.0686 | |
| 191 | G | A | -0.0997 | |
| 192 | N | A | -0.2631 | |
| 193 | M | A | -0.1252 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4120 | |
| 197 | E | A | -2.6163 | |
| 198 | L | A | -1.2426 | |
| 199 | Q | A | -2.5647 | |
| 200 | Q | A | -3.3472 | |
| 201 | D | A | -3.6087 | |
| 202 | R | A | -3.3534 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2043 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3689 | |
| 211 | S | A | -1.8901 | |
| 212 | T | A | -1.4506 | |
| 213 | R | A | -2.1080 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1695 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.2719 | |
| 220 | L | A | 0.4663 | |
| 221 | K | A | -1.3844 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9893 | |
| 224 | N | A | -1.6043 | |
| 225 | E | A | -1.3503 | |
| 226 | A | A | -0.6766 | |
| 227 | Y | A | -0.4543 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7155 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1388 | |
| 234 | F | A | 0.0385 | |
| 235 | G | A | -0.8894 | |
| 236 | R | A | -2.6007 | |
| 237 | R | A | -2.8116 | |
| 238 | E | A | -2.0439 | |
| 239 | Q | A | -0.0857 | |
| 240 | V | A | 1.5528 | |
| 241 | Y | A | 1.2484 | |
| 242 | A | A | 0.1680 | |
| 243 | R | A | -1.1563 | |
| 244 | H | A | -1.2057 | |
| 245 | F | A | -0.2690 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.5886 | |
| 249 | C | A | -0.8544 | |
| 250 | G | A | -0.9244 | |
| 251 | P | A | -0.5261 | |
| 252 | D | A | -0.4065 | |
| 253 | G | A | 0.0531 | |
| 254 | V | A | 1.3124 | |
| 255 | P | A | 0.4458 | |
| 256 | L | A | 0.9659 | |
| 257 | P | A | 0.3516 | |
| 258 | S | A | -0.1321 | |
| 259 | A | A | 0.2074 | |
| 260 | P | A | -0.3006 | |
| 261 | P | A | -0.0274 | |
| 262 | P | A | 0.0596 | |
| 263 | S | A | 0.5147 | |
| 264 | P | A | 0.6764 | |
| 265 | L | A | 1.8692 | |
| 266 | Y | A | 1.7141 | |
| 267 | V | A | 1.9310 | |
| 268 | P | A | 1.1114 | |
| 269 | P | A | 0.6438 | |
| 270 | P | A | -0.1849 | |
| 271 | P | A | -0.1638 | |
| 272 | S | A | -0.3493 | |
| 273 | S | A | 0.1527 | |
| 274 | P | A | 0.4726 | |
| 275 | Y | A | 1.4397 | |
| 276 | A | A | 1.2221 | |
| 277 | V | A | 2.2363 | |
| 278 | L | A | 1.7109 | |
| 279 | P | A | 0.5801 | |
| 280 | P | A | -0.0634 | |
| 281 | T | A | -0.0836 | |
| 282 | D | A | -0.7707 | |
| 283 | Y | A | 0.7502 | |
| 284 | F | A | 0.6631 | |
| 285 | G | A | 0.1251 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.8249 | |
| 291 | L | A | 1.4938 | |
| 292 | V | A | 0.4369 | |
| 293 | S | A | -0.1692 | |
| 294 | S | A | -0.9986 | |
| 295 | D | A | -1.8767 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | -1.0492 | |
| 298 | L | A | -1.1833 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6867 | |
| 301 | R | A | -1.9253 | |
| 302 | P | A | -0.9813 | |
| 303 | F | A | -0.1854 | |
| 304 | W | A | -0.5231 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0828 | |
| 307 | R | A | -2.9315 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.6611 | |
| 310 | G | A | -1.4318 | |
| 311 | N | A | -1.4025 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8949 | |
| 319 | N | A | -0.8831 | |
| 320 | E | A | -1.0500 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.6419 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.5352 | |
| 333 | N | A | 0.2256 | |
| 334 | F | A | 1.4345 | |
| 335 | T | A | 0.7457 | |
| 336 | I | A | 0.4029 | |
| 337 | S | A | -0.9759 | |
| 338 | Q | A | -1.7359 | |
| 339 | Q | A | -1.2981 | |
| 340 | L | A | 0.6668 | |
| 341 | C | A | 0.5238 | |
| 342 | T | A | 0.2450 | |
| 343 | P | A | -0.0065 | |
| 344 | A | A | -0.4338 | |
| 345 | E | A | -1.6898 | |
| 346 | N | A | -1.0474 | |
| 347 | V | A | 1.0160 | |
| 348 | Y | A | 1.2385 | |
| 349 | D | A | 0.2352 | |
| 350 | P | A | -0.3286 | |
| 351 | S | A | -0.2744 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.7560 | |
| 354 | K | A | -1.7846 | |
| 355 | N | A | -1.7596 | |
| 356 | Y | A | -0.0978 | |
| 357 | L | A | 0.5807 | |
| 358 | R | A | 0.8938 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.2768 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.2075 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9742 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6657 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2780 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3217 | |
| 376 | L | A | -1.7495 | |
| 377 | D | A | -2.0292 | |
| 378 | P | A | -1.0624 | |
| 379 | G | A | -1.0244 | |
| 380 | V | A | -0.9327 | |
| 381 | L | A | -0.5453 | |
| 382 | A | A | -0.6655 | |
| 383 | H | A | -0.8471 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4113 | |
| 386 | T | A | -0.5790 | |
| 387 | M | A | -0.3327 | |
| 388 | N | A | -0.8696 | |
| 389 | P | A | -1.2727 | |
| 390 | T | A | -1.5233 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.5379 | |
| 393 | E | A | -2.9120 | |
| 394 | N | A | -2.6315 | |
| 395 | W | A | -1.5352 | |
| 396 | N | A | -1.2367 | |
| 397 | L | A | -0.2480 | |
| 398 | G | A | 0.5079 | |
| 399 | F | A | 2.4037 | |
| 400 | V | A | 1.8347 | |
| 401 | P | A | 0.0519 | |
| 402 | P | A | -1.9072 | |
| 403 | K | A | -3.3796 | |
| 404 | E | A | -3.8177 | |
| 405 | R | A | -4.0426 | |
| 406 | E | A | -3.8093 | |
| 407 | D | A | -2.8519 | |
| 408 | P | A | -1.7539 | |
| 409 | Y | A | -0.9863 | |
| 410 | K | A | -2.0951 | |
| 411 | G | A | -0.6332 | |
| 412 | L | A | 0.6541 | |
| 413 | I | A | 1.5647 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.4207 | |
| 416 | E | A | -1.7174 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9429 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0537 | |
| 421 | E | A | -2.7655 | |
| 422 | R | A | -2.6026 | |
| 423 | F | A | -1.2777 | |
| 424 | S | A | -1.4551 | |
| 425 | Q | A | -1.9035 | |
| 426 | D | A | -2.8970 | |
| 427 | L | A | -2.0021 | |
| 428 | D | A | -2.7894 | |
| 429 | Q | A | -2.6142 | |
| 430 | F | A | -1.4469 | |
| 431 | A | A | -0.9161 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.6412 | |
| 435 | K | A | -0.7701 | |
| 436 | F | A | 0.1220 | |
| 437 | L | A | 1.0086 | |
| 438 | Y | A | 0.8047 | |
| 439 | Q | A | -0.2809 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine