| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVVNGKVLVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTEYVVPGPDDRVSFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRSGPEGHPLPDAPPPSPLYTPPPPSSPFWKRPPTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPALNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9474 | |
| 2 | L | A | 1.9680 | |
| 3 | P | A | 0.6572 | |
| 4 | P | A | 0.3712 | |
| 5 | T | A | 0.1270 | |
| 6 | T | A | 0.1285 | |
| 7 | P | A | 0.1925 | |
| 8 | V | A | 1.2185 | |
| 9 | A | A | 0.0275 | |
| 10 | K | A | -1.1731 | |
| 11 | V | A | -0.4370 | |
| 12 | Q | A | -1.5399 | |
| 13 | S | A | -1.6146 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4303 | |
| 16 | E | A | -2.4457 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4607 | |
| 20 | P | A | 0.1320 | |
| 21 | T | A | 0.1658 | |
| 22 | S | A | -0.0929 | |
| 23 | L | A | 0.1041 | |
| 24 | F | A | -0.0118 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.1745 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.7956 | |
| 31 | R | A | -2.6341 | |
| 32 | L | A | -0.7569 | |
| 33 | L | A | 1.2333 | |
| 34 | T | A | 1.6527 | |
| 35 | V | A | 2.0023 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2703 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6626 | |
| 40 | K | A | -1.8866 | |
| 41 | D | A | -0.7573 | |
| 42 | I | A | 1.2401 | |
| 43 | V | A | 2.1997 | |
| 44 | V | A | 1.6742 | |
| 45 | N | A | -0.5149 | |
| 46 | G | A | -0.3560 | |
| 47 | K | A | -0.1243 | |
| 48 | V | A | 2.2045 | |
| 49 | L | A | 2.5336 | |
| 50 | V | A | 1.4770 | |
| 51 | P | A | 0.3580 | |
| 52 | K | A | -0.6758 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1304 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4386 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2469 | |
| 70 | K | A | -1.7898 | |
| 71 | F | A | -0.6445 | |
| 72 | A | A | -0.5966 | |
| 73 | L | A | -0.8818 | |
| 74 | P | A | -1.2728 | |
| 75 | Q | A | -2.4968 | |
| 76 | K | A | -3.1079 | |
| 77 | D | A | -2.9906 | |
| 78 | F | A | -1.6505 | |
| 79 | Y | A | -1.9178 | |
| 80 | D | A | -2.7581 | |
| 81 | P | A | -2.3521 | |
| 82 | E | A | -3.0754 | |
| 83 | K | A | -3.4335 | |
| 84 | E | A | -2.4947 | |
| 85 | R | A | -1.3151 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6344 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9595 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3148 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6767 | |
| 99 | G | A | -0.5358 | |
| 100 | P | A | -0.4331 | |
| 101 | L | A | -0.0088 | |
| 102 | G | A | -0.2720 | |
| 103 | K | A | -0.7541 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4617 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.0934 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.2886 | |
| 110 | L | A | 0.2014 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.2107 | |
| 113 | K | A | -0.5970 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | -0.5022 | |
| 116 | D | A | -1.3954 | |
| 117 | T | A | -0.9723 | |
| 118 | E | A | -1.8918 | |
| 119 | N | A | -2.2657 | |
| 120 | P | A | -1.7556 | |
| 121 | T | A | -1.4326 | |
| 122 | E | A | -1.4910 | |
| 123 | Y | A | 0.4774 | |
| 124 | V | A | 1.1451 | |
| 125 | V | A | 1.7051 | |
| 126 | P | A | 0.0605 | |
| 127 | G | A | -0.7265 | |
| 128 | P | A | -1.5088 | |
| 129 | D | A | -2.3579 | |
| 130 | D | A | -1.5426 | |
| 131 | R | A | -1.2623 | |
| 132 | V | A | 0.0593 | |
| 133 | S | A | 0.1632 | |
| 134 | F | A | 0.1439 | |
| 135 | S | A | -0.1323 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.7098 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | -0.2685 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5581 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2091 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1731 | |
| 157 | D | A | 0.3735 | |
| 158 | L | A | 0.8818 | |
| 159 | A | A | 0.2104 | |
| 160 | E | A | -1.4358 | |
| 161 | P | A | -0.2394 | |
| 162 | C | A | 0.1588 | |
| 163 | P | A | -0.1912 | |
| 164 | G | A | -0.1119 | |
| 165 | L | A | 0.5192 | |
| 166 | P | A | -0.1461 | |
| 167 | P | A | -0.3566 | |
| 168 | G | A | -0.4301 | |
| 169 | A | A | -0.0427 | |
| 170 | C | A | 0.6534 | |
| 171 | P | A | 0.5378 | |
| 172 | P | A | 0.7238 | |
| 173 | I | A | 2.0554 | |
| 174 | Q | A | 0.8827 | |
| 175 | L | A | 1.5040 | |
| 176 | V | A | 0.8572 | |
| 177 | N | A | -0.3043 | |
| 178 | S | A | 0.0484 | |
| 179 | V | A | 0.4623 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3809 | |
| 182 | D | A | 0.0812 | |
| 183 | G | A | -0.1643 | |
| 184 | D | A | -0.5528 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | -0.4733 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.0851 | |
| 190 | F | A | 0.0177 | |
| 191 | G | A | -0.1622 | |
| 192 | N | A | -0.3118 | |
| 193 | M | A | -0.1219 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3827 | |
| 197 | E | A | -2.5606 | |
| 198 | L | A | -1.1818 | |
| 199 | Q | A | -2.5327 | |
| 200 | Q | A | -3.3384 | |
| 201 | D | A | -3.5983 | |
| 202 | R | A | -3.3367 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1579 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3647 | |
| 211 | S | A | -1.8672 | |
| 212 | T | A | -1.4079 | |
| 213 | R | A | -2.0615 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.2054 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3237 | |
| 220 | L | A | 0.5471 | |
| 221 | K | A | -1.2189 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9381 | |
| 224 | N | A | -1.6646 | |
| 225 | E | A | -1.2955 | |
| 226 | A | A | -0.8126 | |
| 227 | Y | A | -0.4425 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6941 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1339 | |
| 234 | F | A | 0.0335 | |
| 235 | G | A | -0.9661 | |
| 236 | R | A | -2.7694 | |
| 237 | R | A | -3.1510 | |
| 238 | E | A | -2.2624 | |
| 239 | Q | A | -0.2379 | |
| 240 | V | A | 1.5098 | |
| 241 | Y | A | 1.2389 | |
| 242 | A | A | 0.1986 | |
| 243 | R | A | -1.1930 | |
| 244 | H | A | -0.9967 | |
| 245 | F | A | 0.0546 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.8324 | |
| 249 | S | A | -0.9718 | |
| 250 | G | A | -1.1306 | |
| 251 | P | A | -1.0291 | |
| 252 | E | A | -1.4145 | |
| 253 | G | A | -1.3005 | |
| 254 | H | A | -1.4829 | |
| 255 | P | A | -1.3513 | |
| 256 | L | A | -0.3843 | |
| 257 | P | A | -0.9109 | |
| 258 | D | A | -1.7552 | |
| 259 | A | A | -0.8976 | |
| 260 | P | A | -0.9338 | |
| 261 | P | A | -0.6202 | |
| 262 | P | A | -0.3189 | |
| 263 | S | A | -0.1951 | |
| 264 | P | A | 0.4019 | |
| 265 | L | A | 1.3261 | |
| 266 | Y | A | 0.6336 | |
| 267 | T | A | -0.0775 | |
| 268 | P | A | 0.0024 | |
| 269 | P | A | 0.1710 | |
| 270 | P | A | -0.0077 | |
| 271 | P | A | -0.1830 | |
| 272 | S | A | -0.1826 | |
| 273 | S | A | 0.2516 | |
| 274 | P | A | 0.6292 | |
| 275 | F | A | 1.4242 | |
| 276 | W | A | 0.6282 | |
| 277 | K | A | -0.7618 | |
| 278 | R | A | -0.2159 | |
| 279 | P | A | -0.0417 | |
| 280 | P | A | 0.0000 | |
| 281 | T | A | -0.5350 | |
| 282 | D | A | -1.0071 | |
| 283 | Y | A | 0.8070 | |
| 284 | F | A | 0.7085 | |
| 285 | G | A | 0.2432 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9083 | |
| 291 | L | A | 1.6087 | |
| 292 | V | A | 0.6224 | |
| 293 | S | A | -0.1520 | |
| 294 | S | A | -0.9672 | |
| 295 | D | A | -1.8403 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1739 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6288 | |
| 301 | R | A | -1.8712 | |
| 302 | P | A | -0.9649 | |
| 303 | F | A | -0.1878 | |
| 304 | W | A | -0.5188 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0799 | |
| 307 | R | A | -2.9235 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.7824 | |
| 310 | G | A | -1.4173 | |
| 311 | N | A | -1.3932 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9508 | |
| 319 | N | A | -0.8893 | |
| 320 | E | A | -1.0577 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3609 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.1812 | |
| 333 | N | A | 0.3994 | |
| 334 | F | A | 1.4204 | |
| 335 | T | A | 0.7155 | |
| 336 | I | A | 0.3829 | |
| 337 | S | A | -0.9002 | |
| 338 | Q | A | -1.5570 | |
| 339 | Q | A | -0.9336 | |
| 340 | L | A | 0.7612 | |
| 341 | C | A | 0.6987 | |
| 342 | T | A | 0.3016 | |
| 343 | P | A | -0.0583 | |
| 344 | A | A | 0.4857 | |
| 345 | L | A | 0.8846 | |
| 346 | N | A | 0.1540 | |
| 347 | V | A | 1.8725 | |
| 348 | Y | A | 1.7137 | |
| 349 | D | A | 0.2055 | |
| 350 | P | A | -0.3149 | |
| 351 | S | A | -0.2665 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.6057 | |
| 354 | K | A | -1.7519 | |
| 355 | N | A | -1.7272 | |
| 356 | Y | A | -0.1423 | |
| 357 | L | A | 0.5418 | |
| 358 | R | A | 0.8869 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.4721 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0002 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9356 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6806 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2771 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3127 | |
| 376 | L | A | -1.7362 | |
| 377 | D | A | -1.9989 | |
| 378 | P | A | -1.0475 | |
| 379 | G | A | -1.0096 | |
| 380 | V | A | -0.9195 | |
| 381 | L | A | -0.5299 | |
| 382 | A | A | -0.6532 | |
| 383 | H | A | -0.8463 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3984 | |
| 386 | T | A | -0.5783 | |
| 387 | M | A | -0.3348 | |
| 388 | N | A | -0.8709 | |
| 389 | P | A | -1.2797 | |
| 390 | T | A | -1.6110 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.5676 | |
| 393 | E | A | -3.0023 | |
| 394 | N | A | -2.7847 | |
| 395 | W | A | -1.5789 | |
| 396 | N | A | -1.2602 | |
| 397 | L | A | -0.2671 | |
| 398 | G | A | 0.4852 | |
| 399 | F | A | 2.4139 | |
| 400 | V | A | 1.8396 | |
| 401 | P | A | 0.0492 | |
| 402 | P | A | -2.0011 | |
| 403 | K | A | -3.5639 | |
| 404 | E | A | -4.1442 | |
| 405 | R | A | -4.7354 | |
| 406 | E | A | -4.1557 | |
| 407 | D | A | -3.0334 | |
| 408 | P | A | -1.8514 | |
| 409 | Y | A | -0.9744 | |
| 410 | K | A | -2.0986 | |
| 411 | G | A | -0.6386 | |
| 412 | L | A | 0.6710 | |
| 413 | I | A | 1.5836 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.4028 | |
| 416 | E | A | -1.6731 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.8486 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8785 | |
| 421 | E | A | -2.4978 | |
| 422 | R | A | -2.0675 | |
| 423 | F | A | -1.0106 | |
| 424 | S | A | -1.3092 | |
| 425 | Q | A | -1.8030 | |
| 426 | D | A | -2.8882 | |
| 427 | L | A | -1.9984 | |
| 428 | D | A | -2.7910 | |
| 429 | Q | A | -2.6190 | |
| 430 | F | A | -1.4596 | |
| 431 | A | A | -0.9201 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.6469 | |
| 435 | K | A | -0.7612 | |
| 436 | F | A | 0.1302 | |
| 437 | L | A | 1.0133 | |
| 438 | Y | A | 0.8096 | |
| 439 | Q | A | -0.2773 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine