Project name: 343ac61ee947cfc

Chain sequence(s)	H: QVQLLESGGGLVQPGGSLRLSCAASGFTFSTAAMSWVRQAPGKGLEWVSGISGSGSSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARELSYLYSGYYFDYWGQGTLVTVSS; L: QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNDVSWYQQLPGTAPKLLIYKNYNRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCSAWDQRQFDVVFGGGTKLTVL
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:35)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:36)

• Minimal score value: -3.0008
• Maximal score value: 2.4977
• Average score: -0.5133
• Total score value: -119.0854

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.4077
2	V	H	-0.7686
3	Q	H	-0.7695
4	L	H	0.0000
5	L	H	0.8326
6	E	H	0.0000
7	S	H	-0.3268
8	G	H	-0.6958
9	G	H	0.1117
10	G	H	0.6538
11	L	H	1.3772
12	V	H	-0.1092
13	Q	H	-1.4659
14	P	H	-1.8796
15	G	H	-1.5650
16	G	H	-1.0520
17	S	H	-1.2493
18	L	H	-0.7574
19	R	H	-1.8318
20	L	H	0.0000
21	S	H	-0.3854
22	C	H	0.0000
23	A	H	-0.1595
24	A	H	0.0000
25	S	H	-0.8058
26	G	H	-0.9151
27	F	H	-0.3713
28	T	H	-0.2556
29	F	H	0.0000
30	S	H	-0.6816
31	T	H	-0.2664
32	A	H	0.0000
33	A	H	-0.1640
34	M	H	0.0000
35	S	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.7686
40	A	H	-1.1427
41	P	H	-0.9983
42	G	H	-1.4581
43	K	H	-2.3708
44	G	H	-1.6246
45	L	H	0.0000
46	E	H	-1.5684
47	W	H	0.0000
48	V	H	0.0000
49	S	H	0.0000
50	G	H	0.0000
51	I	H	0.0000
52	S	H	-0.3187
53	G	H	-0.4871
54	S	H	-0.6541
55	G	H	-0.6958
56	S	H	-0.4382
57	S	H	-0.2052
58	T	H	0.0885
59	Y	H	0.2950
60	Y	H	-0.6256
61	A	H	0.0000
62	D	H	-2.6540
63	S	H	-1.9059
64	V	H	0.0000
65	K	H	-2.6724
66	G	H	-1.8859
67	R	H	-1.7415
68	F	H	0.0000
69	T	H	-0.7867
70	I	H	0.0000
71	S	H	-0.4634
72	R	H	-1.1129
73	D	H	-1.8105
74	N	H	-1.9466
75	S	H	-1.7277
76	K	H	-2.4711
77	N	H	-1.8445
78	T	H	0.0000
79	L	H	0.0000
80	Y	H	-0.5335
81	L	H	0.0000
82	Q	H	-1.1123
83	M	H	0.0000
84	N	H	-1.5246
85	S	H	-1.5023
86	L	H	0.0000
87	R	H	-3.0008
88	A	H	-2.1070
89	E	H	-2.5622
90	D	H	-1.6980
91	T	H	-0.5618
92	A	H	0.0000
93	V	H	0.8004
94	Y	H	0.0000
95	Y	H	0.0000
96	C	H	0.0000
97	A	H	0.0000
98	R	H	-0.0847
99	E	H	0.0000
100	L	H	0.5974
101	S	H	0.8833
102	Y	H	1.6000
103	L	H	2.4977
104	Y	H	2.2142
105	S	H	1.0236
106	G	H	0.0000
107	Y	H	0.9434
108	Y	H	0.0000
109	F	H	0.0000
110	D	H	-0.2952
111	Y	H	-0.1146
112	W	H	-0.2642
113	G	H	0.0000
114	Q	H	-0.7782
115	G	H	0.0000
116	T	H	0.5653
117	L	H	1.6136
118	V	H	0.0000
119	T	H	0.2699
120	V	H	0.0000
121	S	H	-0.7666
122	S	H	-0.4958
123	Q	L	-0.7890
124	S	L	-0.4968
125	V	L	0.8737
126	L	L	0.0000
127	T	L	0.0198
128	Q	L	0.0000
129	P	L	-0.6760
130	P	L	-0.9923
131	S	L	-1.1380
132	A	L	-0.7269
133	S	L	-0.5711
134	G	L	0.0000
135	T	L	-0.3744
136	P	L	-0.9245
137	G	L	-1.7106
138	Q	L	-2.4564
139	R	L	-2.7241
140	V	L	0.0000
141	T	L	-0.5979
142	I	L	0.0000
143	S	L	-0.3658
144	C	L	0.0000
145	S	L	-0.2814
146	G	L	-0.2505
147	S	L	-0.4827
148	S	L	-0.7580
149	S	L	-1.2329
150	N	L	0.0000
151	I	L	0.0000
152	G	L	-0.9043
153	S	L	-0.7426
154	N	L	0.0000
155	D	L	-0.3822
156	V	L	0.0000
157	S	L	0.0000
158	W	L	0.0000
159	Y	L	0.0000
160	Q	L	0.0000
161	Q	L	0.0000
162	L	L	-0.6176
163	P	L	-0.4079
164	G	L	-0.6332
165	T	L	-0.6547
166	A	L	-0.6918
167	P	L	0.0000
168	K	L	-1.3523
169	L	L	0.0000
170	L	L	0.0000
171	I	L	0.0000
172	Y	L	-0.4299
173	K	L	-0.7399
174	N	L	-0.5813
175	Y	L	-0.0522
176	N	L	-0.8434
177	R	L	-1.5528
178	P	L	-1.0059
179	S	L	-0.7147
180	G	L	-0.8868
181	V	L	-1.0770
182	P	L	-1.4092
183	D	L	-2.3411
184	R	L	-1.7579
185	F	L	0.0000
186	S	L	-0.7876
187	G	L	-0.3385
188	S	L	-0.5144
189	K	L	-0.9328
190	S	L	-0.8519
191	G	L	-0.9344
192	T	L	-0.7779
193	S	L	-0.7402
194	A	L	0.0000
195	S	L	-0.3728
196	L	L	0.0000
197	A	L	-0.6802
198	I	L	0.0000
199	S	L	-1.9176
200	G	L	-1.6619
201	L	L	0.0000
202	Q	L	-1.4938
203	S	L	-1.4107
204	E	L	-2.2994
205	D	L	0.0000
206	E	L	-1.8079
207	A	L	0.0000
208	D	L	-1.2220
209	Y	L	0.0000
210	Y	L	0.0000
211	C	L	0.0000
212	S	L	0.0000
213	A	L	0.0000
214	W	L	0.0000
215	D	L	0.0000
216	Q	L	-1.7412
217	R	L	-2.3237
218	Q	L	-1.3470
219	F	L	0.6832
220	D	L	-0.1802
221	V	L	0.0000
222	V	L	0.2687
223	F	L	0.0000
224	G	L	0.0000
225	G	L	-1.0372
226	G	L	-1.1592
227	T	L	0.0000
228	K	L	-2.1733
229	L	L	0.0000
230	T	L	-0.7158
231	V	L	-0.2249
232	L	L	1.3405