Project name: 345f022b6e7844b

Chain sequence(s)	H: EVQLVQSGAEVKKPGASVKVSCKASGYRFTNYWIHWVRQAPGQGLEWIGGINPGNNYATYRRKFQGRVTMTADTSTSTVYMELSSLRSEDTAVYYCTREGYGNYGAWFAYWGQGTLVTVSS; L: DVQVTQSPSSLSASVGDRVTITCRSSQSLANSYGNTFLSWYLHKPGKAPQLLIYGISNRFSGVPDRFSGSGSGTDFTLTISSLQPEDFATYYCLQGTHQPYTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:33)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:35)

• Minimal score value: -3.4334
• Maximal score value: 1.039
• Average score: -0.632
• Total score value: -147.2636

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.9807
2	V	H	-1.1119
3	Q	H	-0.8721
4	L	H	0.0000
5	V	H	0.7538
6	Q	H	0.0000
7	S	H	-0.3962
8	G	H	-0.4075
9	A	H	0.2928
11	E	H	0.1227
12	V	H	0.9998
13	K	H	-0.9750
14	K	H	-2.1954
15	P	H	-2.3068
16	G	H	-1.6110
17	A	H	-1.2624
18	S	H	-1.4363
19	V	H	0.0000
20	K	H	-2.0868
21	V	H	0.0000
22	S	H	-0.4505
23	C	H	0.0000
24	K	H	-0.5530
25	A	H	0.0000
26	S	H	-1.0129
27	G	H	-1.4496
28	Y	H	-1.4176
29	R	H	-2.1801
30	F	H	0.0000
35	T	H	-1.5886
36	N	H	-1.5385
37	Y	H	-0.4152
38	W	H	0.3073
39	I	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.5457
45	A	H	-0.9273
46	P	H	-1.0424
47	G	H	-1.2284
48	Q	H	-1.8705
49	G	H	-1.3762
50	L	H	0.0000
51	E	H	-0.8039
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	G	H	0.0000
56	I	H	0.0000
57	N	H	-0.5488
58	P	H	0.0000
59	G	H	-1.5885
62	N	H	-1.5994
63	N	H	-0.9337
64	Y	H	0.4586
65	A	H	0.3066
66	T	H	-0.3134
67	Y	H	-1.2302
68	R	H	-2.2610
69	R	H	-3.4334
70	K	H	-3.0617
71	F	H	0.0000
72	Q	H	-2.7098
74	G	H	-1.7464
75	R	H	-1.6269
76	V	H	0.0000
77	T	H	-0.8108
78	M	H	0.0000
79	T	H	-0.1945
80	A	H	0.0000
81	D	H	-0.8544
82	T	H	-0.9379
83	S	H	-0.4412
84	T	H	-0.5293
85	S	H	-0.8210
86	T	H	0.0000
87	V	H	0.0000
88	Y	H	-0.4769
89	M	H	0.0000
90	E	H	-1.5629
91	L	H	0.0000
92	S	H	-1.1788
93	S	H	-1.2454
94	L	H	0.0000
95	R	H	-3.1365
96	S	H	-2.3401
97	E	H	-2.4922
98	D	H	0.0000
99	T	H	-0.6711
100	A	H	0.0000
101	V	H	0.6357
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	T	H	0.0000
106	R	H	0.0000
107	E	H	0.0000
108	G	H	0.5018
109	Y	H	0.7175
110	G	H	-0.2108
111	N	H	-0.7620
112A	Y	H	0.1085
112	G	H	0.0000
113	A	H	0.2473
114	W	H	0.0000
115	F	H	0.0000
116	A	H	0.3397
117	Y	H	0.2627
118	W	H	-0.0621
119	G	H	0.0000
120	Q	H	-1.1148
121	G	H	-0.3612
122	T	H	0.0000
123	L	H	1.0390
124	V	H	0.0000
125	T	H	-0.0547
126	V	H	0.0000
127	S	H	-0.9495
128	S	H	-1.0408
1	D	L	-2.7976
2	V	L	0.0000
3	Q	L	-2.3883
4	V	L	0.0000
5	T	L	-1.4443
6	Q	L	0.0000
7	S	L	-0.9186
8	P	L	-0.6876
9	S	L	-0.9786
10	S	L	-1.0584
11	L	L	-0.7678
12	S	L	-0.7376
13	A	L	-0.8876
14	S	L	-0.8097
15	V	L	0.0183
16	G	L	-0.9108
17	D	L	-1.9236
18	R	L	-2.3740
19	V	L	0.0000
20	T	L	-0.6615
21	I	L	0.0000
22	T	L	-0.7370
23	C	L	0.0000
24	R	L	-2.6252
25	S	L	0.0000
26	S	L	-1.9890
27	Q	L	-2.2237
28	S	L	-1.2775
29	L	L	0.0000
30	A	L	-0.5224
31	N	L	-0.3853
32	S	L	0.0074
34	Y	L	0.7349
35	G	L	-0.2070
36	N	L	-0.2066
37	T	L	0.0000
38	F	L	0.1135
39	L	L	0.0000
40	S	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	L	L	0.0000
44	H	L	-0.9513
45	K	L	-1.3301
46	P	L	-1.0419
47	G	L	-1.6363
48	K	L	-2.4412
49	A	L	-1.4574
50	P	L	0.0000
51	Q	L	-0.8671
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.1251
56	G	L	-0.0419
57	I	L	-0.1585
65	S	L	-0.4932
66	N	L	-0.5661
67	R	L	-1.2338
68	F	L	-0.5938
69	S	L	-0.5087
70	G	L	-0.8654
71	V	L	0.0000
72	P	L	-1.3334
74	D	L	-2.1995
75	R	L	-1.6788
76	F	L	0.0000
77	S	L	-0.8895
78	G	L	0.0000
79	S	L	-0.5098
80	G	L	-0.8163
83	S	L	-0.8302
84	G	L	-1.0109
85	T	L	-1.4973
86	D	L	-1.7511
87	F	L	0.0000
88	T	L	-0.5861
89	L	L	0.0000
90	T	L	-0.6201
91	I	L	0.0000
92	S	L	-1.7373
93	S	L	-1.3263
94	L	L	0.0000
95	Q	L	-0.9525
96	P	L	-1.0723
97	E	L	-1.7057
98	D	L	0.0000
99	F	L	-0.3743
100	A	L	0.0000
101	T	L	-0.8988
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	L	L	0.0000
106	Q	L	0.0000
107	G	L	-0.4073
108	T	L	0.0000
109	H	L	-1.4895
114	Q	L	-1.7379
115	P	L	0.0000
116	Y	L	0.0000
117	T	L	-1.0668
118	F	L	0.0000
119	G	L	0.0000
120	Q	L	-1.8316
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.7485
124	V	L	0.0000
125	E	L	-1.1798
126	I	L	-0.6890
127	K	L	-1.3650