Chain sequence(s) |
A: MGSSHHHHHHSSGENLYFQGAMAVERNSGDLQLPQEIAMLVPNKTQVVPKSGGEGKVKDIFASPALVRAGGVMIAFVEGRTKNKLFPEVIDLSSSDIVAGYIKAPETWQSLVAEVTKEYWQAHTVLESANNSNHRVGVARLPTGITRGNKVFLLVGSYEERREIDDYIWKAEAWNIKVIEGEATQSTEVQPTQPINWSEPKPLFQTDSPNNKGDLKEFLGGGGSGIVMGNGTLVFPLTAKDESNKVFSLITYSTDDGQKWEIPGGVSSVACRSPRVTEWEEGTLLMVTYCEDGRKVFESRDMGKTWTEARGTLPGVWLKSGPELPEVSLRVDALITATIEGRKVMLYTQKVRHFREVDEPNALHLWVTDNNRTFHLGPFSVDSAENKTFANTLLYSDDALHLLQAKGDHESTAVSLARLTEELNTI
input PDB |
Selected Chain(s) | A |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | No |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:00) [INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00) [INFO] runJob: Creating pdb object from: input.pdb (00:00:00) [INFO] FoldX: Starting FoldX energy minimalization (00:00:00) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:06:14) [INFO] Main: Simulation completed successfully. (00:06:16) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | M | A | 0.7572 | |
2 | G | A | -0.2285 | |
3 | S | A | -0.6533 | |
4 | S | A | -1.1468 | |
5 | H | A | -2.0673 | |
6 | H | A | -2.3670 | |
7 | H | A | -2.6057 | |
8 | H | A | -2.5838 | |
9 | H | A | -2.3971 | |
10 | H | A | -1.9832 | |
11 | S | A | -1.4768 | |
12 | S | A | -1.2537 | |
13 | G | A | -1.6676 | |
14 | E | A | -2.1972 | |
15 | N | A | -0.9640 | |
16 | L | A | 1.4106 | |
17 | Y | A | 2.0861 | |
18 | F | A | 2.1575 | |
19 | Q | A | 0.0376 | |
20 | G | A | -0.1273 | |
21 | A | A | 0.5238 | |
22 | M | A | 1.1760 | |
23 | A | A | 0.7295 | |
24 | V | A | 0.3540 | |
25 | E | A | -2.0167 | |
26 | R | A | -2.8860 | |
27 | N | A | -2.8341 | |
28 | S | A | -2.2524 | |
29 | G | A | -2.1928 | |
30 | D | A | -2.2956 | |
31 | L | A | -1.4535 | |
32 | Q | A | -1.5512 | |
33 | L | A | -0.4663 | |
34 | P | A | -1.3429 | |
35 | Q | A | -2.3021 | |
36 | E | A | -2.1737 | |
37 | I | A | -0.8100 | |
38 | A | A | -0.0446 | |
39 | M | A | 0.0000 | |
40 | L | A | 0.0000 | |
41 | V | A | -0.2580 | |
42 | P | A | -1.1554 | |
43 | N | A | -2.1106 | |
44 | K | A | -2.3330 | |
45 | T | A | 0.0000 | |
46 | Q | A | -1.8312 | |
47 | V | A | 0.0000 | |
48 | V | A | -1.6128 | |
49 | P | A | -2.0598 | |
50 | K | A | -2.2251 | |
51 | S | A | -1.5997 | |
52 | G | A | -1.6063 | |
53 | G | A | -2.0159 | |
54 | E | A | -2.6517 | |
55 | G | A | -2.2314 | |
56 | K | A | -2.2598 | |
57 | V | A | -1.0037 | |
58 | K | A | 0.0000 | |
59 | D | A | -1.2310 | |
60 | I | A | 0.0000 | |
61 | F | A | 0.0000 | |
62 | A | A | 0.0064 | |
63 | S | A | 0.0495 | |
64 | P | A | 0.0000 | |
65 | A | A | 0.0000 | |
66 | L | A | 0.0000 | |
67 | V | A | 0.0000 | |
68 | R | A | -0.9800 | |
69 | A | A | 0.0000 | |
70 | G | A | -1.5996 | |
71 | G | A | -1.3083 | |
72 | V | A | 0.0000 | |
73 | M | A | 0.0000 | |
74 | I | A | 0.0000 | |
75 | A | A | 0.0000 | |
76 | F | A | 0.0000 | |
77 | V | A | 0.0000 | |
78 | E | A | 0.0000 | |
79 | G | A | 0.0000 | |
80 | R | A | 0.0000 | |
81 | T | A | -0.9248 | |
82 | K | A | -1.4774 | |
83 | N | A | -1.5717 | |
84 | K | A | -1.9099 | |
85 | L | A | -0.6817 | |
86 | F | A | 0.0000 | |
87 | P | A | -1.2172 | |
88 | E | A | -1.4519 | |
89 | V | A | 0.0660 | |
90 | I | A | 0.4685 | |
91 | D | A | -1.5397 | |
92 | L | A | 0.0000 | |
93 | S | A | 0.0000 | |
94 | S | A | 0.0000 | |
95 | S | A | 0.0000 | |
96 | D | A | -0.7607 | |
97 | I | A | 0.0000 | |
98 | V | A | 0.0000 | |
99 | A | A | 0.0000 | |
100 | G | A | 0.0000 | |
101 | Y | A | 0.0000 | |
102 | I | A | 0.0000 | |
103 | K | A | -0.9914 | |
104 | A | A | -0.9669 | |
105 | P | A | -1.3081 | |
106 | E | A | -2.3672 | |
107 | T | A | -1.3105 | |
108 | W | A | 0.0000 | |
109 | Q | A | -1.4070 | |
110 | S | A | -1.1097 | |
111 | L | A | 0.0000 | |
112 | V | A | -0.5415 | |
113 | A | A | -0.8722 | |
114 | E | A | -0.9831 | |
115 | V | A | 0.0000 | |
116 | T | A | -1.1011 | |
117 | K | A | -2.2083 | |
118 | E | A | -2.0556 | |
119 | Y | A | -0.3405 | |
120 | W | A | -0.8036 | |
121 | Q | A | -1.0251 | |
122 | A | A | 0.0000 | |
123 | H | A | -1.0032 | |
124 | T | A | 0.0000 | |
125 | V | A | 0.0000 | |
126 | L | A | 0.0000 | |
127 | E | A | -1.8947 | |
128 | S | A | -1.3179 | |
129 | A | A | -1.4112 | |
130 | N | A | -2.5118 | |
131 | N | A | -2.6150 | |
132 | S | A | -2.2421 | |
133 | N | A | -2.3513 | |
134 | H | A | -1.9600 | |
135 | R | A | -2.8054 | |
136 | V | A | 0.0000 | |
137 | G | A | 0.0000 | |
138 | V | A | 0.0000 | |
139 | A | A | 0.0000 | |
140 | R | A | -0.2306 | |
141 | L | A | 0.0707 | |
142 | P | A | 0.0000 | |
143 | T | A | 0.0000 | |
144 | G | A | 0.0000 | |
145 | I | A | 0.0000 | |
146 | T | A | -1.2737 | |
147 | R | A | -2.2197 | |
148 | G | A | -1.9207 | |
149 | N | A | -2.3549 | |
150 | K | A | -2.9331 | |
151 | V | A | 0.0000 | |
152 | F | A | 0.0000 | |
153 | L | A | 0.0000 | |
154 | L | A | 0.0000 | |
155 | V | A | 0.0000 | |
156 | G | A | 0.0000 | |
157 | S | A | -0.7974 | |
158 | Y | A | -1.1024 | |
159 | E | A | -2.1398 | |
160 | E | A | -2.2922 | |
161 | R | A | -2.5200 | |
162 | R | A | -1.5122 | |
163 | E | A | -1.2294 | |
164 | I | A | 0.4441 | |
165 | D | A | -1.4967 | |
166 | D | A | -1.4589 | |
167 | Y | A | 0.4963 | |
168 | I | A | 0.1579 | |
169 | W | A | -0.8293 | |
170 | K | A | -2.1167 | |
171 | A | A | -1.8987 | |
172 | E | A | -2.6100 | |
173 | A | A | -1.5523 | |
174 | W | A | -1.2117 | |
175 | N | A | -1.7306 | |
176 | I | A | 0.0000 | |
177 | K | A | -1.3678 | |
178 | V | A | 0.0000 | |
179 | I | A | 0.0000 | |
180 | E | A | -2.1576 | |
181 | G | A | 0.0000 | |
182 | E | A | -3.1613 | |
183 | A | A | 0.0000 | |
184 | T | A | -1.7016 | |
185 | Q | A | -1.8522 | |
186 | S | A | -1.2827 | |
187 | T | A | -1.0081 | |
188 | E | A | -1.6143 | |
189 | V | A | 0.2822 | |
190 | Q | A | -1.1132 | |
191 | P | A | -1.1255 | |
192 | T | A | -0.7591 | |
193 | Q | A | -1.0219 | |
194 | P | A | 0.0000 | |
195 | I | A | 0.0000 | |
196 | N | A | -2.1226 | |
197 | W | A | -1.8994 | |
198 | S | A | -1.9496 | |
199 | E | A | -2.4543 | |
200 | P | A | -1.9937 | |
201 | K | A | -2.5167 | |
202 | P | A | -1.7448 | |
203 | L | A | 0.0000 | |
204 | F | A | -1.8007 | |
205 | Q | A | -1.9994 | |
206 | T | A | -1.5672 | |
207 | D | A | -2.4283 | |
208 | S | A | -2.4747 | |
209 | P | A | -1.9683 | |
210 | N | A | -2.6365 | |
211 | N | A | -2.5999 | |
212 | K | A | -3.0564 | |
213 | G | A | -2.9102 | |
214 | D | A | -3.6332 | |
215 | L | A | -2.7256 | |
216 | K | A | -3.0021 | |
217 | E | A | -2.1073 | |
218 | F | A | 0.0000 | |
219 | L | A | 0.0000 | |
220 | G | A | 0.0000 | |
221 | G | A | 0.0000 | |
222 | G | A | 0.0000 | |
223 | G | A | 0.0000 | |
224 | S | A | 0.0616 | |
225 | G | A | 0.0000 | |
226 | I | A | 0.2992 | |
227 | V | A | 0.1007 | |
228 | M | A | 0.0000 | |
229 | G | A | -1.6000 | |
230 | N | A | -1.7147 | |
231 | G | A | -1.1695 | |
232 | T | A | 0.0000 | |
233 | L | A | 0.0000 | |
234 | V | A | 0.0000 | |
235 | F | A | 0.0000 | |
236 | P | A | 0.0000 | |
237 | L | A | 0.0000 | |
238 | T | A | 0.0000 | |
239 | A | A | 0.0000 | |
240 | K | A | -1.8204 | |
241 | D | A | 0.0000 | |
242 | E | A | -3.4332 | |
243 | S | A | -2.4451 | |
244 | N | A | -2.8411 | |
245 | K | A | -1.9071 | |
246 | V | A | 0.0000 | |
247 | F | A | -0.0344 | |
248 | S | A | 0.0000 | |
249 | L | A | 0.0000 | |
250 | I | A | 0.0000 | |
251 | T | A | 0.0000 | |
252 | Y | A | -0.7974 | |
253 | S | A | 0.0000 | |
254 | T | A | -1.6950 | |
255 | D | A | -2.1370 | |
256 | D | A | -2.9493 | |
257 | G | A | 0.0000 | |
258 | Q | A | -2.7713 | |
259 | K | A | -3.1765 | |
260 | W | A | -2.2301 | |
261 | E | A | -2.1648 | |
262 | I | A | 0.0000 | |
263 | P | A | 0.0000 | |
264 | G | A | -1.6631 | |
265 | G | A | 0.0000 | |
266 | V | A | 0.4787 | |
267 | S | A | 0.0000 | |
268 | S | A | 0.0076 | |
269 | V | A | 0.6667 | |
270 | A | A | -0.8258 | |
271 | C | A | 0.0000 | |
272 | R | A | -1.6125 | |
273 | S | A | -0.8162 | |
274 | P | A | 0.0000 | |
275 | R | A | -0.3574 | |
276 | V | A | 0.0000 | |
277 | T | A | 0.0000 | |
278 | E | A | -1.2202 | |
279 | W | A | 0.0000 | |
280 | E | A | -3.1945 | |
281 | E | A | -3.3353 | |
282 | G | A | -2.4072 | |
283 | T | A | -2.0098 | |
284 | L | A | 0.0000 | |
285 | L | A | 0.0000 | |
286 | M | A | 0.0000 | |
287 | V | A | 0.0000 | |
288 | T | A | 0.0000 | |
289 | Y | A | -1.4718 | |
290 | C | A | 0.0000 | |
291 | E | A | -3.1891 | |
292 | D | A | -3.1836 | |
293 | G | A | 0.0000 | |
294 | R | A | 0.0000 | |
295 | K | A | -1.4920 | |
296 | V | A | 0.0000 | |
297 | F | A | 0.0000 | |
298 | E | A | -1.3553 | |
299 | S | A | 0.0000 | |
300 | R | A | -2.5370 | |
301 | D | A | -1.7300 | |
302 | M | A | -1.0643 | |
303 | G | A | 0.0000 | |
304 | K | A | -2.0516 | |
305 | T | A | -1.1796 | |
306 | W | A | -0.9151 | |
307 | T | A | -1.1500 | |
308 | E | A | -2.1455 | |
309 | A | A | -1.8971 | |
310 | R | A | -2.5666 | |
311 | G | A | -1.7762 | |
312 | T | A | -1.3934 | |
313 | L | A | 0.0000 | |
314 | P | A | -1.1553 | |
315 | G | A | -0.2979 | |
316 | V | A | 0.0000 | |
317 | W | A | -0.5219 | |
318 | L | A | -0.7627 | |
319 | K | A | -2.2893 | |
320 | S | A | -2.3995 | |
321 | G | A | -1.7772 | |
322 | P | A | -1.2486 | |
323 | E | A | -2.1789 | |
324 | L | A | -1.4595 | |
325 | P | A | -1.2221 | |
326 | E | A | -1.8918 | |
327 | V | A | 0.1358 | |
328 | S | A | 0.0000 | |
329 | L | A | 0.0000 | |
330 | R | A | -0.5309 | |
331 | V | A | 0.0000 | |
332 | D | A | 0.0000 | |
333 | A | A | 0.0000 | |
334 | L | A | 0.0000 | |
335 | I | A | 0.2431 | |
336 | T | A | -0.1451 | |
337 | A | A | 0.0000 | |
338 | T | A | -1.9196 | |
339 | I | A | 0.0000 | |
340 | E | A | -2.9050 | |
341 | G | A | -2.5179 | |
342 | R | A | -3.1781 | |
343 | K | A | -2.6276 | |
344 | V | A | 0.0000 | |
345 | M | A | 0.0000 | |
346 | L | A | 0.0000 | |
347 | Y | A | 0.0000 | |
348 | T | A | 0.0000 | |
349 | Q | A | 0.0000 | |
350 | K | A | 0.0000 | |
351 | V | A | 0.0722 | |
352 | R | A | -0.8776 | |
353 | H | A | -1.3026 | |
354 | F | A | 0.0392 | |
355 | R | A | -1.9635 | |
356 | E | A | -2.0119 | |
357 | V | A | -0.1657 | |
358 | D | A | -2.0776 | |
359 | E | A | -2.0646 | |
360 | P | A | -1.1958 | |
361 | N | A | -0.6924 | |
362 | A | A | -0.2031 | |
363 | L | A | 0.0000 | |
364 | H | A | 0.0000 | |
365 | L | A | 0.0000 | |
366 | W | A | 0.1096 | |
367 | V | A | 0.0000 | |
368 | T | A | 0.0000 | |
369 | D | A | -1.7174 | |
370 | N | A | -1.7161 | |
371 | N | A | -2.4568 | |
372 | R | A | -2.4221 | |
373 | T | A | -1.0310 | |
374 | F | A | 0.3194 | |
375 | H | A | -0.1618 | |
376 | L | A | -0.4113 | |
377 | G | A | -0.6818 | |
378 | P | A | -0.2383 | |
379 | F | A | 0.0000 | |
380 | S | A | 0.0000 | |
381 | V | A | 0.5088 | |
382 | D | A | 0.0000 | |
383 | S | A | -1.3868 | |
384 | A | A | -1.5626 | |
385 | E | A | -2.6978 | |
386 | N | A | -2.2304 | |
387 | K | A | -1.7849 | |
388 | T | A | 0.0000 | |
389 | F | A | -0.0477 | |
390 | A | A | 0.1458 | |
391 | N | A | 0.0000 | |
392 | T | A | 0.0000 | |
393 | L | A | 0.0000 | |
394 | L | A | 0.0156 | |
395 | Y | A | -0.4710 | |
396 | S | A | -1.3720 | |
397 | D | A | -2.8971 | |
398 | D | A | -2.8203 | |
399 | A | A | -1.6182 | |
400 | L | A | 0.0000 | |
401 | H | A | 0.0000 | |
402 | L | A | 0.0000 | |
403 | L | A | 0.0000 | |
404 | Q | A | 0.0000 | |
405 | A | A | 0.0000 | |
406 | K | A | -1.1302 | |
407 | G | A | 0.0000 | |
408 | D | A | -2.7887 | |
409 | H | A | -2.7219 | |
410 | E | A | -2.8169 | |
411 | S | A | -2.0508 | |
412 | T | A | 0.0000 | |
413 | A | A | -0.1893 | |
414 | V | A | 0.0000 | |
415 | S | A | 0.0000 | |
416 | L | A | 0.0000 | |
417 | A | A | 0.0000 | |
418 | R | A | -1.4773 | |
419 | L | A | 0.0000 | |
420 | T | A | -1.7209 | |
421 | E | A | -2.3782 | |
422 | E | A | 0.0000 | |
423 | L | A | -1.1578 | |
424 | N | A | -1.6953 | |
425 | T | A | -0.8259 | |
426 | I | A | -0.2570 |