| Chain sequence(s) |
A: MGSSHHHHHHSSGENLYFQGAMAVERNSGDLQLPQEIAMLVPNKTQVVPKSGGEGKVKDIFASPALVRAGGVMIAFVEGRTKNKLFPEVIDLSSSDIVAGYIKAPETWQSLVAEVTKEYWQAHTVLESANNSNHRVGVARLPTGITRGNKVFLLVGSYEERREIDDYIWKAEAWNIKVIEGEATQSTEVQPTQPINWSEPKPLFQTDSPNNKGDLKEFLGGGGSGIVMGNGTLVFPLTAKDESNKVFSLITYSTDDGQKWEIPGGVSSVACRSPRVTEWEEGTLLMVTYCEDGRKVFESRDMGKTWTEARGTLPGVWLKSGPELPEVSLRVDALITATIEGRKVMLYTQKVRHFREVDEPNALHLWVTDNNRTFHLGPFSVDSAENKTFANTLLYSDDALHLLQAKGDHESTAVSLARLTEELNTI
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:06:14)
[INFO] Main: Simulation completed successfully. (00:06:16)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 0.7572 | |
| 2 | G | A | -0.2285 | |
| 3 | S | A | -0.6533 | |
| 4 | S | A | -1.1468 | |
| 5 | H | A | -2.0673 | |
| 6 | H | A | -2.3670 | |
| 7 | H | A | -2.6057 | |
| 8 | H | A | -2.5838 | |
| 9 | H | A | -2.3971 | |
| 10 | H | A | -1.9832 | |
| 11 | S | A | -1.4768 | |
| 12 | S | A | -1.2537 | |
| 13 | G | A | -1.6676 | |
| 14 | E | A | -2.1972 | |
| 15 | N | A | -0.9640 | |
| 16 | L | A | 1.4106 | |
| 17 | Y | A | 2.0861 | |
| 18 | F | A | 2.1575 | |
| 19 | Q | A | 0.0376 | |
| 20 | G | A | -0.1273 | |
| 21 | A | A | 0.5238 | |
| 22 | M | A | 1.1760 | |
| 23 | A | A | 0.7295 | |
| 24 | V | A | 0.3540 | |
| 25 | E | A | -2.0167 | |
| 26 | R | A | -2.8860 | |
| 27 | N | A | -2.8341 | |
| 28 | S | A | -2.2524 | |
| 29 | G | A | -2.1928 | |
| 30 | D | A | -2.2956 | |
| 31 | L | A | -1.4535 | |
| 32 | Q | A | -1.5512 | |
| 33 | L | A | -0.4663 | |
| 34 | P | A | -1.3429 | |
| 35 | Q | A | -2.3021 | |
| 36 | E | A | -2.1737 | |
| 37 | I | A | -0.8100 | |
| 38 | A | A | -0.0446 | |
| 39 | M | A | 0.0000 | |
| 40 | L | A | 0.0000 | |
| 41 | V | A | -0.2580 | |
| 42 | P | A | -1.1554 | |
| 43 | N | A | -2.1106 | |
| 44 | K | A | -2.3330 | |
| 45 | T | A | 0.0000 | |
| 46 | Q | A | -1.8312 | |
| 47 | V | A | 0.0000 | |
| 48 | V | A | -1.6128 | |
| 49 | P | A | -2.0598 | |
| 50 | K | A | -2.2251 | |
| 51 | S | A | -1.5997 | |
| 52 | G | A | -1.6063 | |
| 53 | G | A | -2.0159 | |
| 54 | E | A | -2.6517 | |
| 55 | G | A | -2.2314 | |
| 56 | K | A | -2.2598 | |
| 57 | V | A | -1.0037 | |
| 58 | K | A | 0.0000 | |
| 59 | D | A | -1.2310 | |
| 60 | I | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | A | A | 0.0064 | |
| 63 | S | A | 0.0495 | |
| 64 | P | A | 0.0000 | |
| 65 | A | A | 0.0000 | |
| 66 | L | A | 0.0000 | |
| 67 | V | A | 0.0000 | |
| 68 | R | A | -0.9800 | |
| 69 | A | A | 0.0000 | |
| 70 | G | A | -1.5996 | |
| 71 | G | A | -1.3083 | |
| 72 | V | A | 0.0000 | |
| 73 | M | A | 0.0000 | |
| 74 | I | A | 0.0000 | |
| 75 | A | A | 0.0000 | |
| 76 | F | A | 0.0000 | |
| 77 | V | A | 0.0000 | |
| 78 | E | A | 0.0000 | |
| 79 | G | A | 0.0000 | |
| 80 | R | A | 0.0000 | |
| 81 | T | A | -0.9248 | |
| 82 | K | A | -1.4774 | |
| 83 | N | A | -1.5717 | |
| 84 | K | A | -1.9099 | |
| 85 | L | A | -0.6817 | |
| 86 | F | A | 0.0000 | |
| 87 | P | A | -1.2172 | |
| 88 | E | A | -1.4519 | |
| 89 | V | A | 0.0660 | |
| 90 | I | A | 0.4685 | |
| 91 | D | A | -1.5397 | |
| 92 | L | A | 0.0000 | |
| 93 | S | A | 0.0000 | |
| 94 | S | A | 0.0000 | |
| 95 | S | A | 0.0000 | |
| 96 | D | A | -0.7607 | |
| 97 | I | A | 0.0000 | |
| 98 | V | A | 0.0000 | |
| 99 | A | A | 0.0000 | |
| 100 | G | A | 0.0000 | |
| 101 | Y | A | 0.0000 | |
| 102 | I | A | 0.0000 | |
| 103 | K | A | -0.9914 | |
| 104 | A | A | -0.9669 | |
| 105 | P | A | -1.3081 | |
| 106 | E | A | -2.3672 | |
| 107 | T | A | -1.3105 | |
| 108 | W | A | 0.0000 | |
| 109 | Q | A | -1.4070 | |
| 110 | S | A | -1.1097 | |
| 111 | L | A | 0.0000 | |
| 112 | V | A | -0.5415 | |
| 113 | A | A | -0.8722 | |
| 114 | E | A | -0.9831 | |
| 115 | V | A | 0.0000 | |
| 116 | T | A | -1.1011 | |
| 117 | K | A | -2.2083 | |
| 118 | E | A | -2.0556 | |
| 119 | Y | A | -0.3405 | |
| 120 | W | A | -0.8036 | |
| 121 | Q | A | -1.0251 | |
| 122 | A | A | 0.0000 | |
| 123 | H | A | -1.0032 | |
| 124 | T | A | 0.0000 | |
| 125 | V | A | 0.0000 | |
| 126 | L | A | 0.0000 | |
| 127 | E | A | -1.8947 | |
| 128 | S | A | -1.3179 | |
| 129 | A | A | -1.4112 | |
| 130 | N | A | -2.5118 | |
| 131 | N | A | -2.6150 | |
| 132 | S | A | -2.2421 | |
| 133 | N | A | -2.3513 | |
| 134 | H | A | -1.9600 | |
| 135 | R | A | -2.8054 | |
| 136 | V | A | 0.0000 | |
| 137 | G | A | 0.0000 | |
| 138 | V | A | 0.0000 | |
| 139 | A | A | 0.0000 | |
| 140 | R | A | -0.2306 | |
| 141 | L | A | 0.0707 | |
| 142 | P | A | 0.0000 | |
| 143 | T | A | 0.0000 | |
| 144 | G | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | T | A | -1.2737 | |
| 147 | R | A | -2.2197 | |
| 148 | G | A | -1.9207 | |
| 149 | N | A | -2.3549 | |
| 150 | K | A | -2.9331 | |
| 151 | V | A | 0.0000 | |
| 152 | F | A | 0.0000 | |
| 153 | L | A | 0.0000 | |
| 154 | L | A | 0.0000 | |
| 155 | V | A | 0.0000 | |
| 156 | G | A | 0.0000 | |
| 157 | S | A | -0.7974 | |
| 158 | Y | A | -1.1024 | |
| 159 | E | A | -2.1398 | |
| 160 | E | A | -2.2922 | |
| 161 | R | A | -2.5200 | |
| 162 | R | A | -1.5122 | |
| 163 | E | A | -1.2294 | |
| 164 | I | A | 0.4441 | |
| 165 | D | A | -1.4967 | |
| 166 | D | A | -1.4589 | |
| 167 | Y | A | 0.4963 | |
| 168 | I | A | 0.1579 | |
| 169 | W | A | -0.8293 | |
| 170 | K | A | -2.1167 | |
| 171 | A | A | -1.8987 | |
| 172 | E | A | -2.6100 | |
| 173 | A | A | -1.5523 | |
| 174 | W | A | -1.2117 | |
| 175 | N | A | -1.7306 | |
| 176 | I | A | 0.0000 | |
| 177 | K | A | -1.3678 | |
| 178 | V | A | 0.0000 | |
| 179 | I | A | 0.0000 | |
| 180 | E | A | -2.1576 | |
| 181 | G | A | 0.0000 | |
| 182 | E | A | -3.1613 | |
| 183 | A | A | 0.0000 | |
| 184 | T | A | -1.7016 | |
| 185 | Q | A | -1.8522 | |
| 186 | S | A | -1.2827 | |
| 187 | T | A | -1.0081 | |
| 188 | E | A | -1.6143 | |
| 189 | V | A | 0.2822 | |
| 190 | Q | A | -1.1132 | |
| 191 | P | A | -1.1255 | |
| 192 | T | A | -0.7591 | |
| 193 | Q | A | -1.0219 | |
| 194 | P | A | 0.0000 | |
| 195 | I | A | 0.0000 | |
| 196 | N | A | -2.1226 | |
| 197 | W | A | -1.8994 | |
| 198 | S | A | -1.9496 | |
| 199 | E | A | -2.4543 | |
| 200 | P | A | -1.9937 | |
| 201 | K | A | -2.5167 | |
| 202 | P | A | -1.7448 | |
| 203 | L | A | 0.0000 | |
| 204 | F | A | -1.8007 | |
| 205 | Q | A | -1.9994 | |
| 206 | T | A | -1.5672 | |
| 207 | D | A | -2.4283 | |
| 208 | S | A | -2.4747 | |
| 209 | P | A | -1.9683 | |
| 210 | N | A | -2.6365 | |
| 211 | N | A | -2.5999 | |
| 212 | K | A | -3.0564 | |
| 213 | G | A | -2.9102 | |
| 214 | D | A | -3.6332 | |
| 215 | L | A | -2.7256 | |
| 216 | K | A | -3.0021 | |
| 217 | E | A | -2.1073 | |
| 218 | F | A | 0.0000 | |
| 219 | L | A | 0.0000 | |
| 220 | G | A | 0.0000 | |
| 221 | G | A | 0.0000 | |
| 222 | G | A | 0.0000 | |
| 223 | G | A | 0.0000 | |
| 224 | S | A | 0.0616 | |
| 225 | G | A | 0.0000 | |
| 226 | I | A | 0.2992 | |
| 227 | V | A | 0.1007 | |
| 228 | M | A | 0.0000 | |
| 229 | G | A | -1.6000 | |
| 230 | N | A | -1.7147 | |
| 231 | G | A | -1.1695 | |
| 232 | T | A | 0.0000 | |
| 233 | L | A | 0.0000 | |
| 234 | V | A | 0.0000 | |
| 235 | F | A | 0.0000 | |
| 236 | P | A | 0.0000 | |
| 237 | L | A | 0.0000 | |
| 238 | T | A | 0.0000 | |
| 239 | A | A | 0.0000 | |
| 240 | K | A | -1.8204 | |
| 241 | D | A | 0.0000 | |
| 242 | E | A | -3.4332 | |
| 243 | S | A | -2.4451 | |
| 244 | N | A | -2.8411 | |
| 245 | K | A | -1.9071 | |
| 246 | V | A | 0.0000 | |
| 247 | F | A | -0.0344 | |
| 248 | S | A | 0.0000 | |
| 249 | L | A | 0.0000 | |
| 250 | I | A | 0.0000 | |
| 251 | T | A | 0.0000 | |
| 252 | Y | A | -0.7974 | |
| 253 | S | A | 0.0000 | |
| 254 | T | A | -1.6950 | |
| 255 | D | A | -2.1370 | |
| 256 | D | A | -2.9493 | |
| 257 | G | A | 0.0000 | |
| 258 | Q | A | -2.7713 | |
| 259 | K | A | -3.1765 | |
| 260 | W | A | -2.2301 | |
| 261 | E | A | -2.1648 | |
| 262 | I | A | 0.0000 | |
| 263 | P | A | 0.0000 | |
| 264 | G | A | -1.6631 | |
| 265 | G | A | 0.0000 | |
| 266 | V | A | 0.4787 | |
| 267 | S | A | 0.0000 | |
| 268 | S | A | 0.0076 | |
| 269 | V | A | 0.6667 | |
| 270 | A | A | -0.8258 | |
| 271 | C | A | 0.0000 | |
| 272 | R | A | -1.6125 | |
| 273 | S | A | -0.8162 | |
| 274 | P | A | 0.0000 | |
| 275 | R | A | -0.3574 | |
| 276 | V | A | 0.0000 | |
| 277 | T | A | 0.0000 | |
| 278 | E | A | -1.2202 | |
| 279 | W | A | 0.0000 | |
| 280 | E | A | -3.1945 | |
| 281 | E | A | -3.3353 | |
| 282 | G | A | -2.4072 | |
| 283 | T | A | -2.0098 | |
| 284 | L | A | 0.0000 | |
| 285 | L | A | 0.0000 | |
| 286 | M | A | 0.0000 | |
| 287 | V | A | 0.0000 | |
| 288 | T | A | 0.0000 | |
| 289 | Y | A | -1.4718 | |
| 290 | C | A | 0.0000 | |
| 291 | E | A | -3.1891 | |
| 292 | D | A | -3.1836 | |
| 293 | G | A | 0.0000 | |
| 294 | R | A | 0.0000 | |
| 295 | K | A | -1.4920 | |
| 296 | V | A | 0.0000 | |
| 297 | F | A | 0.0000 | |
| 298 | E | A | -1.3553 | |
| 299 | S | A | 0.0000 | |
| 300 | R | A | -2.5370 | |
| 301 | D | A | -1.7300 | |
| 302 | M | A | -1.0643 | |
| 303 | G | A | 0.0000 | |
| 304 | K | A | -2.0516 | |
| 305 | T | A | -1.1796 | |
| 306 | W | A | -0.9151 | |
| 307 | T | A | -1.1500 | |
| 308 | E | A | -2.1455 | |
| 309 | A | A | -1.8971 | |
| 310 | R | A | -2.5666 | |
| 311 | G | A | -1.7762 | |
| 312 | T | A | -1.3934 | |
| 313 | L | A | 0.0000 | |
| 314 | P | A | -1.1553 | |
| 315 | G | A | -0.2979 | |
| 316 | V | A | 0.0000 | |
| 317 | W | A | -0.5219 | |
| 318 | L | A | -0.7627 | |
| 319 | K | A | -2.2893 | |
| 320 | S | A | -2.3995 | |
| 321 | G | A | -1.7772 | |
| 322 | P | A | -1.2486 | |
| 323 | E | A | -2.1789 | |
| 324 | L | A | -1.4595 | |
| 325 | P | A | -1.2221 | |
| 326 | E | A | -1.8918 | |
| 327 | V | A | 0.1358 | |
| 328 | S | A | 0.0000 | |
| 329 | L | A | 0.0000 | |
| 330 | R | A | -0.5309 | |
| 331 | V | A | 0.0000 | |
| 332 | D | A | 0.0000 | |
| 333 | A | A | 0.0000 | |
| 334 | L | A | 0.0000 | |
| 335 | I | A | 0.2431 | |
| 336 | T | A | -0.1451 | |
| 337 | A | A | 0.0000 | |
| 338 | T | A | -1.9196 | |
| 339 | I | A | 0.0000 | |
| 340 | E | A | -2.9050 | |
| 341 | G | A | -2.5179 | |
| 342 | R | A | -3.1781 | |
| 343 | K | A | -2.6276 | |
| 344 | V | A | 0.0000 | |
| 345 | M | A | 0.0000 | |
| 346 | L | A | 0.0000 | |
| 347 | Y | A | 0.0000 | |
| 348 | T | A | 0.0000 | |
| 349 | Q | A | 0.0000 | |
| 350 | K | A | 0.0000 | |
| 351 | V | A | 0.0722 | |
| 352 | R | A | -0.8776 | |
| 353 | H | A | -1.3026 | |
| 354 | F | A | 0.0392 | |
| 355 | R | A | -1.9635 | |
| 356 | E | A | -2.0119 | |
| 357 | V | A | -0.1657 | |
| 358 | D | A | -2.0776 | |
| 359 | E | A | -2.0646 | |
| 360 | P | A | -1.1958 | |
| 361 | N | A | -0.6924 | |
| 362 | A | A | -0.2031 | |
| 363 | L | A | 0.0000 | |
| 364 | H | A | 0.0000 | |
| 365 | L | A | 0.0000 | |
| 366 | W | A | 0.1096 | |
| 367 | V | A | 0.0000 | |
| 368 | T | A | 0.0000 | |
| 369 | D | A | -1.7174 | |
| 370 | N | A | -1.7161 | |
| 371 | N | A | -2.4568 | |
| 372 | R | A | -2.4221 | |
| 373 | T | A | -1.0310 | |
| 374 | F | A | 0.3194 | |
| 375 | H | A | -0.1618 | |
| 376 | L | A | -0.4113 | |
| 377 | G | A | -0.6818 | |
| 378 | P | A | -0.2383 | |
| 379 | F | A | 0.0000 | |
| 380 | S | A | 0.0000 | |
| 381 | V | A | 0.5088 | |
| 382 | D | A | 0.0000 | |
| 383 | S | A | -1.3868 | |
| 384 | A | A | -1.5626 | |
| 385 | E | A | -2.6978 | |
| 386 | N | A | -2.2304 | |
| 387 | K | A | -1.7849 | |
| 388 | T | A | 0.0000 | |
| 389 | F | A | -0.0477 | |
| 390 | A | A | 0.1458 | |
| 391 | N | A | 0.0000 | |
| 392 | T | A | 0.0000 | |
| 393 | L | A | 0.0000 | |
| 394 | L | A | 0.0156 | |
| 395 | Y | A | -0.4710 | |
| 396 | S | A | -1.3720 | |
| 397 | D | A | -2.8971 | |
| 398 | D | A | -2.8203 | |
| 399 | A | A | -1.6182 | |
| 400 | L | A | 0.0000 | |
| 401 | H | A | 0.0000 | |
| 402 | L | A | 0.0000 | |
| 403 | L | A | 0.0000 | |
| 404 | Q | A | 0.0000 | |
| 405 | A | A | 0.0000 | |
| 406 | K | A | -1.1302 | |
| 407 | G | A | 0.0000 | |
| 408 | D | A | -2.7887 | |
| 409 | H | A | -2.7219 | |
| 410 | E | A | -2.8169 | |
| 411 | S | A | -2.0508 | |
| 412 | T | A | 0.0000 | |
| 413 | A | A | -0.1893 | |
| 414 | V | A | 0.0000 | |
| 415 | S | A | 0.0000 | |
| 416 | L | A | 0.0000 | |
| 417 | A | A | 0.0000 | |
| 418 | R | A | -1.4773 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.7209 | |
| 421 | E | A | -2.3782 | |
| 422 | E | A | 0.0000 | |
| 423 | L | A | -1.1578 | |
| 424 | N | A | -1.6953 | |
| 425 | T | A | -0.8259 | |
| 426 | I | A | -0.2570 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine