| Chain sequence(s) |
A: GLLPLNPEPAPRSTSDFVTPTDLLYYAETEEITETGDPTKDIVVNGKVVVPRVSAYDYKVFLLKLPDPNTLPLPSEDFLDPSTEIAIWRLLAFKIERGGALGKGSYGHDKFNAFGDVTNPTAYQHEGADDTVALSWTPVRKQSFIIGDRPPLGVYTTLAPPQPGLPPGAPPPTTLKSDIIEHGDRADVGFGAKDFAALLPRKDDVPDYILNTTTKRYDLDGMKAEKYGRRMFTYDEKESSSASKTYRRSGPDLFPLPSAPPPSPLYTRPPPTSPYAVPPSTNLFTLPDAGAITAADELFNKPFWLTKTEGLNNGILWYNRLYITVLDNSRAAIETKTTQISTPAINVYDPSNYVTSKTYTRTYKLSLIVQLCRIPLTPETLAYLERLDPRFLVNANLPFVPKVERPDPYAGRKFIELDLTDKLSSNLADSELGRAYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | 0.6636 | |
| 2 | L | A | 2.2238 | |
| 3 | L | A | 2.2409 | |
| 4 | P | A | 1.1712 | |
| 5 | L | A | 1.1295 | |
| 6 | N | A | -1.0028 | |
| 7 | P | A | -1.4328 | |
| 8 | E | A | -2.1798 | |
| 9 | P | A | -1.5027 | |
| 10 | A | A | -1.0857 | |
| 11 | P | A | -1.1315 | |
| 12 | R | A | -1.5149 | |
| 13 | S | A | -0.9459 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -1.3568 | |
| 16 | D | A | -1.9818 | |
| 17 | F | A | -1.1599 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.5986 | |
| 20 | P | A | -0.7738 | |
| 21 | T | A | 0.0000 | |
| 22 | D | A | -1.6526 | |
| 23 | L | A | -0.5422 | |
| 24 | L | A | -0.2270 | |
| 25 | Y | A | -0.1229 | |
| 26 | Y | A | -0.3576 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.3733 | |
| 29 | T | A | 0.0000 | |
| 30 | E | A | -2.9325 | |
| 31 | E | A | -2.9197 | |
| 32 | I | A | -1.3554 | |
| 33 | T | A | -0.9280 | |
| 34 | E | A | -0.5095 | |
| 35 | T | A | -0.3230 | |
| 36 | G | A | 0.0000 | |
| 37 | D | A | 0.0000 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.3858 | |
| 40 | K | A | -1.9771 | |
| 41 | D | A | -0.6272 | |
| 42 | I | A | 1.6463 | |
| 43 | V | A | 2.4839 | |
| 44 | V | A | 1.9625 | |
| 45 | N | A | -0.4407 | |
| 46 | G | A | -0.2598 | |
| 47 | K | A | 0.0374 | |
| 48 | V | A | 2.2231 | |
| 49 | V | A | 2.9250 | |
| 50 | V | A | 1.6635 | |
| 51 | P | A | 0.1013 | |
| 52 | R | A | -1.0080 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | D | A | 0.0000 | |
| 58 | Y | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -1.7145 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -0.9295 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.9890 | |
| 70 | T | A | -0.3919 | |
| 71 | L | A | -0.0904 | |
| 72 | P | A | -0.3359 | |
| 73 | L | A | -0.4660 | |
| 74 | P | A | -0.7030 | |
| 75 | S | A | -1.5495 | |
| 76 | E | A | -2.8631 | |
| 77 | D | A | -2.8782 | |
| 78 | F | A | -1.5688 | |
| 79 | L | A | 0.0000 | |
| 80 | D | A | -2.2454 | |
| 81 | P | A | -1.3353 | |
| 82 | S | A | -0.8832 | |
| 83 | T | A | -0.8337 | |
| 84 | E | A | -1.0892 | |
| 85 | I | A | 0.0000 | |
| 86 | A | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3734 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | 0.0560 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | E | A | -1.3177 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7519 | |
| 99 | G | A | -0.3715 | |
| 100 | A | A | -0.0092 | |
| 101 | L | A | 0.3353 | |
| 102 | G | A | -0.1415 | |
| 103 | K | A | -0.7738 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.4032 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -1.0826 | |
| 108 | H | A | -1.9256 | |
| 109 | D | A | -2.5815 | |
| 110 | K | A | -2.8986 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | F | A | 0.0000 | |
| 115 | G | A | -0.7609 | |
| 116 | D | A | -0.8215 | |
| 117 | V | A | -0.3520 | |
| 118 | T | A | -1.0497 | |
| 119 | N | A | -1.5626 | |
| 120 | P | A | -0.9117 | |
| 121 | T | A | -0.5218 | |
| 122 | A | A | -0.3384 | |
| 123 | Y | A | -0.0588 | |
| 124 | Q | A | -1.2161 | |
| 125 | H | A | -1.5222 | |
| 126 | E | A | -2.1222 | |
| 127 | G | A | -1.9204 | |
| 128 | A | A | -1.3108 | |
| 129 | D | A | -2.3085 | |
| 130 | D | A | -1.7312 | |
| 131 | T | A | -1.2742 | |
| 132 | V | A | -0.4072 | |
| 133 | A | A | -0.8790 | |
| 134 | L | A | -0.4747 | |
| 135 | S | A | -0.4841 | |
| 136 | W | A | 0.0000 | |
| 137 | T | A | -0.5877 | |
| 138 | P | A | 0.0000 | |
| 139 | V | A | 0.0000 | |
| 140 | R | A | 0.0000 | |
| 141 | K | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | S | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | R | A | -0.3543 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.3441 | |
| 153 | G | A | 0.0000 | |
| 154 | V | A | -0.6553 | |
| 155 | Y | A | 0.0000 | |
| 156 | T | A | -0.0818 | |
| 157 | T | A | 0.1527 | |
| 158 | L | A | 0.5247 | |
| 159 | A | A | -0.0122 | |
| 160 | P | A | -0.5655 | |
| 161 | P | A | -0.8765 | |
| 162 | Q | A | -1.4314 | |
| 163 | P | A | -0.9101 | |
| 164 | G | A | -0.5182 | |
| 165 | L | A | 0.0788 | |
| 166 | P | A | -0.1861 | |
| 167 | P | A | -0.4422 | |
| 168 | G | A | -0.3558 | |
| 169 | A | A | -0.1102 | |
| 170 | P | A | -0.1962 | |
| 171 | P | A | -0.3032 | |
| 172 | P | A | -0.2140 | |
| 173 | T | A | 0.1704 | |
| 174 | T | A | 0.4035 | |
| 175 | L | A | 0.8990 | |
| 176 | K | A | -0.6274 | |
| 177 | S | A | -0.6074 | |
| 178 | D | A | -0.5377 | |
| 179 | I | A | -0.2999 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.0631 | |
| 182 | H | A | -0.8715 | |
| 183 | G | A | -0.6268 | |
| 184 | D | A | -0.7863 | |
| 185 | R | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | V | A | 0.0000 | |
| 189 | G | A | -0.2951 | |
| 190 | F | A | -0.0308 | |
| 191 | G | A | -0.5150 | |
| 192 | A | A | -0.6452 | |
| 193 | K | A | -0.7996 | |
| 194 | D | A | -0.7433 | |
| 195 | F | A | 0.0000 | |
| 196 | A | A | -0.8997 | |
| 197 | A | A | -0.1804 | |
| 198 | L | A | -0.0858 | |
| 199 | L | A | -0.7184 | |
| 200 | P | A | -1.1225 | |
| 201 | R | A | -1.9597 | |
| 202 | K | A | -2.8363 | |
| 203 | D | A | -2.1734 | |
| 204 | D | A | -1.2789 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -2.0752 | |
| 208 | Y | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.1963 | |
| 211 | N | A | -1.6412 | |
| 212 | T | A | -0.8529 | |
| 213 | T | A | -0.6137 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | R | A | -1.5724 | |
| 217 | Y | A | 0.0000 | |
| 218 | D | A | -1.3445 | |
| 219 | L | A | -1.3388 | |
| 220 | D | A | -2.3552 | |
| 221 | G | A | -1.5980 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -3.0481 | |
| 224 | A | A | -1.8968 | |
| 225 | E | A | -1.9469 | |
| 226 | K | A | -2.1023 | |
| 227 | Y | A | -1.2055 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.5616 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.6643 | |
| 234 | Y | A | -0.2657 | |
| 235 | D | A | -0.9763 | |
| 236 | E | A | -1.7676 | |
| 237 | K | A | -2.4727 | |
| 238 | E | A | -2.4986 | |
| 239 | S | A | -1.3463 | |
| 240 | S | A | -0.9439 | |
| 241 | S | A | -0.6016 | |
| 242 | A | A | -0.6071 | |
| 243 | S | A | -0.8726 | |
| 244 | K | A | -1.4151 | |
| 245 | T | A | -0.4196 | |
| 246 | Y | A | -0.2234 | |
| 247 | R | A | -0.1029 | |
| 248 | R | A | -0.5830 | |
| 249 | S | A | -1.1122 | |
| 250 | G | A | -0.6337 | |
| 251 | P | A | -0.1277 | |
| 252 | D | A | 0.6889 | |
| 253 | L | A | 1.7828 | |
| 254 | F | A | 2.3217 | |
| 255 | P | A | 0.9845 | |
| 256 | L | A | 1.3435 | |
| 257 | P | A | 0.4891 | |
| 258 | S | A | -0.3307 | |
| 259 | A | A | -0.3439 | |
| 260 | P | A | -0.8349 | |
| 261 | P | A | -0.8151 | |
| 262 | P | A | -0.5719 | |
| 263 | S | A | -0.1395 | |
| 264 | P | A | 0.4517 | |
| 265 | L | A | 1.4014 | |
| 266 | Y | A | 0.5331 | |
| 267 | T | A | -0.7002 | |
| 268 | R | A | -1.5334 | |
| 269 | P | A | -0.5957 | |
| 270 | P | A | -0.7006 | |
| 271 | P | A | -0.2947 | |
| 272 | T | A | 0.0140 | |
| 273 | S | A | 0.1438 | |
| 274 | P | A | 0.4222 | |
| 275 | Y | A | 1.1347 | |
| 276 | A | A | 0.8229 | |
| 277 | V | A | 1.5919 | |
| 278 | P | A | 0.5755 | |
| 279 | P | A | -0.2365 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | 0.1785 | |
| 282 | N | A | -0.0697 | |
| 283 | L | A | 1.0266 | |
| 284 | F | A | 0.5215 | |
| 285 | T | A | -0.0059 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -0.9181 | |
| 289 | A | A | 0.0000 | |
| 290 | G | A | -0.3796 | |
| 291 | A | A | -0.0868 | |
| 292 | I | A | 0.0034 | |
| 293 | T | A | -0.1420 | |
| 294 | A | A | -0.2131 | |
| 295 | A | A | -0.5472 | |
| 296 | D | A | -1.3587 | |
| 297 | E | A | -1.0618 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.4608 | |
| 301 | K | A | -1.6706 | |
| 302 | P | A | -0.8940 | |
| 303 | F | A | 0.0650 | |
| 304 | W | A | -0.0546 | |
| 305 | L | A | 0.0000 | |
| 306 | T | A | -0.7710 | |
| 307 | K | A | -2.1130 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -2.4111 | |
| 310 | G | A | -1.7460 | |
| 311 | L | A | -1.0000 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | -0.8846 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | Y | A | -0.3958 | |
| 319 | N | A | -0.6692 | |
| 320 | R | A | -0.9093 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | A | A | -0.4841 | |
| 333 | I | A | -0.9356 | |
| 334 | E | A | -2.2088 | |
| 335 | T | A | -2.0225 | |
| 336 | K | A | -2.1164 | |
| 337 | T | A | -0.3401 | |
| 338 | T | A | 0.4244 | |
| 339 | Q | A | 0.9325 | |
| 340 | I | A | 2.1069 | |
| 341 | S | A | 0.6299 | |
| 342 | T | A | 0.0875 | |
| 343 | P | A | -0.3996 | |
| 344 | A | A | -0.0594 | |
| 345 | I | A | 0.4033 | |
| 346 | N | A | -0.0055 | |
| 347 | V | A | 1.7018 | |
| 348 | Y | A | 1.5132 | |
| 349 | D | A | -0.0229 | |
| 350 | P | A | -0.0007 | |
| 351 | S | A | 0.1315 | |
| 352 | N | A | 0.7792 | |
| 353 | Y | A | 1.1677 | |
| 354 | V | A | 1.8260 | |
| 355 | T | A | -0.0151 | |
| 356 | S | A | -0.9735 | |
| 357 | K | A | -1.7587 | |
| 358 | T | A | -1.2373 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.4810 | |
| 361 | R | A | 0.0000 | |
| 362 | T | A | -0.8147 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -1.9127 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.3836 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | R | A | -0.7326 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.6448 | |
| 376 | L | A | -0.4209 | |
| 377 | T | A | -0.6806 | |
| 378 | P | A | -1.0129 | |
| 379 | E | A | -1.7860 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -1.0652 | |
| 382 | A | A | -1.5092 | |
| 383 | Y | A | -1.6190 | |
| 384 | L | A | 0.0000 | |
| 385 | E | A | -2.5878 | |
| 386 | R | A | -2.6051 | |
| 387 | L | A | -1.4697 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -1.5980 | |
| 390 | R | A | -1.6247 | |
| 391 | F | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.2197 | |
| 394 | N | A | -1.6895 | |
| 395 | A | A | -1.0855 | |
| 396 | N | A | -1.5848 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.2013 | |
| 399 | F | A | 1.5286 | |
| 400 | V | A | 0.5409 | |
| 401 | P | A | -0.3131 | |
| 402 | K | A | -1.6853 | |
| 403 | V | A | -0.5315 | |
| 404 | E | A | -2.5792 | |
| 405 | R | A | -2.8895 | |
| 406 | P | A | -1.7924 | |
| 407 | D | A | -1.6917 | |
| 408 | P | A | -0.9968 | |
| 409 | Y | A | -0.8108 | |
| 410 | A | A | -0.9349 | |
| 411 | G | A | -1.3006 | |
| 412 | R | A | -1.8729 | |
| 413 | K | A | -2.3997 | |
| 414 | F | A | -1.3496 | |
| 415 | I | A | -1.0709 | |
| 416 | E | A | -2.2944 | |
| 417 | L | A | -1.8535 | |
| 418 | D | A | -2.7822 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8019 | |
| 421 | D | A | -2.4103 | |
| 422 | K | A | -2.0086 | |
| 423 | L | A | -0.8020 | |
| 424 | S | A | -0.9838 | |
| 425 | S | A | -0.7214 | |
| 426 | N | A | -1.7743 | |
| 427 | L | A | 0.0000 | |
| 428 | A | A | -1.8876 | |
| 429 | D | A | -2.8684 | |
| 430 | S | A | 0.0000 | |
| 431 | E | A | -2.8435 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.8901 | |
| 435 | A | A | -1.7976 | |
| 436 | Y | A | -0.7542 | |
| 437 | L | A | -0.1633 | |
| 438 | N | A | -1.8181 | |
| 439 | R | A | -2.0938 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine