Chain sequence(s) |
A: MGSSHHHHHHSSGENLYFQGAMAIAMLVPNKTQVVPKSGGEGKVKDIFASPALVRAGGVMIAFVEGRTKNKLFPEVIDLSSSDIVAGYIKAPETWQSLVAEVTKEYWQAHTVLESANNSNHRVGVARLPTGITRGNKVFLLVGSYEERREIDDYIWKAEAWNIKVIEGEATQSTEVQPTQPINWSEPKPLFQTDSPNNKGDLKEFLGGGGSGIVMGNGTLVFPLTAKDESNKVFSLITYSTDDGQKWEIPGGVSSVACRSPRVTEWEEGTLLMVTYCEDGRKVFESRDMGKTWTEAKGTLPGVWLKSGPELPEVSLRVDALITATIEGRKVMLYTQKVRHFREVDEPNALHLWVTDNNRTFHLGPFSVDSAENKTFANTLLYSDDALHLLQAKGDHESTAVSLARLTEELNTI
input PDB |
Selected Chain(s) | A |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | No |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:00) [INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00) [INFO] runJob: Creating pdb object from: input.pdb (00:00:00) [INFO] FoldX: Starting FoldX energy minimalization (00:00:00) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:06:32) [INFO] Main: Simulation completed successfully. (00:06:35) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | M | A | 0.7468 | |
2 | G | A | -0.1965 | |
3 | S | A | -0.6468 | |
4 | S | A | -1.1492 | |
5 | H | A | -2.0464 | |
6 | H | A | -2.3931 | |
7 | H | A | -2.6121 | |
8 | H | A | -2.5697 | |
9 | H | A | -2.3982 | |
10 | H | A | -2.0248 | |
11 | S | A | -1.5408 | |
12 | S | A | -1.5330 | |
13 | G | A | -1.8471 | |
14 | E | A | -2.3064 | |
15 | N | A | -1.3207 | |
16 | L | A | 0.3929 | |
17 | Y | A | 1.1289 | |
18 | F | A | 0.6464 | |
19 | Q | A | -0.9535 | |
20 | G | A | -1.0291 | |
21 | A | A | 0.0000 | |
22 | M | A | 0.6745 | |
23 | A | A | 0.0000 | |
24 | I | A | 0.0000 | |
25 | A | A | -0.3193 | |
26 | M | A | 0.0000 | |
27 | L | A | 0.0000 | |
28 | V | A | -0.2563 | |
29 | P | A | -1.0428 | |
30 | N | A | -1.8337 | |
31 | K | A | -2.2408 | |
32 | T | A | 0.0000 | |
33 | Q | A | -1.9553 | |
34 | V | A | 0.0000 | |
35 | V | A | -1.5690 | |
36 | P | A | -1.7921 | |
37 | K | A | -1.5526 | |
38 | S | A | -1.3556 | |
39 | G | A | -1.5240 | |
40 | G | A | -2.0266 | |
41 | E | A | -2.7661 | |
42 | G | A | -2.3609 | |
43 | K | A | -2.5425 | |
44 | V | A | -1.1108 | |
45 | K | A | 0.0000 | |
46 | D | A | -1.2757 | |
47 | I | A | 0.0000 | |
48 | F | A | 0.0000 | |
49 | A | A | -0.0574 | |
50 | S | A | 0.0074 | |
51 | P | A | 0.0000 | |
52 | A | A | 0.0000 | |
53 | L | A | 0.0000 | |
54 | V | A | 0.0000 | |
55 | R | A | -1.1535 | |
56 | A | A | 0.0000 | |
57 | G | A | -1.6259 | |
58 | G | A | -1.4503 | |
59 | V | A | 0.0000 | |
60 | M | A | 0.0000 | |
61 | I | A | 0.0000 | |
62 | A | A | 0.0000 | |
63 | F | A | 0.0000 | |
64 | V | A | 0.0000 | |
65 | E | A | 0.0000 | |
66 | G | A | 0.0000 | |
67 | R | A | -0.6853 | |
68 | T | A | -1.1416 | |
69 | K | A | -1.4746 | |
70 | N | A | -1.3822 | |
71 | K | A | -1.5841 | |
72 | L | A | -0.0754 | |
73 | F | A | -0.2267 | |
74 | P | A | -0.9455 | |
75 | E | A | -1.3297 | |
76 | V | A | 0.4287 | |
77 | I | A | 0.7107 | |
78 | D | A | -1.5583 | |
79 | L | A | 0.0000 | |
80 | S | A | 0.0000 | |
81 | S | A | 0.0000 | |
82 | S | A | 0.0000 | |
83 | D | A | -0.7658 | |
84 | I | A | 0.0000 | |
85 | V | A | 0.0000 | |
86 | A | A | 0.0000 | |
87 | G | A | 0.0000 | |
88 | Y | A | 0.0000 | |
89 | I | A | 0.0000 | |
90 | K | A | -1.6761 | |
91 | A | A | -1.3066 | |
92 | P | A | -1.5202 | |
93 | E | A | -2.4015 | |
94 | T | A | -1.3160 | |
95 | W | A | 0.0000 | |
96 | Q | A | -1.4908 | |
97 | S | A | -1.2992 | |
98 | L | A | 0.0000 | |
99 | V | A | -0.5192 | |
100 | A | A | -0.8531 | |
101 | E | A | -1.1504 | |
102 | V | A | 0.0000 | |
103 | T | A | -0.9342 | |
104 | K | A | -1.4102 | |
105 | E | A | -1.6628 | |
106 | Y | A | -0.1094 | |
107 | W | A | -0.5940 | |
108 | Q | A | -1.0065 | |
109 | A | A | 0.0000 | |
110 | H | A | -0.9031 | |
111 | T | A | 0.0000 | |
112 | V | A | 0.0000 | |
113 | L | A | -0.9110 | |
114 | E | A | -1.4864 | |
115 | S | A | -1.1922 | |
116 | A | A | -1.3484 | |
117 | N | A | -2.2648 | |
118 | N | A | -2.5053 | |
119 | S | A | -1.9013 | |
120 | N | A | -2.0444 | |
121 | H | A | -1.4328 | |
122 | R | A | -2.4198 | |
123 | V | A | 0.0000 | |
124 | G | A | 0.0000 | |
125 | V | A | 0.0000 | |
126 | A | A | 0.0000 | |
127 | R | A | -0.5176 | |
128 | L | A | -0.0305 | |
129 | P | A | 0.0000 | |
130 | T | A | 0.0000 | |
131 | G | A | 0.0000 | |
132 | I | A | 0.0000 | |
133 | T | A | -0.8928 | |
134 | R | A | -1.3198 | |
135 | G | A | -1.4516 | |
136 | N | A | -1.7799 | |
137 | K | A | -2.0520 | |
138 | V | A | 0.0000 | |
139 | F | A | 0.0000 | |
140 | L | A | 0.0000 | |
141 | L | A | 0.0000 | |
142 | V | A | 0.0000 | |
143 | G | A | 0.0000 | |
144 | S | A | -0.6595 | |
145 | Y | A | 0.0000 | |
146 | E | A | -1.4062 | |
147 | E | A | -1.5514 | |
148 | R | A | -1.4087 | |
149 | R | A | -0.9150 | |
150 | E | A | -0.6680 | |
151 | I | A | 0.7231 | |
152 | D | A | -1.3864 | |
153 | D | A | -1.2963 | |
154 | Y | A | 0.7343 | |
155 | I | A | 0.5720 | |
156 | W | A | -0.2506 | |
157 | K | A | -1.3121 | |
158 | A | A | -1.0678 | |
159 | E | A | -1.0635 | |
160 | A | A | -0.6685 | |
161 | W | A | -0.8369 | |
162 | N | A | -1.2586 | |
163 | I | A | 0.0000 | |
164 | K | A | -1.0365 | |
165 | V | A | 0.0000 | |
166 | I | A | 0.0000 | |
167 | E | A | -1.9150 | |
168 | G | A | 0.0000 | |
169 | E | A | -2.3696 | |
170 | A | A | 0.0000 | |
171 | T | A | -1.7063 | |
172 | Q | A | -1.8368 | |
173 | S | A | -1.3550 | |
174 | T | A | -1.0625 | |
175 | E | A | -1.6645 | |
176 | V | A | 0.2809 | |
177 | Q | A | -1.1032 | |
178 | P | A | -1.2375 | |
179 | T | A | -0.7291 | |
180 | Q | A | -0.9489 | |
181 | P | A | -1.3111 | |
182 | I | A | 0.0000 | |
183 | N | A | -1.9204 | |
184 | W | A | 0.0000 | |
185 | S | A | -1.8305 | |
186 | E | A | -2.2545 | |
187 | P | A | -1.5526 | |
188 | K | A | -1.7358 | |
189 | P | A | -1.2359 | |
190 | L | A | 0.0000 | |
191 | F | A | -1.5820 | |
192 | Q | A | -2.2428 | |
193 | T | A | -1.6565 | |
194 | D | A | -2.4934 | |
195 | S | A | -2.2904 | |
196 | P | A | -2.4766 | |
197 | N | A | -3.6174 | |
198 | N | A | -3.2193 | |
199 | K | A | -3.3802 | |
200 | G | A | -3.1505 | |
201 | D | A | -3.8683 | |
202 | L | A | -2.9552 | |
203 | K | A | -3.1765 | |
204 | E | A | -1.8869 | |
205 | F | A | 0.0000 | |
206 | L | A | -0.4013 | |
207 | G | A | 0.0000 | |
208 | G | A | 0.0000 | |
209 | G | A | 0.0000 | |
210 | G | A | 0.0000 | |
211 | S | A | 0.1127 | |
212 | G | A | 0.0000 | |
213 | I | A | 0.4226 | |
214 | V | A | 0.3422 | |
215 | M | A | 0.0000 | |
216 | G | A | -1.5439 | |
217 | N | A | -1.7200 | |
218 | G | A | -0.9036 | |
219 | T | A | 0.0000 | |
220 | L | A | 0.0000 | |
221 | V | A | 0.0000 | |
222 | F | A | 0.0000 | |
223 | P | A | 0.0000 | |
224 | L | A | 0.0000 | |
225 | T | A | -0.5470 | |
226 | A | A | 0.0000 | |
227 | K | A | -2.4195 | |
228 | D | A | -3.2397 | |
229 | E | A | -3.6211 | |
230 | S | A | -2.5165 | |
231 | N | A | -3.0054 | |
232 | K | A | -2.0882 | |
233 | V | A | 0.0000 | |
234 | F | A | -0.1651 | |
235 | S | A | 0.0000 | |
236 | L | A | 0.0000 | |
237 | I | A | 0.0000 | |
238 | T | A | 0.0000 | |
239 | Y | A | -0.5784 | |
240 | S | A | 0.0000 | |
241 | T | A | -1.4274 | |
242 | D | A | -1.6980 | |
243 | D | A | -1.7614 | |
244 | G | A | -1.9218 | |
245 | Q | A | -2.4727 | |
246 | K | A | -3.0175 | |
247 | W | A | -2.0347 | |
248 | E | A | -2.0659 | |
249 | I | A | -1.0253 | |
250 | P | A | 0.0000 | |
251 | G | A | -1.7611 | |
252 | G | A | 0.0000 | |
253 | V | A | 0.4629 | |
254 | S | A | 0.0000 | |
255 | S | A | -0.0394 | |
256 | V | A | 0.5486 | |
257 | A | A | -0.8764 | |
258 | C | A | 0.0000 | |
259 | R | A | -1.5393 | |
260 | S | A | -0.7520 | |
261 | P | A | 0.0000 | |
262 | R | A | -0.3287 | |
263 | V | A | 0.0000 | |
264 | T | A | 0.0000 | |
265 | E | A | -0.9131 | |
266 | W | A | -1.3508 | |
267 | E | A | -2.6655 | |
268 | E | A | -3.1105 | |
269 | G | A | -2.3426 | |
270 | T | A | 0.0000 | |
271 | L | A | 0.0000 | |
272 | L | A | 0.0000 | |
273 | M | A | 0.0000 | |
274 | V | A | 0.0000 | |
275 | T | A | 0.0000 | |
276 | Y | A | -1.2709 | |
277 | C | A | 0.0000 | |
278 | E | A | -3.2173 | |
279 | D | A | -3.2057 | |
280 | G | A | 0.0000 | |
281 | R | A | 0.0000 | |
282 | K | A | -1.4307 | |
283 | V | A | 0.0000 | |
284 | F | A | 0.0000 | |
285 | E | A | -1.4120 | |
286 | S | A | 0.0000 | |
287 | R | A | -2.9059 | |
288 | D | A | -2.0643 | |
289 | M | A | -1.1638 | |
290 | G | A | 0.0000 | |
291 | K | A | -2.1254 | |
292 | T | A | -1.3374 | |
293 | W | A | -0.9835 | |
294 | T | A | -1.1186 | |
295 | E | A | -1.8773 | |
296 | A | A | -1.7120 | |
297 | K | A | -2.3717 | |
298 | G | A | -1.6788 | |
299 | T | A | -1.3632 | |
300 | L | A | 0.0000 | |
301 | P | A | -1.0956 | |
302 | G | A | -0.0677 | |
303 | V | A | 0.0000 | |
304 | W | A | -0.5654 | |
305 | L | A | -0.8874 | |
306 | K | A | -2.3624 | |
307 | S | A | -2.4667 | |
308 | G | A | -1.7889 | |
309 | P | A | -1.2194 | |
310 | E | A | -2.1707 | |
311 | L | A | -1.4058 | |
312 | P | A | -1.0178 | |
313 | E | A | -1.6348 | |
314 | V | A | 0.5735 | |
315 | S | A | 0.0000 | |
316 | L | A | 0.0000 | |
317 | R | A | -0.3684 | |
318 | V | A | 0.0000 | |
319 | D | A | 0.0000 | |
320 | A | A | 0.0000 | |
321 | L | A | 0.0000 | |
322 | I | A | 0.2668 | |
323 | T | A | -0.0840 | |
324 | A | A | 0.0000 | |
325 | T | A | -1.8394 | |
326 | I | A | 0.0000 | |
327 | E | A | -2.8836 | |
328 | G | A | -2.4797 | |
329 | R | A | -3.0989 | |
330 | K | A | -2.3872 | |
331 | V | A | 0.0000 | |
332 | M | A | 0.0000 | |
333 | L | A | 0.0000 | |
334 | Y | A | 0.0000 | |
335 | T | A | 0.0000 | |
336 | Q | A | 0.0000 | |
337 | K | A | 0.0000 | |
338 | V | A | 0.3282 | |
339 | R | A | -0.4842 | |
340 | H | A | -0.5873 | |
341 | F | A | 0.3918 | |
342 | R | A | -1.8353 | |
343 | E | A | -2.1389 | |
344 | V | A | -0.1563 | |
345 | D | A | -1.8996 | |
346 | E | A | -1.5159 | |
347 | P | A | -0.7753 | |
348 | N | A | -0.4661 | |
349 | A | A | 0.0000 | |
350 | L | A | 0.0000 | |
351 | H | A | 0.0000 | |
352 | L | A | 0.0000 | |
353 | W | A | 0.1434 | |
354 | V | A | 0.0000 | |
355 | T | A | 0.0000 | |
356 | D | A | -1.7926 | |
357 | N | A | -1.8860 | |
358 | N | A | -2.5427 | |
359 | R | A | -2.4700 | |
360 | T | A | -1.0567 | |
361 | F | A | 0.3220 | |
362 | H | A | -0.1206 | |
363 | L | A | -0.2311 | |
364 | G | A | -0.5558 | |
365 | P | A | -0.1755 | |
366 | F | A | 0.0000 | |
367 | S | A | 0.0000 | |
368 | V | A | 0.8330 | |
369 | D | A | 0.0000 | |
370 | S | A | -1.0161 | |
371 | A | A | -1.3488 | |
372 | E | A | -2.6686 | |
373 | N | A | -2.1121 | |
374 | K | A | -1.4536 | |
375 | T | A | 0.0000 | |
376 | F | A | 0.0999 | |
377 | A | A | 0.2135 | |
378 | N | A | 0.0000 | |
379 | T | A | 0.0000 | |
380 | L | A | 0.0000 | |
381 | L | A | 0.0441 | |
382 | Y | A | -0.4930 | |
383 | S | A | -1.4099 | |
384 | D | A | -2.8738 | |
385 | D | A | -2.8064 | |
386 | A | A | -1.5232 | |
387 | L | A | 0.0000 | |
388 | H | A | 0.0000 | |
389 | L | A | 0.0000 | |
390 | L | A | 0.0000 | |
391 | Q | A | 0.0000 | |
392 | A | A | 0.0000 | |
393 | K | A | -1.0738 | |
394 | G | A | 0.0000 | |
395 | D | A | -2.6507 | |
396 | H | A | -2.6902 | |
397 | E | A | -2.9590 | |
398 | S | A | -1.9867 | |
399 | T | A | 0.0000 | |
400 | A | A | -0.1904 | |
401 | V | A | 0.0000 | |
402 | S | A | 0.1075 | |
403 | L | A | 0.0000 | |
404 | A | A | 0.0000 | |
405 | R | A | -0.3388 | |
406 | L | A | 0.0000 | |
407 | T | A | -1.4066 | |
408 | E | A | -2.4368 | |
409 | E | A | 0.0000 | |
410 | L | A | -1.0989 | |
411 | N | A | -1.7144 | |
412 | T | A | -0.8239 | |
413 | I | A | -0.2742 |