Project name: 15E6G3

Chain sequence(s)	H: EVRLVETGGGLVQPKGSLKLSCAASGFTFNNTAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSLKARFTISRDDSQSMVYLQMNNLKTEDTAMYYCVRGGNPYAMDYWGQGTSVTVSS; L: DVVMTQSPDILYVTPGHRVSLSCRASQSISDYLHWYQQKSHESPRLLIKYASQSISGIPSRFSGSGSGSDFTLSINSVEPEDVGVYYCQNGHSFPPTFGAGTKLELK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:35)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:37)

• Minimal score value: -3.1019
• Maximal score value: 1.3107
• Average score: -0.6382
• Total score value: -144.8814

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.1811
2	V	H	-1.4018
3	R	H	-1.6875
4	L	H	0.0000
5	V	H	1.0340
6	E	H	0.0000
7	T	H	-0.0442
8	G	H	-0.5376
9	G	H	-0.2955
11	G	H	0.3681
12	L	H	1.1320
13	V	H	-0.1887
14	Q	H	-1.7151
15	P	H	-2.3449
16	K	H	-3.1019
17	G	H	-2.0901
18	S	H	-1.6645
19	L	H	-0.8106
20	K	H	-1.4056
21	L	H	0.0000
22	S	H	-0.0665
23	C	H	0.0000
24	A	H	0.1068
25	A	H	-0.3229
26	S	H	-0.8801
27	G	H	-1.2343
28	F	H	-0.6256
29	T	H	-0.5420
30	F	H	0.0000
35	N	H	-1.4992
36	N	H	-1.6483
37	T	H	-1.1965
38	A	H	-1.0905
39	M	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	-0.6095
44	Q	H	-0.9448
45	A	H	-1.2907
46	P	H	-1.0382
47	G	H	-1.4540
48	K	H	-2.1972
49	G	H	-1.2021
50	L	H	0.0000
51	E	H	-0.9032
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	R	H	-0.2024
56	I	H	0.0000
57	R	H	-1.3959
58	S	H	0.0000
59	K	H	-1.7524
60	Y	H	-0.2815
61	N	H	-1.1281
62	N	H	-1.4648
63	Y	H	-0.6865
64	A	H	-0.5458
65	T	H	-0.1353
66	Y	H	0.2287
67	Y	H	-0.2976
68	A	H	0.0000
69	D	H	-2.3650
70	S	H	-1.5975
71	L	H	0.0000
72	K	H	-2.3129
74	A	H	-1.3210
75	R	H	-1.3115
76	F	H	0.0000
77	T	H	-0.5675
78	I	H	0.0000
79	S	H	-0.2406
80	R	H	0.0000
81	D	H	-1.3401
82	D	H	-1.5713
83	S	H	-1.1779
84	Q	H	-1.5989
85	S	H	-0.9487
86	M	H	-0.4048
87	V	H	0.0000
88	Y	H	-0.2802
89	L	H	0.0000
90	Q	H	-0.9836
91	M	H	0.0000
92	N	H	-1.9480
93	N	H	-2.8038
94	L	H	0.0000
95	K	H	-2.8801
96	T	H	-1.9596
97	E	H	-2.2861
98	D	H	0.0000
99	T	H	-0.7429
100	A	H	0.0000
101	M	H	-0.1299
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	V	H	0.0000
106	R	H	-0.4422
107	G	H	0.0000
108	G	H	-0.7923
109	N	H	-1.4060
110	P	H	-0.9031
113	Y	H	-0.3855
114	A	H	0.0000
115	M	H	0.0000
116	D	H	-0.4757
117	Y	H	-0.0663
118	W	H	-0.2345
119	G	H	0.0000
120	Q	H	-1.2119
121	G	H	0.0000
122	T	H	-0.2167
123	S	H	-0.2351
124	V	H	0.0000
125	T	H	-0.1162
126	V	H	0.0000
127	S	H	-0.8459
128	S	H	-0.6909
1	D	L	-1.3078
2	V	L	-0.0478
3	V	L	0.8527
4	M	L	0.0000
5	T	L	-0.6550
6	Q	L	-0.9189
7	S	L	-1.0216
8	P	L	-0.8354
9	D	L	-1.5337
10	I	L	0.1302
11	L	L	0.4952
12	Y	L	0.9082
13	V	L	0.0000
14	T	L	-1.2616
15	P	L	-1.5004
16	G	L	-1.9052
17	H	L	-2.5469
18	R	L	-3.0388
19	V	L	0.0000
20	S	L	-0.8050
21	L	L	0.0000
22	S	L	-1.0720
23	C	L	0.0000
24	R	L	-2.3880
25	A	L	0.0000
26	S	L	-0.9875
27	Q	L	-1.6866
28	S	L	-1.4776
29	I	L	0.0000
36	S	L	-0.9428
37	D	L	-1.0849
38	Y	L	-0.3233
39	L	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	-0.8356
45	K	L	-1.2811
46	S	L	-1.0220
47	H	L	-1.7775
48	E	L	-1.9093
49	S	L	-1.2163
50	P	L	0.0000
51	R	L	-0.8724
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	K	L	-0.6055
56	Y	L	-0.4357
57	A	L	0.0000
65	S	L	-0.8441
66	Q	L	-1.0539
67	S	L	-0.6550
68	I	L	-0.3103
69	S	L	-0.3607
70	G	L	-0.4408
71	I	L	-0.2055
72	P	L	-0.2769
74	S	L	-0.5882
75	R	L	-1.1337
76	F	L	0.0000
77	S	L	-0.7563
78	G	L	-0.5885
79	S	L	-0.8119
80	G	L	-1.1514
83	S	L	-1.1933
84	G	L	-1.3288
85	S	L	-1.9135
86	D	L	-2.3005
87	F	L	0.0000
88	T	L	-0.8197
89	L	L	0.0000
90	S	L	0.0000
91	I	L	0.0000
92	N	L	-2.5269
93	S	L	-2.1991
94	V	L	0.0000
95	E	L	-1.8345
96	P	L	-1.5780
97	E	L	-2.0372
98	D	L	0.0000
99	V	L	-0.2150
100	G	L	0.0000
101	V	L	-0.1008
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	N	L	0.0000
107	G	L	0.0326
108	H	L	-0.3218
109	S	L	0.3329
114	F	L	1.3107
115	P	L	0.4072
116	P	L	0.0000
117	T	L	0.2661
118	F	L	0.3179
119	G	L	0.0000
120	A	L	-0.5275
121	G	L	-0.6961
122	T	L	0.0000
123	K	L	-0.5020
124	L	L	0.0000
125	E	L	0.2801
126	L	L	-0.3387
127	K	L	-1.2788