Project name: 2510-9.pdb

Chain sequence(s)	H: QVQLQQSAAELARPGASVKMSCKASGYTFIKYTMHWVKQRPGQGLEWIGYINPSSGYIEYNQKFKDKTTLTADKSSSTAYMQLSSLTSEDSAVYYCARGTLLGLSWGQGTTLTVSA; L: DIQMTQSPSSLSASLGERVSLTCRASQEISGYLSWLQQKPDGTIKRLIYAASTLDSGVPKRFSGSRSGSDYSLTISSLESEDFADYYCLQYASYPLTFGAGTKLELK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:02)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:02)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:02)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:02)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:02)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:31)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:33)

• Minimal score value: -3.4637
• Maximal score value: 1.9733
• Average score: -0.5514
• Total score value: -122.9536

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.2655
2	V	H	-0.4419
3	Q	H	-1.7565
4	L	H	0.0000
5	Q	H	-2.0136
6	Q	H	0.0000
7	S	H	-0.7619
8	A	H	-0.4853
9	A	H	-0.0322
11	E	H	-0.3498
12	L	H	0.6787
13	A	H	-0.5344
14	R	H	-1.8180
15	P	H	-1.3863
16	G	H	-1.1219
17	A	H	-0.9807
18	S	H	-1.0125
19	V	H	0.0000
20	K	H	-1.2313
21	M	H	0.0000
22	S	H	-0.4880
23	C	H	0.0000
24	K	H	-1.3470
25	A	H	0.0000
26	S	H	-1.0101
27	G	H	-0.8290
28	Y	H	-0.3857
29	T	H	-0.3690
30	F	H	0.0000
35	I	H	-0.5274
36	K	H	-1.2483
37	Y	H	-0.3817
38	T	H	-0.1132
39	M	H	0.0000
40	H	H	-0.0524
41	W	H	0.0000
42	V	H	0.0000
43	K	H	0.0000
44	Q	H	-0.8494
45	R	H	-1.5158
46	P	H	-1.0781
47	G	H	-1.3491
48	Q	H	-1.8402
49	G	H	-1.1189
50	L	H	0.0000
51	E	H	-0.8778
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	Y	H	0.0000
56	I	H	0.0000
57	N	H	-0.0662
58	P	H	0.0000
59	S	H	-0.5567
62	S	H	0.1345
63	G	H	0.0661
64	Y	H	1.1618
65	I	H	0.8800
66	E	H	0.0786
67	Y	H	-0.8382
68	N	H	0.0000
69	Q	H	-2.9283
70	K	H	-3.0524
71	F	H	0.0000
72	K	H	-3.4637
74	D	H	-3.1750
75	K	H	-2.2107
76	T	H	0.0000
77	T	H	-0.8002
78	L	H	0.0000
79	T	H	-0.2095
80	A	H	-0.6754
81	D	H	-1.5355
82	K	H	-1.9405
83	S	H	-1.1771
84	S	H	-1.0233
85	S	H	-0.9968
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.1235
89	M	H	0.0000
90	Q	H	-0.8911
91	L	H	0.0000
92	S	H	-1.0201
93	S	H	-1.0402
94	L	H	0.0000
95	T	H	-1.3212
96	S	H	-1.3961
97	E	H	-2.0352
98	D	H	0.0000
99	S	H	-0.7325
100	A	H	0.0000
101	V	H	0.0502
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	G	H	0.2440
108	T	H	0.7830
109	L	H	1.7846
114	L	H	1.9733
115	G	H	0.8689
116	L	H	0.7012
117	S	H	-0.1963
118	W	H	-0.5492
119	G	H	0.0000
120	Q	H	-1.7840
121	G	H	-0.6970
122	T	H	0.0000
123	T	H	-0.1002
124	L	H	0.0000
125	T	H	-0.2209
126	V	H	0.0000
127	S	H	-0.5483
128	A	H	-0.5907
1	D	L	-2.2151
2	I	L	0.0000
3	Q	L	-2.1954
4	M	L	0.0000
5	T	L	-1.1373
6	Q	L	0.0000
7	S	L	-0.5853
8	P	L	-0.4872
9	S	L	-0.6864
10	S	L	-0.9638
11	L	L	-0.4834
12	S	L	-0.6637
13	A	L	0.0000
14	S	L	-0.6160
15	L	L	0.2729
16	G	L	-1.1226
17	E	L	-2.1677
18	R	L	-2.4972
19	V	L	0.0000
20	S	L	-0.6384
21	L	L	0.0000
22	T	L	-0.8317
23	C	L	0.0000
24	R	L	-2.8276
25	A	L	0.0000
26	S	L	-2.2428
27	Q	L	-2.9016
28	E	L	-2.6771
29	I	L	0.0000
36	S	L	-0.7783
37	G	L	-0.1522
38	Y	L	0.8373
39	L	L	0.0000
40	S	L	0.0000
41	W	L	0.0000
42	L	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.5114
46	P	L	-1.3673
47	D	L	-2.2382
48	G	L	-1.5026
49	T	L	-1.2473
50	I	L	0.0000
51	K	L	-0.7489
52	R	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.8456
56	A	L	0.6026
57	A	L	0.0000
65	S	L	-0.2307
66	T	L	0.2402
67	L	L	0.1736
68	D	L	0.1008
69	S	L	-0.1943
70	G	L	-0.6920
71	V	L	-0.5767
72	P	L	-1.0120
74	K	L	-1.7101
75	R	L	0.0000
76	F	L	0.0000
77	S	L	-0.4874
78	G	L	-0.4032
79	S	L	-0.9235
80	R	L	-1.6811
83	S	L	-1.2932
84	G	L	-1.4106
85	S	L	-1.9553
86	D	L	-1.6834
87	Y	L	0.0000
88	S	L	-0.8524
89	L	L	0.0000
90	T	L	-0.5951
91	I	L	0.0000
92	S	L	-1.5613
93	S	L	-1.6119
94	L	L	0.0000
95	E	L	-1.5553
96	S	L	-1.0274
97	E	L	-2.1661
98	D	L	0.0000
99	F	L	-0.7691
100	A	L	0.0000
101	D	L	-1.1223
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	L	L	0.0000
106	Q	L	0.0000
107	Y	L	0.7985
108	A	L	0.0621
109	S	L	-0.1481
114	Y	L	0.4310
115	P	L	-0.5011
116	L	L	0.0000
117	T	L	-0.4568
118	F	L	-0.1375
119	G	L	0.0000
120	A	L	-0.4191
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.7490
124	L	L	0.0000
125	E	L	-1.1322
126	L	L	0.3427
127	K	L	-1.0522