Chain sequence(s) |
A: MVERNSGDLQLPQEIAMLVPNKTQVVPKSGGEGKVKDIFASPALVRAGGVMIAFVEGRTKNKLFPEVIDLSSSDIVAGYIKAPETWQSLVAEVTKEYWQAHTVLESANNSNHRVGVARLPTGITRGNKVFLLVGSYEERREIDDYIWKAEAWNIKVIEGEATQSTEVQPTQPINWSEPKPLFQTDSPNNKGDLKEFLGGGGSGIVMGNGTLVFPLTAKDESNKVFSLITYSTDDGQKWEIPGGVSSVACRSPRVTEWEEGTLLMVTYCEDGRKVFESRDMGKTWTEAFGTLPGVWLKSGPELPEKSLRVDALITATIEGRKVMLYTQKVRHFKEVDEPNALHLWVTDNNRTFHLGPFSVDSAENKTFANTLLYSDDALHLLQAKGDHESTAVSLARLTEELNTI
input PDB |
Selected Chain(s) | A |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | No |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:00) [INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00) [INFO] runJob: Creating pdb object from: input.pdb (00:00:00) [INFO] FoldX: Starting FoldX energy minimalization (00:00:01) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:12:50) [INFO] Main: Simulation completed successfully. (00:12:58) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | M | A | 1.1406 | |
2 | V | A | 0.7352 | |
3 | E | A | -1.9089 | |
4 | R | A | -2.8079 | |
5 | N | A | -2.7234 | |
6 | S | A | -1.9613 | |
7 | G | A | -1.7713 | |
8 | D | A | -1.7810 | |
9 | L | A | -0.1193 | |
10 | Q | A | -0.8968 | |
11 | L | A | -0.0080 | |
12 | P | A | -0.7387 | |
13 | Q | A | -0.9714 | |
14 | E | A | -0.7013 | |
15 | I | A | -0.1415 | |
16 | A | A | 0.1416 | |
17 | M | A | 0.0000 | |
18 | L | A | 0.0000 | |
19 | V | A | -0.2398 | |
20 | P | A | -1.1161 | |
21 | N | A | -2.1003 | |
22 | K | A | -2.3441 | |
23 | T | A | 0.0000 | |
24 | Q | A | -1.7733 | |
25 | V | A | 0.0000 | |
26 | V | A | -1.5670 | |
27 | P | A | -1.9629 | |
28 | K | A | -2.0134 | |
29 | S | A | -1.5483 | |
30 | G | A | -1.6398 | |
31 | G | A | -2.0657 | |
32 | E | A | -2.7072 | |
33 | G | A | -2.2693 | |
34 | K | A | -2.4646 | |
35 | V | A | -1.0871 | |
36 | K | A | 0.0000 | |
37 | D | A | -1.3329 | |
38 | I | A | -0.8815 | |
39 | F | A | 0.0000 | |
40 | A | A | -0.0668 | |
41 | S | A | -0.0133 | |
42 | P | A | 0.0000 | |
43 | A | A | 0.0000 | |
44 | L | A | 0.0000 | |
45 | V | A | 0.0000 | |
46 | R | A | -1.0056 | |
47 | A | A | 0.0000 | |
48 | G | A | -1.5945 | |
49 | G | A | -1.4754 | |
50 | V | A | 0.0000 | |
51 | M | A | 0.0000 | |
52 | I | A | 0.0000 | |
53 | A | A | 0.0000 | |
54 | F | A | 0.0000 | |
55 | V | A | 0.0000 | |
56 | E | A | 0.0000 | |
57 | G | A | 0.0000 | |
58 | R | A | -0.6580 | |
59 | T | A | -1.2036 | |
60 | K | A | -1.6683 | |
61 | N | A | -1.7001 | |
62 | K | A | -1.9914 | |
63 | L | A | -0.7940 | |
64 | F | A | 0.0000 | |
65 | P | A | -1.2761 | |
66 | E | A | -1.5340 | |
67 | V | A | 0.2152 | |
68 | I | A | 0.6192 | |
69 | D | A | -1.5794 | |
70 | L | A | 0.0000 | |
71 | S | A | 0.0000 | |
72 | S | A | 0.0000 | |
73 | S | A | 0.0000 | |
74 | D | A | -0.7223 | |
75 | I | A | 0.0000 | |
76 | V | A | 0.0000 | |
77 | A | A | 0.0000 | |
78 | G | A | 0.0000 | |
79 | Y | A | 0.0000 | |
80 | I | A | 0.0000 | |
81 | K | A | -1.6460 | |
82 | A | A | -1.2812 | |
83 | P | A | -1.4248 | |
84 | E | A | -2.4340 | |
85 | T | A | -1.2585 | |
86 | W | A | -0.9501 | |
87 | Q | A | -1.2915 | |
88 | S | A | -1.0847 | |
89 | L | A | 0.0000 | |
90 | V | A | -0.0891 | |
91 | A | A | -0.2763 | |
92 | E | A | 0.0000 | |
93 | V | A | 0.0000 | |
94 | T | A | -0.5392 | |
95 | K | A | -1.1382 | |
96 | E | A | -1.5567 | |
97 | Y | A | 0.0200 | |
98 | W | A | -0.3859 | |
99 | Q | A | -0.8111 | |
100 | A | A | 0.0000 | |
101 | H | A | -0.9332 | |
102 | T | A | 0.0000 | |
103 | V | A | 0.0000 | |
104 | L | A | 0.0000 | |
105 | E | A | -1.4751 | |
106 | S | A | -1.1740 | |
107 | A | A | -1.3197 | |
108 | N | A | -2.4984 | |
109 | N | A | -2.6680 | |
110 | S | A | -2.3487 | |
111 | N | A | -2.4415 | |
112 | H | A | -2.0747 | |
113 | R | A | -2.8966 | |
114 | V | A | 0.0000 | |
115 | G | A | 0.0000 | |
116 | V | A | 0.0000 | |
117 | A | A | 0.0000 | |
118 | R | A | -0.4769 | |
119 | L | A | -0.0412 | |
120 | P | A | 0.0000 | |
121 | T | A | 0.0000 | |
122 | G | A | 0.0000 | |
123 | I | A | 0.0000 | |
124 | T | A | -1.0932 | |
125 | R | A | -1.9609 | |
126 | G | A | -1.7545 | |
127 | N | A | -2.0777 | |
128 | K | A | -2.4865 | |
129 | V | A | 0.0000 | |
130 | F | A | 0.0000 | |
131 | L | A | 0.0000 | |
132 | L | A | 0.0000 | |
133 | V | A | 0.0000 | |
134 | G | A | 0.0000 | |
135 | S | A | -0.7457 | |
136 | Y | A | 0.0000 | |
137 | E | A | -1.9270 | |
138 | E | A | -2.1124 | |
139 | R | A | -2.2995 | |
140 | R | A | -1.2617 | |
141 | E | A | -0.9506 | |
142 | I | A | 0.5536 | |
143 | D | A | -1.4260 | |
144 | D | A | -1.3096 | |
145 | Y | A | 0.8146 | |
146 | I | A | 0.6169 | |
147 | W | A | -0.4203 | |
148 | K | A | -1.4700 | |
149 | A | A | -1.5163 | |
150 | E | A | -2.0984 | |
151 | A | A | -1.1882 | |
152 | W | A | -1.1528 | |
153 | N | A | -1.4468 | |
154 | I | A | 0.0000 | |
155 | K | A | -0.9195 | |
156 | V | A | 0.0000 | |
157 | I | A | 0.0000 | |
158 | E | A | -1.4350 | |
159 | G | A | 0.0000 | |
160 | E | A | -2.6313 | |
161 | A | A | 0.0000 | |
162 | T | A | -1.7923 | |
163 | Q | A | -1.8254 | |
164 | S | A | -1.3124 | |
165 | T | A | -1.0281 | |
166 | E | A | -1.6549 | |
167 | V | A | 0.2740 | |
168 | Q | A | -1.1383 | |
169 | P | A | -1.3103 | |
170 | T | A | -0.6927 | |
171 | Q | A | -1.0733 | |
172 | P | A | 0.0000 | |
173 | I | A | 0.0000 | |
174 | N | A | -1.8975 | |
175 | W | A | -1.6323 | |
176 | S | A | -1.5997 | |
177 | E | A | -2.0871 | |
178 | P | A | -1.3568 | |
179 | K | A | -1.3847 | |
180 | P | A | -1.0784 | |
181 | L | A | 0.0000 | |
182 | F | A | -1.3274 | |
183 | Q | A | -2.0941 | |
184 | T | A | -1.5936 | |
185 | D | A | -2.4972 | |
186 | S | A | -2.3209 | |
187 | P | A | -2.3925 | |
188 | N | A | -3.4516 | |
189 | N | A | -3.2102 | |
190 | K | A | -3.3392 | |
191 | G | A | -3.0899 | |
192 | D | A | -3.8910 | |
193 | L | A | -3.0208 | |
194 | K | A | -2.9807 | |
195 | E | A | -1.9347 | |
196 | F | A | -0.6667 | |
197 | L | A | -0.3189 | |
198 | G | A | 0.0000 | |
199 | G | A | 0.0000 | |
200 | G | A | 0.0000 | |
201 | G | A | 0.0000 | |
202 | S | A | 0.1654 | |
203 | G | A | 0.0000 | |
204 | I | A | 0.4029 | |
205 | V | A | 0.2593 | |
206 | M | A | 0.0000 | |
207 | G | A | -1.5551 | |
208 | N | A | -1.7575 | |
209 | G | A | -1.1648 | |
210 | T | A | 0.0000 | |
211 | L | A | 0.0000 | |
212 | V | A | 0.0000 | |
213 | F | A | 0.0000 | |
214 | P | A | 0.0000 | |
215 | L | A | 0.0000 | |
216 | T | A | 0.0000 | |
217 | A | A | 0.0000 | |
218 | K | A | -2.3451 | |
219 | D | A | -3.1846 | |
220 | E | A | -3.6259 | |
221 | S | A | -2.5043 | |
222 | N | A | -2.9848 | |
223 | K | A | -2.0743 | |
224 | V | A | 0.0000 | |
225 | F | A | -0.2507 | |
226 | S | A | 0.0000 | |
227 | L | A | 0.0000 | |
228 | I | A | 0.0000 | |
229 | T | A | 0.0000 | |
230 | Y | A | -0.6836 | |
231 | S | A | 0.0000 | |
232 | T | A | -1.6227 | |
233 | D | A | -1.9994 | |
234 | D | A | -2.5765 | |
235 | G | A | 0.0000 | |
236 | Q | A | -2.6280 | |
237 | K | A | -3.0741 | |
238 | W | A | -2.0793 | |
239 | E | A | -2.0989 | |
240 | I | A | -1.1073 | |
241 | P | A | 0.0000 | |
242 | G | A | -1.5144 | |
243 | G | A | -0.7506 | |
244 | V | A | 0.4715 | |
245 | S | A | 0.0000 | |
246 | S | A | -0.0241 | |
247 | V | A | 0.3958 | |
248 | A | A | -1.0092 | |
249 | C | A | 0.0000 | |
250 | R | A | -1.9022 | |
251 | S | A | -0.8946 | |
252 | P | A | 0.0000 | |
253 | R | A | 0.0000 | |
254 | V | A | 0.0000 | |
255 | T | A | 0.0000 | |
256 | E | A | -0.9139 | |
257 | W | A | 0.0000 | |
258 | E | A | -2.7603 | |
259 | E | A | -3.1557 | |
260 | G | A | -2.3697 | |
261 | T | A | 0.0000 | |
262 | L | A | 0.0000 | |
263 | L | A | 0.0000 | |
264 | M | A | 0.0000 | |
265 | V | A | 0.0000 | |
266 | T | A | 0.0000 | |
267 | Y | A | -1.7022 | |
268 | C | A | 0.0000 | |
269 | E | A | -3.2742 | |
270 | D | A | -3.1608 | |
271 | G | A | 0.0000 | |
272 | R | A | 0.0000 | |
273 | K | A | -0.6528 | |
274 | V | A | 0.0000 | |
275 | F | A | 0.0000 | |
276 | E | A | -0.7916 | |
277 | S | A | 0.0000 | |
278 | R | A | -2.8652 | |
279 | D | A | -1.9713 | |
280 | M | A | -1.1232 | |
281 | G | A | 0.0000 | |
282 | K | A | -2.0317 | |
283 | T | A | -1.2740 | |
284 | W | A | -0.8023 | |
285 | T | A | -0.3377 | |
286 | E | A | -0.2149 | |
287 | A | A | 0.3701 | |
288 | F | A | 1.4805 | |
289 | G | A | 0.1473 | |
290 | T | A | 0.0000 | |
291 | L | A | 0.0000 | |
292 | P | A | -0.4382 | |
293 | G | A | -0.2828 | |
294 | V | A | 0.0000 | |
295 | W | A | 0.1474 | |
296 | L | A | -0.6962 | |
297 | K | A | -2.2277 | |
298 | S | A | -2.3632 | |
299 | G | A | -1.7443 | |
300 | P | A | -1.2071 | |
301 | E | A | -2.1650 | |
302 | L | A | -1.8678 | |
303 | P | A | -1.9763 | |
304 | E | A | -3.1922 | |
305 | K | A | -2.6374 | |
306 | S | A | -1.6325 | |
307 | L | A | 0.0000 | |
308 | R | A | -1.2616 | |
309 | V | A | 0.0000 | |
310 | D | A | 0.0000 | |
311 | A | A | 0.0000 | |
312 | L | A | 0.0000 | |
313 | I | A | 0.2875 | |
314 | T | A | -0.0768 | |
315 | A | A | 0.0000 | |
316 | T | A | -1.7394 | |
317 | I | A | -2.0058 | |
318 | E | A | -2.7862 | |
319 | G | A | -2.4084 | |
320 | R | A | -3.0376 | |
321 | K | A | -2.3670 | |
322 | V | A | 0.0000 | |
323 | M | A | 0.0000 | |
324 | L | A | 0.0000 | |
325 | Y | A | 0.0000 | |
326 | T | A | 0.0000 | |
327 | Q | A | 0.0000 | |
328 | K | A | 0.0000 | |
329 | V | A | -0.1186 | |
330 | R | A | -1.2249 | |
331 | H | A | -1.3878 | |
332 | F | A | -0.0178 | |
333 | K | A | -2.0429 | |
334 | E | A | -2.5272 | |
335 | V | A | -0.5024 | |
336 | D | A | -2.4875 | |
337 | E | A | -2.7053 | |
338 | P | A | -1.4976 | |
339 | N | A | -1.0161 | |
340 | A | A | 0.0000 | |
341 | L | A | 0.0000 | |
342 | H | A | 0.0000 | |
343 | L | A | 0.0000 | |
344 | W | A | 0.1837 | |
345 | V | A | 0.0000 | |
346 | T | A | 0.0000 | |
347 | D | A | -1.9050 | |
348 | N | A | -2.0008 | |
349 | N | A | -2.5952 | |
350 | R | A | -2.5300 | |
351 | T | A | -1.0917 | |
352 | F | A | 0.2847 | |
353 | H | A | -0.0818 | |
354 | L | A | 0.0583 | |
355 | G | A | 0.0614 | |
356 | P | A | 0.3012 | |
357 | F | A | 0.0000 | |
358 | S | A | 0.2344 | |
359 | V | A | 0.5371 | |
360 | D | A | -0.8536 | |
361 | S | A | -1.4088 | |
362 | A | A | -1.5030 | |
363 | E | A | -3.1333 | |
364 | N | A | -2.6618 | |
365 | K | A | -1.9113 | |
366 | T | A | 0.0000 | |
367 | F | A | -0.7858 | |
368 | A | A | 0.0000 | |
369 | N | A | 0.0000 | |
370 | T | A | 0.0000 | |
371 | L | A | 0.0000 | |
372 | L | A | 0.0684 | |
373 | Y | A | -0.4384 | |
374 | S | A | -1.3546 | |
375 | D | A | -2.8933 | |
376 | D | A | -2.7750 | |
377 | A | A | 0.0000 | |
378 | L | A | 0.0000 | |
379 | H | A | 0.0000 | |
380 | L | A | 0.0000 | |
381 | L | A | 0.0000 | |
382 | Q | A | 0.0000 | |
383 | A | A | 0.0000 | |
384 | K | A | -1.4839 | |
385 | G | A | 0.0000 | |
386 | D | A | -2.8307 | |
387 | H | A | -2.7447 | |
388 | E | A | -3.1214 | |
389 | S | A | -2.0972 | |
390 | T | A | 0.0000 | |
391 | A | A | -0.3094 | |
392 | V | A | 0.0000 | |
393 | S | A | 0.0000 | |
394 | L | A | 0.0000 | |
395 | A | A | 0.0000 | |
396 | R | A | -0.7844 | |
397 | L | A | 0.0000 | |
398 | T | A | -1.5700 | |
399 | E | A | -2.3248 | |
400 | E | A | -1.4301 | |
401 | L | A | -1.1949 | |
402 | N | A | -1.7669 | |
403 | T | A | -0.9034 | |
404 | I | A | -0.3058 |