| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVVDGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGSIGHPLWNKLGDTENPTEPVHEGADDRVAFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRSGPDGHPLPAAPPPSPLYVPPPPSSPYAVLPSTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPAINVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9431 | |
| 2 | L | A | 1.9643 | |
| 3 | P | A | 0.6560 | |
| 4 | P | A | 0.3688 | |
| 5 | T | A | 0.1202 | |
| 6 | T | A | 0.1277 | |
| 7 | P | A | 0.1689 | |
| 8 | V | A | 1.2404 | |
| 9 | A | A | 0.0881 | |
| 10 | K | A | -1.0196 | |
| 11 | V | A | -0.1548 | |
| 12 | Q | A | -1.3951 | |
| 13 | S | A | -1.5574 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4420 | |
| 16 | E | A | -2.4485 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4540 | |
| 20 | P | A | 0.1237 | |
| 21 | T | A | 0.1581 | |
| 22 | S | A | -0.0989 | |
| 23 | L | A | 0.0883 | |
| 24 | F | A | -0.0464 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.3005 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.9016 | |
| 31 | R | A | -2.6829 | |
| 32 | L | A | -0.8022 | |
| 33 | L | A | 1.1562 | |
| 34 | T | A | 1.3620 | |
| 35 | V | A | 1.8162 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2553 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6299 | |
| 40 | K | A | -1.6812 | |
| 41 | D | A | -0.6801 | |
| 42 | I | A | 1.3914 | |
| 43 | V | A | 2.2630 | |
| 44 | V | A | 1.7166 | |
| 45 | D | A | -0.9066 | |
| 46 | G | A | -0.5056 | |
| 47 | K | A | -0.1404 | |
| 48 | V | A | 2.0957 | |
| 49 | V | A | 2.7368 | |
| 50 | V | A | 1.5849 | |
| 51 | P | A | 0.3642 | |
| 52 | K | A | -0.6796 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1707 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4117 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2766 | |
| 70 | K | A | -1.7981 | |
| 71 | F | A | -0.6510 | |
| 72 | A | A | -0.5796 | |
| 73 | L | A | -0.8614 | |
| 74 | P | A | -1.2668 | |
| 75 | Q | A | -2.5037 | |
| 76 | K | A | -3.1067 | |
| 77 | D | A | -2.9910 | |
| 78 | F | A | -1.6698 | |
| 79 | Y | A | -1.8922 | |
| 80 | D | A | -2.6896 | |
| 81 | P | A | -2.3065 | |
| 82 | E | A | -3.0475 | |
| 83 | K | A | -3.3936 | |
| 84 | E | A | -2.4572 | |
| 85 | R | A | -1.2898 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6783 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9755 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3601 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6970 | |
| 99 | G | A | -0.5413 | |
| 100 | P | A | -0.4033 | |
| 101 | L | A | 0.0472 | |
| 102 | G | A | -0.1744 | |
| 103 | K | A | -0.5586 | |
| 104 | G | A | -0.4550 | |
| 105 | S | A | -0.5232 | |
| 106 | I | A | 0.0000 | |
| 107 | G | A | 0.1257 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4165 | |
| 110 | L | A | 0.1166 | |
| 111 | W | A | 0.0000 | |
| 112 | N | A | -1.1768 | |
| 113 | K | A | -0.7287 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | -1.3166 | |
| 116 | D | A | -1.4470 | |
| 117 | T | A | -0.8675 | |
| 118 | E | A | -1.8495 | |
| 119 | N | A | -2.2402 | |
| 120 | P | A | -1.8758 | |
| 121 | T | A | -1.5381 | |
| 122 | E | A | -2.1621 | |
| 123 | P | A | -1.0373 | |
| 124 | V | A | -0.8536 | |
| 125 | H | A | -1.7234 | |
| 126 | E | A | -2.6290 | |
| 127 | G | A | -2.1848 | |
| 128 | A | A | -1.5782 | |
| 129 | D | A | -2.4799 | |
| 130 | D | A | -2.0993 | |
| 131 | R | A | -1.1026 | |
| 132 | V | A | 0.2573 | |
| 133 | A | A | 0.4480 | |
| 134 | F | A | 0.2855 | |
| 135 | S | A | -0.0902 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.4908 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5582 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.1846 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1859 | |
| 157 | D | A | 0.3595 | |
| 158 | L | A | 0.8211 | |
| 159 | A | A | 0.1957 | |
| 160 | E | A | -1.4435 | |
| 161 | P | A | -0.2040 | |
| 162 | C | A | 0.1870 | |
| 163 | P | A | -0.1711 | |
| 164 | G | A | -0.0798 | |
| 165 | L | A | 0.5826 | |
| 166 | P | A | -0.1201 | |
| 167 | P | A | -0.3427 | |
| 168 | G | A | -0.4500 | |
| 169 | A | A | -0.0223 | |
| 170 | C | A | 0.6642 | |
| 171 | P | A | 0.5377 | |
| 172 | P | A | 0.8705 | |
| 173 | I | A | 2.0566 | |
| 174 | Q | A | 0.8974 | |
| 175 | L | A | 1.5313 | |
| 176 | V | A | 0.8755 | |
| 177 | N | A | -0.2944 | |
| 178 | S | A | -0.0904 | |
| 179 | V | A | 0.4283 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3866 | |
| 182 | D | A | 0.0832 | |
| 183 | G | A | -0.1572 | |
| 184 | D | A | -0.5182 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1194 | |
| 190 | F | A | 0.0608 | |
| 191 | G | A | -0.1054 | |
| 192 | N | A | -0.2417 | |
| 193 | M | A | -0.0889 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3789 | |
| 197 | E | A | -2.5921 | |
| 198 | L | A | -1.2191 | |
| 199 | Q | A | -2.5641 | |
| 200 | Q | A | -3.3122 | |
| 201 | D | A | -3.4908 | |
| 202 | R | A | -3.3325 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2154 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3425 | |
| 211 | S | A | -1.8608 | |
| 212 | T | A | -1.4019 | |
| 213 | R | A | -2.0101 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1477 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3469 | |
| 220 | L | A | 0.6128 | |
| 221 | K | A | -1.0945 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8077 | |
| 224 | N | A | -1.4859 | |
| 225 | E | A | -1.2263 | |
| 226 | A | A | -0.5974 | |
| 227 | Y | A | -0.3607 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6551 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0860 | |
| 234 | F | A | 0.2766 | |
| 235 | G | A | -0.7903 | |
| 236 | R | A | -2.5564 | |
| 237 | R | A | -2.7748 | |
| 238 | E | A | -2.0834 | |
| 239 | Q | A | -0.1545 | |
| 240 | V | A | 1.4307 | |
| 241 | Y | A | 1.1305 | |
| 242 | A | A | 0.2433 | |
| 243 | R | A | -0.8755 | |
| 244 | H | A | -0.9212 | |
| 245 | F | A | 0.0458 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.6600 | |
| 249 | S | A | -1.6411 | |
| 250 | G | A | -1.2673 | |
| 251 | P | A | -1.1852 | |
| 252 | D | A | -1.2814 | |
| 253 | G | A | -1.2661 | |
| 254 | H | A | -1.4329 | |
| 255 | P | A | -0.8639 | |
| 256 | L | A | 0.3533 | |
| 257 | P | A | 0.0337 | |
| 258 | A | A | 0.1865 | |
| 259 | A | A | 0.3420 | |
| 260 | P | A | -0.2407 | |
| 261 | P | A | -0.1456 | |
| 262 | P | A | 0.0587 | |
| 263 | S | A | 0.5669 | |
| 264 | P | A | 0.6819 | |
| 265 | L | A | 1.9127 | |
| 266 | Y | A | 1.7175 | |
| 267 | V | A | 1.9274 | |
| 268 | P | A | 0.9870 | |
| 269 | P | A | 0.6691 | |
| 270 | P | A | -0.1590 | |
| 271 | P | A | -0.1352 | |
| 272 | S | A | -0.3207 | |
| 273 | S | A | 0.2196 | |
| 274 | P | A | 0.5075 | |
| 275 | Y | A | 1.6485 | |
| 276 | A | A | 1.2519 | |
| 277 | V | A | 2.2055 | |
| 278 | L | A | 1.6624 | |
| 279 | P | A | 0.3126 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.3199 | |
| 282 | D | A | -0.7892 | |
| 283 | Y | A | 0.9280 | |
| 284 | F | A | 0.7186 | |
| 285 | G | A | 0.2608 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9442 | |
| 291 | L | A | 1.6370 | |
| 292 | V | A | 0.6530 | |
| 293 | S | A | -0.1617 | |
| 294 | S | A | -0.9628 | |
| 295 | D | A | -1.8418 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.0862 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6450 | |
| 301 | R | A | -1.8717 | |
| 302 | P | A | -0.9894 | |
| 303 | F | A | -0.2026 | |
| 304 | W | A | -0.5792 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0918 | |
| 307 | R | A | -2.8373 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2448 | |
| 310 | G | A | -1.2185 | |
| 311 | N | A | -1.2682 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8035 | |
| 319 | N | A | -0.8537 | |
| 320 | E | A | -1.0412 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3253 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0762 | |
| 333 | N | A | 0.5435 | |
| 334 | F | A | 1.7392 | |
| 335 | T | A | 0.8720 | |
| 336 | I | A | 0.4633 | |
| 337 | S | A | -0.8312 | |
| 338 | Q | A | -1.5119 | |
| 339 | Q | A | -0.8623 | |
| 340 | L | A | 0.8473 | |
| 341 | C | A | 0.5299 | |
| 342 | T | A | 0.2708 | |
| 343 | P | A | -0.1053 | |
| 344 | A | A | 0.3805 | |
| 345 | I | A | 0.7427 | |
| 346 | N | A | 0.0237 | |
| 347 | V | A | 1.7541 | |
| 348 | Y | A | 1.5918 | |
| 349 | D | A | 0.0944 | |
| 350 | P | A | -0.3394 | |
| 351 | S | A | -0.2815 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.6179 | |
| 354 | K | A | -1.6881 | |
| 355 | N | A | -1.7090 | |
| 356 | Y | A | -0.0912 | |
| 357 | L | A | 0.6403 | |
| 358 | R | A | 0.9635 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3782 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0822 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0425 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6870 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3015 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3099 | |
| 376 | L | A | -1.7062 | |
| 377 | D | A | -1.9877 | |
| 378 | P | A | -1.0362 | |
| 379 | G | A | -1.0117 | |
| 380 | V | A | -0.9322 | |
| 381 | L | A | -0.5298 | |
| 382 | A | A | -0.6549 | |
| 383 | H | A | -0.8058 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4126 | |
| 386 | T | A | -0.5522 | |
| 387 | M | A | -0.2978 | |
| 388 | N | A | -0.8628 | |
| 389 | P | A | -1.2437 | |
| 390 | T | A | -1.4327 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4311 | |
| 393 | E | A | -2.7674 | |
| 394 | N | A | -2.3372 | |
| 395 | W | A | -1.3609 | |
| 396 | N | A | -1.1096 | |
| 397 | L | A | -0.1827 | |
| 398 | G | A | 0.5332 | |
| 399 | F | A | 2.4163 | |
| 400 | V | A | 1.8237 | |
| 401 | P | A | 0.0424 | |
| 402 | P | A | -1.8424 | |
| 403 | K | A | -3.3043 | |
| 404 | E | A | -3.7464 | |
| 405 | R | A | -3.8541 | |
| 406 | E | A | -3.7665 | |
| 407 | D | A | -2.8787 | |
| 408 | P | A | -1.7663 | |
| 409 | Y | A | -0.9965 | |
| 410 | K | A | -2.1177 | |
| 411 | G | A | -0.6464 | |
| 412 | L | A | 0.6693 | |
| 413 | I | A | 1.5851 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3989 | |
| 416 | E | A | -1.7032 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9659 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0774 | |
| 421 | E | A | -2.8074 | |
| 422 | R | A | -2.6775 | |
| 423 | F | A | -1.3049 | |
| 424 | S | A | -1.4788 | |
| 425 | Q | A | -1.8778 | |
| 426 | D | A | -2.8914 | |
| 427 | L | A | -1.9829 | |
| 428 | D | A | -2.7676 | |
| 429 | Q | A | -2.6066 | |
| 430 | F | A | -1.4107 | |
| 431 | A | A | -0.8912 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5786 | |
| 435 | K | A | -0.7125 | |
| 436 | F | A | 0.1410 | |
| 437 | L | A | 1.0286 | |
| 438 | Y | A | 0.8249 | |
| 439 | Q | A | -0.2769 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine