Project name: 3a06afb532f5bf9

Chain sequence(s)	A: MATTVMASATASSPAFSAPGARARRAARLPAGFRGRVAAPPRRLALLARASQQADDAAADTSASAAPAARKLGLWDALAFSGPAPERINGRLAMVGFVSALAVEATRGDGILSQAGNGAGLAWFAYTAAVLSAASLVPLLQGESAEGRSGRFMTADAELWNGRLAMLGLVALAVTEYLTGAPFVNRKRRRRRPRPPPPPSFSSPHTPAAAAAPTARAKAAGPRLWDALAFGGPAPERTNGRLAMVGFVSALAVETDAGSGLACDSAEVRSGAVMSADAELWNGRFAMLGLVALAFTAHRRPAHQRLD
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:10)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:12)

• Minimal score value: -5.1564
• Maximal score value: 3.126
• Average score: -0.2023
• Total score value: -62.093

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	1.0674
2	A	A	0.5188
3	T	A	0.5053
4	T	A	0.9907
5	V	A	2.2877
6	M	A	1.9477
7	A	A	0.8896
8	S	A	0.0540
9	A	A	-0.0584
10	T	A	-0.0997
11	A	A	-0.1119
12	S	A	-0.3599
13	S	A	-0.4141
14	P	A	0.0098
15	A	A	0.8154
16	F	A	1.8287
17	S	A	0.7055
18	A	A	0.0887
19	P	A	-0.4818
20	G	A	-0.9018
21	A	A	-1.0882
22	R	A	-2.2662
23	A	A	-2.2091
24	R	A	-3.0808
25	R	A	-2.6700
26	A	A	-1.7210
27	A	A	-0.9561
28	R	A	-1.1145
29	L	A	0.4956
30	P	A	0.1365
31	A	A	0.4207
32	G	A	0.2251
33	F	A	0.7530
34	R	A	-1.5988
35	G	A	-1.5255
36	R	A	-1.4394
37	V	A	0.7055
38	A	A	0.4783
39	A	A	0.2516
40	P	A	-0.7312
41	P	A	-1.6384
42	R	A	-2.6305
43	R	A	-2.0575
44	L	A	0.6279
45	A	A	1.5897
46	L	A	2.4377
47	L	A	1.9507
48	A	A	0.2265
49	R	A	-1.4793
50	A	A	-1.1882
51	S	A	-1.5379
52	Q	A	-2.2801
53	Q	A	-2.4754
54	A	A	-2.3417
55	D	A	-3.0867
56	D	A	-2.7650
57	A	A	-1.3037
58	A	A	-0.8761
59	A	A	-0.8646
60	D	A	-1.8142
61	T	A	-1.0361
62	S	A	-0.6469
63	A	A	-0.3309
64	S	A	-0.2337
65	A	A	-0.0585
66	A	A	-0.0505
67	P	A	-0.5138
68	A	A	-0.7169
69	A	A	-1.0862
70	R	A	-2.2517
71	K	A	-1.8754
72	L	A	0.2411
73	G	A	0.6447
74	L	A	2.0704
75	W	A	2.0848
76	D	A	0.2656
77	A	A	1.3845
78	L	A	2.3287
79	A	A	1.4421
80	F	A	1.8644
81	S	A	0.4480
82	G	A	-0.3531
83	P	A	-1.0198
84	A	A	-0.7913
85	P	A	-1.3245
86	E	A	-2.8064
87	R	A	-2.8296
88	I	A	-1.1023
89	N	A	-2.2046
90	G	A	-2.1589
91	R	A	-1.3645
92	L	A	0.0918
93	A	A	0.3293
94	M	A	0.9616
95	V	A	1.2007
96	G	A	1.1731
97	F	A	1.8143
98	V	A	1.8936
99	S	A	0.9187
100	A	A	0.7424
101	L	A	0.6417
102	A	A	0.2283
103	V	A	-0.3856
104	E	A	-1.4751
105	A	A	-0.8748
106	T	A	-1.4850
107	R	A	-2.9031
108	G	A	-2.1807
109	D	A	-2.3274
110	G	A	-0.8522
111	I	A	0.8137
112	L	A	-0.4905
113	S	A	-0.8956
114	Q	A	-0.9408
115	A	A	-0.4139
116	G	A	-0.7785
117	N	A	-1.7488
118	G	A	-0.8980
119	A	A	-0.1390
120	G	A	0.1628
121	L	A	0.7300
122	A	A	1.0650
123	W	A	2.0129
124	F	A	1.9244
125	A	A	1.8890
126	Y	A	2.5574
127	T	A	2.0587
128	A	A	1.9373
129	A	A	1.7335
130	V	A	2.3813
131	L	A	2.3623
132	S	A	1.9034
133	A	A	1.7177
134	A	A	1.9304
135	S	A	2.0907
136	L	A	3.0380
137	V	A	2.8055
138	P	A	1.2173
139	L	A	2.0466
140	L	A	1.9728
141	Q	A	-0.3416
142	G	A	-1.0088
143	E	A	-2.4028
144	S	A	-2.1163
145	A	A	-1.9536
146	E	A	-2.8359
147	G	A	-2.5864
148	R	A	-3.0427
149	S	A	-1.9059
150	G	A	-1.5091
151	R	A	-1.2377
152	F	A	1.4277
153	M	A	1.2199
154	T	A	-0.0391
155	A	A	-0.3982
156	D	A	-1.5196
157	A	A	-1.2700
158	E	A	-2.3334
159	L	A	-0.6806
160	W	A	-0.2605
161	N	A	-1.3460
162	G	A	-1.5447
163	R	A	-0.9157
164	L	A	0.6319
165	A	A	0.6643
166	M	A	1.2277
167	L	A	1.8047
168	G	A	1.6326
169	L	A	2.3580
170	V	A	3.1260
171	A	A	2.2574
172	L	A	2.4748
173	A	A	2.2048
174	V	A	2.5727
175	T	A	1.7518
176	E	A	1.4605
177	Y	A	2.1125
178	L	A	2.2259
179	T	A	0.7833
180	G	A	0.5154
181	A	A	0.5364
182	P	A	0.7108
183	F	A	1.5345
184	V	A	1.1939
185	N	A	-1.5552
186	R	A	-3.3180
187	K	A	-4.4142
188	R	A	-5.0641
189	R	A	-5.1564
190	R	A	-4.9521
191	R	A	-4.7470
192	R	A	-4.1604
193	P	A	-2.8916
194	R	A	-2.9112
195	P	A	-1.6565
196	P	A	-1.0975
197	P	A	-0.8802
198	P	A	-0.4175
199	P	A	-0.0750
200	S	A	0.4298
201	F	A	1.5564
202	S	A	0.3764
203	S	A	-0.2192
204	P	A	-0.7055
205	H	A	-1.2668
206	T	A	-0.7179
207	P	A	-0.4829
208	A	A	-0.1455
209	A	A	0.0754
210	A	A	0.0745
211	A	A	0.0659
212	A	A	-0.0241
213	P	A	-0.5331
214	T	A	-0.6503
215	A	A	-1.1555
216	R	A	-2.3152
217	A	A	-1.6278
218	K	A	-2.1983
219	A	A	-1.1287
220	A	A	-1.0034
221	G	A	-1.1715
222	P	A	-1.0231
223	R	A	-0.9845
224	L	A	1.2533
225	W	A	1.6396
226	D	A	0.0892
227	A	A	1.0117
228	L	A	2.1278
229	A	A	1.6222
230	F	A	1.6770
231	G	A	0.3353
232	G	A	-0.2664
233	P	A	-0.6655
234	A	A	-1.1780
235	P	A	-1.3778
236	E	A	-3.2679
237	R	A	-3.3756
238	T	A	-2.1093
239	N	A	-1.8548
240	G	A	-2.1783
241	R	A	-1.6164
242	L	A	0.8346
243	A	A	0.8106
244	M	A	1.8155
245	V	A	2.4314
246	G	A	1.7491
247	F	A	2.7383
248	V	A	3.1084
249	S	A	1.9534
250	A	A	1.7975
251	L	A	1.9989
252	A	A	1.0079
253	V	A	1.0155
254	E	A	-0.9458
255	T	A	-1.0232
256	D	A	-1.7367
257	A	A	-1.3195
258	G	A	-1.2360
259	S	A	-0.7343
260	G	A	0.1620
261	L	A	1.2075
262	A	A	0.6013
263	C	A	0.0460
264	D	A	-1.2727
265	S	A	-1.0850
266	A	A	-1.1406
267	E	A	-1.5195
268	V	A	-0.1257
269	R	A	-1.7002
270	S	A	-1.1566
271	G	A	-0.3366
272	A	A	0.8478
273	V	A	2.1522
274	M	A	1.6206
275	S	A	0.5292
276	A	A	-0.5124
277	D	A	-1.0023
278	A	A	-0.8263
279	E	A	-1.8575
280	L	A	0.1430
281	W	A	0.1773
282	N	A	-0.8702
283	G	A	-0.7804
284	R	A	-0.5139
285	F	A	1.6054
286	A	A	0.8989
287	M	A	1.4534
288	L	A	1.7895
289	G	A	1.9458
290	L	A	2.9993
291	V	A	2.8585
292	A	A	2.3056
293	L	A	2.8353
294	A	A	1.8258
295	F	A	1.7540
296	T	A	0.3278
297	A	A	-0.4524
298	H	A	-1.5558
299	R	A	-2.7874
300	R	A	-3.0456
301	P	A	-2.2031
302	A	A	-1.7686
303	H	A	-2.1192
304	Q	A	-2.5224
305	R	A	-2.3573
306	L	A	-0.6901
307	D	A	-1.6325