| Chain sequence(s) |
A: CGEQNMIGMTPTVIAVHYLDQTEQWEKFGLEKRQEALELIKKGYTQQLAFKQPISAYAAFNNRPPSTWLTAYVSRVFSLAANLIAIDSQVLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNTKEADVSLTAFVLIALQEARDICEGQVNSLPGSINKAGEYLEASYLNLQRPYTVAIAGYALALMNKLEEPYLTKFLNTAKDRNRWEEPGQQLYNVEATSYALLALLLLKDFDSVPPVVRWLNDERYYGGGYGSTQATFMVFQALAQYRADV
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:04:07)
[INFO] Main: Simulation completed successfully. (00:04:08)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1010 | C | A | 0.1123 | |
| 1011 | G | A | 0.0000 | |
| 1012 | E | A | 0.0000 | |
| 1013 | Q | A | -0.8489 | |
| 1014 | N | A | -0.8317 | |
| 1015 | M | A | 0.0000 | |
| 1016 | I | A | -0.1510 | |
| 1017 | G | A | -0.5165 | |
| 1018 | M | A | 0.0000 | |
| 1019 | T | A | 0.0000 | |
| 1020 | P | A | -0.2562 | |
| 1021 | T | A | 0.1301 | |
| 1022 | V | A | 0.0000 | |
| 1023 | I | A | 0.0000 | |
| 1024 | A | A | -0.1585 | |
| 1025 | V | A | 0.0000 | |
| 1026 | H | A | -0.8162 | |
| 1027 | Y | A | -0.7930 | |
| 1028 | L | A | 0.0000 | |
| 1029 | D | A | -1.6772 | |
| 1030 | Q | A | -1.8620 | |
| 1031 | T | A | -1.7233 | |
| 1032 | E | A | -2.6454 | |
| 1033 | Q | A | -1.7970 | |
| 1034 | W | A | 0.0000 | |
| 1035 | E | A | -2.3490 | |
| 1036 | K | A | -1.8784 | |
| 1037 | F | A | -0.3003 | |
| 1038 | G | A | -0.7506 | |
| 1039 | L | A | -0.7144 | |
| 1040 | E | A | -2.3696 | |
| 1041 | K | A | -2.4031 | |
| 1042 | R | A | -2.2477 | |
| 1043 | Q | A | -2.9351 | |
| 1044 | E | A | -3.4276 | |
| 1045 | A | A | -1.9489 | |
| 1046 | L | A | -1.8657 | |
| 1047 | E | A | -2.7020 | |
| 1048 | L | A | -0.8246 | |
| 1049 | I | A | 0.0000 | |
| 1050 | K | A | -2.0508 | |
| 1051 | K | A | -2.2334 | |
| 1052 | G | A | 0.0000 | |
| 1053 | Y | A | 0.0000 | |
| 1054 | T | A | -0.7667 | |
| 1055 | Q | A | -1.0015 | |
| 1056 | Q | A | 0.0000 | |
| 1057 | L | A | 0.1787 | |
| 1058 | A | A | 0.0181 | |
| 1059 | F | A | -0.2697 | |
| 1060 | K | A | -0.4652 | |
| 1061 | Q | A | 0.0000 | |
| 1062 | P | A | -0.1271 | |
| 1063 | I | A | 0.4901 | |
| 1064 | S | A | -0.1269 | |
| 1065 | A | A | 0.0000 | |
| 1066 | Y | A | 0.0000 | |
| 1067 | A | A | 0.0000 | |
| 1068 | A | A | 0.0000 | |
| 1069 | F | A | -0.1144 | |
| 1070 | N | A | -1.5856 | |
| 1071 | N | A | -1.8048 | |
| 1072 | R | A | -1.2461 | |
| 1073 | P | A | -1.1962 | |
| 1074 | P | A | -0.8575 | |
| 1075 | S | A | 0.0000 | |
| 1076 | T | A | 0.0000 | |
| 1077 | W | A | 0.0000 | |
| 1078 | L | A | 0.0000 | |
| 1079 | T | A | 0.0000 | |
| 1080 | A | A | 0.0000 | |
| 1081 | Y | A | 0.0000 | |
| 1082 | V | A | 0.0000 | |
| 1083 | S | A | 0.0000 | |
| 1084 | R | A | 0.0000 | |
| 1085 | V | A | 0.0000 | |
| 1086 | F | A | 0.0000 | |
| 1087 | S | A | 0.0000 | |
| 1088 | L | A | -0.2807 | |
| 1089 | A | A | 0.0000 | |
| 1090 | A | A | -0.4735 | |
| 1091 | N | A | -1.1175 | |
| 1092 | L | A | -0.5305 | |
| 1093 | I | A | 0.0000 | |
| 1094 | A | A | -0.3755 | |
| 1095 | I | A | -0.6203 | |
| 1096 | D | A | -1.1836 | |
| 1097 | S | A | -1.0883 | |
| 1098 | Q | A | -1.6506 | |
| 1099 | V | A | 0.0000 | |
| 1100 | L | A | 0.0000 | |
| 1101 | C | A | 0.0000 | |
| 1102 | G | A | -0.9544 | |
| 1103 | A | A | 0.0000 | |
| 1104 | V | A | 0.0000 | |
| 1105 | K | A | -0.9949 | |
| 1106 | W | A | 0.0000 | |
| 1107 | L | A | 0.0000 | |
| 1108 | I | A | 0.0000 | |
| 1109 | L | A | 0.2717 | |
| 1110 | E | A | -1.4166 | |
| 1111 | K | A | 0.0000 | |
| 1112 | Q | A | -1.2481 | |
| 1113 | K | A | -1.7905 | |
| 1114 | P | A | -1.6326 | |
| 1115 | D | A | -2.5646 | |
| 1116 | G | A | 0.0000 | |
| 1117 | V | A | 0.0000 | |
| 1118 | F | A | 0.0000 | |
| 1119 | Q | A | -1.7324 | |
| 1120 | E | A | -1.6476 | |
| 1121 | D | A | -2.1609 | |
| 1122 | G | A | 0.0000 | |
| 1123 | P | A | -0.6272 | |
| 1124 | V | A | 0.0000 | |
| 1125 | I | A | 0.9443 | |
| 1126 | H | A | 0.2450 | |
| 1127 | Q | A | -0.4148 | |
| 1128 | E | A | 0.0000 | |
| 1129 | M | A | 0.0000 | |
| 1130 | I | A | 0.0000 | |
| 1131 | G | A | 0.0000 | |
| 1132 | G | A | 0.0000 | |
| 1133 | F | A | -0.8318 | |
| 1134 | R | A | -1.2136 | |
| 1135 | N | A | -1.4502 | |
| 1136 | T | A | -1.4636 | |
| 1137 | K | A | -2.1346 | |
| 1138 | E | A | -1.6559 | |
| 1139 | A | A | -1.5232 | |
| 1140 | D | A | -1.7458 | |
| 1141 | V | A | 0.0000 | |
| 1142 | S | A | 0.0000 | |
| 1143 | L | A | 0.0000 | |
| 1144 | T | A | 0.0000 | |
| 1145 | A | A | 0.0000 | |
| 1146 | F | A | 0.0000 | |
| 1147 | V | A | 0.0000 | |
| 1148 | L | A | 0.0000 | |
| 1149 | I | A | 0.0000 | |
| 1150 | A | A | 0.0000 | |
| 1151 | L | A | 0.0000 | |
| 1152 | Q | A | -0.7973 | |
| 1153 | E | A | -0.8890 | |
| 1154 | A | A | 0.0000 | |
| 1155 | R | A | -1.8946 | |
| 1156 | D | A | -2.1521 | |
| 1157 | I | A | -1.3359 | |
| 1158 | C | A | 0.0000 | |
| 1159 | E | A | -2.1819 | |
| 1160 | G | A | -1.9785 | |
| 1161 | Q | A | -2.2581 | |
| 1162 | V | A | 0.0000 | |
| 1163 | N | A | -2.1543 | |
| 1164 | S | A | -1.1448 | |
| 1165 | L | A | 0.0000 | |
| 1166 | P | A | -1.1876 | |
| 1167 | G | A | -1.2555 | |
| 1168 | S | A | 0.0000 | |
| 1169 | I | A | 0.0000 | |
| 1170 | N | A | -1.8639 | |
| 1171 | K | A | -2.4564 | |
| 1172 | A | A | 0.0000 | |
| 1173 | G | A | 0.0000 | |
| 1174 | E | A | -2.6343 | |
| 1175 | Y | A | -1.7279 | |
| 1176 | L | A | 0.0000 | |
| 1177 | E | A | -0.9007 | |
| 1178 | A | A | -0.5660 | |
| 1179 | S | A | -0.6191 | |
| 1180 | Y | A | 0.0000 | |
| 1181 | L | A | -0.0019 | |
| 1182 | N | A | -1.1778 | |
| 1183 | L | A | 0.0000 | |
| 1184 | Q | A | -1.6203 | |
| 1185 | R | A | 0.0000 | |
| 1186 | P | A | -0.9555 | |
| 1187 | Y | A | 0.0000 | |
| 1188 | T | A | 0.0000 | |
| 1189 | V | A | 0.0000 | |
| 1190 | A | A | 0.0000 | |
| 1191 | I | A | 0.0000 | |
| 1192 | A | A | 0.0000 | |
| 1193 | G | A | 0.0000 | |
| 1194 | Y | A | 0.0000 | |
| 1195 | A | A | 0.0000 | |
| 1196 | L | A | 0.0000 | |
| 1197 | A | A | 0.0000 | |
| 1198 | L | A | 0.1107 | |
| 1199 | M | A | -0.6853 | |
| 1200 | N | A | -1.4765 | |
| 1201 | K | A | -1.9654 | |
| 1202 | L | A | 0.0000 | |
| 1203 | E | A | -2.9697 | |
| 1204 | E | A | -2.8130 | |
| 1205 | P | A | -1.6817 | |
| 1206 | Y | A | -1.1936 | |
| 1207 | L | A | -1.2089 | |
| 1208 | T | A | -1.0371 | |
| 1209 | K | A | -1.0231 | |
| 1210 | F | A | 0.0000 | |
| 1211 | L | A | -0.9026 | |
| 1212 | N | A | -1.8842 | |
| 1213 | T | A | -1.7362 | |
| 1214 | A | A | -2.3663 | |
| 1215 | K | A | -3.5094 | |
| 1216 | D | A | -3.5829 | |
| 1217 | R | A | -3.3122 | |
| 1218 | N | A | -2.5287 | |
| 1219 | R | A | -2.0540 | |
| 1220 | W | A | 0.0000 | |
| 1221 | E | A | -1.6649 | |
| 1222 | E | A | 0.0000 | |
| 1223 | P | A | -0.9759 | |
| 1224 | G | A | -1.0976 | |
| 1225 | Q | A | -1.2658 | |
| 1226 | Q | A | -1.4085 | |
| 1227 | L | A | -0.4463 | |
| 1228 | Y | A | 0.0000 | |
| 1229 | N | A | 0.0000 | |
| 1230 | V | A | 0.0000 | |
| 1231 | E | A | 0.0000 | |
| 1232 | A | A | 0.0000 | |
| 1233 | T | A | 0.0000 | |
| 1234 | S | A | 0.0000 | |
| 1235 | Y | A | 0.0000 | |
| 1236 | A | A | 0.0000 | |
| 1237 | L | A | 0.0000 | |
| 1238 | L | A | 0.0000 | |
| 1239 | A | A | 0.0000 | |
| 1240 | L | A | 0.0000 | |
| 1241 | L | A | 0.0000 | |
| 1242 | L | A | -0.2282 | |
| 1243 | L | A | -0.7164 | |
| 1244 | K | A | -1.7457 | |
| 1245 | D | A | -1.7920 | |
| 1246 | F | A | -0.6927 | |
| 1247 | D | A | -1.9625 | |
| 1248 | S | A | -1.4239 | |
| 1249 | V | A | 0.0000 | |
| 1250 | P | A | -1.0108 | |
| 1251 | P | A | -1.8520 | |
| 1252 | V | A | 0.0000 | |
| 1253 | V | A | 0.0000 | |
| 1254 | R | A | -2.8165 | |
| 1255 | W | A | -2.3607 | |
| 1256 | L | A | 0.0000 | |
| 1257 | N | A | -3.0963 | |
| 1258 | D | A | -3.3945 | |
| 1259 | E | A | -2.5950 | |
| 1260 | R | A | -2.2038 | |
| 1261 | Y | A | -0.6004 | |
| 1262 | Y | A | 0.7808 | |
| 1263 | G | A | -0.0222 | |
| 1264 | G | A | -0.1043 | |
| 1265 | G | A | 0.6181 | |
| 1266 | Y | A | 1.2820 | |
| 1267 | G | A | 0.6469 | |
| 1268 | S | A | 0.0000 | |
| 1269 | T | A | 0.0000 | |
| 1270 | Q | A | 0.0000 | |
| 1271 | A | A | 0.0000 | |
| 1272 | T | A | 0.0000 | |
| 1273 | F | A | 0.0000 | |
| 1274 | M | A | 0.0000 | |
| 1275 | V | A | 0.0000 | |
| 1276 | F | A | 0.2251 | |
| 1277 | Q | A | -0.1322 | |
| 1278 | A | A | 0.0000 | |
| 1279 | L | A | 0.0000 | |
| 1280 | A | A | 0.0000 | |
| 1281 | Q | A | -0.5739 | |
| 1282 | Y | A | -0.0888 | |
| 1283 | R | A | -0.7100 | |
| 1284 | A | A | -0.6535 | |
| 1285 | D | A | -0.2421 | |
| 1286 | V | A | 1.1249 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine