| Chain sequence(s) |
A: MAMEQWLAGIDLGGTTTKMAFITEDGIIVHKWEIPTDTSNRGERIVAHIARSLDETLARLGGTKEQLLAIGIGAPGPVQEETGMLYEAVNLGWKHYPLKRQLEEETGLPVAVDNDANIAALGEMWKGAGGGARHLLFVTLGTGVGGGVIANGAIVRGTNGAGGEIGHMTMVADGGAPCNCGKTGCLETIASATGIVRIAGEKLAASERPSALRGGDVTAKAVFDAAKTGDALALEVVEEVTRYLGLALANAANVTNPEKIVIGGGVSKAGALLVEHVAAHFRRYAFPRVAAGAEIVLATLGNDAGVIGGAWLAKSLIGA
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:02)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 1.0927 | |
| 2 | A | A | 0.5532 | |
| 3 | M | A | 0.1400 | |
| 4 | E | A | -1.4108 | |
| 5 | Q | A | -1.3012 | |
| 6 | W | A | 0.0000 | |
| 7 | L | A | 0.0000 | |
| 8 | A | A | 0.0000 | |
| 9 | G | A | 0.0000 | |
| 10 | I | A | 0.0000 | |
| 11 | D | A | -1.1001 | |
| 12 | L | A | 0.0000 | |
| 13 | G | A | -0.7615 | |
| 14 | G | A | -0.5651 | |
| 15 | T | A | -0.5162 | |
| 16 | T | A | -0.8027 | |
| 17 | T | A | 0.0000 | |
| 18 | K | A | -1.5993 | |
| 19 | M | A | 0.0000 | |
| 20 | A | A | 0.0000 | |
| 21 | F | A | 0.0000 | |
| 22 | I | A | 0.0000 | |
| 23 | T | A | -0.3217 | |
| 24 | E | A | -1.2951 | |
| 25 | D | A | -1.5041 | |
| 26 | G | A | 0.0000 | |
| 27 | I | A | 1.7237 | |
| 28 | I | A | 1.3349 | |
| 29 | V | A | 1.3113 | |
| 30 | H | A | 0.1642 | |
| 31 | K | A | -1.3327 | |
| 32 | W | A | -1.3667 | |
| 33 | E | A | -2.0765 | |
| 34 | I | A | -0.8716 | |
| 35 | P | A | -0.7675 | |
| 36 | T | A | -0.8800 | |
| 37 | D | A | -1.6581 | |
| 38 | T | A | -2.0648 | |
| 39 | S | A | -2.1219 | |
| 40 | N | A | -3.0756 | |
| 41 | R | A | -3.5730 | |
| 42 | G | A | 0.0000 | |
| 43 | E | A | -3.5546 | |
| 44 | R | A | -2.9565 | |
| 45 | I | A | 0.0000 | |
| 46 | V | A | 0.0000 | |
| 47 | A | A | -1.9893 | |
| 48 | H | A | -1.6589 | |
| 49 | I | A | 0.0000 | |
| 50 | A | A | 0.0000 | |
| 51 | R | A | -2.9622 | |
| 52 | S | A | 0.0000 | |
| 53 | L | A | 0.0000 | |
| 54 | D | A | -2.7773 | |
| 55 | E | A | -3.1903 | |
| 56 | T | A | 0.0000 | |
| 57 | L | A | 0.0000 | |
| 58 | A | A | -1.7902 | |
| 59 | R | A | -2.2697 | |
| 60 | L | A | -0.7397 | |
| 61 | G | A | -0.9358 | |
| 62 | G | A | -1.3601 | |
| 63 | T | A | -1.2187 | |
| 64 | K | A | -2.0681 | |
| 65 | E | A | -2.2000 | |
| 66 | Q | A | -1.5553 | |
| 67 | L | A | 0.0000 | |
| 68 | L | A | -0.1235 | |
| 69 | A | A | 0.0000 | |
| 70 | I | A | 0.0000 | |
| 71 | G | A | 0.0000 | |
| 72 | I | A | 0.0000 | |
| 73 | G | A | 0.0000 | |
| 74 | A | A | 0.0000 | |
| 75 | P | A | -0.7241 | |
| 76 | G | A | -0.7699 | |
| 77 | P | A | -1.2717 | |
| 78 | V | A | 0.0000 | |
| 79 | Q | A | -2.2237 | |
| 80 | E | A | -3.1864 | |
| 81 | E | A | -2.8293 | |
| 82 | T | A | -1.9360 | |
| 83 | G | A | 0.0000 | |
| 84 | M | A | -1.5879 | |
| 85 | L | A | 0.0000 | |
| 86 | Y | A | -1.3499 | |
| 87 | E | A | -1.9925 | |
| 88 | A | A | 0.0000 | |
| 89 | V | A | 0.1928 | |
| 90 | N | A | -0.9135 | |
| 91 | L | A | 0.0000 | |
| 92 | G | A | -1.8330 | |
| 93 | W | A | 0.0000 | |
| 94 | K | A | -2.5846 | |
| 95 | H | A | -1.9964 | |
| 96 | Y | A | -1.6058 | |
| 97 | P | A | -1.1833 | |
| 98 | L | A | 0.0000 | |
| 99 | K | A | -1.9547 | |
| 100 | R | A | -3.1990 | |
| 101 | Q | A | -2.6987 | |
| 102 | L | A | 0.0000 | |
| 103 | E | A | -2.9672 | |
| 104 | E | A | -3.7180 | |
| 105 | E | A | -3.4705 | |
| 106 | T | A | 0.0000 | |
| 107 | G | A | -1.9975 | |
| 108 | L | A | -1.1244 | |
| 109 | P | A | -0.4528 | |
| 110 | V | A | 0.0000 | |
| 111 | A | A | -0.5558 | |
| 112 | V | A | 0.0000 | |
| 113 | D | A | 0.0000 | |
| 114 | N | A | -0.7998 | |
| 115 | D | A | -1.2271 | |
| 116 | A | A | 0.0000 | |
| 117 | N | A | 0.0000 | |
| 118 | I | A | 0.0000 | |
| 119 | A | A | -0.5972 | |
| 120 | A | A | 0.0000 | |
| 121 | L | A | 0.0000 | |
| 122 | G | A | 0.0000 | |
| 123 | E | A | 0.0000 | |
| 124 | M | A | 0.0000 | |
| 125 | W | A | -0.9376 | |
| 126 | K | A | -1.0250 | |
| 127 | G | A | -0.6700 | |
| 128 | A | A | -0.2435 | |
| 129 | G | A | 0.0000 | |
| 130 | G | A | -1.1598 | |
| 131 | G | A | -1.3817 | |
| 132 | A | A | 0.0000 | |
| 133 | R | A | -2.8710 | |
| 134 | H | A | -2.2772 | |
| 135 | L | A | 0.0000 | |
| 136 | L | A | 0.0000 | |
| 137 | F | A | 0.0000 | |
| 138 | V | A | 0.0000 | |
| 139 | T | A | -0.2267 | |
| 140 | L | A | 0.0000 | |
| 141 | G | A | -0.4906 | |
| 142 | T | A | -0.3508 | |
| 143 | G | A | -0.4822 | |
| 144 | V | A | 0.0000 | |
| 145 | G | A | -0.6982 | |
| 146 | G | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | V | A | 0.0000 | |
| 149 | I | A | 0.0000 | |
| 150 | A | A | -1.3796 | |
| 151 | N | A | -1.9588 | |
| 152 | G | A | -1.6527 | |
| 153 | A | A | -0.6493 | |
| 154 | I | A | 0.0000 | |
| 155 | V | A | 0.3650 | |
| 156 | R | A | -0.9465 | |
| 157 | G | A | -1.0752 | |
| 158 | T | A | -1.1830 | |
| 159 | N | A | -1.8569 | |
| 160 | G | A | 0.0000 | |
| 161 | A | A | -0.9062 | |
| 162 | G | A | -0.7045 | |
| 163 | G | A | -0.5799 | |
| 164 | E | A | -1.2075 | |
| 165 | I | A | 0.0000 | |
| 166 | G | A | 0.0000 | |
| 167 | H | A | -0.7538 | |
| 168 | M | A | -0.2748 | |
| 169 | T | A | -0.2446 | |
| 170 | M | A | 0.1403 | |
| 171 | V | A | -0.1933 | |
| 172 | A | A | -0.8351 | |
| 173 | D | A | -1.8977 | |
| 174 | G | A | -1.3070 | |
| 175 | G | A | -0.8940 | |
| 176 | A | A | -0.6661 | |
| 177 | P | A | -0.9507 | |
| 178 | C | A | -1.1526 | |
| 179 | N | A | -1.5678 | |
| 180 | C | A | -0.8995 | |
| 181 | G | A | -1.2960 | |
| 182 | K | A | -1.5911 | |
| 183 | T | A | -1.2291 | |
| 184 | G | A | 0.0000 | |
| 185 | C | A | 0.0000 | |
| 186 | L | A | 0.0000 | |
| 187 | E | A | -0.4290 | |
| 188 | T | A | -0.4388 | |
| 189 | I | A | 0.0000 | |
| 190 | A | A | 0.0000 | |
| 191 | S | A | 0.0000 | |
| 192 | A | A | -0.4481 | |
| 193 | T | A | -0.1354 | |
| 194 | G | A | 0.0000 | |
| 195 | I | A | 0.0000 | |
| 196 | V | A | -0.3496 | |
| 197 | R | A | -0.8609 | |
| 198 | I | A | 0.0000 | |
| 199 | A | A | 0.0000 | |
| 200 | G | A | -1.0932 | |
| 201 | E | A | -1.8438 | |
| 202 | K | A | -1.5762 | |
| 203 | L | A | -1.2881 | |
| 204 | A | A | -0.9573 | |
| 205 | A | A | -0.9313 | |
| 206 | S | A | -1.4646 | |
| 207 | E | A | -2.4458 | |
| 208 | R | A | -2.0931 | |
| 209 | P | A | -1.3120 | |
| 210 | S | A | -0.9769 | |
| 211 | A | A | -0.5391 | |
| 212 | L | A | 0.0000 | |
| 213 | R | A | -1.6652 | |
| 214 | G | A | -1.3638 | |
| 215 | G | A | -1.6870 | |
| 216 | D | A | -2.0035 | |
| 217 | V | A | -1.0759 | |
| 218 | T | A | -0.9949 | |
| 219 | A | A | -1.0387 | |
| 220 | K | A | -2.1275 | |
| 221 | A | A | -1.4548 | |
| 222 | V | A | 0.0000 | |
| 223 | F | A | 0.0000 | |
| 224 | D | A | -1.8314 | |
| 225 | A | A | 0.0000 | |
| 226 | A | A | 0.0000 | |
| 227 | K | A | -2.0202 | |
| 228 | T | A | -1.2575 | |
| 229 | G | A | -1.0740 | |
| 230 | D | A | -0.8181 | |
| 231 | A | A | -0.3393 | |
| 232 | L | A | 0.0000 | |
| 233 | A | A | 0.0000 | |
| 234 | L | A | -0.6347 | |
| 235 | E | A | -1.0812 | |
| 236 | V | A | 0.0000 | |
| 237 | V | A | 0.0000 | |
| 238 | E | A | -1.6202 | |
| 239 | E | A | -1.2888 | |
| 240 | V | A | 0.0000 | |
| 241 | T | A | 0.0000 | |
| 242 | R | A | -1.0790 | |
| 243 | Y | A | -0.2018 | |
| 244 | L | A | 0.0000 | |
| 245 | G | A | 0.0000 | |
| 246 | L | A | -0.4141 | |
| 247 | A | A | 0.0000 | |
| 248 | L | A | 0.0000 | |
| 249 | A | A | 0.0000 | |
| 250 | N | A | -0.3458 | |
| 251 | A | A | -0.1969 | |
| 252 | A | A | 0.0000 | |
| 253 | N | A | -0.3033 | |
| 254 | V | A | 1.0540 | |
| 255 | T | A | -0.1925 | |
| 256 | N | A | -1.5664 | |
| 257 | P | A | 0.0000 | |
| 258 | E | A | -2.4339 | |
| 259 | K | A | -1.9275 | |
| 260 | I | A | 0.0000 | |
| 261 | V | A | 0.0000 | |
| 262 | I | A | 0.0000 | |
| 263 | G | A | 0.0000 | |
| 264 | G | A | -1.1003 | |
| 265 | G | A | -1.5637 | |
| 266 | V | A | 0.0000 | |
| 267 | S | A | -1.1146 | |
| 268 | K | A | -2.1308 | |
| 269 | A | A | -1.4695 | |
| 270 | G | A | -0.6594 | |
| 271 | A | A | -0.4779 | |
| 272 | L | A | -0.9161 | |
| 273 | L | A | 0.0000 | |
| 274 | V | A | -0.4316 | |
| 275 | E | A | -1.6721 | |
| 276 | H | A | -1.3377 | |
| 277 | V | A | 0.0000 | |
| 278 | A | A | -1.5727 | |
| 279 | A | A | -1.5953 | |
| 280 | H | A | -1.7243 | |
| 281 | F | A | 0.0000 | |
| 282 | R | A | -2.3013 | |
| 283 | R | A | -2.3288 | |
| 284 | Y | A | -0.8695 | |
| 285 | A | A | 0.0000 | |
| 286 | F | A | 0.5153 | |
| 287 | P | A | -0.8862 | |
| 288 | R | A | -1.7558 | |
| 289 | V | A | 0.0000 | |
| 290 | A | A | -1.6849 | |
| 291 | A | A | -1.2719 | |
| 292 | G | A | -1.8957 | |
| 293 | A | A | -2.1762 | |
| 294 | E | A | -1.9174 | |
| 295 | I | A | -0.7735 | |
| 296 | V | A | -0.0024 | |
| 297 | L | A | 0.3500 | |
| 298 | A | A | -0.1410 | |
| 299 | T | A | -0.2973 | |
| 300 | L | A | -0.6074 | |
| 301 | G | A | -1.3519 | |
| 302 | N | A | -1.7691 | |
| 303 | D | A | -1.2754 | |
| 304 | A | A | 0.0000 | |
| 305 | G | A | 0.0000 | |
| 306 | V | A | 0.0000 | |
| 307 | I | A | 0.0000 | |
| 308 | G | A | 0.0000 | |
| 309 | G | A | 0.0000 | |
| 310 | A | A | 0.0000 | |
| 311 | W | A | -0.1493 | |
| 312 | L | A | 0.0000 | |
| 313 | A | A | 0.0000 | |
| 314 | K | A | -0.1453 | |
| 315 | S | A | 0.2132 | |
| 316 | L | A | 0.9036 | |
| 317 | I | A | 0.8375 | |
| 318 | G | A | 0.0349 | |
| 319 | A | A | -0.2073 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine