Project name: 3bed8eeba2ae63

Chain sequence(s)	A: EVKLEESGGGLVQQPGGSMKLSCVASGFIFSNHWMNWVRQSPEKGLEWVAEIRSKSINSATHYAESVKGRFTISRDDSKSAVYLQMTDLRTEDTGVYYCSRNYYGSTYDYWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:02)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:02)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:02)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:02)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:02)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:03:23)
[INFO]       Main:     Simulation completed successfully.                                          (00:03:25)

• Minimal score value: -2.9854
• Maximal score value: 2.4908
• Average score: -0.5993
• Total score value: -132.4502

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	A	-2.2196
2	V	A	-1.3428
3	K	A	-2.4051
4	L	A	0.0000
5	E	A	-2.3546
6	E	A	-1.2069
7	S	A	-1.0203
8	G	A	-0.8526
9	G	A	0.0000
10	G	A	-0.5596
11	L	A	-0.3843
12	V	A	0.0000
13	Q	A	-1.8587
14	P	A	-1.9895
15	G	A	-2.0388
16	G	A	-1.4992
17	S	A	-1.3971
18	M	A	-1.1411
19	K	A	-1.6798
20	L	A	0.0000
21	S	A	-0.6552
22	C	A	0.0000
23	V	A	-0.5756
24	A	A	0.0000
25	S	A	-1.0314
26	G	A	-0.9016
27	F	A	0.3558
28	I	A	1.5680
29	F	A	0.0000
30	S	A	-0.9920
31	N	A	-0.9625
32	H	A	-0.2305
33	W	A	-0.2736
34	M	A	0.0000
35	N	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	R	A	0.0000
39	Q	A	-0.6004
40	S	A	-1.4667
41	P	A	-1.5779
42	E	A	-2.9854
43	K	A	-2.7978
44	G	A	-1.1472
45	L	A	0.5665
46	E	A	0.1003
47	W	A	0.5533
48	V	A	0.0000
49	A	A	0.0000
50	E	A	0.0000
51	I	A	0.0000
52	R	A	-1.0240
53	S	A	0.0000
54	K	A	-2.2160
55	S	A	-1.0145
56	I	A	-0.0233
57	N	A	-1.3390
58	S	A	-1.2399
59	A	A	-0.6545
60	T	A	-0.4863
61	H	A	-0.8686
62	Y	A	-1.0759
63	A	A	0.0000
64	E	A	-2.5003
65	S	A	-1.4805
66	V	A	0.0000
67	K	A	-2.5782
68	G	A	-1.7574
69	R	A	0.0000
70	F	A	0.0000
71	T	A	-0.7188
72	I	A	0.0000
73	S	A	-0.3946
74	R	A	-0.9869
75	D	A	-1.3217
76	D	A	-1.4275
77	S	A	-1.4216
78	K	A	-1.9947
79	S	A	-0.7320
80	A	A	0.0000
81	V	A	0.0000
82	Y	A	-0.2681
83	L	A	0.0000
84	Q	A	-0.9808
85	M	A	0.0000
86	T	A	-1.5792
87	D	A	-2.5411
88	L	A	0.0000
89	R	A	-2.5515
90	T	A	-1.8075
91	E	A	-2.7030
92	D	A	0.0000
93	T	A	-1.0504
94	G	A	0.0000
95	V	A	0.2601
96	Y	A	0.0000
97	Y	A	-0.0505
98	C	A	0.0000
99	S	A	0.0000
100	R	A	0.0000
101	N	A	0.0000
102	Y	A	1.0853
103	Y	A	0.6809
104	G	A	0.0614
105	S	A	0.0191
106	T	A	0.1940
107	Y	A	0.5238
108	D	A	0.1065
109	Y	A	0.5515
110	W	A	-0.0475
111	G	A	-1.1289
112	Q	A	-1.7417
113	G	A	-0.8961
114	T	A	-0.5589
115	T	A	-0.1930
116	L	A	0.0000
117	T	A	-0.5678
118	V	A	0.0000
119	S	A	-1.0070
120	S	A	-0.7574
121	A	A	-0.5104
122	S	A	-0.6114
123	T	A	-0.7578
124	K	A	-1.1932
125	G	A	-1.4144
126	P	A	0.0000
127	S	A	-0.0903
128	V	A	0.0000
129	F	A	1.0174
130	P	A	0.1845
131	L	A	0.5036
132	A	A	-0.9793
133	P	A	0.0000
134	S	A	-1.4221
135	S	A	-1.4300
136	K	A	-2.0687
137	S	A	-1.0245
138	T	A	-1.0330
139	S	A	-0.9516
140	G	A	-0.8906
141	G	A	-0.9158
142	T	A	-0.6564
143	A	A	0.0000
144	A	A	-0.1277
145	L	A	0.0000
146	G	A	0.0000
147	C	A	0.0000
148	L	A	0.7396
149	V	A	0.0000
150	K	A	-0.2143
151	D	A	-0.3978
152	Y	A	0.0000
153	F	A	0.0000
154	P	A	0.0000
155	E	A	-0.5031
156	P	A	-0.7098
157	V	A	-0.6347
158	T	A	-0.5534
159	V	A	-0.3834
160	S	A	-0.3759
161	W	A	0.0000
162	N	A	-0.7670
163	S	A	-0.6656
164	G	A	-0.5127
165	A	A	-0.2319
166	L	A	0.0344
167	T	A	-0.2388
168	S	A	-0.2900
169	G	A	-0.3244
170	V	A	0.1308
171	H	A	-0.3138
172	T	A	0.2006
173	F	A	0.9750
174	P	A	0.7194
175	A	A	1.2765
176	V	A	2.4908
177	L	A	2.1688
178	Q	A	0.7320
179	S	A	0.0927
180	S	A	-0.2214
181	G	A	0.1844
182	L	A	0.2798
183	Y	A	0.8426
184	S	A	0.0000
185	L	A	0.0000
186	S	A	0.6635
187	S	A	0.0000
188	V	A	0.4948
189	V	A	0.0000
190	T	A	-0.2560
191	V	A	0.0000
192	P	A	-0.5556
193	S	A	-0.6081
194	S	A	-0.5583
195	S	A	-0.5592
196	L	A	-0.8860
197	G	A	-1.2685
198	T	A	-0.7242
199	Q	A	-1.2819
200	T	A	-1.1054
201	Y	A	0.0000
202	I	A	-1.2387
203	C	A	0.0000
204	N	A	-1.5340
205	V	A	0.0000
206	N	A	-1.9684
207	H	A	0.0000
208	K	A	-2.6666
209	P	A	-1.5130
210	S	A	-1.7935
211	N	A	-2.5638
212	T	A	-2.0438
213	K	A	-2.6993
214	V	A	-1.8311
215	D	A	-2.6322
216	K	A	-1.9916
217	K	A	-2.3949
218	V	A	0.0000
219	E	A	-2.7489
220	P	A	-1.8011
221	K	A	-2.3342