| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFEDIVKDGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTTGHPLFNKLGDTENPTAPQHCGADDRVDFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRCGPDGHPLPDDPPPSPLYVPPPPTSPYAVRPPTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLSTPPINVYDPSNFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9418 | |
| 2 | L | A | 1.9654 | |
| 3 | P | A | 0.6621 | |
| 4 | P | A | 0.3448 | |
| 5 | T | A | 0.1069 | |
| 6 | T | A | 0.1265 | |
| 7 | P | A | 0.1391 | |
| 8 | V | A | 1.2332 | |
| 9 | A | A | 0.0712 | |
| 10 | K | A | -1.0437 | |
| 11 | V | A | -0.2027 | |
| 12 | Q | A | -1.4231 | |
| 13 | S | A | -1.5706 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4372 | |
| 16 | E | A | -2.4454 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4561 | |
| 20 | P | A | 0.1035 | |
| 21 | T | A | 0.1089 | |
| 22 | S | A | -0.1712 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.1059 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2936 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8909 | |
| 31 | R | A | -2.6713 | |
| 32 | L | A | -0.7927 | |
| 33 | L | A | 1.1549 | |
| 34 | T | A | 1.3563 | |
| 35 | V | A | 1.8042 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2443 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6553 | |
| 40 | E | A | -1.7443 | |
| 41 | D | A | -0.9827 | |
| 42 | I | A | 0.8331 | |
| 43 | V | A | 0.8880 | |
| 44 | K | A | -1.4175 | |
| 45 | D | A | -2.4453 | |
| 46 | G | A | -1.4798 | |
| 47 | K | A | -1.1360 | |
| 48 | V | A | 1.3159 | |
| 49 | V | A | 1.9459 | |
| 50 | V | A | 1.2214 | |
| 51 | P | A | 0.4034 | |
| 52 | K | A | -0.7010 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1603 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4137 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2694 | |
| 70 | K | A | -1.7925 | |
| 71 | F | A | -0.6455 | |
| 72 | A | A | -0.5782 | |
| 73 | L | A | -0.8806 | |
| 74 | P | A | -1.2859 | |
| 75 | Q | A | -2.4990 | |
| 76 | K | A | -3.1004 | |
| 77 | D | A | -2.9838 | |
| 78 | F | A | -1.6669 | |
| 79 | Y | A | -1.8755 | |
| 80 | D | A | -2.6678 | |
| 81 | P | A | -2.2900 | |
| 82 | E | A | -3.0378 | |
| 83 | K | A | -3.3833 | |
| 84 | E | A | -2.4463 | |
| 85 | R | A | -1.2820 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6456 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9598 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3384 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6910 | |
| 99 | G | A | -0.5434 | |
| 100 | P | A | -0.4169 | |
| 101 | L | A | 0.0175 | |
| 102 | G | A | -0.2511 | |
| 103 | K | A | -0.6791 | |
| 104 | G | A | -0.4863 | |
| 105 | T | A | -0.4727 | |
| 106 | T | A | 0.0000 | |
| 107 | G | A | -0.1993 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -0.4115 | |
| 110 | L | A | -0.2783 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.3231 | |
| 113 | K | A | -0.5752 | |
| 114 | L | A | -0.7969 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.0652 | |
| 117 | T | A | -0.8233 | |
| 118 | E | A | -1.7748 | |
| 119 | N | A | -1.9354 | |
| 120 | P | A | -1.3970 | |
| 121 | T | A | -0.7346 | |
| 122 | A | A | -0.5157 | |
| 123 | P | A | -0.1373 | |
| 124 | Q | A | -0.5097 | |
| 125 | H | A | -0.4981 | |
| 126 | C | A | -0.6519 | |
| 127 | G | A | -1.2386 | |
| 128 | A | A | -1.1706 | |
| 129 | D | A | -2.1879 | |
| 130 | D | A | -1.7089 | |
| 131 | R | A | -1.5285 | |
| 132 | V | A | -0.7071 | |
| 133 | D | A | -1.4106 | |
| 134 | F | A | -0.6384 | |
| 135 | S | A | -0.4835 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.7230 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5541 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2047 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1291 | |
| 157 | D | A | 0.2977 | |
| 158 | I | A | 0.8351 | |
| 159 | A | A | 0.1223 | |
| 160 | E | A | -1.4735 | |
| 161 | P | A | -0.2227 | |
| 162 | C | A | 0.1821 | |
| 163 | P | A | -0.1795 | |
| 164 | G | A | -0.0928 | |
| 165 | L | A | 0.5621 | |
| 166 | P | A | -0.1272 | |
| 167 | P | A | -0.3455 | |
| 168 | G | A | -0.4256 | |
| 169 | A | A | -0.0302 | |
| 170 | C | A | 0.7400 | |
| 171 | P | A | 0.5540 | |
| 172 | P | A | 0.7903 | |
| 173 | I | A | 2.0498 | |
| 174 | Q | A | 0.8607 | |
| 175 | L | A | 1.4509 | |
| 176 | V | A | 0.8409 | |
| 177 | N | A | -0.3015 | |
| 178 | S | A | 0.0231 | |
| 179 | V | A | 0.4298 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3821 | |
| 182 | D | A | 0.0781 | |
| 183 | G | A | -0.1583 | |
| 184 | D | A | -0.5378 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1462 | |
| 190 | F | A | 0.0649 | |
| 191 | G | A | -0.1040 | |
| 192 | N | A | -0.2657 | |
| 193 | M | A | -0.1303 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3658 | |
| 197 | E | A | -2.5846 | |
| 198 | L | A | -1.1991 | |
| 199 | Q | A | -2.5352 | |
| 200 | Q | A | -3.3028 | |
| 201 | D | A | -3.5750 | |
| 202 | R | A | -3.3263 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1841 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3524 | |
| 211 | S | A | -1.9053 | |
| 212 | T | A | -1.4386 | |
| 213 | R | A | -2.0794 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1603 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3470 | |
| 220 | L | A | 0.6186 | |
| 221 | K | A | -1.0820 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.7999 | |
| 224 | N | A | -1.5610 | |
| 225 | E | A | -1.2199 | |
| 226 | A | A | -0.6135 | |
| 227 | Y | A | -0.3704 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6497 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0759 | |
| 234 | F | A | 0.2568 | |
| 235 | G | A | -0.8240 | |
| 236 | R | A | -2.6164 | |
| 237 | R | A | -2.8941 | |
| 238 | E | A | -2.1649 | |
| 239 | Q | A | -0.1523 | |
| 240 | V | A | 1.4793 | |
| 241 | Y | A | 1.2145 | |
| 242 | A | A | 0.1437 | |
| 243 | R | A | -1.2526 | |
| 244 | H | A | -1.0254 | |
| 245 | F | A | 0.0608 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.5322 | |
| 249 | C | A | -0.8924 | |
| 250 | G | A | -0.8522 | |
| 251 | P | A | -0.8908 | |
| 252 | D | A | -1.4372 | |
| 253 | G | A | -1.2780 | |
| 254 | H | A | -1.4438 | |
| 255 | P | A | -1.3332 | |
| 256 | L | A | -0.3974 | |
| 257 | P | A | -0.9922 | |
| 258 | D | A | -2.0459 | |
| 259 | D | A | -1.4355 | |
| 260 | P | A | -1.0916 | |
| 261 | P | A | -0.4234 | |
| 262 | P | A | -0.0732 | |
| 263 | S | A | -0.0208 | |
| 264 | P | A | 0.5474 | |
| 265 | L | A | 1.5767 | |
| 266 | Y | A | 1.4215 | |
| 267 | V | A | 1.8138 | |
| 268 | P | A | 0.4870 | |
| 269 | P | A | 0.5226 | |
| 270 | P | A | -0.1013 | |
| 271 | P | A | -0.0427 | |
| 272 | T | A | 0.0413 | |
| 273 | S | A | 0.3697 | |
| 274 | P | A | 0.4345 | |
| 275 | Y | A | 1.2783 | |
| 276 | A | A | 0.9937 | |
| 277 | V | A | 1.5580 | |
| 278 | R | A | 0.1833 | |
| 279 | P | A | -0.2933 | |
| 280 | P | A | 0.0000 | |
| 281 | T | A | -0.6463 | |
| 282 | D | A | -0.9614 | |
| 283 | Y | A | 0.8426 | |
| 284 | F | A | 0.6887 | |
| 285 | G | A | 0.2080 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9180 | |
| 291 | L | A | 1.6191 | |
| 292 | V | A | 0.6277 | |
| 293 | S | A | -0.1613 | |
| 294 | S | A | -0.9621 | |
| 295 | D | A | -1.8424 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1021 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6209 | |
| 301 | R | A | -1.8356 | |
| 302 | P | A | -0.9737 | |
| 303 | F | A | -0.1876 | |
| 304 | W | A | -0.5615 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0810 | |
| 307 | R | A | -2.8304 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.3664 | |
| 310 | G | A | -1.2175 | |
| 311 | N | A | -1.2846 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8412 | |
| 319 | N | A | -0.8633 | |
| 320 | E | A | -1.0421 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3642 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0997 | |
| 333 | N | A | 0.5498 | |
| 334 | F | A | 1.7679 | |
| 335 | T | A | 0.8732 | |
| 336 | I | A | 0.4241 | |
| 337 | S | A | -0.9595 | |
| 338 | Q | A | -1.6777 | |
| 339 | Q | A | -1.1975 | |
| 340 | L | A | 0.4392 | |
| 341 | S | A | 0.1550 | |
| 342 | T | A | -0.1067 | |
| 343 | P | A | -0.4237 | |
| 344 | P | A | -0.2584 | |
| 345 | I | A | 0.4205 | |
| 346 | N | A | -0.0711 | |
| 347 | V | A | 1.6583 | |
| 348 | Y | A | 1.4932 | |
| 349 | D | A | -0.0481 | |
| 350 | P | A | -0.7134 | |
| 351 | S | A | -0.5566 | |
| 352 | N | A | -0.2867 | |
| 353 | F | A | -0.9082 | |
| 354 | K | A | -1.9450 | |
| 355 | N | A | -1.7933 | |
| 356 | Y | A | -0.1322 | |
| 357 | L | A | 0.6414 | |
| 358 | R | A | 0.9700 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3670 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0797 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0135 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6846 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3000 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3057 | |
| 376 | L | A | -1.7022 | |
| 377 | D | A | -1.9738 | |
| 378 | P | A | -1.0295 | |
| 379 | G | A | -1.0079 | |
| 380 | V | A | -0.9274 | |
| 381 | L | A | -0.5281 | |
| 382 | A | A | -0.6510 | |
| 383 | H | A | -0.8111 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4046 | |
| 386 | T | A | -0.5521 | |
| 387 | M | A | -0.3030 | |
| 388 | N | A | -0.8630 | |
| 389 | P | A | -1.2500 | |
| 390 | T | A | -1.4626 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4581 | |
| 393 | E | A | -2.7989 | |
| 394 | N | A | -2.4173 | |
| 395 | W | A | -1.3974 | |
| 396 | N | A | -1.1209 | |
| 397 | L | A | -0.1901 | |
| 398 | G | A | 0.5343 | |
| 399 | F | A | 2.4132 | |
| 400 | V | A | 1.8151 | |
| 401 | P | A | 0.0439 | |
| 402 | P | A | -1.8474 | |
| 403 | K | A | -3.3301 | |
| 404 | E | A | -3.7871 | |
| 405 | R | A | -3.9419 | |
| 406 | E | A | -3.8043 | |
| 407 | D | A | -2.8906 | |
| 408 | P | A | -1.7745 | |
| 409 | Y | A | -0.9859 | |
| 410 | K | A | -2.1252 | |
| 411 | G | A | -0.6400 | |
| 412 | L | A | 0.6770 | |
| 413 | I | A | 1.5897 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3878 | |
| 416 | E | A | -1.6791 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9509 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0582 | |
| 421 | E | A | -2.7827 | |
| 422 | R | A | -2.5656 | |
| 423 | F | A | -1.2789 | |
| 424 | S | A | -1.4682 | |
| 425 | Q | A | -1.7867 | |
| 426 | D | A | -2.9700 | |
| 427 | L | A | -2.1553 | |
| 428 | D | A | -3.0140 | |
| 429 | Q | A | -2.7527 | |
| 430 | F | A | -1.6027 | |
| 431 | A | A | -1.1228 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.2313 | |
| 435 | K | A | -1.0574 | |
| 436 | F | A | -0.0808 | |
| 437 | L | A | 0.8041 | |
| 438 | Y | A | 0.6463 | |
| 439 | Q | A | -0.3792 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine