| Chain sequence(s) |
A: EVNPAAHLTGANSSLTGSGGPLLWETQLGLAFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMVEGGSGEVNPAAHLTGANSSLTGSGGPLLWETQLGLAFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMVEGGSGEVNPAAHLTGANSSLTGSGGPLLWETQLGLAFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:06:03)
[INFO] Main: Simulation completed successfully. (00:06:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | E | A | -1.3017 | |
| 2 | V | A | 0.2797 | |
| 3 | N | A | -0.5347 | |
| 4 | P | A | 0.0000 | |
| 5 | A | A | 0.0000 | |
| 6 | A | A | 0.0000 | |
| 7 | H | A | 0.0000 | |
| 8 | L | A | 0.0000 | |
| 9 | T | A | 0.0000 | |
| 10 | G | A | 0.0000 | |
| 11 | A | A | -1.1598 | |
| 12 | N | A | -1.8840 | |
| 13 | S | A | -0.5659 | |
| 14 | S | A | 0.0000 | |
| 15 | L | A | -0.1827 | |
| 16 | T | A | -0.1007 | |
| 17 | G | A | -0.8975 | |
| 18 | S | A | -0.6376 | |
| 19 | G | A | -0.6272 | |
| 20 | G | A | -0.5874 | |
| 21 | P | A | -0.4732 | |
| 22 | L | A | 0.0000 | |
| 23 | L | A | -0.1975 | |
| 24 | W | A | 0.0000 | |
| 25 | E | A | -0.5160 | |
| 26 | T | A | -0.2101 | |
| 27 | Q | A | -0.5008 | |
| 28 | L | A | 0.7163 | |
| 29 | G | A | -0.0093 | |
| 30 | L | A | -0.0552 | |
| 31 | A | A | 0.0000 | |
| 32 | F | A | 0.0283 | |
| 33 | L | A | 0.0819 | |
| 34 | R | A | 0.0041 | |
| 35 | G | A | -0.4815 | |
| 36 | L | A | 0.0000 | |
| 37 | S | A | -0.2134 | |
| 38 | Y | A | -0.5591 | |
| 39 | H | A | -1.6830 | |
| 40 | D | A | -2.0825 | |
| 41 | G | A | 0.0000 | |
| 42 | A | A | 0.0000 | |
| 43 | L | A | 0.0000 | |
| 44 | V | A | -0.8316 | |
| 45 | V | A | 0.0000 | |
| 46 | T | A | -1.0748 | |
| 47 | K | A | -1.7221 | |
| 48 | A | A | -1.4361 | |
| 49 | G | A | 0.0000 | |
| 50 | Y | A | -0.6113 | |
| 51 | Y | A | 0.0000 | |
| 52 | Y | A | 0.0000 | |
| 53 | I | A | 0.0000 | |
| 54 | Y | A | 0.0000 | |
| 55 | S | A | 0.0000 | |
| 56 | K | A | 0.0000 | |
| 57 | V | A | 0.0000 | |
| 58 | Q | A | 0.0000 | |
| 59 | L | A | 0.0000 | |
| 60 | G | A | 0.0000 | |
| 61 | G | A | 0.9051 | |
| 62 | V | A | 2.1174 | |
| 63 | G | A | 0.0000 | |
| 64 | C | A | 0.8191 | |
| 65 | P | A | 0.7699 | |
| 66 | L | A | 1.2944 | |
| 67 | G | A | 0.3514 | |
| 68 | L | A | 0.1865 | |
| 69 | A | A | 0.2912 | |
| 70 | S | A | 0.2036 | |
| 71 | T | A | 0.3284 | |
| 72 | I | A | 0.0000 | |
| 73 | T | A | 0.2811 | |
| 74 | H | A | 0.0000 | |
| 75 | G | A | 0.0000 | |
| 76 | L | A | 0.0000 | |
| 77 | Y | A | 0.0000 | |
| 78 | K | A | 0.0000 | |
| 79 | R | A | -1.8283 | |
| 80 | T | A | 0.0000 | |
| 81 | P | A | -1.4354 | |
| 82 | R | A | -1.9523 | |
| 83 | Y | A | -0.9413 | |
| 84 | P | A | -1.3308 | |
| 85 | E | A | -2.2447 | |
| 86 | E | A | -1.4569 | |
| 87 | L | A | -0.6577 | |
| 88 | E | A | -0.9955 | |
| 89 | L | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | V | A | 0.0000 | |
| 92 | S | A | 0.0000 | |
| 93 | Q | A | 0.0000 | |
| 94 | Q | A | 0.0000 | |
| 95 | S | A | 0.0000 | |
| 96 | P | A | 0.0000 | |
| 97 | C | A | 0.2547 | |
| 98 | G | A | 0.0000 | |
| 99 | R | A | 0.0000 | |
| 100 | A | A | 0.0000 | |
| 101 | T | A | -0.1938 | |
| 102 | S | A | -0.1835 | |
| 103 | S | A | 0.1550 | |
| 104 | S | A | 0.1111 | |
| 105 | R | A | 0.2930 | |
| 106 | V | A | 1.9912 | |
| 107 | W | A | 0.0000 | |
| 108 | W | A | 0.6231 | |
| 109 | D | A | 0.0000 | |
| 110 | S | A | -0.1210 | |
| 111 | S | A | 0.0000 | |
| 112 | F | A | 0.0000 | |
| 113 | L | A | 0.0000 | |
| 114 | G | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | V | A | 0.0000 | |
| 117 | V | A | 0.0000 | |
| 118 | H | A | -0.9814 | |
| 119 | L | A | 0.0000 | |
| 120 | E | A | -2.0810 | |
| 121 | A | A | -1.3527 | |
| 122 | G | A | -1.1041 | |
| 123 | E | A | 0.0000 | |
| 124 | K | A | -1.2007 | |
| 125 | V | A | 0.0000 | |
| 126 | V | A | 0.0000 | |
| 127 | V | A | 0.0000 | |
| 128 | R | A | -0.4891 | |
| 129 | V | A | 0.0000 | |
| 130 | L | A | 0.6057 | |
| 131 | D | A | -0.4870 | |
| 132 | E | A | -1.0626 | |
| 133 | R | A | -1.8612 | |
| 134 | L | A | 0.0000 | |
| 135 | V | A | 0.0000 | |
| 136 | R | A | -1.5969 | |
| 137 | L | A | 0.0000 | |
| 138 | R | A | -2.7968 | |
| 139 | D | A | -2.3196 | |
| 140 | G | A | -1.3312 | |
| 141 | T | A | -0.9872 | |
| 142 | R | A | -1.1505 | |
| 143 | S | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | F | A | 0.0000 | |
| 146 | G | A | 0.0000 | |
| 147 | A | A | 0.0000 | |
| 148 | F | A | 0.0000 | |
| 149 | M | A | 0.0000 | |
| 150 | V | A | 0.0000 | |
| 151 | E | A | -0.6720 | |
| 152 | G | A | -1.1910 | |
| 153 | G | A | -1.3808 | |
| 154 | S | A | -1.3014 | |
| 155 | G | A | -1.2899 | |
| 156 | E | A | -1.5599 | |
| 157 | V | A | 0.3662 | |
| 158 | N | A | -0.5445 | |
| 159 | P | A | 0.0000 | |
| 160 | A | A | 0.0000 | |
| 161 | A | A | 0.0000 | |
| 162 | H | A | 0.0000 | |
| 163 | L | A | 0.0000 | |
| 164 | T | A | 0.0000 | |
| 165 | G | A | 0.0000 | |
| 166 | A | A | -1.1121 | |
| 167 | N | A | -1.7662 | |
| 168 | S | A | -0.5803 | |
| 169 | S | A | 0.0000 | |
| 170 | L | A | -0.2836 | |
| 171 | T | A | -0.4775 | |
| 172 | G | A | -0.9301 | |
| 173 | S | A | -0.6433 | |
| 174 | G | A | -0.6074 | |
| 175 | G | A | -0.5448 | |
| 176 | P | A | -0.3873 | |
| 177 | L | A | 0.0000 | |
| 178 | L | A | -0.3032 | |
| 179 | W | A | 0.0000 | |
| 180 | E | A | -0.5306 | |
| 181 | T | A | -0.2090 | |
| 182 | Q | A | -0.5003 | |
| 183 | L | A | 0.7200 | |
| 184 | G | A | -0.0609 | |
| 185 | L | A | -0.0099 | |
| 186 | A | A | 0.0000 | |
| 187 | F | A | -0.0111 | |
| 188 | L | A | 0.0701 | |
| 189 | R | A | 0.0601 | |
| 190 | G | A | -0.1877 | |
| 191 | L | A | 0.0000 | |
| 192 | S | A | -0.2095 | |
| 193 | Y | A | -0.5554 | |
| 194 | H | A | -1.6858 | |
| 195 | D | A | -2.0801 | |
| 196 | G | A | 0.0000 | |
| 197 | A | A | 0.0000 | |
| 198 | L | A | 0.0000 | |
| 199 | V | A | -0.8040 | |
| 200 | V | A | 0.0000 | |
| 201 | T | A | -1.0425 | |
| 202 | K | A | -1.6240 | |
| 203 | A | A | -1.3899 | |
| 204 | G | A | 0.0000 | |
| 205 | Y | A | 0.0000 | |
| 206 | Y | A | 0.0000 | |
| 207 | Y | A | 0.0000 | |
| 208 | I | A | 0.0000 | |
| 209 | Y | A | 0.0000 | |
| 210 | S | A | 0.0000 | |
| 211 | K | A | 0.0000 | |
| 212 | V | A | 0.0000 | |
| 213 | Q | A | 0.0000 | |
| 214 | L | A | 0.0000 | |
| 215 | G | A | 0.0000 | |
| 216 | G | A | 0.9055 | |
| 217 | V | A | 2.1930 | |
| 218 | G | A | 0.0000 | |
| 219 | C | A | 0.8158 | |
| 220 | P | A | 0.7465 | |
| 221 | L | A | 1.2761 | |
| 222 | G | A | 0.3245 | |
| 223 | L | A | 0.3383 | |
| 224 | A | A | 0.2694 | |
| 225 | S | A | 0.1776 | |
| 226 | T | A | 0.2835 | |
| 227 | I | A | 0.0000 | |
| 228 | T | A | 0.2428 | |
| 229 | H | A | 0.0000 | |
| 230 | G | A | 0.0000 | |
| 231 | L | A | 0.0000 | |
| 232 | Y | A | -0.6229 | |
| 233 | K | A | -0.7695 | |
| 234 | R | A | -1.4395 | |
| 235 | T | A | 0.0000 | |
| 236 | P | A | -1.2994 | |
| 237 | R | A | -1.8204 | |
| 238 | Y | A | -0.7342 | |
| 239 | P | A | -1.1969 | |
| 240 | E | A | -2.1507 | |
| 241 | E | A | -1.3428 | |
| 242 | L | A | -0.5237 | |
| 243 | E | A | -0.9321 | |
| 244 | L | A | 0.0000 | |
| 245 | L | A | 0.0000 | |
| 246 | V | A | 0.0000 | |
| 247 | S | A | 0.0000 | |
| 248 | Q | A | -0.0368 | |
| 249 | Q | A | 0.0000 | |
| 250 | S | A | 0.0000 | |
| 251 | P | A | 0.0000 | |
| 252 | C | A | 0.0000 | |
| 253 | G | A | 0.0000 | |
| 254 | R | A | 0.0000 | |
| 255 | A | A | 0.4351 | |
| 256 | T | A | -0.1257 | |
| 257 | S | A | -0.0455 | |
| 258 | S | A | 0.2624 | |
| 259 | S | A | 0.3415 | |
| 260 | R | A | 0.7767 | |
| 261 | V | A | 2.0366 | |
| 262 | W | A | 0.0000 | |
| 263 | W | A | 0.5911 | |
| 264 | D | A | 0.0000 | |
| 265 | S | A | -0.0487 | |
| 266 | S | A | 0.0000 | |
| 267 | F | A | 0.0000 | |
| 268 | L | A | 0.0000 | |
| 269 | G | A | 0.0000 | |
| 270 | G | A | 0.0000 | |
| 271 | V | A | 0.0000 | |
| 272 | V | A | 0.0000 | |
| 273 | H | A | -0.9065 | |
| 274 | L | A | 0.0000 | |
| 275 | E | A | -2.0553 | |
| 276 | A | A | -1.2947 | |
| 277 | G | A | -0.9962 | |
| 278 | E | A | 0.0000 | |
| 279 | K | A | -1.0852 | |
| 280 | V | A | 0.0000 | |
| 281 | V | A | 0.0000 | |
| 282 | V | A | 0.0000 | |
| 283 | R | A | -0.2305 | |
| 284 | V | A | 0.0000 | |
| 285 | L | A | 0.6452 | |
| 286 | D | A | -0.4729 | |
| 287 | E | A | -1.0345 | |
| 288 | R | A | -1.9140 | |
| 289 | L | A | 0.0000 | |
| 290 | V | A | 0.0000 | |
| 291 | R | A | -1.5057 | |
| 292 | L | A | -1.5600 | |
| 293 | R | A | -2.7832 | |
| 294 | D | A | -2.6146 | |
| 295 | G | A | -1.3444 | |
| 296 | T | A | -0.8558 | |
| 297 | R | A | 0.0000 | |
| 298 | S | A | 0.0000 | |
| 299 | Y | A | 0.0000 | |
| 300 | F | A | 0.0000 | |
| 301 | G | A | 0.0000 | |
| 302 | A | A | 0.0000 | |
| 303 | F | A | 0.0000 | |
| 304 | M | A | 0.0000 | |
| 305 | V | A | 0.0000 | |
| 306 | E | A | -1.2422 | |
| 307 | G | A | -1.5576 | |
| 308 | G | A | -1.6095 | |
| 309 | S | A | -1.5534 | |
| 310 | G | A | -1.3379 | |
| 311 | E | A | -1.6123 | |
| 312 | V | A | -0.0250 | |
| 313 | N | A | -0.8523 | |
| 314 | P | A | 0.0000 | |
| 315 | A | A | 0.0000 | |
| 316 | A | A | 0.0000 | |
| 317 | H | A | 0.0000 | |
| 318 | L | A | 0.0000 | |
| 319 | T | A | 0.0000 | |
| 320 | G | A | 0.0000 | |
| 321 | A | A | -1.3313 | |
| 322 | N | A | -1.9756 | |
| 323 | S | A | -0.5766 | |
| 324 | S | A | 0.0000 | |
| 325 | L | A | -0.2011 | |
| 326 | T | A | -0.2300 | |
| 327 | G | A | -0.8896 | |
| 328 | S | A | -0.6225 | |
| 329 | G | A | -0.5617 | |
| 330 | G | A | -0.4864 | |
| 331 | P | A | -0.3381 | |
| 332 | L | A | 0.0000 | |
| 333 | L | A | -0.1912 | |
| 334 | W | A | 0.0000 | |
| 335 | E | A | -0.5559 | |
| 336 | T | A | -0.3001 | |
| 337 | Q | A | -0.5865 | |
| 338 | L | A | 0.6730 | |
| 339 | G | A | -0.1366 | |
| 340 | L | A | -0.0428 | |
| 341 | A | A | 0.0000 | |
| 342 | F | A | 0.0000 | |
| 343 | L | A | -0.6521 | |
| 344 | R | A | -1.1796 | |
| 345 | G | A | -0.9750 | |
| 346 | L | A | 0.0000 | |
| 347 | S | A | -0.4801 | |
| 348 | Y | A | -0.6008 | |
| 349 | H | A | -1.7111 | |
| 350 | D | A | -2.0868 | |
| 351 | G | A | 0.0000 | |
| 352 | A | A | 0.0000 | |
| 353 | L | A | 0.0000 | |
| 354 | V | A | -0.9405 | |
| 355 | V | A | 0.0000 | |
| 356 | T | A | -1.1688 | |
| 357 | K | A | -1.8427 | |
| 358 | A | A | -1.4799 | |
| 359 | G | A | -0.7707 | |
| 360 | Y | A | -0.2751 | |
| 361 | Y | A | 0.0000 | |
| 362 | Y | A | 0.0000 | |
| 363 | I | A | 0.0000 | |
| 364 | Y | A | 0.0000 | |
| 365 | S | A | 0.0000 | |
| 366 | K | A | 0.0000 | |
| 367 | V | A | 0.0000 | |
| 368 | Q | A | 0.0000 | |
| 369 | L | A | 0.0000 | |
| 370 | G | A | 0.0000 | |
| 371 | G | A | 0.8845 | |
| 372 | V | A | 2.1216 | |
| 373 | G | A | 0.0000 | |
| 374 | C | A | 0.9136 | |
| 375 | P | A | 0.8394 | |
| 376 | L | A | 1.3250 | |
| 377 | G | A | 0.3395 | |
| 378 | L | A | 0.1566 | |
| 379 | A | A | 0.2612 | |
| 380 | S | A | 0.1549 | |
| 381 | T | A | 0.3081 | |
| 382 | I | A | 0.0000 | |
| 383 | T | A | 0.2727 | |
| 384 | H | A | 0.0000 | |
| 385 | G | A | 0.0000 | |
| 386 | L | A | 0.0000 | |
| 387 | Y | A | -0.9011 | |
| 388 | K | A | 0.0000 | |
| 389 | R | A | -2.0192 | |
| 390 | T | A | 0.0000 | |
| 391 | P | A | -1.4598 | |
| 392 | R | A | -1.9488 | |
| 393 | Y | A | -0.9238 | |
| 394 | P | A | -1.3365 | |
| 395 | E | A | -2.3176 | |
| 396 | E | A | -1.6149 | |
| 397 | L | A | -0.8790 | |
| 398 | E | A | -1.4391 | |
| 399 | L | A | 0.0000 | |
| 400 | L | A | 0.0000 | |
| 401 | V | A | 0.0000 | |
| 402 | S | A | 0.0000 | |
| 403 | Q | A | -0.0136 | |
| 404 | Q | A | 0.0000 | |
| 405 | S | A | 0.0000 | |
| 406 | P | A | 0.0000 | |
| 407 | C | A | 0.0000 | |
| 408 | G | A | 0.0000 | |
| 409 | R | A | 0.0000 | |
| 410 | A | A | 0.0000 | |
| 411 | T | A | -0.1625 | |
| 412 | S | A | -0.1156 | |
| 413 | S | A | 0.2366 | |
| 414 | S | A | 0.2187 | |
| 415 | R | A | 0.4864 | |
| 416 | V | A | 1.8920 | |
| 417 | W | A | 0.0000 | |
| 418 | W | A | 0.5602 | |
| 419 | D | A | 0.0000 | |
| 420 | S | A | -0.1058 | |
| 421 | S | A | 0.0000 | |
| 422 | F | A | 0.0000 | |
| 423 | L | A | 0.0000 | |
| 424 | G | A | 0.0000 | |
| 425 | G | A | 0.0000 | |
| 426 | V | A | 0.0000 | |
| 427 | V | A | 0.0000 | |
| 428 | H | A | -0.7708 | |
| 429 | L | A | 0.0000 | |
| 430 | E | A | -2.1491 | |
| 431 | A | A | -1.4367 | |
| 432 | G | A | -1.1574 | |
| 433 | E | A | 0.0000 | |
| 434 | K | A | -1.3432 | |
| 435 | V | A | 0.0000 | |
| 436 | V | A | 0.0000 | |
| 437 | V | A | 0.0000 | |
| 438 | R | A | -0.1980 | |
| 439 | V | A | 0.0000 | |
| 440 | L | A | 0.6782 | |
| 441 | D | A | -0.4679 | |
| 442 | E | A | -1.0040 | |
| 443 | R | A | -1.8599 | |
| 444 | L | A | 0.0000 | |
| 445 | V | A | 0.0000 | |
| 446 | R | A | -1.6527 | |
| 447 | L | A | 0.0000 | |
| 448 | R | A | -3.1508 | |
| 449 | D | A | -3.0985 | |
| 450 | G | A | -1.5711 | |
| 451 | T | A | 0.0000 | |
| 452 | R | A | -1.2060 | |
| 453 | S | A | 0.0000 | |
| 454 | Y | A | 0.0000 | |
| 455 | F | A | 0.0000 | |
| 456 | G | A | 0.0000 | |
| 457 | A | A | 0.0000 | |
| 458 | F | A | 0.0000 | |
| 459 | M | A | -0.1524 | |
| 460 | V | A | 0.0206 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine