| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVVDGKVLVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTVYVHETEDDRVAFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRSGPEGHPLPAAPPPSPLYVPPPPDSPYAVLPSYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPLPNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9445 | |
| 2 | L | A | 1.9676 | |
| 3 | P | A | 0.8237 | |
| 4 | P | A | 0.3812 | |
| 5 | T | A | 0.1190 | |
| 6 | T | A | 0.1302 | |
| 7 | P | A | 0.1758 | |
| 8 | V | A | 1.1832 | |
| 9 | A | A | 0.0426 | |
| 10 | K | A | -1.1314 | |
| 11 | V | A | -0.3766 | |
| 12 | Q | A | -1.4991 | |
| 13 | S | A | -1.5816 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.3997 | |
| 16 | E | A | -2.4279 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4643 | |
| 20 | P | A | 0.1103 | |
| 21 | T | A | 0.1146 | |
| 22 | S | A | -0.1707 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.1143 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.1647 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.7738 | |
| 31 | R | A | -2.6246 | |
| 32 | L | A | -0.7580 | |
| 33 | L | A | 1.2211 | |
| 34 | T | A | 1.4506 | |
| 35 | V | A | 1.9687 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2573 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6287 | |
| 40 | K | A | -1.8569 | |
| 41 | D | A | -0.7189 | |
| 42 | I | A | 1.2771 | |
| 43 | V | A | 2.1384 | |
| 44 | V | A | 1.4873 | |
| 45 | D | A | -0.9989 | |
| 46 | G | A | -0.5920 | |
| 47 | K | A | -0.2531 | |
| 48 | V | A | 2.1467 | |
| 49 | L | A | 2.4940 | |
| 50 | V | A | 1.4888 | |
| 51 | P | A | 0.3707 | |
| 52 | K | A | -0.6699 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1258 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4531 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2890 | |
| 70 | K | A | -1.8048 | |
| 71 | F | A | -0.6611 | |
| 72 | A | A | -0.5652 | |
| 73 | L | A | -0.8514 | |
| 74 | P | A | -1.2556 | |
| 75 | Q | A | -2.4737 | |
| 76 | K | A | -3.0940 | |
| 77 | D | A | -2.9936 | |
| 78 | F | A | -1.6464 | |
| 79 | Y | A | -1.9297 | |
| 80 | D | A | -2.7722 | |
| 81 | P | A | -2.4186 | |
| 82 | E | A | -3.0781 | |
| 83 | K | A | -3.4411 | |
| 84 | E | A | -2.4982 | |
| 85 | R | A | -1.3157 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6662 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9465 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.2968 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7312 | |
| 99 | G | A | -0.5300 | |
| 100 | P | A | -0.4306 | |
| 101 | L | A | -0.0140 | |
| 102 | G | A | -0.3463 | |
| 103 | K | A | -0.8869 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4997 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1406 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.3954 | |
| 110 | L | A | 0.2850 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1552 | |
| 113 | K | A | -0.5473 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | -0.6393 | |
| 116 | D | A | -1.0856 | |
| 117 | T | A | -0.6706 | |
| 118 | E | A | -2.0036 | |
| 119 | N | A | -1.8545 | |
| 120 | P | A | -0.7087 | |
| 121 | T | A | 0.2384 | |
| 122 | V | A | 1.6734 | |
| 123 | Y | A | 1.5367 | |
| 124 | V | A | 0.6111 | |
| 125 | H | A | -0.2656 | |
| 126 | E | A | -2.0690 | |
| 127 | T | A | -2.3864 | |
| 128 | E | A | -3.1630 | |
| 129 | D | A | -3.1680 | |
| 130 | D | A | -2.2586 | |
| 131 | R | A | -1.3139 | |
| 132 | V | A | 0.2166 | |
| 133 | A | A | 0.4218 | |
| 134 | F | A | 0.2613 | |
| 135 | S | A | -0.0798 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.7362 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5597 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2319 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.0708 | |
| 157 | D | A | 0.2318 | |
| 158 | L | A | 0.6042 | |
| 159 | A | A | 0.0245 | |
| 160 | E | A | -1.5456 | |
| 161 | P | A | -0.3511 | |
| 162 | C | A | 0.1277 | |
| 163 | P | A | -0.2073 | |
| 164 | G | A | -0.1221 | |
| 165 | L | A | 0.5050 | |
| 166 | P | A | -0.1513 | |
| 167 | P | A | -0.3608 | |
| 168 | G | A | -0.4323 | |
| 169 | A | A | -0.0439 | |
| 170 | C | A | 0.6367 | |
| 171 | P | A | 0.4425 | |
| 172 | P | A | 0.5784 | |
| 173 | I | A | 1.8349 | |
| 174 | Q | A | 0.7473 | |
| 175 | L | A | 1.4364 | |
| 176 | V | A | 0.8145 | |
| 177 | N | A | -0.3236 | |
| 178 | S | A | 0.0294 | |
| 179 | V | A | 0.4289 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3728 | |
| 182 | D | A | 0.0668 | |
| 183 | G | A | -0.1651 | |
| 184 | D | A | -0.5916 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | -0.4870 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1007 | |
| 190 | F | A | 0.0187 | |
| 191 | G | A | -0.1569 | |
| 192 | N | A | -0.3423 | |
| 193 | M | A | -0.1910 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3510 | |
| 197 | E | A | -2.5019 | |
| 198 | L | A | -1.2107 | |
| 199 | Q | A | -2.5073 | |
| 200 | Q | A | -3.3279 | |
| 201 | D | A | -3.5997 | |
| 202 | R | A | -3.3396 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1828 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3735 | |
| 211 | S | A | -1.8863 | |
| 212 | T | A | -1.4559 | |
| 213 | R | A | -2.1793 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.2227 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3109 | |
| 220 | L | A | 0.5248 | |
| 221 | K | A | -1.2694 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9544 | |
| 224 | N | A | -1.6841 | |
| 225 | E | A | -1.3156 | |
| 226 | A | A | -0.6672 | |
| 227 | Y | A | -0.4511 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7088 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1383 | |
| 234 | F | A | 0.0345 | |
| 235 | G | A | -0.9040 | |
| 236 | R | A | -2.6562 | |
| 237 | R | A | -2.8856 | |
| 238 | E | A | -2.1222 | |
| 239 | Q | A | -0.0449 | |
| 240 | V | A | 1.5948 | |
| 241 | Y | A | 1.2734 | |
| 242 | A | A | 0.1508 | |
| 243 | R | A | -1.3065 | |
| 244 | H | A | -1.1032 | |
| 245 | F | A | -0.0677 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.6298 | |
| 249 | S | A | -1.4578 | |
| 250 | G | A | -1.2846 | |
| 251 | P | A | -1.0452 | |
| 252 | E | A | -1.1902 | |
| 253 | G | A | -1.2174 | |
| 254 | H | A | -1.2610 | |
| 255 | P | A | -0.6615 | |
| 256 | L | A | 0.4285 | |
| 257 | P | A | 0.0493 | |
| 258 | A | A | -0.0180 | |
| 259 | A | A | 0.3007 | |
| 260 | P | A | -0.2196 | |
| 261 | P | A | -0.1404 | |
| 262 | P | A | 0.0512 | |
| 263 | S | A | 0.5691 | |
| 264 | P | A | 0.6886 | |
| 265 | L | A | 1.9174 | |
| 266 | Y | A | 1.7441 | |
| 267 | V | A | 1.9393 | |
| 268 | P | A | 1.0434 | |
| 269 | P | A | 0.5197 | |
| 270 | P | A | -0.5905 | |
| 271 | P | A | -0.9031 | |
| 272 | D | A | -1.6892 | |
| 273 | S | A | -0.5069 | |
| 274 | P | A | 0.3642 | |
| 275 | Y | A | 1.4646 | |
| 276 | A | A | 1.0292 | |
| 277 | V | A | 2.0139 | |
| 278 | L | A | 1.9744 | |
| 279 | P | A | 0.6286 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | 0.3325 | |
| 282 | D | A | -0.2092 | |
| 283 | Y | A | 1.1041 | |
| 284 | F | A | 0.8225 | |
| 285 | G | A | 0.1814 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.8234 | |
| 291 | L | A | 1.6094 | |
| 292 | V | A | 0.5510 | |
| 293 | S | A | -0.1652 | |
| 294 | S | A | -0.9707 | |
| 295 | D | A | -1.8448 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1183 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6083 | |
| 301 | R | A | -1.8287 | |
| 302 | P | A | -0.9390 | |
| 303 | F | A | -0.1656 | |
| 304 | W | A | -0.5144 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0841 | |
| 307 | R | A | -2.9247 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.7835 | |
| 310 | G | A | -1.4243 | |
| 311 | N | A | -1.3798 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9104 | |
| 319 | N | A | -0.9946 | |
| 320 | E | A | -1.0488 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3930 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.2214 | |
| 333 | N | A | 0.3880 | |
| 334 | F | A | 1.4766 | |
| 335 | T | A | 0.7442 | |
| 336 | I | A | 0.4134 | |
| 337 | S | A | -0.9637 | |
| 338 | Q | A | -1.7066 | |
| 339 | Q | A | -1.0872 | |
| 340 | L | A | 0.7636 | |
| 341 | C | A | 0.6978 | |
| 342 | T | A | 0.5394 | |
| 343 | P | A | 0.3737 | |
| 344 | L | A | 1.4570 | |
| 345 | P | A | 0.6518 | |
| 346 | N | A | 0.0951 | |
| 347 | V | A | 1.7641 | |
| 348 | Y | A | 1.6492 | |
| 349 | D | A | 0.2526 | |
| 350 | P | A | -0.3944 | |
| 351 | S | A | -0.3404 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.6541 | |
| 354 | K | A | -1.8170 | |
| 355 | N | A | -1.7645 | |
| 356 | Y | A | -0.0999 | |
| 357 | L | A | 0.5736 | |
| 358 | R | A | 0.9144 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.4754 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0032 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9069 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6700 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3116 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3235 | |
| 376 | L | A | -1.7565 | |
| 377 | D | A | -2.0305 | |
| 378 | P | A | -1.0611 | |
| 379 | G | A | -1.0204 | |
| 380 | V | A | -0.9309 | |
| 381 | L | A | -0.5410 | |
| 382 | A | A | -0.6617 | |
| 383 | H | A | -0.8452 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4063 | |
| 386 | T | A | -0.5740 | |
| 387 | M | A | -0.3286 | |
| 388 | N | A | -0.8690 | |
| 389 | P | A | -1.2694 | |
| 390 | T | A | -1.5419 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.5398 | |
| 393 | E | A | -2.9293 | |
| 394 | N | A | -2.6712 | |
| 395 | W | A | -1.5374 | |
| 396 | N | A | -1.2588 | |
| 397 | L | A | -0.2441 | |
| 398 | G | A | 0.4868 | |
| 399 | F | A | 2.4109 | |
| 400 | V | A | 1.8405 | |
| 401 | P | A | 0.0469 | |
| 402 | P | A | -1.9423 | |
| 403 | K | A | -3.4317 | |
| 404 | E | A | -3.9229 | |
| 405 | R | A | -4.2606 | |
| 406 | E | A | -3.9258 | |
| 407 | D | A | -2.9173 | |
| 408 | P | A | -1.7926 | |
| 409 | Y | A | -0.9847 | |
| 410 | K | A | -2.0979 | |
| 411 | G | A | -0.6345 | |
| 412 | L | A | 0.6679 | |
| 413 | I | A | 1.5799 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3962 | |
| 416 | E | A | -1.6614 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.8428 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8901 | |
| 421 | E | A | -2.4973 | |
| 422 | R | A | -2.0671 | |
| 423 | F | A | -1.0215 | |
| 424 | S | A | -1.3332 | |
| 425 | Q | A | -1.8807 | |
| 426 | D | A | -2.9190 | |
| 427 | L | A | -2.0326 | |
| 428 | D | A | -2.8370 | |
| 429 | Q | A | -2.6394 | |
| 430 | F | A | -1.4715 | |
| 431 | A | A | -0.9271 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.6367 | |
| 435 | K | A | -0.7745 | |
| 436 | F | A | 0.1216 | |
| 437 | L | A | 1.0087 | |
| 438 | Y | A | 0.8055 | |
| 439 | Q | A | -0.2797 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine