Project name: 3d5e90777bad9

Chain sequence(s)	A: EVQLVQSGAEVKKPGQSLKISCKASGYSLTDNWIGWVRQKPGKGLEWMGIIYPGDSDTRYSPSFQGQVTISADKSINTAYLQWSSLKASDTAIYYCVGLDWNYNPLRYWGPGTLVTVSSGGGGSGGGGSGGGGSGGGGSQSVLTQPPSVSAAPGQKVTISCSGSSSDIGSNYVSWYQQFPGTAPKLLIYDNNKRPSAIPDRFSGSKSGTSATLGITGLQTGDEADYYCGTWDSRLGIAVFGGGTQLTVL
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	No
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:04)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:04)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:04)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:04)
[INFO]       runJob:   FoldX not utilized. Treating input pdb file as it was already optimized.    (00:00:04)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:04)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:06)

• Minimal score value: -2.7231
• Maximal score value: 1.4314
• Average score: -0.6164
• Total score value: -153.4768

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
36	E	A	-2.1200
37	V	A	-1.1408
38	Q	A	-1.2054
39	L	A	0.0000
40	V	A	0.8135
41	Q	A	0.0868
42	S	A	-0.4164
43	G	A	-0.1381
44	A	A	0.2097
45	E	A	0.0986
46	V	A	0.9520
47	K	A	-1.2093
48	K	A	-2.4577
49	P	A	-2.3742
50	G	A	-2.0531
51	Q	A	-2.2399
52	S	A	-1.8412
53	L	A	0.0000
54	K	A	-2.0333
55	I	A	0.0000
56	S	A	-0.6663
57	C	A	0.0000
58	K	A	-1.1361
59	A	A	-0.6617
60	S	A	-1.1621
61	G	A	-1.2563
62	Y	A	-1.0766
63	S	A	-0.7766
64	L	A	0.0000
65	T	A	-1.7959
66	D	A	-1.9505
67	N	A	0.0000
68	W	A	0.0000
69	I	A	0.0000
70	G	A	0.0000
71	W	A	0.0000
72	V	A	0.0000
73	R	A	-0.1342
74	Q	A	0.0000
75	K	A	-0.6981
76	P	A	-0.7288
77	G	A	-0.9358
78	K	A	-0.9504
79	G	A	0.0000
80	L	A	-0.1026
81	E	A	0.0000
82	W	A	0.3704
83	M	A	0.0000
84	G	A	-0.2162
85	I	A	0.0914
86	I	A	0.0000
87	Y	A	-1.2869
88	P	A	0.0000
89	G	A	-2.0557
90	D	A	-2.3737
91	S	A	-1.9199
92	D	A	-1.7382
93	T	A	-0.9940
94	R	A	-1.0628
95	Y	A	-0.5990
96	S	A	0.0000
97	P	A	-0.5623
98	S	A	-0.5564
99	F	A	0.0000
100	Q	A	-1.8819
101	G	A	-1.5941
102	Q	A	-1.8634
103	V	A	0.0000
104	T	A	-0.9595
105	I	A	0.0000
106	S	A	-0.4215
107	A	A	-0.8123
108	D	A	-1.1602
109	K	A	-1.7636
110	S	A	-0.2325
111	I	A	0.8427
112	N	A	-0.7067
113	T	A	0.0000
114	A	A	0.0000
115	Y	A	-0.7352
116	L	A	0.0000
117	Q	A	-1.5841
118	W	A	0.0000
119	S	A	-1.3899
120	S	A	-1.6960
121	L	A	0.0000
122	K	A	-2.4860
123	A	A	-1.5613
124	S	A	-0.9957
125	D	A	0.0000
126	T	A	0.0000
127	A	A	0.0000
128	I	A	0.3460
129	Y	A	0.0000
130	Y	A	0.6082
131	C	A	0.0000
132	V	A	0.0000
133	G	A	0.0000
134	L	A	0.0000
135	D	A	-0.9103
136	W	A	0.1759
137	N	A	0.2671
138	Y	A	1.0032
139	N	A	-0.2078
140	P	A	-0.6180
141	L	A	-0.2945
142	R	A	-1.4909
143	Y	A	-0.0632
144	W	A	1.0425
145	G	A	0.0000
146	P	A	0.3193
147	G	A	0.4200
148	T	A	0.0000
149	L	A	0.7028
150	V	A	0.0000
151	T	A	0.0099
152	V	A	0.0000
153	S	A	-0.8637
154	S	A	-0.6307
155	G	A	0.0000
156	G	A	-1.0813
157	G	A	-0.9814
158	G	A	-1.1214
159	S	A	-1.0369
160	G	A	-1.3310
161	G	A	-1.3036
162	G	A	-1.6567
163	G	A	-1.5176
164	S	A	-1.3646
165	G	A	-1.1395
166	G	A	-1.4320
167	G	A	-1.4895
168	G	A	-1.2866
169	S	A	-1.3037
170	G	A	-1.3655
171	G	A	-1.3588
172	G	A	-1.4740
173	G	A	-1.5352
174	S	A	-1.1130
175	Q	A	-1.1981
176	S	A	-0.1212
177	V	A	1.0666
178	L	A	0.0000
179	T	A	-0.0303
180	Q	A	-0.3115
181	P	A	-0.5752
182	P	A	-0.7725
183	S	A	-0.8354
184	V	A	-0.3569
185	S	A	-0.2184
186	A	A	-0.4035
187	A	A	-0.4002
188	P	A	-1.1610
189	G	A	-1.8573
190	Q	A	-2.5110
191	K	A	-2.7231
192	V	A	0.0000
193	T	A	-0.5124
194	I	A	0.0000
195	S	A	-0.4150
196	C	A	0.0000
197	S	A	-0.3937
198	G	A	-0.1442
199	S	A	-0.4077
200	S	A	-0.7866
201	S	A	-0.8541
202	D	A	0.0000
203	I	A	0.0000
204	G	A	-0.8958
205	S	A	-0.6972
206	N	A	0.0064
207	Y	A	0.7354
208	V	A	0.0000
209	S	A	0.0000
210	W	A	0.0000
211	Y	A	0.0000
212	Q	A	0.0000
213	Q	A	0.0000
214	F	A	-0.3775
215	P	A	-0.4530
216	G	A	-0.4943
217	T	A	-0.4198
218	A	A	-0.5430
219	P	A	0.0000
220	K	A	-1.2725
221	L	A	-0.2273
222	L	A	0.0000
223	I	A	0.0000
224	Y	A	-0.4600
225	D	A	-0.8825
226	N	A	0.0000
227	N	A	-2.1545
228	K	A	-2.4939
229	R	A	-2.4304
230	P	A	-0.9349
231	S	A	-0.7772
232	A	A	-0.3656
233	I	A	-0.7771
234	P	A	-1.4693
235	D	A	-2.6588
236	R	A	-2.2436
237	F	A	0.0000
238	S	A	-1.5912
239	G	A	-1.2594
240	S	A	-1.2254
241	K	A	-1.2157
242	S	A	-0.9296
243	G	A	-1.0375
244	T	A	-0.9311
245	S	A	-0.8438
246	A	A	0.0000
247	T	A	-0.5058
248	L	A	0.0000
249	G	A	0.0000
250	I	A	0.0000
251	T	A	-2.0389
252	G	A	-1.8048
253	L	A	0.0000
254	Q	A	-1.8996
255	T	A	-0.9467
256	G	A	-1.1653
257	D	A	-1.1975
258	E	A	-1.5136
259	A	A	0.0000
260	D	A	-1.1662
261	Y	A	0.0000
262	Y	A	0.0000
263	C	A	0.0000
264	G	A	0.0000
265	T	A	0.0000
266	W	A	0.2089
267	D	A	-0.2806
268	S	A	-1.0151
269	R	A	-1.3596
270	L	A	0.3442
271	G	A	-0.3249
272	I	A	0.1769
273	A	A	0.0000
274	V	A	0.0000
275	F	A	0.3991
276	G	A	0.0000
277	G	A	-0.6924
278	G	A	-0.8822
279	T	A	0.0000
280	Q	A	-1.6283
281	L	A	0.0000
282	T	A	-0.4306
283	V	A	0.1394
284	L	A	1.4314