| Chain sequence(s) |
A: GPPPLNPAPEVRDTDEFVEETDLLLIAETDLLTETGHPEKDIIVNGKVLIPQVSAYQYDVFKLTLPDPNTYPLPSPDFLDPATEIAIWRLKALKIHVFGPLGKGSYGHPNYNALGNVDNPTSYQQETADDTQNLSWYPKLLQEYIVGDLPPLGKYIARAAPEPGLPPGARPPLEIKTDYIQHGDRADIGFGARDFKELLPEKNDVPTIILDTVTKVPDYEGMKAEPYGRRMFDYDRYEKSKSIKNYVRDGPDLYPLPDSPPPSPLYTPPPPSSPYWKLPSYDYFTLPDSGEITEEDLLFNKPRFFEKAPGKNNFVLWHNQLYITVVDNSRAEIETITTKISTPENNVYNPDNYVTSKRYTRELRIELIVQLCRIPLTPETLAYLARLDRSILVDAKLPEIPPEERPDPYAGLKFREIDLKDKLSRDLSKFELGRLYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.7025 | |
| 2 | P | A | -0.4255 | |
| 3 | P | A | -0.4314 | |
| 4 | P | A | -0.1800 | |
| 5 | L | A | 0.6454 | |
| 6 | N | A | -0.7942 | |
| 7 | P | A | -0.8209 | |
| 8 | A | A | -0.6931 | |
| 9 | P | A | -1.4369 | |
| 10 | E | A | -1.9495 | |
| 11 | V | A | -1.0713 | |
| 12 | R | A | -1.7225 | |
| 13 | D | A | -2.0556 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -3.4157 | |
| 16 | E | A | -3.0177 | |
| 17 | F | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | E | A | -2.6253 | |
| 20 | E | A | -3.0237 | |
| 21 | T | A | -2.0322 | |
| 22 | D | A | -2.0951 | |
| 23 | L | A | 0.0000 | |
| 24 | L | A | -0.6092 | |
| 25 | L | A | 0.0000 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.1723 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.5619 | |
| 31 | L | A | -0.3049 | |
| 32 | L | A | -0.3868 | |
| 33 | T | A | -0.4160 | |
| 34 | E | A | -0.4924 | |
| 35 | T | A | -0.5250 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.4439 | |
| 38 | P | A | 0.0000 | |
| 39 | E | A | -1.5835 | |
| 40 | K | A | -1.7381 | |
| 41 | D | A | -0.3043 | |
| 42 | I | A | 1.6889 | |
| 43 | I | A | 2.6793 | |
| 44 | V | A | 1.7783 | |
| 45 | N | A | -0.5379 | |
| 46 | G | A | -0.3504 | |
| 47 | K | A | 0.0365 | |
| 48 | V | A | 2.3278 | |
| 49 | L | A | 2.9799 | |
| 50 | I | A | 1.9614 | |
| 51 | P | A | 0.4546 | |
| 52 | Q | A | -0.9182 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | Y | A | 0.0000 | |
| 59 | D | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | -1.3345 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.5099 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -0.9248 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.9875 | |
| 70 | T | A | -0.4958 | |
| 71 | Y | A | -0.2778 | |
| 72 | P | A | -0.1303 | |
| 73 | L | A | -0.0007 | |
| 74 | P | A | -0.2782 | |
| 75 | S | A | -0.6674 | |
| 76 | P | A | -1.2032 | |
| 77 | D | A | -2.0573 | |
| 78 | F | A | -1.1722 | |
| 79 | L | A | 0.0000 | |
| 80 | D | A | -1.8210 | |
| 81 | P | A | -1.3274 | |
| 82 | A | A | -0.5191 | |
| 83 | T | A | -0.5800 | |
| 84 | E | A | -0.8653 | |
| 85 | I | A | 0.0000 | |
| 86 | A | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | K | A | -0.5214 | |
| 92 | A | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -0.5737 | |
| 97 | V | A | 0.0000 | |
| 98 | F | A | 0.1710 | |
| 99 | G | A | -0.5274 | |
| 100 | P | A | -0.4391 | |
| 101 | L | A | -0.3210 | |
| 102 | G | A | -0.8505 | |
| 103 | K | A | -1.0790 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.2661 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.5807 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -1.6000 | |
| 110 | N | A | -2.4139 | |
| 111 | Y | A | 0.0000 | |
| 112 | N | A | -1.6631 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | N | A | -1.0537 | |
| 117 | V | A | -0.8444 | |
| 118 | D | A | -2.0806 | |
| 119 | N | A | -2.1656 | |
| 120 | P | A | -1.2063 | |
| 121 | T | A | -0.7013 | |
| 122 | S | A | -0.4717 | |
| 123 | Y | A | 0.0039 | |
| 124 | Q | A | -0.8419 | |
| 125 | Q | A | -1.9777 | |
| 126 | E | A | -2.3856 | |
| 127 | T | A | -1.6494 | |
| 128 | A | A | -1.2110 | |
| 129 | D | A | -2.4185 | |
| 130 | D | A | -2.0501 | |
| 131 | T | A | -1.8529 | |
| 132 | Q | A | -1.9141 | |
| 133 | N | A | -2.0165 | |
| 134 | L | A | -1.0247 | |
| 135 | S | A | -0.4144 | |
| 136 | W | A | 0.0000 | |
| 137 | Y | A | 0.3324 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | L | A | 0.0889 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.0614 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.2541 | |
| 155 | Y | A | 0.1372 | |
| 156 | I | A | 0.7101 | |
| 157 | A | A | 0.0000 | |
| 158 | R | A | -1.6588 | |
| 159 | A | A | -0.5516 | |
| 160 | A | A | -0.8052 | |
| 161 | P | A | -1.2089 | |
| 162 | E | A | -1.9775 | |
| 163 | P | A | -1.2113 | |
| 164 | G | A | -0.7405 | |
| 165 | L | A | -0.4331 | |
| 166 | P | A | -0.4450 | |
| 167 | P | A | -0.6927 | |
| 168 | G | A | -0.7787 | |
| 169 | A | A | -0.7707 | |
| 170 | R | A | -1.7028 | |
| 171 | P | A | -1.5184 | |
| 172 | P | A | -0.8580 | |
| 173 | L | A | 0.4317 | |
| 174 | E | A | 0.2757 | |
| 175 | I | A | 1.3509 | |
| 176 | K | A | -0.2829 | |
| 177 | T | A | -0.3997 | |
| 178 | D | A | -0.8116 | |
| 179 | Y | A | -0.2188 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -0.8698 | |
| 182 | H | A | -0.8902 | |
| 183 | G | A | -0.7454 | |
| 184 | D | A | -0.5796 | |
| 185 | R | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.3917 | |
| 190 | F | A | -0.1071 | |
| 191 | G | A | -0.1637 | |
| 192 | A | A | 0.0729 | |
| 193 | R | A | -0.8888 | |
| 194 | D | A | -1.6006 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4120 | |
| 197 | E | A | -3.0598 | |
| 198 | L | A | -1.8158 | |
| 199 | L | A | -1.7482 | |
| 200 | P | A | -1.9605 | |
| 201 | E | A | -1.9876 | |
| 202 | K | A | -2.5235 | |
| 203 | N | A | -1.6745 | |
| 204 | D | A | -1.0327 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | T | A | -0.8840 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.2152 | |
| 211 | D | A | -2.2308 | |
| 212 | T | A | -1.2387 | |
| 213 | V | A | -0.6417 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.1208 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | -1.1446 | |
| 219 | Y | A | -1.3582 | |
| 220 | E | A | -2.4986 | |
| 221 | G | A | -1.7593 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.4375 | |
| 224 | A | A | -1.4429 | |
| 225 | E | A | -1.2902 | |
| 226 | P | A | -0.8866 | |
| 227 | Y | A | -0.5069 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.4410 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.8479 | |
| 234 | Y | A | -0.4989 | |
| 235 | D | A | -1.2253 | |
| 236 | R | A | -1.4966 | |
| 237 | Y | A | -0.8594 | |
| 238 | E | A | -1.2706 | |
| 239 | K | A | -1.7456 | |
| 240 | S | A | -1.6622 | |
| 241 | K | A | -2.0332 | |
| 242 | S | A | -0.7747 | |
| 243 | I | A | 0.1027 | |
| 244 | K | A | -1.1113 | |
| 245 | N | A | -0.7713 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -1.0200 | |
| 249 | D | A | -1.6909 | |
| 250 | G | A | -1.1782 | |
| 251 | P | A | -0.7296 | |
| 252 | D | A | -0.5754 | |
| 253 | L | A | 0.7058 | |
| 254 | Y | A | 1.4095 | |
| 255 | P | A | 0.2537 | |
| 256 | L | A | 0.3998 | |
| 257 | P | A | -0.5587 | |
| 258 | D | A | -1.9854 | |
| 259 | S | A | -0.9904 | |
| 260 | P | A | -0.9633 | |
| 261 | P | A | -0.6407 | |
| 262 | P | A | -0.3272 | |
| 263 | S | A | -0.1399 | |
| 264 | P | A | 0.4573 | |
| 265 | L | A | 1.5079 | |
| 266 | Y | A | 0.6562 | |
| 267 | T | A | 0.0913 | |
| 268 | P | A | -0.2575 | |
| 269 | P | A | -0.1145 | |
| 270 | P | A | -0.2455 | |
| 271 | P | A | -0.4106 | |
| 272 | S | A | -0.2034 | |
| 273 | S | A | -0.0792 | |
| 274 | P | A | 0.0717 | |
| 275 | Y | A | 0.5360 | |
| 276 | W | A | -0.0041 | |
| 277 | K | A | -1.3039 | |
| 278 | L | A | -0.3255 | |
| 279 | P | A | -0.6815 | |
| 280 | S | A | -1.1193 | |
| 281 | Y | A | -0.2262 | |
| 282 | D | A | -1.2980 | |
| 283 | Y | A | 0.5134 | |
| 284 | F | A | 0.2112 | |
| 285 | T | A | -0.0498 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | 0.0000 | |
| 289 | S | A | 0.0000 | |
| 290 | G | A | -1.3577 | |
| 291 | E | A | -2.1256 | |
| 292 | I | A | -1.4754 | |
| 293 | T | A | -1.8090 | |
| 294 | E | A | -2.5835 | |
| 295 | E | A | -2.7069 | |
| 296 | D | A | -1.8792 | |
| 297 | L | A | -1.0955 | |
| 298 | L | A | -1.0903 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.3015 | |
| 301 | K | A | -1.8746 | |
| 302 | P | A | -0.9962 | |
| 303 | R | A | -0.6245 | |
| 304 | F | A | -0.4048 | |
| 305 | F | A | 0.0000 | |
| 306 | E | A | -2.5777 | |
| 307 | K | A | -2.9870 | |
| 308 | A | A | 0.0000 | |
| 309 | P | A | -1.2392 | |
| 310 | G | A | -1.4376 | |
| 311 | K | A | -1.8802 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | F | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.4476 | |
| 319 | N | A | -0.6479 | |
| 320 | Q | A | -0.4792 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | -0.6898 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.1476 | |
| 333 | I | A | -1.5266 | |
| 334 | E | A | -1.4421 | |
| 335 | T | A | -0.7528 | |
| 336 | I | A | 0.4097 | |
| 337 | T | A | 0.4210 | |
| 338 | T | A | 0.2728 | |
| 339 | K | A | -0.6554 | |
| 340 | I | A | 1.1666 | |
| 341 | S | A | -0.1151 | |
| 342 | T | A | -0.9419 | |
| 343 | P | A | -1.3236 | |
| 344 | E | A | -2.3189 | |
| 345 | N | A | -2.0738 | |
| 346 | N | A | -1.4195 | |
| 347 | V | A | 0.6645 | |
| 348 | Y | A | 0.8289 | |
| 349 | N | A | -0.7072 | |
| 350 | P | A | -0.8436 | |
| 351 | D | A | -1.5640 | |
| 352 | N | A | -0.5854 | |
| 353 | Y | A | 0.1814 | |
| 354 | V | A | 1.2259 | |
| 355 | T | A | 0.3897 | |
| 356 | S | A | -0.4244 | |
| 357 | K | A | -1.6024 | |
| 358 | R | A | -1.8188 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.9345 | |
| 361 | R | A | -0.7248 | |
| 362 | E | A | -0.5190 | |
| 363 | L | A | 0.0000 | |
| 364 | R | A | -0.8346 | |
| 365 | I | A | 0.0000 | |
| 366 | E | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | R | A | -1.6715 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.6891 | |
| 376 | L | A | -0.2300 | |
| 377 | T | A | -0.5768 | |
| 378 | P | A | -0.9448 | |
| 379 | E | A | -1.7594 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.4511 | |
| 382 | A | A | -0.7972 | |
| 383 | Y | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | A | A | -1.1461 | |
| 386 | R | A | -1.3123 | |
| 387 | L | A | -0.7889 | |
| 388 | D | A | -1.4612 | |
| 389 | R | A | -2.1792 | |
| 390 | S | A | -2.0356 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -2.0641 | |
| 394 | D | A | -1.9474 | |
| 395 | A | A | -1.2174 | |
| 396 | K | A | -2.3927 | |
| 397 | L | A | -1.4179 | |
| 398 | P | A | -1.4111 | |
| 399 | E | A | -2.0215 | |
| 400 | I | A | -1.3553 | |
| 401 | P | A | -1.5769 | |
| 402 | P | A | -2.2881 | |
| 403 | E | A | -3.3104 | |
| 404 | E | A | -3.4144 | |
| 405 | R | A | -2.6941 | |
| 406 | P | A | -1.8915 | |
| 407 | D | A | -1.6706 | |
| 408 | P | A | -0.8875 | |
| 409 | Y | A | -0.5147 | |
| 410 | A | A | -0.7001 | |
| 411 | G | A | -0.7809 | |
| 412 | L | A | -0.7529 | |
| 413 | K | A | -1.9716 | |
| 414 | F | A | -1.3891 | |
| 415 | R | A | -1.7051 | |
| 416 | E | A | -2.5257 | |
| 417 | I | A | -2.0623 | |
| 418 | D | A | -3.1614 | |
| 419 | L | A | 0.0000 | |
| 420 | K | A | -3.2804 | |
| 421 | D | A | -3.4147 | |
| 422 | K | A | -2.9245 | |
| 423 | L | A | -1.7408 | |
| 424 | S | A | -1.6198 | |
| 425 | R | A | -1.8038 | |
| 426 | D | A | -1.9145 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.6388 | |
| 429 | K | A | -2.5143 | |
| 430 | F | A | -1.6277 | |
| 431 | E | A | -1.8121 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.7532 | |
| 435 | L | A | -0.4749 | |
| 436 | Y | A | -0.2620 | |
| 437 | L | A | 0.1703 | |
| 438 | N | A | -1.4844 | |
| 439 | R | A | -1.8743 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine