| Chain sequence(s) |
A: GPLPLNPEPELIHTDEYVTPTDLLYVAKTDLITETGNPTADIVTNGKVTTKRVSAYDYKVFLLKLPDPNTLPLPSEDFINKETERLIWRLLAFKIHVGGPLGKGTYGHPNFNRLGNVDNPTAPVHEGPDDTVALSWEPKLKQEYIIGSEPPIGKYTAKAAPEPGLPPGAVPPTEIKYTIIEHGDVADIGFGAKDFKELDPEKNRVPDIILDTSTKVVDYEGMKAEPWGRRMFTYDKYEKSYNKENYVLDGPVKHPLPDAGPPSPLYTPPPPASPYAVPPSYDYFSLPDRGEITEEDLLFNKPIYFTKSAGKNNFVLWHNKLYVTILDNTRAEIATNTTRTSTPANNVYDPSNYTTSKTYTREYQLELIIQLCKIPLTPETLELLRRLDPSILVDWNLPFIPPVERPDPYAGKKFLEIDLTNKLSSDLSKYPLGREYLNK
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2022 | |
| 2 | P | A | 0.4219 | |
| 3 | L | A | 1.3929 | |
| 4 | P | A | 0.7041 | |
| 5 | L | A | 0.8487 | |
| 6 | N | A | -1.0253 | |
| 7 | P | A | -1.7434 | |
| 8 | E | A | -2.5899 | |
| 9 | P | A | -2.0809 | |
| 10 | E | A | -2.1136 | |
| 11 | L | A | -0.8183 | |
| 12 | I | A | -0.5814 | |
| 13 | H | A | -1.2901 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.6020 | |
| 16 | E | A | -2.5002 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.9137 | |
| 20 | P | A | -0.8716 | |
| 21 | T | A | -0.9067 | |
| 22 | D | A | -1.6253 | |
| 23 | L | A | -0.4913 | |
| 24 | L | A | -0.1052 | |
| 25 | Y | A | -0.0153 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | K | A | -0.8208 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.1629 | |
| 31 | L | A | 0.4848 | |
| 32 | I | A | 0.2525 | |
| 33 | T | A | -0.1765 | |
| 34 | E | A | -0.6675 | |
| 35 | T | A | -0.6949 | |
| 36 | G | A | 0.0000 | |
| 37 | N | A | -1.2206 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -0.7647 | |
| 40 | A | A | -0.5600 | |
| 41 | D | A | -1.0134 | |
| 42 | I | A | 0.6658 | |
| 43 | V | A | 1.0125 | |
| 44 | T | A | -0.1905 | |
| 45 | N | A | -1.4952 | |
| 46 | G | A | -1.1120 | |
| 47 | K | A | -1.3019 | |
| 48 | V | A | -0.0175 | |
| 49 | T | A | -0.2016 | |
| 50 | T | A | -0.6052 | |
| 51 | K | A | -1.7306 | |
| 52 | R | A | -1.4765 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | D | A | 0.0000 | |
| 58 | Y | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -1.9066 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -0.9649 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.7523 | |
| 70 | T | A | -0.2705 | |
| 71 | L | A | -0.0215 | |
| 72 | P | A | -0.2794 | |
| 73 | L | A | -0.4240 | |
| 74 | P | A | -0.7067 | |
| 75 | S | A | -1.5623 | |
| 76 | E | A | -3.0061 | |
| 77 | D | A | -3.0143 | |
| 78 | F | A | -1.6794 | |
| 79 | I | A | 0.0000 | |
| 80 | N | A | -3.3834 | |
| 81 | K | A | -3.7338 | |
| 82 | E | A | -3.2061 | |
| 83 | T | A | -2.0420 | |
| 84 | E | A | -2.0654 | |
| 85 | R | A | -1.4455 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | 0.1934 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | -0.7766 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -0.7355 | |
| 97 | V | A | 0.0000 | |
| 98 | G | A | -0.4539 | |
| 99 | G | A | -0.8136 | |
| 100 | P | A | -0.6223 | |
| 101 | L | A | -0.4835 | |
| 102 | G | A | -1.1262 | |
| 103 | K | A | -2.0481 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.7315 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.6884 | |
| 108 | H | A | -1.0082 | |
| 109 | P | A | -0.8777 | |
| 110 | N | A | -1.8770 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | R | A | -0.8676 | |
| 114 | L | A | -0.9897 | |
| 115 | G | A | -0.8470 | |
| 116 | N | A | -1.0445 | |
| 117 | V | A | -0.8829 | |
| 118 | D | A | -2.4614 | |
| 119 | N | A | -2.1766 | |
| 120 | P | A | -1.1797 | |
| 121 | T | A | -0.6442 | |
| 122 | A | A | -0.3238 | |
| 123 | P | A | -0.2441 | |
| 124 | V | A | -0.6219 | |
| 125 | H | A | -1.5804 | |
| 126 | E | A | -2.7011 | |
| 127 | G | A | -2.1345 | |
| 128 | P | A | -1.7328 | |
| 129 | D | A | -2.6593 | |
| 130 | D | A | -2.0978 | |
| 131 | T | A | -1.2725 | |
| 132 | V | A | -0.3766 | |
| 133 | A | A | -0.2770 | |
| 134 | L | A | -0.1660 | |
| 135 | S | A | -0.2727 | |
| 136 | W | A | 0.0000 | |
| 137 | E | A | -0.7888 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | K | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | S | A | 0.0000 | |
| 149 | E | A | -0.3618 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | I | A | 0.6479 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | 0.5148 | |
| 155 | Y | A | 0.2453 | |
| 156 | T | A | -0.0431 | |
| 157 | A | A | 0.0000 | |
| 158 | K | A | -1.5334 | |
| 159 | A | A | -0.9789 | |
| 160 | A | A | -0.9316 | |
| 161 | P | A | -1.1440 | |
| 162 | E | A | -2.0675 | |
| 163 | P | A | -1.3035 | |
| 164 | G | A | -0.9230 | |
| 165 | L | A | -0.2783 | |
| 166 | P | A | -0.3414 | |
| 167 | P | A | -0.2936 | |
| 168 | G | A | -0.3573 | |
| 169 | A | A | 0.3783 | |
| 170 | V | A | 1.3047 | |
| 171 | P | A | 0.0657 | |
| 172 | P | A | -0.4749 | |
| 173 | T | A | -0.5116 | |
| 174 | E | A | -0.5091 | |
| 175 | I | A | 1.1114 | |
| 176 | K | A | 0.2700 | |
| 177 | Y | A | 1.2720 | |
| 178 | T | A | 0.5557 | |
| 179 | I | A | 0.1486 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.0441 | |
| 182 | H | A | -1.1251 | |
| 183 | G | A | -0.7081 | |
| 184 | D | A | -0.6355 | |
| 185 | V | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.3545 | |
| 190 | F | A | -0.0381 | |
| 191 | G | A | -0.2635 | |
| 192 | A | A | -0.0742 | |
| 193 | K | A | -0.9993 | |
| 194 | D | A | -1.8151 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.5454 | |
| 197 | E | A | -2.9089 | |
| 198 | L | A | -1.6578 | |
| 199 | D | A | -2.0996 | |
| 200 | P | A | -2.2556 | |
| 201 | E | A | -2.2780 | |
| 202 | K | A | -2.9069 | |
| 203 | N | A | -1.9505 | |
| 204 | R | A | -1.5770 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.2307 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.6047 | |
| 211 | D | A | -2.6127 | |
| 212 | T | A | -1.4649 | |
| 213 | S | A | -1.1252 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.3403 | |
| 217 | V | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | Y | A | -1.1371 | |
| 220 | E | A | -2.3743 | |
| 221 | G | A | -1.4358 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.2142 | |
| 224 | A | A | -1.3742 | |
| 225 | E | A | -1.2990 | |
| 226 | P | A | -0.6442 | |
| 227 | W | A | -0.5227 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | -0.7816 | |
| 230 | R | A | -0.6025 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.3773 | |
| 234 | Y | A | -0.4340 | |
| 235 | D | A | -1.3599 | |
| 236 | K | A | -2.1359 | |
| 237 | Y | A | -1.6368 | |
| 238 | E | A | -2.4000 | |
| 239 | K | A | -1.8248 | |
| 240 | S | A | -1.1201 | |
| 241 | Y | A | -0.5203 | |
| 242 | N | A | -1.7764 | |
| 243 | K | A | -2.2914 | |
| 244 | E | A | -2.1147 | |
| 245 | N | A | -1.4945 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | L | A | 0.0000 | |
| 249 | D | A | -1.2919 | |
| 250 | G | A | -1.0406 | |
| 251 | P | A | -1.0048 | |
| 252 | V | A | -0.8622 | |
| 253 | K | A | -1.7846 | |
| 254 | H | A | -1.7083 | |
| 255 | P | A | -1.1249 | |
| 256 | L | A | -0.1407 | |
| 257 | P | A | -0.8310 | |
| 258 | D | A | -1.6886 | |
| 259 | A | A | -0.7625 | |
| 260 | G | A | -0.9269 | |
| 261 | P | A | -0.7596 | |
| 262 | P | A | -0.6528 | |
| 263 | S | A | -0.4510 | |
| 264 | P | A | 0.0858 | |
| 265 | L | A | 1.2014 | |
| 266 | Y | A | 0.7048 | |
| 267 | T | A | 0.1274 | |
| 268 | P | A | 0.1978 | |
| 269 | P | A | 0.1997 | |
| 270 | P | A | -0.2922 | |
| 271 | P | A | -0.0142 | |
| 272 | A | A | 0.1275 | |
| 273 | S | A | 0.3489 | |
| 274 | P | A | 0.3963 | |
| 275 | Y | A | 1.2837 | |
| 276 | A | A | 1.0761 | |
| 277 | V | A | 1.5857 | |
| 278 | P | A | 0.8882 | |
| 279 | P | A | -0.0809 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | 0.3200 | |
| 282 | D | A | 0.0538 | |
| 283 | Y | A | 1.0449 | |
| 284 | F | A | 0.2973 | |
| 285 | S | A | -0.6326 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | 0.0000 | |
| 289 | R | A | 0.0000 | |
| 290 | G | A | -1.4182 | |
| 291 | E | A | -2.0493 | |
| 292 | I | A | -1.6029 | |
| 293 | T | A | -1.8818 | |
| 294 | E | A | -2.6819 | |
| 295 | E | A | -2.8582 | |
| 296 | D | A | -2.1316 | |
| 297 | L | A | -1.2436 | |
| 298 | L | A | -1.1076 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.3736 | |
| 301 | K | A | -1.7468 | |
| 302 | P | A | -0.8941 | |
| 303 | I | A | 0.0061 | |
| 304 | Y | A | -0.0208 | |
| 305 | F | A | 0.0000 | |
| 306 | T | A | -0.7607 | |
| 307 | K | A | -1.9383 | |
| 308 | S | A | 0.0000 | |
| 309 | A | A | -0.7743 | |
| 310 | G | A | -1.1846 | |
| 311 | K | A | -1.4087 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | F | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7944 | |
| 319 | N | A | -0.9340 | |
| 320 | K | A | -1.0630 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | I | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.1425 | |
| 333 | I | A | -1.2601 | |
| 334 | A | A | -0.9866 | |
| 335 | T | A | -1.1774 | |
| 336 | N | A | -1.2325 | |
| 337 | T | A | -1.1291 | |
| 338 | T | A | -1.2004 | |
| 339 | R | A | -1.9614 | |
| 340 | T | A | -1.0645 | |
| 341 | S | A | -0.8430 | |
| 342 | T | A | -0.6054 | |
| 343 | P | A | -0.4475 | |
| 344 | A | A | -0.4382 | |
| 345 | N | A | -1.1196 | |
| 346 | N | A | -0.8038 | |
| 347 | V | A | 1.1385 | |
| 348 | Y | A | 1.2129 | |
| 349 | D | A | -0.1001 | |
| 350 | P | A | -0.4537 | |
| 351 | S | A | -0.6676 | |
| 352 | N | A | -0.8431 | |
| 353 | Y | A | -0.8625 | |
| 354 | T | A | -0.7268 | |
| 355 | T | A | -0.9608 | |
| 356 | S | A | -1.2276 | |
| 357 | K | A | -1.6892 | |
| 358 | T | A | -1.1493 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.6175 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.4440 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.5118 | |
| 365 | L | A | 0.0000 | |
| 366 | E | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | I | A | 0.0000 | |
| 370 | Q | A | -0.2725 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.6427 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -1.0532 | |
| 376 | L | A | -1.1740 | |
| 377 | T | A | -0.9108 | |
| 378 | P | A | -1.4337 | |
| 379 | E | A | -2.5388 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -1.7164 | |
| 382 | E | A | -2.8631 | |
| 383 | L | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | R | A | -2.9422 | |
| 386 | R | A | -1.9752 | |
| 387 | L | A | 0.0000 | |
| 388 | D | A | -1.1225 | |
| 389 | P | A | -1.5261 | |
| 390 | S | A | -0.8366 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -0.5579 | |
| 394 | D | A | -1.2633 | |
| 395 | W | A | -0.9891 | |
| 396 | N | A | -0.9620 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.2288 | |
| 399 | F | A | 1.7243 | |
| 400 | I | A | 0.9858 | |
| 401 | P | A | 0.3496 | |
| 402 | P | A | -0.0268 | |
| 403 | V | A | 0.3626 | |
| 404 | E | A | -1.6093 | |
| 405 | R | A | -1.6487 | |
| 406 | P | A | -1.5124 | |
| 407 | D | A | -2.0473 | |
| 408 | P | A | -1.1438 | |
| 409 | Y | A | -1.0331 | |
| 410 | A | A | -1.1979 | |
| 411 | G | A | -1.4085 | |
| 412 | K | A | -1.9906 | |
| 413 | K | A | -2.4289 | |
| 414 | F | A | -1.3513 | |
| 415 | L | A | -1.0409 | |
| 416 | E | A | -2.3004 | |
| 417 | I | A | -1.7953 | |
| 418 | D | A | -2.6758 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.5267 | |
| 421 | N | A | -1.7767 | |
| 422 | K | A | -1.5730 | |
| 423 | L | A | -0.5112 | |
| 424 | S | A | -0.7088 | |
| 425 | S | A | -0.5279 | |
| 426 | D | A | -1.3750 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.7755 | |
| 429 | K | A | -2.2795 | |
| 430 | Y | A | -1.4421 | |
| 431 | P | A | -1.2200 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.5615 | |
| 435 | E | A | -1.8162 | |
| 436 | Y | A | -0.7893 | |
| 437 | L | A | -0.3591 | |
| 438 | N | A | -1.9859 | |
| 439 | K | A | -2.1079 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine