Chain sequence(s) |
C: EVQLVESGGGLVQPGGSLRLSCAASDFTFRSYEMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARLRDGFNKGFDYWGQGTLVTVSS
input PDB |
Selected Chain(s) | C |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | No |
Mutated residues | QE112C,YR109C,GD111C,WN110C |
Energy difference between WT (input) and mutated protein (by FoldX) | 25.0002 kcal/mol
CAUTION: Your mutation/s can destabilize the protein structure |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:00) [INFO] runJob: Starting aggrescan3d job on: input.pdb with C chain(s) selected (00:00:00) [INFO] runJob: Creating pdb object from: input.pdb (00:00:00) [INFO] FoldX: Starting FoldX energy minimalization (00:00:00) [INFO] FoldX: Building mutant model (00:00:24) [INFO] FoldX: Starting FoldX energy minimalization (00:00:59) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:01:24) [INFO] Main: Simulation completed successfully. (00:01:25) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | E | C | -2.1898 | |
2 | V | C | -1.4661 | |
3 | Q | C | -1.9752 | |
4 | L | C | 0.0000 | |
5 | V | C | -0.0136 | |
6 | E | C | 0.0000 | |
7 | S | C | -0.4507 | |
8 | G | C | -0.7887 | |
9 | G | C | 0.0128 | |
10 | G | C | 0.8739 | |
11 | L | C | 1.4107 | |
12 | V | C | -0.0640 | |
13 | Q | C | -1.3422 | |
14 | P | C | -1.4907 | |
15 | G | C | -1.4157 | |
16 | G | C | -0.9828 | |
17 | S | C | -1.2339 | |
18 | L | C | -0.9720 | |
19 | R | C | -2.1463 | |
20 | L | C | 0.0000 | |
21 | S | C | -0.5291 | |
22 | C | C | 0.0000 | |
23 | A | C | -0.2436 | |
24 | A | C | 0.0000 | |
25 | S | C | -0.2420 | |
26 | D | C | 0.0000 | |
27 | F | C | 1.5432 | |
28 | T | C | 0.2505 | |
29 | F | C | 0.0000 | |
30 | R | C | -2.0325 | |
31 | S | C | -0.8863 | |
32 | Y | C | -1.2160 | |
33 | E | C | -1.0741 | |
34 | M | C | 0.0000 | |
35 | S | C | 0.0000 | |
36 | W | C | 0.0000 | |
37 | V | C | 0.0000 | |
38 | R | C | 0.0000 | |
39 | Q | C | -0.3125 | |
40 | A | C | -0.9954 | |
41 | P | C | -1.3128 | |
42 | G | C | -1.4330 | |
43 | K | C | -2.1226 | |
44 | G | C | -1.0118 | |
45 | L | C | 0.5126 | |
46 | E | C | -0.3411 | |
47 | W | C | 0.3643 | |
48 | V | C | 0.0000 | |
49 | S | C | 0.0000 | |
50 | A | C | 0.0000 | |
51 | I | C | 0.0000 | |
52 | S | C | -0.5831 | |
53 | G | C | -1.2447 | |
54 | S | C | -1.2286 | |
55 | G | C | -1.0817 | |
56 | G | C | -0.7345 | |
57 | S | C | -0.3025 | |
58 | T | C | 0.1989 | |
59 | Y | C | 0.6077 | |
60 | Y | C | -0.3562 | |
61 | A | C | -1.1390 | |
62 | D | C | -2.3443 | |
63 | S | C | -1.7150 | |
64 | V | C | 0.0000 | |
65 | K | C | -2.3847 | |
66 | G | C | -1.6175 | |
67 | R | C | 0.0000 | |
68 | F | C | 0.0000 | |
69 | T | C | -0.6722 | |
70 | I | C | 0.0000 | |
71 | S | C | -0.5624 | |
72 | R | C | -1.3626 | |
73 | D | C | -1.9805 | |
74 | N | C | -2.1901 | |
75 | S | C | -1.7905 | |
76 | K | C | -2.3163 | |
77 | N | C | -1.6491 | |
78 | T | C | 0.0000 | |
79 | L | C | 0.0000 | |
80 | Y | C | -0.6488 | |
81 | L | C | 0.0000 | |
82 | Q | C | -1.2337 | |
83 | M | C | 0.0000 | |
84 | N | C | -1.3327 | |
85 | S | C | -1.2322 | |
86 | L | C | 0.0000 | |
87 | R | C | -2.4732 | |
88 | A | C | -1.8896 | |
89 | E | C | -2.3442 | |
90 | D | C | 0.0000 | |
91 | T | C | -0.4417 | |
92 | A | C | 0.0000 | |
93 | I | C | 1.0031 | |
94 | Y | C | 0.0000 | |
95 | Y | C | 0.1082 | |
96 | C | C | 0.0000 | |
97 | A | C | 0.0000 | |
98 | R | C | 0.0000 | |
99 | L | C | 0.0000 | |
100 | R | C | -3.1421 | |
101 | D | C | -3.2210 | |
102 | G | C | -2.0097 | |
103 | F | C | -1.1479 | |
104 | N | C | -2.3446 | |
105 | K | C | -3.0349 | |
106 | G | C | -1.7075 | |
107 | F | C | -1.0403 | |
108 | D | C | -1.7612 | |
109 | R | C | -2.2192 | mutated: YR109C |
110 | N | C | -2.0474 | mutated: WN110C |
111 | D | C | 0.0000 | mutated: GD111C |
112 | E | C | -1.9539 | mutated: QE112C |
113 | G | C | -0.4689 | |
114 | T | C | 0.4838 | |
115 | L | C | 1.7701 | |
116 | V | C | 0.0000 | |
117 | T | C | 0.3151 | |
118 | V | C | 0.0000 | |
119 | S | C | -0.7692 | |
120 | S | C | -1.0574 |