Project name: 297

Chain sequence(s)	H: EVQLVESGGGLVQAGDSLRLSCAASGRSFSNDAMGWFRQAPGKERSFVAAINWSGELTGYAGSVKGRFTISRDGVENMVFLQMNSLVPEDTGVYYCAAVEGRDYYRGAQYYDYWGQGTQVTVSS
Selected Chain(s)	H
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with H chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:50)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:51)

• Minimal score value: -3.2808
• Maximal score value: 1.0525
• Average score: -0.7729
• Total score value: -95.8373

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.3879
2	V	H	-1.9182
3	Q	H	-1.6776
4	L	H	0.0000
5	V	H	0.2362
6	E	H	-0.2422
7	S	H	-0.7250
8	G	H	-1.0569
9	G	H	-0.6311
11	G	H	0.2113
12	L	H	1.0525
13	V	H	0.0353
14	Q	H	-1.2069
15	A	H	-1.1426
16	G	H	-1.2539
17	D	H	-1.4171
18	S	H	-1.3660
19	L	H	-0.9745
20	R	H	-1.8627
21	L	H	0.0000
22	S	H	-0.5023
23	C	H	0.0000
24	A	H	-0.4336
25	A	H	0.0000
26	S	H	-1.2265
27	G	H	-2.0995
28	R	H	-2.6808
29	S	H	-1.2457
30	F	H	0.0000
35	S	H	-0.7864
36	N	H	-1.3511
37	D	H	0.0000
38	A	H	0.0000
39	M	H	0.0000
40	G	H	0.0000
41	W	H	0.0000
42	F	H	0.0000
43	R	H	-1.0100
44	Q	H	-1.9132
45	A	H	-1.8484
46	P	H	-1.3969
47	G	H	-1.9294
48	K	H	-3.2120
49	E	H	-3.2808
50	R	H	-2.1901
51	S	H	-1.2906
52	F	H	-0.3000
53	V	H	0.0000
54	A	H	0.0000
55	A	H	0.0000
56	I	H	0.0000
57	N	H	0.0000
58	W	H	-1.2678
59	S	H	-0.9893
62	G	H	-1.0361
63	E	H	-1.6086
64	L	H	-0.5123
65	T	H	-0.1876
66	G	H	-0.1854
67	Y	H	-0.4049
68	A	H	-0.5177
69	G	H	-0.9896
70	S	H	-1.1515
71	V	H	0.0000
72	K	H	-2.1496
74	G	H	-1.5889
75	R	H	-1.3687
76	F	H	0.0000
77	T	H	-0.8417
78	I	H	0.0000
79	S	H	-0.6539
80	R	H	-0.8183
81	D	H	-1.2839
82	G	H	-0.7155
83	V	H	0.2975
84	E	H	-1.5061
85	N	H	-1.3561
86	M	H	-0.6519
87	V	H	0.0000
88	F	H	-0.5802
89	L	H	0.0000
90	Q	H	-1.1458
91	M	H	0.0000
92	N	H	-1.2765
93	S	H	-1.0153
94	L	H	0.0000
95	V	H	-0.5557
96	P	H	-0.9219
97	E	H	-1.6764
98	D	H	0.0000
99	T	H	-0.4960
100	G	H	0.0000
101	V	H	-0.3762
102	Y	H	0.0000
103	Y	H	-0.2150
104	C	H	0.0000
105	A	H	0.0000
106	A	H	0.0000
107	V	H	0.0000
108	E	H	-2.4530
109	G	H	-2.0252
110	R	H	-2.6532
111	D	H	-2.1051
111A	Y	H	0.0078
111B	Y	H	-0.6944
112B	R	H	-0.7687
112A	G	H	-0.6688
112	A	H	-0.5256
113	Q	H	-0.9474
114	Y	H	-0.1680
115	Y	H	-0.6085
116	D	H	-1.5734
117	Y	H	-0.9563
118	W	H	-0.2981
119	G	H	-0.4004
120	Q	H	-1.1644
121	G	H	-0.6216
122	T	H	-0.6617
123	Q	H	-0.7259
124	V	H	0.0000
125	T	H	0.0405
126	V	H	0.0000
127	S	H	-0.5505
128	S	H	-0.5439