Project name: 401e6ec796c8599

Chain sequence(s)	H: EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKYDGIYGELDFWGQGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPPTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	No
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       runJob:   FoldX not utilized. Treating input pdb file as it was already optimized.    (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:01)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:02)

• Minimal score value: -2.8486
• Maximal score value: 1.9542
• Average score: -0.5556
• Total score value: -125.5612

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.9544
2	V	H	-0.8679
3	Q	H	-0.9042
4	L	H	0.0000
5	L	H	0.6711
6	E	H	0.0828
7	S	H	-0.3764
8	G	H	-0.8402
9	G	H	0.0472
10	G	H	0.7913
11	L	H	1.3875
12	V	H	0.0148
13	Q	H	-1.2733
14	P	H	-1.4579
15	G	H	-1.2852
16	G	H	-0.9012
17	S	H	-1.2601
18	L	H	-0.9218
19	R	H	-2.1172
20	L	H	0.0000
21	S	H	-0.4756
22	C	H	0.0000
23	A	H	-0.2426
24	A	H	0.0000
25	S	H	-0.9298
26	G	H	-1.0452
27	F	H	-0.3642
28	T	H	-0.2890
29	F	H	0.0000
30	S	H	-0.7961
31	S	H	-0.2420
32	Y	H	0.2370
33	A	H	-0.2036
34	M	H	0.0000
35	S	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.6446
40	A	H	-1.0205
41	P	H	-0.9991
42	G	H	-1.4532
43	K	H	-2.4035
44	G	H	-1.6279
45	L	H	0.0000
46	E	H	-1.1872
47	W	H	0.0000
48	V	H	0.0000
49	S	H	0.0000
50	A	H	0.0000
51	I	H	0.0000
52	S	H	-0.3252
53	G	H	-0.6040
54	S	H	-0.7693
55	G	H	-0.9557
56	G	H	-0.7400
57	S	H	-0.2791
58	T	H	0.3246
59	Y	H	0.7146
60	Y	H	-0.4145
61	A	H	-1.2084
62	D	H	-2.4204
63	S	H	-1.7592
64	V	H	0.0000
65	K	H	-2.6168
66	G	H	-2.0123
67	R	H	-2.0191
68	F	H	0.0000
69	T	H	-0.8425
70	I	H	0.0000
71	S	H	-0.4022
72	R	H	-1.2632
73	D	H	-1.9941
74	N	H	-2.5518
75	S	H	-2.0659
76	K	H	-2.7218
77	N	H	-2.2603
78	T	H	0.0000
79	L	H	0.0000
80	Y	H	-0.4951
81	L	H	0.0000
82	Q	H	-1.3776
83	M	H	0.0000
84	N	H	-1.4964
85	S	H	-1.2459
86	L	H	0.0000
87	R	H	-1.7974
88	A	H	-1.4860
89	E	H	-2.0786
90	D	H	0.0000
91	T	H	-0.2268
92	A	H	0.0000
93	V	H	0.8037
94	Y	H	0.0000
95	Y	H	0.0000
96	C	H	0.0000
97	A	H	0.0000
98	K	H	0.0000
99	Y	H	0.0000
100	D	H	0.2296
101	G	H	0.5103
102	I	H	1.9542
103	Y	H	1.5501
104	G	H	0.6683
105	E	H	0.0000
106	L	H	0.0000
107	D	H	-0.2601
108	F	H	0.3058
109	W	H	-0.2925
110	G	H	0.0000
111	Q	H	-1.4952
112	G	H	-0.3907
113	T	H	0.4885
114	L	H	1.6836
115	V	H	0.0000
116	T	H	0.4091
117	V	H	0.0000
118	S	H	-0.6690
119	S	H	-0.4796
120	D	L	-2.2574
121	I	L	0.0000
122	Q	L	-2.1696
123	M	L	0.0000
124	T	L	-1.4631
125	Q	L	0.0000
126	S	L	-0.8799
127	P	L	-0.5250
128	S	L	-0.9523
129	S	L	-1.0526
130	L	L	-0.5862
131	S	L	-1.0223
132	A	L	0.0000
133	S	L	-0.8934
134	V	L	-0.2221
135	G	L	-1.0328
136	D	L	-1.8374
137	R	L	-2.4728
138	V	L	0.0000
139	T	L	-0.5801
140	I	L	0.0000
141	T	L	-0.9118
142	C	L	0.0000
143	R	L	-2.8486
144	A	L	0.0000
145	S	L	-1.8367
146	Q	L	-1.7708
147	S	L	-0.9494
148	I	L	0.0000
149	S	L	-0.2832
150	S	L	0.0145
151	Y	L	0.9686
152	L	L	0.0000
153	N	L	0.0000
154	W	L	0.0000
155	Y	L	0.0000
156	Q	L	0.0000
157	Q	L	-1.5607
158	K	L	-2.0357
159	P	L	-1.2703
160	G	L	-1.7843
161	K	L	-2.7924
162	A	L	-1.7740
163	P	L	0.0000
164	K	L	-1.9621
165	L	L	0.0000
166	L	L	0.0000
167	I	L	0.0000
168	Y	L	0.4350
169	A	L	0.3700
170	A	L	0.0000
171	S	L	-0.2144
172	S	L	0.0612
173	L	L	0.2177
174	Q	L	-0.4084
175	S	L	-0.4163
176	G	L	-0.5313
177	V	L	-0.4507
178	P	L	-0.4542
179	S	L	-0.5092
180	R	L	-1.0118
181	F	L	0.0000
182	S	L	-0.3785
183	G	L	-0.3033
184	S	L	-0.8132
185	G	L	-1.3491
186	S	L	-1.1487
187	G	L	-1.1369
188	T	L	-1.7862
189	D	L	-2.4454
190	F	L	0.0000
191	T	L	-0.8629
192	L	L	0.0000
193	T	L	-0.6414
194	I	L	0.0000
195	S	L	-1.3762
196	S	L	-1.2514
197	L	L	0.0000
198	Q	L	-1.0055
199	P	L	-0.8063
200	E	L	-1.6518
201	D	L	0.0000
202	F	L	-0.3644
203	A	L	0.0000
204	T	L	-1.1296
205	Y	L	0.0000
206	Y	L	0.0000
207	C	L	0.0000
208	Q	L	0.0000
209	Q	L	0.0000
210	S	L	0.7335
211	Y	L	1.1219
212	S	L	0.1067
213	T	L	-0.1123
214	P	L	-0.4003
215	P	L	0.0000
216	T	L	-0.8121
217	F	L	0.0000
218	G	L	0.0000
219	Q	L	-1.7533
220	G	L	0.0000
221	T	L	0.0000
222	K	L	-2.0664
223	V	L	0.0000
224	E	L	-1.0997
225	I	L	-0.5143
226	K	L	-1.4313