| Chain sequence(s) |
A: GALPLNPEPELRPTSEYVTPTDLYYVAETDLLTETGDPEKDIVVNGKVLKPRVSAYQWRVFKLTLPDPNKLPLPSADFVNPETEILIWRLLAFKIHRFGPLGKGSYGHPNFNAFGDVDNPTAVQHEGADVTQNLSFYPKYLQMFIVGDEPPTGKYTAKAPPAPGLPPGAQPPTTVVSTTIEHGDMADIGFGAKDFAALEPEKNRVPDIILNTKTVVPDLEGMRAEPTGRRMFTYGEKEKSYNSKNLRRSGPDLFPPPDAPPPSPLYVPPAPSSPAAVRPSTDYFTLPDYGEIKEEDLLFNKPYFIEKTEGLNNGVLWHNRLYVTVVDNSRAEIETNVTKISTPAINVYNPADYVTSKTYTREYKLSLIVQLCKIPLTPEILEEIRRLDPRILVDAKLPDIPAVERPDPLAGKKFIEIDLTSKLSSNLEETELGRLFLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.0567 | |
| 2 | A | A | 0.7334 | |
| 3 | L | A | 1.5402 | |
| 4 | P | A | 0.7902 | |
| 5 | L | A | 0.9114 | |
| 6 | N | A | -1.0184 | |
| 7 | P | A | -1.7141 | |
| 8 | E | A | -2.5861 | |
| 9 | P | A | -2.2681 | |
| 10 | E | A | -2.5224 | |
| 11 | L | A | -1.3230 | |
| 12 | R | A | -1.4588 | |
| 13 | P | A | -1.0417 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -1.4300 | |
| 16 | E | A | -2.0806 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.6222 | |
| 20 | P | A | -0.6881 | |
| 21 | T | A | -0.8468 | |
| 22 | D | A | -1.5952 | |
| 23 | L | A | -0.4065 | |
| 24 | Y | A | -0.0402 | |
| 25 | Y | A | 0.1504 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.8743 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.3051 | |
| 31 | L | A | 0.3655 | |
| 32 | L | A | 0.1814 | |
| 33 | T | A | -0.1880 | |
| 34 | E | A | -0.5504 | |
| 35 | T | A | -0.7375 | |
| 36 | G | A | 0.0000 | |
| 37 | D | A | -1.7840 | |
| 38 | P | A | 0.0000 | |
| 39 | E | A | -1.7786 | |
| 40 | K | A | -2.4179 | |
| 41 | D | A | -1.1727 | |
| 42 | I | A | 0.7289 | |
| 43 | V | A | 1.9572 | |
| 44 | V | A | 1.4847 | |
| 45 | N | A | -0.5437 | |
| 46 | G | A | -0.3465 | |
| 47 | K | A | -0.3144 | |
| 48 | V | A | 1.4776 | |
| 49 | L | A | 1.6698 | |
| 50 | K | A | -0.6124 | |
| 51 | P | A | -0.8819 | |
| 52 | R | A | -1.5283 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.3567 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | -1.0498 | |
| 67 | D | A | -1.3809 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.7406 | |
| 70 | K | A | -2.0205 | |
| 71 | L | A | -0.8900 | |
| 72 | P | A | -0.4751 | |
| 73 | L | A | -0.2002 | |
| 74 | P | A | -0.2802 | |
| 75 | S | A | -0.6057 | |
| 76 | A | A | -0.8763 | |
| 77 | D | A | -1.8462 | |
| 78 | F | A | -0.7588 | |
| 79 | V | A | -1.2856 | |
| 80 | N | A | -2.1544 | |
| 81 | P | A | -1.9835 | |
| 82 | E | A | -2.3832 | |
| 83 | T | A | -1.5321 | |
| 84 | E | A | -1.4087 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3277 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | -0.1244 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | H | A | -0.3414 | |
| 97 | R | A | 0.0000 | |
| 98 | F | A | 0.5687 | |
| 99 | G | A | -0.1643 | |
| 100 | P | A | -0.5004 | |
| 101 | L | A | -0.7494 | |
| 102 | G | A | -0.9711 | |
| 103 | K | A | -1.1378 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.2704 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.8712 | |
| 108 | H | A | -1.7814 | |
| 109 | P | A | -1.9152 | |
| 110 | N | A | -2.8041 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | F | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.4338 | |
| 117 | V | A | -0.9276 | |
| 118 | D | A | -2.5624 | |
| 119 | N | A | -2.0103 | |
| 120 | P | A | -0.9421 | |
| 121 | T | A | -0.3024 | |
| 122 | A | A | 0.0652 | |
| 123 | V | A | 1.0604 | |
| 124 | Q | A | -0.4316 | |
| 125 | H | A | -1.4170 | |
| 126 | E | A | -1.9831 | |
| 127 | G | A | -1.6838 | |
| 128 | A | A | -1.3724 | |
| 129 | D | A | -2.1833 | |
| 130 | V | A | -1.5515 | |
| 131 | T | A | -1.7801 | |
| 132 | Q | A | -2.3233 | |
| 133 | N | A | -2.2869 | |
| 134 | L | A | -1.1729 | |
| 135 | S | A | -0.5792 | |
| 136 | F | A | 0.0000 | |
| 137 | Y | A | 0.2404 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Y | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | M | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | E | A | -0.4211 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | -0.5672 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.3347 | |
| 155 | Y | A | -0.0535 | |
| 156 | T | A | -0.1157 | |
| 157 | A | A | -0.6922 | |
| 158 | K | A | -1.6254 | |
| 159 | A | A | -0.7697 | |
| 160 | P | A | -0.8252 | |
| 161 | P | A | -0.6335 | |
| 162 | A | A | -0.2035 | |
| 163 | P | A | -0.3512 | |
| 164 | G | A | -0.2884 | |
| 165 | L | A | 0.0861 | |
| 166 | P | A | -0.3639 | |
| 167 | P | A | -0.5986 | |
| 168 | G | A | -0.8244 | |
| 169 | A | A | -0.7995 | |
| 170 | Q | A | -1.3012 | |
| 171 | P | A | -1.1122 | |
| 172 | P | A | -0.8876 | |
| 173 | T | A | -0.6327 | |
| 174 | T | A | 0.3807 | |
| 175 | V | A | 1.4784 | |
| 176 | V | A | 0.7767 | |
| 177 | S | A | 0.1326 | |
| 178 | T | A | -0.0391 | |
| 179 | T | A | -0.6761 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.1851 | |
| 182 | H | A | -1.0208 | |
| 183 | G | A | -0.7925 | |
| 184 | D | A | -0.9904 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.3791 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.3127 | |
| 190 | F | A | -0.0836 | |
| 191 | G | A | -0.3484 | |
| 192 | A | A | -0.4661 | |
| 193 | K | A | -1.0218 | |
| 194 | D | A | -1.3406 | |
| 195 | F | A | 0.0000 | |
| 196 | A | A | -1.2667 | |
| 197 | A | A | -0.8475 | |
| 198 | L | A | -1.3324 | |
| 199 | E | A | -1.6367 | |
| 200 | P | A | -1.7054 | |
| 201 | E | A | -2.8305 | |
| 202 | K | A | -3.3220 | |
| 203 | N | A | -2.5741 | |
| 204 | R | A | -1.8524 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.8780 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.6883 | |
| 211 | N | A | -1.7840 | |
| 212 | T | A | -1.3545 | |
| 213 | K | A | -1.6578 | |
| 214 | T | A | 0.0000 | |
| 215 | V | A | 0.0000 | |
| 216 | V | A | -0.0615 | |
| 217 | P | A | -0.4072 | |
| 218 | D | A | -1.1610 | |
| 219 | L | A | -1.2853 | |
| 220 | E | A | -2.4113 | |
| 221 | G | A | -1.7934 | |
| 222 | M | A | 0.0000 | |
| 223 | R | A | -2.5627 | |
| 224 | A | A | -1.5648 | |
| 225 | E | A | -1.1599 | |
| 226 | P | A | -0.8708 | |
| 227 | T | A | -0.5132 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.6403 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.6727 | |
| 234 | Y | A | -0.1110 | |
| 235 | G | A | -0.3812 | |
| 236 | E | A | -1.3708 | |
| 237 | K | A | -1.9076 | |
| 238 | E | A | -2.4512 | |
| 239 | K | A | -1.9280 | |
| 240 | S | A | -0.9110 | |
| 241 | Y | A | 0.0411 | |
| 242 | N | A | -1.1606 | |
| 243 | S | A | -1.0275 | |
| 244 | K | A | -2.0299 | |
| 245 | N | A | -1.5698 | |
| 246 | L | A | 0.0000 | |
| 247 | R | A | -0.2837 | |
| 248 | R | A | 0.0000 | |
| 249 | S | A | -0.9184 | |
| 250 | G | A | -0.8042 | |
| 251 | P | A | -0.3487 | |
| 252 | D | A | 0.1182 | |
| 253 | L | A | 1.2107 | |
| 254 | F | A | 1.0360 | |
| 255 | P | A | 0.5526 | |
| 256 | P | A | -0.2808 | |
| 257 | P | A | -0.8200 | |
| 258 | D | A | -2.0025 | |
| 259 | A | A | -0.9856 | |
| 260 | P | A | -1.0255 | |
| 261 | P | A | -0.3499 | |
| 262 | P | A | 0.0672 | |
| 263 | S | A | 0.3470 | |
| 264 | P | A | 0.7066 | |
| 265 | L | A | 1.9042 | |
| 266 | Y | A | 1.7537 | |
| 267 | V | A | 1.9462 | |
| 268 | P | A | 0.7340 | |
| 269 | P | A | 0.3168 | |
| 270 | A | A | -0.0552 | |
| 271 | P | A | -0.1899 | |
| 272 | S | A | -0.2017 | |
| 273 | S | A | -0.0701 | |
| 274 | P | A | 0.0133 | |
| 275 | A | A | 0.1812 | |
| 276 | A | A | 0.3930 | |
| 277 | V | A | 1.0825 | |
| 278 | R | A | 0.0754 | |
| 279 | P | A | -0.5052 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | 0.1158 | |
| 282 | D | A | -0.0310 | |
| 283 | Y | A | 0.8718 | |
| 284 | F | A | 0.1620 | |
| 285 | T | A | -0.4025 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -0.6798 | |
| 289 | Y | A | 0.0000 | |
| 290 | G | A | -1.1020 | |
| 291 | E | A | -2.1979 | |
| 292 | I | A | -2.3937 | |
| 293 | K | A | -3.5787 | |
| 294 | E | A | -3.6598 | |
| 295 | E | A | -3.5301 | |
| 296 | D | A | -2.6940 | |
| 297 | L | A | 0.0000 | |
| 298 | L | A | -1.1076 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.1955 | |
| 301 | K | A | -1.1813 | |
| 302 | P | A | -0.4529 | |
| 303 | Y | A | 0.1075 | |
| 304 | F | A | -0.0776 | |
| 305 | I | A | -0.8811 | |
| 306 | E | A | -2.3924 | |
| 307 | K | A | -2.8899 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -2.4409 | |
| 310 | G | A | -1.5226 | |
| 311 | L | A | -0.7989 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | -1.3843 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7992 | |
| 319 | N | A | -0.8632 | |
| 320 | R | A | -0.9860 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | -0.5340 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.0398 | |
| 333 | I | A | -1.8015 | |
| 334 | E | A | -2.3772 | |
| 335 | T | A | -1.3838 | |
| 336 | N | A | -0.3882 | |
| 337 | V | A | 1.6319 | |
| 338 | T | A | 1.3658 | |
| 339 | K | A | 1.1190 | |
| 340 | I | A | 2.2125 | |
| 341 | S | A | 0.6356 | |
| 342 | T | A | 0.1075 | |
| 343 | P | A | -0.1790 | |
| 344 | A | A | 0.0530 | |
| 345 | I | A | 0.4573 | |
| 346 | N | A | 0.0132 | |
| 347 | V | A | 1.7253 | |
| 348 | Y | A | 1.5334 | |
| 349 | N | A | -0.0049 | |
| 350 | P | A | -0.1529 | |
| 351 | A | A | 0.2888 | |
| 352 | D | A | 0.8764 | |
| 353 | Y | A | 1.6318 | |
| 354 | V | A | 2.3637 | |
| 355 | T | A | 0.8956 | |
| 356 | S | A | -0.3765 | |
| 357 | K | A | -1.6961 | |
| 358 | T | A | -1.5418 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.7476 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.0708 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -0.4647 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.5565 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.7967 | |
| 376 | L | A | -0.9078 | |
| 377 | T | A | -0.8625 | |
| 378 | P | A | -1.3812 | |
| 379 | E | A | -2.3886 | |
| 380 | I | A | 0.0000 | |
| 381 | L | A | -1.3336 | |
| 382 | E | A | -2.4250 | |
| 383 | E | A | 0.0000 | |
| 384 | I | A | 0.0000 | |
| 385 | R | A | -1.8607 | |
| 386 | R | A | -1.4784 | |
| 387 | L | A | -0.7074 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | 0.0000 | |
| 390 | R | A | -1.3064 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.0028 | |
| 394 | D | A | -1.6967 | |
| 395 | A | A | -1.4051 | |
| 396 | K | A | -2.1812 | |
| 397 | L | A | -1.4774 | |
| 398 | P | A | -1.5479 | |
| 399 | D | A | -1.9080 | |
| 400 | I | A | -0.7167 | |
| 401 | P | A | -0.6389 | |
| 402 | A | A | -0.8377 | |
| 403 | V | A | -0.7484 | |
| 404 | E | A | -2.5822 | |
| 405 | R | A | -2.9545 | |
| 406 | P | A | -1.9825 | |
| 407 | D | A | -1.7098 | |
| 408 | P | A | -1.0297 | |
| 409 | L | A | -0.7692 | |
| 410 | A | A | -0.8966 | |
| 411 | G | A | -1.2457 | |
| 412 | K | A | -1.7421 | |
| 413 | K | A | -2.3979 | |
| 414 | F | A | -1.3271 | |
| 415 | I | A | -1.0570 | |
| 416 | E | A | -2.2513 | |
| 417 | I | A | 0.0000 | |
| 418 | D | A | -2.4067 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -0.9051 | |
| 421 | S | A | -0.7775 | |
| 422 | K | A | -1.1462 | |
| 423 | L | A | -0.3054 | |
| 424 | S | A | -0.8839 | |
| 425 | S | A | -0.8405 | |
| 426 | N | A | -2.0456 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.3896 | |
| 429 | E | A | -3.5143 | |
| 430 | T | A | -2.5351 | |
| 431 | E | A | -2.3122 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.5910 | |
| 435 | L | A | -0.9087 | |
| 436 | F | A | -0.5040 | |
| 437 | L | A | -0.3812 | |
| 438 | N | A | -1.5988 | |
| 439 | R | A | -1.9373 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine