Project name: 4135d822a27474d

Chain sequence(s)	P: GCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLS
Selected Chain(s)	P
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with P chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:48)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:49)

• Minimal score value: -3.6433
• Maximal score value: 1.3348
• Average score: -0.5732
• Total score value: -148.4545

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
244	G	P	-0.2425
245	C	P	0.1151
246	G	P	-0.4117
247	E	P	-0.7310
248	L	P	0.0000
249	V	P	0.3794
250	W	P	0.2215
251	V	P	0.0000
252	G	P	-1.6301
253	E	P	-2.3250
254	P	P	-1.2626
255	L	P	0.2051
256	T	P	0.3506
257	L	P	0.5258
258	R	P	-0.3539
259	T	P	-0.5332
260	A	P	0.0000
261	E	P	-1.5187
262	T	P	0.0190
263	I	P	1.3348
264	T	P	0.7161
265	G	P	0.2940
266	K	P	-0.4576
267	Y	P	-0.2884
268	G	P	0.0000
269	V	P	0.0000
270	W	P	0.0000
271	M	P	0.0000
272	R	P	0.0000
273	D	P	0.0000
274	P	P	0.0000
275	K	P	-1.5125
276	P	P	-0.7212
277	T	P	0.1418
278	Y	P	1.0682
279	P	P	0.4564
280	Y	P	-0.1597
281	T	P	-0.8769
282	Q	P	-1.7181
283	E	P	-1.2106
284	T	P	0.0000
285	T	P	0.0000
286	W	P	0.0000
287	R	P	0.0000
288	I	P	0.0000
289	D	P	-0.3119
290	T	P	0.0000
291	V	P	0.8535
292	G	P	-0.1342
293	T	P	-0.6324
294	D	P	-1.6231
295	V	P	0.0000
296	R	P	-1.6855
297	Q	P	-0.4819
298	V	P	0.0000
299	F	P	0.6528
300	E	P	0.0000
301	Y	P	0.0000
302	D	P	-0.8164
303	L	P	0.3632
304	I	P	0.1541
305	S	P	-0.1698
306	Q	P	-0.3772
307	F	P	0.0000
308	M	P	-0.2179
309	Q	P	-1.4230
310	G	P	-0.2817
311	Y	P	0.6880
312	P	P	0.1805
313	S	P	-0.2331
314	K	P	-0.0710
315	V	P	0.7282
316	H	P	0.0000
317	I	P	1.0705
318	L	P	0.0000
319	P	P	-0.6547
320	R	P	-1.1176
321	P	P	-1.6727
322	L	P	0.0000
323	E	P	-1.4360
324	S	P	-0.3846
325	T	P	-0.3640
326	G	P	0.0000
327	A	P	0.0000
328	V	P	0.0000
329	V	P	0.0000
330	Y	P	0.0000
331	S	P	-0.4934
332	G	P	0.0000
333	S	P	0.0000
334	L	P	0.0000
335	Y	P	0.0000
336	F	P	0.0000
337	Q	P	0.0000
338	G	P	-1.1247
339	A	P	-1.3198
340	E	P	-1.8485
341	S	P	-1.1868
342	R	P	-1.2533
343	T	P	-1.4535
344	V	P	0.0000
345	I	P	0.0000
346	R	P	0.0000
347	Y	P	0.0000
348	E	P	-1.4953
349	L	P	0.0000
350	N	P	-1.5987
351	T	P	-1.6517
352	E	P	-2.1147
353	T	P	-1.2713
354	V	P	-1.2017
355	K	P	-2.3552
356	A	P	-1.9864
357	E	P	-2.0658
358	K	P	-2.6117
359	E	P	-2.4480
360	I	P	0.0000
361	P	P	-0.9612
362	G	P	-0.7515
363	A	P	0.0000
364	G	P	-0.5988
365	Y	P	-0.1147
366	H	P	-0.9284
367	G	P	-0.8874
368	Q	P	-1.3098
369	F	P	0.0152
370	P	P	0.0258
371	Y	P	-0.0195
372	S	P	-0.1812
373	W	P	0.0000
374	G	P	-0.4465
375	G	P	0.2898
376	Y	P	0.8238
377	T	P	-0.1622
378	D	P	-0.2778
379	I	P	0.0000
380	D	P	-0.7232
381	L	P	0.0000
382	A	P	0.0000
383	V	P	0.0000
384	D	P	-1.0865
385	E	P	-1.9935
386	A	P	-1.0954
387	G	P	0.0000
388	L	P	0.0000
389	W	P	0.0000
390	V	P	0.0000
391	I	P	0.0000
392	Y	P	0.0000
393	S	P	0.0000
394	T	P	-2.6973
395	D	P	-3.4537
396	E	P	-3.4472
397	A	P	-3.0635
398	K	P	-3.6433
399	G	P	0.0000
400	A	P	0.0000
401	I	P	0.0000
402	V	P	0.0000
403	L	P	0.0000
404	S	P	0.0000
405	K	P	0.0000
406	L	P	0.0000
407	N	P	-3.0347
408	P	P	-2.2864
409	E	P	-3.1967
410	N	P	-3.4103
411	L	P	0.0000
412	E	P	-3.4691
413	L	P	-1.9081
414	E	P	-2.7871
415	Q	P	-2.0545
416	T	P	-1.1254
417	W	P	-1.1787
418	E	P	-2.3782
419	T	P	0.0000
420	N	P	-2.0403
421	I	P	0.0000
422	R	P	-2.4004
423	K	P	0.0000
424	Q	P	-1.5491
425	S	P	-1.0234
426	V	P	0.0000
427	A	P	0.0000
428	N	P	-0.2137
429	A	P	-0.1677
430	F	P	0.0000
431	I	P	0.0000
432	I	P	0.0000
433	C	P	0.0693
434	G	P	-0.0308
435	T	P	-0.1822
436	L	P	0.0000
437	Y	P	0.0000
438	T	P	0.0000
439	V	P	0.0000
440	S	P	-0.2886
441	S	P	0.0000
442	Y	P	-0.4226
443	T	P	-1.1637
444	S	P	-1.1567
445	A	P	-1.5479
446	D	P	-2.0650
447	A	P	-1.1902
448	T	P	-0.7076
449	V	P	0.0000
450	N	P	-0.2418
451	F	P	-0.4029
452	A	P	0.0000
453	Y	P	0.0000
454	D	P	-0.3553
455	T	P	0.0000
456	G	P	-0.3843
457	T	P	0.0036
458	G	P	-0.0914
459	I	P	1.1561
460	S	P	-0.0511
461	K	P	-0.8565
462	T	P	-0.5262
463	L	P	0.0000
464	T	P	-0.0533
465	I	P	0.0000
466	P	P	-0.8859
467	F	P	0.0000
468	K	P	-2.5459
469	N	P	0.0000
470	R	P	-2.6537
471	Y	P	-1.6637
472	K	P	-2.1654
473	Y	P	-0.7841
474	S	P	0.0000
475	S	P	0.0000
476	M	P	0.0000
477	I	P	0.0000
478	D	P	-0.4045
479	Y	P	0.0000
480	N	P	0.0000
481	P	P	0.0000
482	L	P	-1.4113
483	E	P	-1.8698
484	K	P	-2.4289
485	K	P	-2.0294
486	L	P	0.0000
487	F	P	0.0000
488	A	P	0.0000
489	W	P	0.0000
490	D	P	0.0000
491	N	P	-1.3660
492	L	P	-0.4463
493	N	P	-0.6107
494	M	P	0.0000
495	V	P	0.0000
496	T	P	0.0000
497	Y	P	0.0000
498	D	P	-2.3904
499	I	P	-1.5708
500	K	P	-1.7059
501	L	P	-0.6700
502	S	P	-0.4466