| Chain sequence(s) |
A: SCSALPSSFTLTSNEKLVDLFTHFNGTKVTTKAEFACRQAELSELIQRYELGTLPGRPSTLTASFSGNTLTINCGENGKSISFTVTITYPSSGTAPYPAIIGFGGGSIPQPDGVALINFNNDEIAKQTSSSSRGQGKFYDLYGSSHSAGAMTAWAWGVSRVIDALELTPAANIDTTKIGVTGCSRNGKGALVAGAFEKRIVLTIPQESGMGGSACWRISDYLKSQGYNIQTASEIVGEYPWFSTTFNSYVNNVSLLPFDHHHLAALIAPRGLLVIDNVIDWLGPQSCYGCMTAARRAWQALGVPDNMGYSQIGSHEHCAFPSSQQPALTAFVNKFLLGQSVNTAIFTSDFSANESQWIDWTTPTLS
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:04:56)
[INFO] Main: Simulation completed successfully. (00:04:59)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | S | A | -0.0602 | |
| 2 | C | A | 0.2545 | |
| 3 | S | A | -0.2007 | |
| 4 | A | A | -0.0587 | |
| 5 | L | A | -0.2089 | |
| 6 | P | A | -0.2570 | |
| 7 | S | A | -0.2670 | |
| 8 | S | A | -0.1495 | |
| 9 | F | A | 0.2264 | |
| 10 | T | A | 0.2290 | |
| 11 | L | A | 0.2885 | |
| 12 | T | A | -0.0183 | |
| 13 | S | A | -0.8934 | |
| 14 | N | A | -1.5135 | |
| 15 | E | A | -2.3750 | |
| 16 | K | A | -2.0319 | |
| 17 | L | A | 0.0000 | |
| 18 | V | A | -0.7048 | |
| 19 | D | A | -0.7275 | |
| 20 | L | A | 0.0000 | |
| 21 | F | A | 0.0000 | |
| 22 | T | A | -1.0813 | |
| 23 | H | A | -1.0216 | |
| 24 | F | A | -0.4639 | |
| 25 | N | A | -1.4866 | |
| 26 | G | A | -1.3799 | |
| 27 | T | A | -1.4693 | |
| 28 | K | A | -2.1092 | |
| 29 | V | A | 0.0000 | |
| 30 | T | A | -0.9958 | |
| 31 | T | A | -1.1161 | |
| 32 | K | A | -1.4380 | |
| 33 | A | A | -0.8036 | |
| 34 | E | A | -1.2051 | |
| 35 | F | A | 0.0000 | |
| 36 | A | A | -0.3854 | |
| 37 | C | A | -0.2298 | |
| 38 | R | A | 0.0000 | |
| 39 | Q | A | -0.3925 | |
| 40 | A | A | -0.3293 | |
| 41 | E | A | -0.3707 | |
| 42 | L | A | 0.0000 | |
| 43 | S | A | -0.6958 | |
| 44 | E | A | -1.2219 | |
| 45 | L | A | 0.0000 | |
| 46 | I | A | 0.0000 | |
| 47 | Q | A | -0.7201 | |
| 48 | R | A | -0.8112 | |
| 49 | Y | A | -0.4487 | |
| 50 | E | A | 0.0000 | |
| 51 | L | A | 0.0000 | |
| 52 | G | A | 0.0000 | |
| 53 | T | A | -0.3473 | |
| 54 | L | A | -0.2240 | |
| 55 | P | A | -0.5278 | |
| 56 | G | A | -1.3361 | |
| 57 | R | A | -2.1484 | |
| 58 | P | A | 0.0000 | |
| 59 | S | A | -1.0610 | |
| 60 | T | A | -0.9257 | |
| 61 | L | A | -0.2910 | |
| 62 | T | A | 0.0735 | |
| 63 | A | A | -0.0144 | |
| 64 | S | A | 0.0905 | |
| 65 | F | A | 0.0213 | |
| 66 | S | A | -0.5595 | |
| 67 | G | A | -0.9334 | |
| 68 | N | A | -1.0964 | |
| 69 | T | A | -0.7074 | |
| 70 | L | A | 0.0000 | |
| 71 | T | A | -0.1817 | |
| 72 | I | A | 0.0000 | |
| 73 | N | A | -0.5333 | |
| 74 | C | A | 0.0000 | |
| 75 | G | A | -1.4826 | |
| 76 | E | A | -1.8806 | |
| 77 | N | A | -2.1817 | |
| 78 | G | A | -2.0336 | |
| 79 | K | A | -2.7613 | |
| 80 | S | A | -1.8145 | |
| 81 | I | A | 0.0000 | |
| 82 | S | A | -0.4025 | |
| 83 | F | A | 0.0000 | |
| 84 | T | A | -0.5572 | |
| 85 | V | A | 0.0000 | |
| 86 | T | A | -0.7479 | |
| 87 | I | A | 0.0000 | |
| 88 | T | A | -0.2332 | |
| 89 | Y | A | -0.1750 | |
| 90 | P | A | -0.5758 | |
| 91 | S | A | -0.6147 | |
| 92 | S | A | -0.7993 | |
| 93 | G | A | -0.7767 | |
| 94 | T | A | -0.4472 | |
| 95 | A | A | -0.4654 | |
| 96 | P | A | -0.7743 | |
| 97 | Y | A | -0.3079 | |
| 98 | P | A | -0.2765 | |
| 99 | A | A | 0.0000 | |
| 100 | I | A | 0.0000 | |
| 101 | I | A | 0.0000 | |
| 102 | G | A | 0.0000 | |
| 103 | F | A | 0.0000 | |
| 104 | G | A | -1.3968 | |
| 105 | G | A | -1.0109 | |
| 106 | G | A | -0.5825 | |
| 107 | S | A | -0.3049 | |
| 108 | I | A | 0.0000 | |
| 109 | P | A | -0.6530 | |
| 110 | Q | A | -1.0260 | |
| 111 | P | A | -1.2754 | |
| 112 | D | A | -2.0221 | |
| 113 | G | A | -1.0754 | |
| 114 | V | A | 0.0000 | |
| 115 | A | A | 0.0000 | |
| 116 | L | A | -0.1033 | |
| 117 | I | A | 0.0000 | |
| 118 | N | A | -1.2730 | |
| 119 | F | A | 0.0000 | |
| 120 | N | A | -2.2918 | |
| 121 | N | A | 0.0000 | |
| 122 | D | A | -2.2833 | |
| 123 | E | A | -2.2242 | |
| 124 | I | A | 0.0000 | |
| 125 | A | A | 0.0000 | |
| 126 | K | A | -1.8761 | |
| 127 | Q | A | -1.2434 | |
| 128 | T | A | -0.6274 | |
| 129 | S | A | -0.6155 | |
| 130 | S | A | -0.7303 | |
| 131 | S | A | -0.7654 | |
| 132 | S | A | 0.0000 | |
| 133 | R | A | -1.2304 | |
| 134 | G | A | 0.0000 | |
| 135 | Q | A | -1.9216 | |
| 136 | G | A | -1.8936 | |
| 137 | K | A | -1.7215 | |
| 138 | F | A | 0.0000 | |
| 139 | Y | A | 0.0000 | |
| 140 | D | A | -2.4396 | |
| 141 | L | A | 0.0000 | |
| 142 | Y | A | -1.0674 | |
| 143 | G | A | -1.1738 | |
| 144 | S | A | -1.1727 | |
| 145 | S | A | -0.6479 | |
| 146 | H | A | -0.4992 | |
| 147 | S | A | -0.3745 | |
| 148 | A | A | 0.0000 | |
| 149 | G | A | 0.0000 | |
| 150 | A | A | 0.0000 | |
| 151 | M | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | A | A | 0.0000 | |
| 154 | W | A | 0.0000 | |
| 155 | A | A | 0.0000 | |
| 156 | W | A | 0.0000 | |
| 157 | G | A | 0.0000 | |
| 158 | V | A | 0.0000 | |
| 159 | S | A | -0.7523 | |
| 160 | R | A | 0.0000 | |
| 161 | V | A | 0.0000 | |
| 162 | I | A | 0.0000 | |
| 163 | D | A | -0.7759 | |
| 164 | A | A | 0.0000 | |
| 165 | L | A | 0.0000 | |
| 166 | E | A | -1.2726 | |
| 167 | L | A | 0.5837 | |
| 168 | T | A | -0.0340 | |
| 169 | P | A | -0.5607 | |
| 170 | A | A | -0.3049 | |
| 171 | A | A | 0.0000 | |
| 172 | N | A | -0.8969 | |
| 173 | I | A | 0.0000 | |
| 174 | D | A | -1.0552 | |
| 175 | T | A | -1.0678 | |
| 176 | T | A | -0.6652 | |
| 177 | K | A | -0.5217 | |
| 178 | I | A | 0.0000 | |
| 179 | G | A | 0.0000 | |
| 180 | V | A | 0.0000 | |
| 181 | T | A | 0.0000 | |
| 182 | G | A | 0.0000 | |
| 183 | C | A | 0.0000 | |
| 184 | S | A | -0.7266 | |
| 185 | R | A | -1.2024 | |
| 186 | N | A | -0.9758 | |
| 187 | G | A | 0.0000 | |
| 188 | K | A | 0.0000 | |
| 189 | G | A | 0.0000 | |
| 190 | A | A | 0.0000 | |
| 191 | L | A | 0.0000 | |
| 192 | V | A | 0.0000 | |
| 193 | A | A | 0.0000 | |
| 194 | G | A | 0.0000 | |
| 195 | A | A | 0.0000 | |
| 196 | F | A | 0.0000 | |
| 197 | E | A | 0.0000 | |
| 198 | K | A | -1.9705 | |
| 199 | R | A | -1.4815 | |
| 200 | I | A | 0.0000 | |
| 201 | V | A | -0.3358 | |
| 202 | L | A | 0.0000 | |
| 203 | T | A | 0.0000 | |
| 204 | I | A | 0.0000 | |
| 205 | P | A | 0.0000 | |
| 206 | Q | A | 0.0000 | |
| 207 | E | A | 0.0000 | |
| 208 | S | A | 0.0000 | |
| 209 | G | A | 0.0000 | |
| 210 | M | A | 0.0000 | |
| 211 | G | A | 0.0000 | |
| 212 | G | A | 0.0000 | |
| 213 | S | A | 0.0000 | |
| 214 | A | A | 0.0000 | |
| 215 | C | A | 0.0000 | |
| 216 | W | A | 0.0000 | |
| 217 | R | A | 0.0000 | |
| 218 | I | A | 0.0000 | |
| 219 | S | A | 0.0000 | |
| 220 | D | A | -2.0773 | |
| 221 | Y | A | -0.9721 | |
| 222 | L | A | 0.0000 | |
| 223 | K | A | -1.5461 | |
| 224 | S | A | -1.3800 | |
| 225 | Q | A | -1.6046 | |
| 226 | G | A | -0.9165 | |
| 227 | Y | A | -0.5450 | |
| 228 | N | A | -1.4000 | |
| 229 | I | A | 0.0000 | |
| 230 | Q | A | 0.0000 | |
| 231 | T | A | 0.0000 | |
| 232 | A | A | 0.0000 | |
| 233 | S | A | -1.4268 | |
| 234 | E | A | -1.0202 | |
| 235 | I | A | 0.0000 | |
| 236 | V | A | -0.6133 | |
| 237 | G | A | -0.9722 | |
| 238 | E | A | -0.8556 | |
| 239 | Y | A | -0.5453 | |
| 240 | P | A | 0.0000 | |
| 241 | W | A | 0.0000 | |
| 242 | F | A | 0.0000 | |
| 243 | S | A | 0.0000 | |
| 244 | T | A | -0.6019 | |
| 245 | T | A | -0.5799 | |
| 246 | F | A | 0.0000 | |
| 247 | N | A | -1.6325 | |
| 248 | S | A | -1.0982 | |
| 249 | Y | A | -0.8889 | |
| 250 | V | A | 0.0000 | |
| 251 | N | A | -2.1413 | |
| 252 | N | A | -1.8841 | |
| 253 | V | A | 0.0000 | |
| 254 | S | A | -1.3865 | |
| 255 | L | A | -0.4125 | |
| 256 | L | A | 0.0000 | |
| 257 | P | A | 0.1439 | |
| 258 | F | A | 0.0000 | |
| 259 | D | A | 0.0000 | |
| 260 | H | A | 0.0000 | |
| 261 | H | A | 0.0000 | |
| 262 | H | A | 0.0000 | |
| 263 | L | A | 0.0000 | |
| 264 | A | A | 0.0000 | |
| 265 | A | A | 0.0000 | |
| 266 | L | A | 0.0000 | |
| 267 | I | A | 0.0000 | |
| 268 | A | A | 0.0000 | |
| 269 | P | A | -0.4841 | |
| 270 | R | A | -0.5154 | |
| 271 | G | A | 0.0000 | |
| 272 | L | A | 0.0000 | |
| 273 | L | A | 0.0000 | |
| 274 | V | A | 0.0000 | |
| 275 | I | A | 0.0000 | |
| 276 | D | A | 0.0000 | |
| 277 | N | A | 0.0000 | |
| 278 | V | A | -0.1766 | |
| 279 | I | A | -0.6233 | |
| 280 | D | A | -1.3824 | |
| 281 | W | A | -0.4037 | |
| 282 | L | A | 0.0000 | |
| 283 | G | A | 0.0000 | |
| 284 | P | A | 0.0000 | |
| 285 | Q | A | -0.5309 | |
| 286 | S | A | 0.0000 | |
| 287 | C | A | 0.0000 | |
| 288 | Y | A | -0.0923 | |
| 289 | G | A | 0.0000 | |
| 290 | C | A | 0.0000 | |
| 291 | M | A | 0.0000 | |
| 292 | T | A | -0.3140 | |
| 293 | A | A | 0.0000 | |
| 294 | A | A | 0.0000 | |
| 295 | R | A | -0.7783 | |
| 296 | R | A | -0.9148 | |
| 297 | A | A | 0.0000 | |
| 298 | W | A | 0.0000 | |
| 299 | Q | A | -1.4983 | |
| 300 | A | A | 0.0000 | |
| 301 | L | A | 0.0000 | |
| 302 | G | A | -0.8443 | |
| 303 | V | A | -0.5238 | |
| 304 | P | A | -0.9071 | |
| 305 | D | A | -1.1342 | |
| 306 | N | A | -0.8497 | |
| 307 | M | A | 0.0000 | |
| 308 | G | A | 0.0000 | |
| 309 | Y | A | 0.0000 | |
| 310 | S | A | 0.0000 | |
| 311 | Q | A | 0.0000 | |
| 312 | I | A | 0.4148 | |
| 313 | G | A | -0.1049 | |
| 314 | S | A | -0.5363 | |
| 315 | H | A | -0.9763 | |
| 316 | E | A | -2.0314 | |
| 317 | H | A | -1.3278 | |
| 318 | C | A | -0.5899 | |
| 319 | A | A | -0.6407 | |
| 320 | F | A | -0.2513 | |
| 321 | P | A | -0.3497 | |
| 322 | S | A | -0.4762 | |
| 323 | S | A | -0.3143 | |
| 324 | Q | A | 0.0000 | |
| 325 | Q | A | -0.7193 | |
| 326 | P | A | -0.5311 | |
| 327 | A | A | 0.0000 | |
| 328 | L | A | 0.0000 | |
| 329 | T | A | -0.5781 | |
| 330 | A | A | -0.4933 | |
| 331 | F | A | 0.0000 | |
| 332 | V | A | 0.0000 | |
| 333 | N | A | -0.8023 | |
| 334 | K | A | -0.8414 | |
| 335 | F | A | -0.1938 | |
| 336 | L | A | 0.0000 | |
| 337 | L | A | -0.1783 | |
| 338 | G | A | -0.7463 | |
| 339 | Q | A | -1.2999 | |
| 340 | S | A | -0.8671 | |
| 341 | V | A | -0.6983 | |
| 342 | N | A | -1.3555 | |
| 343 | T | A | 0.0000 | |
| 344 | A | A | -0.3353 | |
| 345 | I | A | 0.1480 | |
| 346 | F | A | 0.4091 | |
| 347 | T | A | 0.1349 | |
| 348 | S | A | -0.3973 | |
| 349 | D | A | -1.3706 | |
| 350 | F | A | -0.4693 | |
| 351 | S | A | -0.6663 | |
| 352 | A | A | -0.7899 | |
| 353 | N | A | -1.1985 | |
| 354 | E | A | -1.6196 | |
| 355 | S | A | -1.3837 | |
| 356 | Q | A | -1.4790 | |
| 357 | W | A | 0.0000 | |
| 358 | I | A | 0.0000 | |
| 359 | D | A | -2.0950 | |
| 360 | W | A | -0.9152 | |
| 361 | T | A | -0.5082 | |
| 362 | T | A | -0.3921 | |
| 363 | P | A | -0.5358 | |
| 364 | T | A | -0.6074 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.7030 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine