| Chain sequence(s) |
A: DVIREYLMFNELSALSSSPESVRSRFSSIYGTNPDGIALNNETYFNAVKPPITAQYGYYCYKNVGTVQYVNRPTDINPNVILAQDTLTNNTNEPFTTTITITGSFTNTSTVTSSTTTGFKFTSKLSIKKVFEIGGEVSFSTTIGTSETTTETITVSKSVTVTVPAQSRRTIQLTAKIAKESADFSAPITVDGYFGANFPKRVGPGGHYFWFNPARDVLNTTSGTLRGTVTNVSSFDFQTIVQPARSL
B: MDVIREYLMFNELSALSSSPESVRSRFSSIYGTNPDGIALNNETYFNAVKPPITAQYGYYCYKNVGTVQYVNRPTDINPNVILAQDTLTNNTNEPFTTTITITGSFTNTSTVTSSTTTGFKFTSKLSIKKVFEIGGEVSFSTTIGTSETTTETITVSKSVTVTVPAQSRRTIQLTAKIAKESADFSAPITVDGYFGANFPKRVGPGGHYFWFNPARDVLNTTSGTLRGTVTNVSSFDFQTIVQPARSL input PDB |
| Selected Chain(s) | A,B |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Mutated residues | VT53A,VT121A,FY146A,FY262A,LQ133A,IT132A,FY260A,IT150A,VW181A |
| Energy difference between WT (input) and mutated protein (by FoldX) | 11.0558 kcal/mol
CAUTION: Your mutation/s can destabilize the protein structure |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with all chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] FoldX: Building mutant model (00:01:21)
[INFO] FoldX: Starting FoldX energy minimalization (00:01:47)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:03:01)
[INFO] Main: Simulation completed successfully. (00:03:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 52 | D | A | -2.1466 | |
| 53 | T | A | -1.4176 | mutated: VT53A |
| 54 | I | A | 0.0000 | |
| 55 | R | A | -2.0176 | |
| 56 | E | A | -0.7513 | |
| 57 | Y | A | 0.1384 | |
| 58 | L | A | 0.0000 | |
| 59 | M | A | -0.4796 | |
| 60 | F | A | 0.0000 | |
| 61 | N | A | -1.4229 | |
| 62 | E | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | S | A | -0.7889 | |
| 65 | A | A | 0.0000 | |
| 66 | L | A | 0.0000 | |
| 67 | S | A | -0.7100 | |
| 68 | S | A | 0.0000 | |
| 69 | S | A | -1.2461 | |
| 70 | P | A | -1.1829 | |
| 71 | E | A | -2.0788 | |
| 72 | S | A | -1.6779 | |
| 73 | V | A | 0.0000 | |
| 74 | R | A | -1.6722 | |
| 75 | S | A | -1.7242 | |
| 76 | R | A | -1.8743 | |
| 77 | F | A | 0.0000 | |
| 78 | S | A | -1.1496 | |
| 79 | S | A | -0.6520 | |
| 80 | I | A | -0.0102 | |
| 81 | Y | A | -0.3880 | |
| 82 | G | A | -0.6979 | |
| 83 | T | A | -1.3620 | |
| 84 | N | A | -1.9123 | |
| 85 | P | A | 0.0000 | |
| 86 | D | A | -1.1640 | |
| 87 | G | A | 0.0000 | |
| 88 | I | A | 0.0000 | |
| 89 | A | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | N | A | 0.0000 | |
| 92 | N | A | -1.9594 | |
| 93 | E | A | -1.7980 | |
| 94 | T | A | -0.8431 | |
| 95 | Y | A | 0.0743 | |
| 96 | F | A | -0.0257 | |
| 97 | N | A | -1.0980 | |
| 98 | A | A | -0.7349 | |
| 99 | V | A | -0.5419 | |
| 100 | K | A | -2.1581 | |
| 101 | P | A | -1.7572 | |
| 102 | P | A | 0.0000 | |
| 103 | I | A | 0.0000 | |
| 104 | T | A | 0.0000 | |
| 105 | A | A | -0.6663 | |
| 106 | Q | A | -0.7462 | |
| 107 | Y | A | 0.9155 | |
| 108 | G | A | 0.3208 | |
| 109 | Y | A | 0.8542 | |
| 110 | Y | A | 0.8114 | |
| 111 | C | A | 0.0000 | |
| 112 | Y | A | -0.0245 | |
| 113 | K | A | 0.0000 | |
| 114 | N | A | -1.0325 | |
| 115 | V | A | 0.0000 | |
| 116 | G | A | -0.9077 | |
| 117 | T | A | -0.6925 | |
| 118 | V | A | -1.0054 | |
| 119 | Q | A | -1.1438 | |
| 120 | Y | A | -1.0352 | |
| 121 | T | A | -1.1865 | mutated: VT121A |
| 122 | N | A | -1.9348 | |
| 123 | R | A | -2.3043 | |
| 124 | P | A | -1.6986 | |
| 125 | T | A | -2.0780 | |
| 126 | D | A | -2.5294 | |
| 127 | I | A | -1.5749 | |
| 128 | N | A | -2.1296 | |
| 129 | P | A | -1.6084 | |
| 130 | N | A | -1.7090 | |
| 131 | V | A | -0.6878 | |
| 132 | T | A | -0.5717 | mutated: IT132A |
| 133 | Q | A | -0.5991 | mutated: LQ133A |
| 134 | A | A | -0.9946 | |
| 135 | Q | A | -1.7890 | |
| 136 | D | A | -1.7500 | |
| 137 | T | A | -1.2237 | |
| 138 | L | A | -0.7731 | |
| 139 | T | A | -1.1638 | |
| 140 | N | A | 0.0000 | |
| 141 | N | A | -2.0815 | |
| 142 | T | A | -2.1043 | |
| 143 | N | A | -2.6912 | |
| 144 | E | A | -2.7685 | |
| 145 | P | A | -1.4678 | |
| 146 | Y | A | -0.2266 | mutated: FY146A |
| 147 | T | A | 0.0686 | |
| 148 | T | A | 0.0114 | |
| 149 | T | A | -0.2127 | |
| 150 | T | A | -0.2655 | mutated: IT150A |
| 151 | T | A | -0.3710 | |
| 152 | I | A | 0.0000 | |
| 153 | T | A | -0.5429 | |
| 154 | G | A | 0.0000 | |
| 155 | S | A | -0.2201 | |
| 156 | F | A | -0.0498 | |
| 157 | T | A | -0.2616 | |
| 158 | N | A | -0.3366 | |
| 159 | T | A | -0.3999 | |
| 160 | S | A | -0.7034 | |
| 161 | T | A | -0.4306 | |
| 162 | V | A | 0.0000 | |
| 163 | T | A | -0.7239 | |
| 164 | S | A | 0.0000 | |
| 165 | S | A | -1.0395 | |
| 166 | T | A | -0.9192 | |
| 167 | T | A | -0.4739 | |
| 168 | T | A | -0.5371 | |
| 169 | G | A | -0.8933 | |
| 170 | F | A | 0.0000 | |
| 171 | K | A | -1.6977 | |
| 172 | F | A | 0.0000 | |
| 173 | T | A | -1.0209 | |
| 174 | S | A | -1.6355 | |
| 175 | K | A | -2.0850 | |
| 176 | L | A | 0.0000 | |
| 177 | S | A | -1.5397 | |
| 178 | I | A | 0.0000 | |
| 179 | K | A | -2.1574 | |
| 180 | K | A | -1.3883 | |
| 181 | W | A | -0.6374 | mutated: VW181A |
| 182 | F | A | 0.0000 | |
| 183 | E | A | -1.7226 | |
| 184 | I | A | -0.7312 | |
| 185 | G | A | -0.8863 | |
| 186 | G | A | 0.0000 | |
| 187 | E | A | -1.9430 | |
| 188 | V | A | 0.0000 | |
| 189 | S | A | -1.3389 | |
| 190 | F | A | 0.0000 | |
| 191 | S | A | -1.3528 | |
| 192 | T | A | 0.0000 | |
| 193 | T | A | -1.1947 | |
| 194 | I | A | 0.0000 | |
| 195 | G | A | -1.0257 | |
| 196 | T | A | -0.6182 | |
| 197 | S | A | -0.8368 | |
| 198 | E | A | -1.1422 | |
| 199 | T | A | -0.6582 | |
| 200 | T | A | -0.5110 | |
| 201 | T | A | -0.4285 | |
| 202 | E | A | -0.6881 | |
| 203 | T | A | -0.4381 | |
| 204 | I | A | 0.0000 | |
| 205 | T | A | -0.1884 | |
| 206 | V | A | 0.0000 | |
| 207 | S | A | -0.2214 | |
| 208 | K | A | -0.3826 | |
| 209 | S | A | -0.3760 | |
| 210 | V | A | 0.0000 | |
| 211 | T | A | -0.1940 | |
| 212 | V | A | 0.0000 | |
| 213 | T | A | -0.0421 | |
| 214 | V | A | 0.0000 | |
| 215 | P | A | -1.5811 | |
| 216 | A | A | -1.9188 | |
| 217 | Q | A | -2.1351 | |
| 218 | S | A | 0.0000 | |
| 219 | R | A | -2.0029 | |
| 220 | R | A | -1.5678 | |
| 221 | T | A | 0.0000 | |
| 222 | I | A | 0.0000 | |
| 223 | Q | A | -0.8973 | |
| 224 | L | A | 0.0000 | |
| 225 | T | A | 0.0000 | |
| 226 | A | A | 0.0000 | |
| 227 | K | A | -1.3063 | |
| 228 | I | A | -1.0620 | |
| 229 | A | A | 0.0000 | |
| 230 | K | A | -2.2468 | |
| 231 | E | A | 0.0000 | |
| 232 | S | A | 0.0000 | |
| 233 | A | A | 0.0000 | |
| 234 | D | A | -1.2851 | |
| 235 | F | A | 0.0000 | |
| 236 | S | A | -0.9377 | |
| 237 | A | A | 0.0000 | |
| 238 | P | A | -0.6550 | |
| 239 | I | A | 0.0000 | |
| 240 | T | A | -0.5679 | |
| 241 | V | A | 0.0000 | |
| 242 | D | A | -0.7147 | |
| 243 | G | A | -0.0629 | |
| 244 | Y | A | 0.2037 | |
| 245 | F | A | 0.0000 | |
| 246 | G | A | 0.0000 | |
| 247 | A | A | 0.0000 | |
| 248 | N | A | 0.0000 | |
| 249 | F | A | 0.0000 | |
| 250 | P | A | -1.6774 | |
| 251 | K | A | -2.7136 | |
| 252 | R | A | -2.7036 | |
| 253 | V | A | 0.0000 | |
| 254 | G | A | -0.7384 | |
| 255 | P | A | -0.9267 | |
| 256 | G | A | -1.1148 | |
| 257 | G | A | -1.4956 | |
| 258 | H | A | -1.2761 | |
| 259 | Y | A | -0.4362 | |
| 260 | Y | A | 0.4717 | mutated: FY260A |
| 261 | W | A | 0.7107 | |
| 262 | Y | A | 0.6130 | mutated: FY262A |
| 263 | N | A | -0.2372 | |
| 264 | P | A | -0.7495 | |
| 265 | A | A | 0.0000 | |
| 266 | R | A | -2.5410 | |
| 267 | D | A | -1.8399 | |
| 268 | V | A | 0.0000 | |
| 269 | L | A | 0.0000 | |
| 270 | N | A | -1.9794 | |
| 271 | T | A | -1.2709 | |
| 272 | T | A | -1.1101 | |
| 273 | S | A | -0.7383 | |
| 274 | G | A | -0.3501 | |
| 275 | T | A | -0.5956 | |
| 276 | L | A | 0.0000 | |
| 277 | R | A | -1.4899 | |
| 278 | G | A | 0.0000 | |
| 279 | T | A | -0.6958 | |
| 280 | V | A | 0.0000 | |
| 281 | T | A | -0.5561 | |
| 282 | N | A | 0.0000 | |
| 283 | V | A | -0.5328 | |
| 284 | S | A | 0.0000 | |
| 285 | S | A | 0.0000 | |
| 286 | F | A | -0.0857 | |
| 287 | D | A | -0.8536 | |
| 288 | F | A | -0.2889 | |
| 289 | Q | A | -0.6435 | |
| 290 | T | A | -0.4751 | |
| 291 | I | A | -0.2262 | |
| 292 | V | A | -0.4537 | |
| 293 | Q | A | -1.0372 | |
| 294 | P | A | -1.1964 | |
| 295 | A | A | -1.6072 | |
| 296 | R | A | -2.3191 | |
| 297 | S | A | -0.9777 | |
| 298 | L | A | 0.2037 | |
| 51 | M | B | 0.5343 | |
| 52 | D | B | -0.9209 | |
| 53 | V | B | -0.3242 | |
| 54 | I | B | 0.0000 | |
| 55 | R | B | -1.5567 | |
| 56 | E | B | -0.6072 | |
| 57 | Y | B | 0.2706 | |
| 58 | L | B | 0.0000 | |
| 59 | M | B | -0.4262 | |
| 60 | F | B | 0.0000 | |
| 61 | N | B | -1.4350 | |
| 62 | E | B | 0.0000 | |
| 63 | L | B | 0.0000 | |
| 64 | S | B | -0.7952 | |
| 65 | A | B | 0.0000 | |
| 66 | L | B | 0.0000 | |
| 67 | S | B | -0.7387 | |
| 68 | S | B | 0.0000 | |
| 69 | S | B | -1.2539 | |
| 70 | P | B | -1.1052 | |
| 71 | E | B | -2.0942 | |
| 72 | S | B | -1.6727 | |
| 73 | V | B | 0.0000 | |
| 74 | R | B | -1.7391 | |
| 75 | S | B | -1.6848 | |
| 76 | R | B | -1.7360 | |
| 77 | F | B | 0.0000 | |
| 78 | S | B | -1.0968 | |
| 79 | S | B | -0.5760 | |
| 80 | I | B | 0.1049 | |
| 81 | Y | B | -0.3244 | |
| 82 | G | B | -0.6608 | |
| 83 | T | B | -1.3307 | |
| 84 | N | B | -1.7229 | |
| 85 | P | B | 0.0000 | |
| 86 | D | B | -1.2539 | |
| 87 | G | B | 0.0000 | |
| 88 | I | B | 0.0000 | |
| 89 | A | B | 0.0000 | |
| 90 | L | B | 0.0000 | |
| 91 | N | B | 0.0000 | |
| 92 | N | B | -1.6593 | |
| 93 | E | B | -1.3536 | |
| 94 | T | B | -0.6029 | |
| 95 | Y | B | 0.1562 | |
| 96 | F | B | -0.0225 | |
| 97 | N | B | -1.0715 | |
| 98 | A | B | -0.6094 | |
| 99 | V | B | -0.4083 | |
| 100 | K | B | -2.0024 | |
| 101 | P | B | -1.5826 | |
| 102 | P | B | 0.0000 | |
| 103 | I | B | 0.0000 | |
| 104 | T | B | 0.0000 | |
| 105 | A | B | -0.6186 | |
| 106 | Q | B | -0.6366 | |
| 107 | Y | B | 0.9938 | |
| 108 | G | B | 0.3886 | |
| 109 | Y | B | 0.8252 | |
| 110 | Y | B | 0.7670 | |
| 111 | C | B | 0.0000 | |
| 112 | Y | B | -0.0025 | |
| 113 | K | B | 0.0000 | |
| 114 | N | B | 0.0000 | |
| 115 | V | B | 0.0000 | |
| 116 | G | B | -0.4578 | |
| 117 | T | B | -0.1381 | |
| 118 | V | B | -0.7297 | |
| 119 | Q | B | -0.8137 | |
| 120 | Y | B | -0.1474 | |
| 121 | V | B | 0.4623 | |
| 122 | N | B | -1.4150 | |
| 123 | R | B | -2.5651 | |
| 124 | P | B | -1.8462 | |
| 125 | T | B | -2.2111 | |
| 126 | D | B | -2.5185 | |
| 127 | I | B | -1.4399 | |
| 128 | N | B | -2.0598 | |
| 129 | P | B | -1.5984 | |
| 130 | N | B | -1.3072 | |
| 131 | V | B | 0.0672 | |
| 132 | I | B | 1.0447 | |
| 133 | L | B | 0.5288 | |
| 134 | A | B | -0.4696 | |
| 135 | Q | B | -1.6496 | |
| 136 | D | B | -2.2242 | |
| 137 | T | B | -1.3624 | |
| 138 | L | B | -0.6022 | |
| 139 | T | B | -1.1002 | |
| 140 | N | B | 0.0000 | |
| 141 | N | B | -2.0876 | |
| 142 | T | B | -2.0426 | |
| 143 | N | B | -2.6721 | |
| 144 | E | B | -2.7238 | |
| 145 | P | B | -1.3660 | |
| 146 | F | B | -0.0113 | |
| 147 | T | B | 0.1957 | |
| 148 | T | B | 0.1665 | |
| 149 | T | B | -0.0269 | |
| 150 | I | B | 0.0710 | |
| 151 | T | B | -0.2587 | |
| 152 | I | B | 0.0000 | |
| 153 | T | B | -0.4977 | |
| 154 | G | B | 0.0000 | |
| 155 | S | B | -0.0988 | |
| 156 | F | B | 0.1040 | |
| 157 | T | B | -0.1896 | |
| 158 | N | B | -0.2467 | |
| 159 | T | B | -0.3245 | |
| 160 | S | B | 0.0000 | |
| 161 | T | B | -0.3879 | |
| 162 | V | B | 0.0000 | |
| 163 | T | B | -0.7855 | |
| 164 | S | B | 0.0000 | |
| 165 | S | B | -1.2047 | |
| 166 | T | B | -1.0954 | |
| 167 | T | B | -0.6260 | |
| 168 | T | B | -0.5748 | |
| 169 | G | B | -0.9708 | |
| 170 | F | B | 0.0000 | |
| 171 | K | B | -1.7136 | |
| 172 | F | B | 0.0000 | |
| 173 | T | B | -0.9260 | |
| 174 | S | B | -1.3328 | |
| 175 | K | B | -1.7684 | |
| 176 | L | B | 0.0000 | |
| 177 | S | B | -1.0181 | |
| 178 | I | B | 0.0000 | |
| 179 | K | B | -1.8567 | |
| 180 | K | B | -1.0316 | |
| 181 | V | B | 0.0706 | |
| 182 | F | B | 0.0000 | |
| 183 | E | B | -1.5945 | |
| 184 | I | B | -0.7440 | |
| 185 | G | B | -0.8295 | |
| 186 | G | B | -0.9009 | |
| 187 | E | B | -1.6620 | |
| 188 | V | B | 0.0000 | |
| 189 | S | B | -1.2095 | |
| 190 | F | B | 0.0000 | |
| 191 | S | B | -1.1836 | |
| 192 | T | B | 0.0000 | |
| 193 | T | B | -1.1033 | |
| 194 | I | B | -1.1021 | |
| 195 | G | B | -1.0019 | |
| 196 | T | B | -0.5539 | |
| 197 | S | B | -0.7830 | |
| 198 | E | B | -1.0501 | |
| 199 | T | B | -0.5850 | |
| 200 | T | B | -0.4405 | |
| 201 | T | B | -0.3503 | |
| 202 | E | B | -0.5630 | |
| 203 | T | B | -0.3509 | |
| 204 | I | B | 0.0000 | |
| 205 | T | B | -0.1459 | |
| 206 | V | B | 0.0000 | |
| 207 | S | B | -0.2305 | |
| 208 | K | B | -0.3516 | |
| 209 | S | B | -0.2937 | |
| 210 | V | B | 0.0000 | |
| 211 | T | B | -0.0724 | |
| 212 | V | B | 0.0000 | |
| 213 | T | B | 0.0878 | |
| 214 | V | B | 0.0000 | |
| 215 | P | B | -1.5541 | |
| 216 | A | B | -2.0212 | |
| 217 | Q | B | -2.2776 | |
| 218 | S | B | 0.0000 | |
| 219 | R | B | -1.7664 | |
| 220 | R | B | -1.4903 | |
| 221 | T | B | -1.3408 | |
| 222 | I | B | 0.0000 | |
| 223 | Q | B | -0.5075 | |
| 224 | L | B | 0.0000 | |
| 225 | T | B | 0.0000 | |
| 226 | A | B | 0.0000 | |
| 227 | K | B | -0.9035 | |
| 228 | I | B | -0.9859 | |
| 229 | A | B | 0.0000 | |
| 230 | K | B | -2.1465 | |
| 231 | E | B | 0.0000 | |
| 232 | S | B | -1.3668 | |
| 233 | A | B | 0.0000 | |
| 234 | D | B | -0.9353 | |
| 235 | F | B | 0.0000 | |
| 236 | S | B | -0.9635 | |
| 237 | A | B | 0.0000 | |
| 238 | P | B | -0.7476 | |
| 239 | I | B | 0.0000 | |
| 240 | T | B | -0.7297 | |
| 241 | V | B | 0.0000 | |
| 242 | D | B | -1.3970 | |
| 243 | G | B | -0.3779 | |
| 244 | Y | B | 0.1382 | |
| 245 | F | B | 0.0000 | |
| 246 | G | B | 0.0000 | |
| 247 | A | B | 0.0000 | |
| 248 | N | B | 0.0000 | |
| 249 | F | B | 0.0000 | |
| 250 | P | B | -1.5861 | |
| 251 | K | B | -2.4642 | |
| 252 | R | B | -2.5487 | |
| 253 | V | B | 0.0000 | |
| 254 | G | B | -0.7395 | |
| 255 | P | B | -0.9763 | |
| 256 | G | B | -1.0257 | |
| 257 | G | B | -1.4624 | |
| 258 | H | B | -1.1472 | |
| 259 | Y | B | -0.0457 | |
| 260 | F | B | 0.7577 | |
| 261 | W | B | 0.5988 | |
| 262 | F | B | 0.8692 | |
| 263 | N | B | 0.0000 | |
| 264 | P | B | -0.7466 | |
| 265 | A | B | 0.0000 | |
| 266 | R | B | -2.5737 | |
| 267 | D | B | -1.5821 | |
| 268 | V | B | 0.0000 | |
| 269 | L | B | 0.0000 | |
| 270 | N | B | -1.9403 | |
| 271 | T | B | -1.2730 | |
| 272 | T | B | -1.2477 | |
| 273 | S | B | -0.8021 | |
| 274 | G | B | -0.3180 | |
| 275 | T | B | -0.7277 | |
| 276 | L | B | 0.0000 | |
| 277 | R | B | -2.1856 | |
| 278 | G | B | -1.1272 | |
| 279 | T | B | -0.7098 | |
| 280 | V | B | 0.0000 | |
| 281 | T | B | -0.6006 | |
| 282 | N | B | 0.0000 | |
| 283 | V | B | -0.4491 | |
| 284 | S | B | -0.1464 | |
| 285 | S | B | 0.0000 | |
| 286 | F | B | -0.0607 | |
| 287 | D | B | -0.7796 | |
| 288 | F | B | 0.0013 | |
| 289 | Q | B | -0.4272 | |
| 290 | T | B | -0.1576 | |
| 291 | I | B | 0.0764 | |
| 292 | V | B | -0.2041 | |
| 293 | Q | B | -0.5896 | |
| 294 | P | B | -0.9095 | |
| 295 | A | B | -1.4538 | |
| 296 | R | B | -2.2359 | |
| 297 | S | B | -1.1191 | |
| 298 | L | B | 0.2013 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine