| Chain sequence(s) |
A: SCRSYRISPGYSVTRTFSSCSAVAPKTGSRCCISAAPYRGVSCYRGLTGFGSRSVSALGSCGPRIAVSGFRAGSCGRSFGYRSGGVGGLSPSCITTVSVNESLLTPLNLEIDPNAQCVKHQEKEQIKNLNSRFAAFIDKVRFLEQQNKLLETKWQFYQNQRCCESNLEPLFNGYIETLRREAEHVEADSGRLASELDHVQEVLEGYKKKYEEEVALRATAENEFVVLKKDVDCAYLRKSDLEANVEALVEESNFLKRLYDEEIQILNAHISDTSVIVKMDNSRDLNMDCVVAEIKAQYDDIASRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRVIQRLTAEIENAKCQRTKLEAAVAEAEQQGEAALNDARSKLAGLEEALQKAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGSVNVCVSSRGGVACGGLTYSSTAGRQIASGPVATGGSITVLAPDSCQPRASSFSCGSSRSVRFA
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:07:44)
[INFO] Main: Simulation completed successfully. (00:07:48)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | S | A | -0.2913 | |
| 2 | C | A | -0.1666 | |
| 3 | R | A | -1.5231 | |
| 4 | S | A | -0.5484 | |
| 5 | Y | A | 0.4333 | |
| 6 | R | A | -0.5712 | |
| 7 | I | A | 1.2058 | |
| 8 | S | A | 0.2098 | |
| 9 | P | A | 0.0072 | |
| 10 | G | A | 0.3596 | |
| 11 | Y | A | 1.3367 | |
| 12 | S | A | 0.9143 | |
| 13 | V | A | 1.3955 | |
| 14 | T | A | 0.2157 | |
| 15 | R | A | -0.9668 | |
| 16 | T | A | 0.1070 | |
| 17 | F | A | 1.3347 | |
| 18 | S | A | 0.5611 | |
| 19 | S | A | 0.4747 | |
| 20 | C | A | 0.9399 | |
| 21 | S | A | 0.5858 | |
| 22 | A | A | 0.9738 | |
| 23 | V | A | 1.5433 | |
| 24 | A | A | 0.3746 | |
| 25 | P | A | -0.6635 | |
| 26 | K | A | -1.7468 | |
| 27 | T | A | -1.4593 | |
| 28 | G | A | -1.5149 | |
| 29 | S | A | -1.2808 | |
| 30 | R | A | -1.2518 | |
| 31 | C | A | 0.5898 | |
| 32 | C | A | 1.4580 | |
| 33 | I | A | 2.2572 | |
| 34 | S | A | 1.0687 | |
| 35 | A | A | 0.4600 | |
| 36 | A | A | 0.4202 | |
| 37 | P | A | -0.0185 | |
| 38 | Y | A | 0.2112 | |
| 39 | R | A | -1.1043 | |
| 40 | G | A | -0.1952 | |
| 41 | V | A | 1.3495 | |
| 42 | S | A | 1.0153 | |
| 43 | C | A | 1.1938 | |
| 44 | Y | A | 1.0142 | |
| 45 | R | A | -0.8269 | |
| 46 | G | A | -0.1484 | |
| 47 | L | A | 1.0099 | |
| 48 | T | A | 0.7617 | |
| 49 | G | A | 0.5956 | |
| 50 | F | A | 1.2329 | |
| 51 | G | A | -0.2254 | |
| 52 | S | A | -0.9603 | |
| 53 | R | A | -1.5538 | |
| 54 | S | A | -0.3175 | |
| 55 | V | A | 1.2765 | |
| 56 | S | A | 0.7315 | |
| 57 | A | A | 1.0280 | |
| 58 | L | A | 1.5187 | |
| 59 | G | A | 0.3487 | |
| 60 | S | A | -0.0922 | |
| 61 | C | A | 0.2167 | |
| 62 | G | A | -0.4717 | |
| 63 | P | A | -0.4962 | |
| 64 | R | A | -0.7530 | |
| 65 | I | A | 1.3685 | |
| 66 | A | A | 1.2361 | |
| 67 | V | A | 2.0946 | |
| 68 | S | A | 1.0406 | |
| 69 | G | A | 0.5667 | |
| 70 | F | A | 0.9399 | |
| 71 | R | A | -1.1785 | |
| 72 | A | A | -0.5854 | |
| 73 | G | A | -0.6475 | |
| 74 | S | A | -0.8058 | |
| 75 | C | A | -0.3212 | |
| 76 | G | A | -0.9946 | |
| 77 | R | A | -1.4944 | |
| 78 | S | A | -0.2049 | |
| 79 | F | A | 1.1045 | |
| 80 | G | A | 0.1056 | |
| 81 | Y | A | 0.5609 | |
| 82 | R | A | -1.4137 | |
| 83 | S | A | -0.8742 | |
| 84 | G | A | -0.7300 | |
| 85 | G | A | -0.4746 | |
| 86 | V | A | 1.2061 | |
| 87 | G | A | 0.3114 | |
| 88 | G | A | 0.3410 | |
| 89 | L | A | 1.2002 | |
| 90 | S | A | 0.3034 | |
| 91 | P | A | 0.3056 | |
| 92 | S | A | 0.7275 | |
| 93 | C | A | 1.4530 | |
| 94 | I | A | 2.4309 | |
| 95 | T | A | 1.6310 | |
| 96 | T | A | 1.4521 | |
| 97 | V | A | 2.1451 | |
| 98 | S | A | 0.9066 | |
| 99 | V | A | 1.3339 | |
| 100 | N | A | -0.5228 | |
| 101 | E | A | -1.0838 | |
| 102 | S | A | -0.0387 | |
| 103 | L | A | 1.6637 | |
| 104 | L | A | 1.7643 | |
| 105 | T | A | 0.9553 | |
| 106 | P | A | 0.9762 | |
| 107 | L | A | 1.4347 | |
| 108 | N | A | -0.0799 | |
| 109 | L | A | 0.8712 | |
| 110 | E | A | -0.7375 | |
| 111 | I | A | 0.1482 | |
| 112 | D | A | -1.6297 | |
| 113 | P | A | -1.3495 | |
| 114 | N | A | -1.5497 | |
| 115 | A | A | -1.1395 | |
| 116 | Q | A | -1.9338 | |
| 117 | C | A | -1.2597 | |
| 118 | V | A | -1.0048 | |
| 119 | K | A | -3.4284 | |
| 120 | H | A | -3.3862 | |
| 121 | Q | A | -3.7090 | |
| 122 | E | A | -4.4509 | |
| 123 | K | A | -4.4868 | |
| 124 | E | A | -4.4865 | |
| 125 | Q | A | -3.8065 | |
| 126 | I | A | -2.6404 | |
| 127 | K | A | -3.6637 | |
| 128 | N | A | -2.9779 | |
| 129 | L | A | -1.4736 | |
| 130 | N | A | -1.6466 | |
| 131 | S | A | -1.2190 | |
| 132 | R | A | -1.0137 | |
| 133 | F | A | 1.0818 | |
| 134 | A | A | 0.5277 | |
| 135 | A | A | 0.2004 | |
| 136 | F | A | 1.7199 | |
| 137 | I | A | 1.4656 | |
| 138 | D | A | -0.7743 | |
| 139 | K | A | -0.6409 | |
| 140 | V | A | -0.1529 | |
| 141 | R | A | -1.4934 | |
| 142 | F | A | -0.0165 | |
| 143 | L | A | -0.4047 | |
| 144 | E | A | -2.0451 | |
| 145 | Q | A | -2.2594 | |
| 146 | Q | A | -1.6427 | |
| 147 | N | A | -2.4922 | |
| 148 | K | A | -2.6856 | |
| 149 | L | A | -1.3181 | |
| 150 | L | A | -1.1909 | |
| 151 | E | A | -1.9894 | |
| 152 | T | A | -1.0153 | |
| 153 | K | A | -0.6670 | |
| 154 | W | A | -0.0366 | |
| 155 | Q | A | -0.8929 | |
| 156 | F | A | 0.3476 | |
| 157 | Y | A | -0.0842 | |
| 158 | Q | A | -1.6101 | |
| 159 | N | A | -1.8539 | |
| 160 | Q | A | -2.0168 | |
| 161 | R | A | -2.5817 | |
| 162 | C | A | -1.3838 | |
| 163 | C | A | -1.3797 | |
| 164 | E | A | -2.3518 | |
| 165 | S | A | -1.6601 | |
| 166 | N | A | -1.5778 | |
| 167 | L | A | -0.3749 | |
| 168 | E | A | -1.0382 | |
| 169 | P | A | 0.1260 | |
| 170 | L | A | 1.8834 | |
| 171 | F | A | 2.1991 | |
| 172 | N | A | 0.5863 | |
| 173 | G | A | 0.7701 | |
| 174 | Y | A | 1.8520 | |
| 175 | I | A | 1.1723 | |
| 176 | E | A | -1.0480 | |
| 177 | T | A | -1.1759 | |
| 178 | L | A | -1.4303 | |
| 179 | R | A | -3.2734 | |
| 180 | R | A | -4.1885 | |
| 181 | E | A | -3.7601 | |
| 182 | A | A | -3.1649 | |
| 183 | E | A | -4.1086 | |
| 184 | H | A | -3.1885 | |
| 185 | V | A | -1.6559 | |
| 186 | E | A | -2.9420 | |
| 187 | A | A | -2.2238 | |
| 188 | D | A | -1.9418 | |
| 189 | S | A | -1.6748 | |
| 190 | G | A | -1.7086 | |
| 191 | R | A | -2.1292 | |
| 192 | L | A | -0.8963 | |
| 193 | A | A | -0.7739 | |
| 194 | S | A | -1.5855 | |
| 195 | E | A | -1.5653 | |
| 196 | L | A | -0.2885 | |
| 197 | D | A | -2.0126 | |
| 198 | H | A | -1.7083 | |
| 199 | V | A | -0.2824 | |
| 200 | Q | A | -1.5865 | |
| 201 | E | A | -2.3842 | |
| 202 | V | A | -0.3973 | |
| 203 | L | A | -0.3347 | |
| 204 | E | A | -1.9644 | |
| 205 | G | A | -1.2301 | |
| 206 | Y | A | -0.8177 | |
| 207 | K | A | -2.8358 | |
| 208 | K | A | -3.7210 | |
| 209 | K | A | -3.4502 | |
| 210 | Y | A | -1.9404 | |
| 211 | E | A | -3.4474 | |
| 212 | E | A | -3.6686 | |
| 213 | E | A | -2.9564 | |
| 214 | V | A | -0.9834 | |
| 215 | A | A | -1.0297 | |
| 216 | L | A | -0.5597 | |
| 217 | R | A | -2.4462 | |
| 218 | A | A | -1.5364 | |
| 219 | T | A | -1.2698 | |
| 220 | A | A | -1.2843 | |
| 221 | E | A | -2.1180 | |
| 222 | N | A | -1.8130 | |
| 223 | E | A | -1.5089 | |
| 224 | F | A | 0.3112 | |
| 225 | V | A | 0.4172 | |
| 226 | V | A | 0.6875 | |
| 227 | L | A | 0.4836 | |
| 228 | K | A | -1.2341 | |
| 229 | K | A | -2.0743 | |
| 230 | D | A | -1.6110 | |
| 231 | V | A | -1.0122 | |
| 232 | D | A | -2.0518 | |
| 233 | C | A | -1.2590 | |
| 234 | A | A | -1.2211 | |
| 235 | Y | A | -0.0140 | |
| 236 | L | A | -0.1395 | |
| 237 | R | A | -1.9917 | |
| 238 | K | A | -2.1325 | |
| 239 | S | A | -1.5314 | |
| 240 | D | A | -2.4393 | |
| 241 | L | A | -1.1015 | |
| 242 | E | A | -2.3190 | |
| 243 | A | A | -1.6944 | |
| 244 | N | A | -1.1318 | |
| 245 | V | A | 0.0133 | |
| 246 | E | A | -1.6343 | |
| 247 | A | A | -0.7979 | |
| 248 | L | A | 0.5997 | |
| 249 | V | A | 0.5243 | |
| 250 | E | A | -1.6560 | |
| 251 | E | A | -1.5678 | |
| 252 | S | A | -0.8587 | |
| 253 | N | A | -1.0274 | |
| 254 | F | A | 0.3856 | |
| 255 | L | A | -0.5174 | |
| 256 | K | A | -2.6063 | |
| 257 | R | A | -2.5872 | |
| 258 | L | A | -0.9439 | |
| 259 | Y | A | -0.7082 | |
| 260 | D | A | -2.7479 | |
| 261 | E | A | -2.9305 | |
| 262 | E | A | -1.8133 | |
| 263 | I | A | -0.0490 | |
| 264 | Q | A | -0.9385 | |
| 265 | I | A | 0.6288 | |
| 266 | L | A | 0.8241 | |
| 267 | N | A | -0.2842 | |
| 268 | A | A | -0.1876 | |
| 269 | H | A | -0.2128 | |
| 270 | I | A | 0.8465 | |
| 271 | S | A | -0.2431 | |
| 272 | D | A | -1.4426 | |
| 273 | T | A | -0.0163 | |
| 274 | S | A | 1.0603 | |
| 275 | V | A | 2.6359 | |
| 276 | I | A | 3.3674 | |
| 277 | V | A | 2.4496 | |
| 278 | K | A | -0.2043 | |
| 279 | M | A | -0.3431 | |
| 280 | D | A | -2.3827 | |
| 281 | N | A | -2.8470 | |
| 282 | S | A | -2.2959 | |
| 283 | R | A | -3.1154 | |
| 284 | D | A | -2.3128 | |
| 285 | L | A | -0.2007 | |
| 286 | N | A | -0.7588 | |
| 287 | M | A | 0.1673 | |
| 288 | D | A | -0.8486 | |
| 289 | C | A | -0.0015 | |
| 290 | V | A | 0.3368 | |
| 291 | V | A | 0.0157 | |
| 292 | A | A | -0.6703 | |
| 293 | E | A | -1.6945 | |
| 294 | I | A | -0.7353 | |
| 295 | K | A | -1.7490 | |
| 296 | A | A | -1.6960 | |
| 297 | Q | A | -1.4591 | |
| 298 | Y | A | -0.5778 | |
| 299 | D | A | -2.2889 | |
| 300 | D | A | -1.9405 | |
| 301 | I | A | -0.4331 | |
| 302 | A | A | -1.3197 | |
| 303 | S | A | -2.2309 | |
| 304 | R | A | -3.0869 | |
| 305 | S | A | -2.6967 | |
| 306 | R | A | -3.3049 | |
| 307 | A | A | -2.5766 | |
| 308 | E | A | -3.1796 | |
| 309 | A | A | -2.1278 | |
| 310 | E | A | -2.7441 | |
| 311 | S | A | -1.6816 | |
| 312 | W | A | -0.5197 | |
| 313 | Y | A | -0.6484 | |
| 314 | R | A | -2.4931 | |
| 315 | S | A | -2.1203 | |
| 316 | K | A | -2.2028 | |
| 317 | C | A | -1.8663 | |
| 318 | E | A | -3.1821 | |
| 319 | E | A | -2.7463 | |
| 320 | M | A | -1.1746 | |
| 321 | K | A | -1.5781 | |
| 322 | A | A | -1.0465 | |
| 323 | T | A | -0.5053 | |
| 324 | V | A | 0.8092 | |
| 325 | I | A | 0.9388 | |
| 326 | R | A | -1.3600 | |
| 327 | H | A | -1.2886 | |
| 328 | G | A | -0.8641 | |
| 329 | E | A | -2.1416 | |
| 330 | T | A | -1.8421 | |
| 331 | L | A | -1.4804 | |
| 332 | R | A | -3.5338 | |
| 333 | R | A | -4.0132 | |
| 334 | T | A | -2.8908 | |
| 335 | K | A | -3.6404 | |
| 336 | E | A | -4.5763 | |
| 337 | E | A | -3.9851 | |
| 338 | I | A | -1.9425 | |
| 339 | N | A | -3.1178 | |
| 340 | E | A | -3.1156 | |
| 341 | L | A | -0.9753 | |
| 342 | N | A | -1.8338 | |
| 343 | R | A | -2.1323 | |
| 344 | V | A | 0.3281 | |
| 345 | I | A | 0.5955 | |
| 346 | Q | A | -1.4256 | |
| 347 | R | A | -1.7563 | |
| 348 | L | A | -0.1364 | |
| 349 | T | A | -0.7462 | |
| 350 | A | A | -1.8556 | |
| 351 | E | A | -2.5750 | |
| 352 | I | A | -1.6955 | |
| 353 | E | A | -3.3472 | |
| 354 | N | A | -3.2146 | |
| 355 | A | A | -2.9759 | |
| 356 | K | A | -3.5693 | |
| 357 | C | A | -2.8254 | |
| 358 | Q | A | -2.9985 | |
| 359 | R | A | -3.6504 | |
| 360 | T | A | -2.3285 | |
| 361 | K | A | -2.3277 | |
| 362 | L | A | -0.9373 | |
| 363 | E | A | -1.8744 | |
| 364 | A | A | -1.3907 | |
| 365 | A | A | -0.7830 | |
| 366 | V | A | -0.0017 | |
| 367 | A | A | -1.5248 | |
| 368 | E | A | -2.8211 | |
| 369 | A | A | -2.3757 | |
| 370 | E | A | -3.4207 | |
| 371 | Q | A | -3.5679 | |
| 372 | Q | A | -3.1414 | |
| 373 | G | A | -2.9391 | |
| 374 | E | A | -3.3113 | |
| 375 | A | A | -2.3103 | |
| 376 | A | A | -1.6910 | |
| 377 | L | A | -1.1370 | |
| 378 | N | A | -2.0298 | |
| 379 | D | A | -2.6744 | |
| 380 | A | A | -1.8121 | |
| 381 | R | A | -2.1432 | |
| 382 | S | A | -2.0079 | |
| 383 | K | A | -2.1497 | |
| 384 | L | A | -0.5715 | |
| 385 | A | A | -1.0869 | |
| 386 | G | A | -1.0612 | |
| 387 | L | A | -0.0836 | |
| 388 | E | A | -1.8667 | |
| 389 | E | A | -2.7775 | |
| 390 | A | A | -1.3477 | |
| 391 | L | A | -1.1786 | |
| 392 | Q | A | -3.2715 | |
| 393 | K | A | -3.6799 | |
| 394 | A | A | -2.6516 | |
| 395 | K | A | -3.2131 | |
| 396 | Q | A | -2.9822 | |
| 397 | D | A | -2.5026 | |
| 398 | M | A | -1.2363 | |
| 399 | A | A | -0.8890 | |
| 400 | C | A | -0.6762 | |
| 401 | L | A | -0.2039 | |
| 402 | L | A | 0.4780 | |
| 403 | K | A | -1.5669 | |
| 404 | E | A | -1.7233 | |
| 405 | Y | A | 0.0993 | |
| 406 | Q | A | -1.8329 | |
| 407 | E | A | -2.3285 | |
| 408 | V | A | -0.0509 | |
| 409 | M | A | -0.4798 | |
| 410 | N | A | -1.5322 | |
| 411 | S | A | -0.5774 | |
| 412 | K | A | -1.1121 | |
| 413 | L | A | 0.2676 | |
| 414 | G | A | 0.3673 | |
| 415 | L | A | 0.7177 | |
| 416 | D | A | -0.1124 | |
| 417 | I | A | 1.2878 | |
| 418 | E | A | -0.2186 | |
| 419 | I | A | 1.1646 | |
| 420 | A | A | 0.1949 | |
| 421 | T | A | -0.0493 | |
| 422 | Y | A | 0.4003 | |
| 423 | R | A | -1.7450 | |
| 424 | R | A | -2.4991 | |
| 425 | L | A | -0.4874 | |
| 426 | L | A | -2.0146 | |
| 427 | E | A | -3.7239 | |
| 428 | G | A | -2.8670 | |
| 429 | E | A | -3.5010 | |
| 430 | E | A | -3.8415 | |
| 431 | Q | A | -3.5473 | |
| 432 | R | A | -3.2696 | |
| 433 | L | A | -0.9373 | |
| 434 | C | A | -0.6662 | |
| 435 | E | A | -2.0162 | |
| 436 | G | A | -0.6913 | |
| 437 | V | A | 1.4629 | |
| 438 | G | A | 0.5584 | |
| 439 | S | A | 0.7844 | |
| 440 | V | A | 1.8967 | |
| 441 | N | A | 0.7624 | |
| 442 | V | A | 2.4593 | |
| 443 | C | A | 2.2265 | |
| 444 | V | A | 2.1017 | |
| 445 | S | A | 0.5478 | |
| 446 | S | A | -0.9389 | |
| 447 | R | A | -1.9446 | |
| 448 | G | A | -1.1447 | |
| 449 | G | A | -0.2193 | |
| 450 | V | A | 1.3383 | |
| 451 | A | A | 0.9061 | |
| 452 | C | A | 0.9488 | |
| 453 | G | A | 0.3280 | |
| 454 | G | A | 0.4407 | |
| 455 | L | A | 1.5931 | |
| 456 | T | A | 1.0391 | |
| 457 | Y | A | 1.4820 | |
| 458 | S | A | 0.5067 | |
| 459 | S | A | -0.0471 | |
| 460 | T | A | -0.3942 | |
| 461 | A | A | -0.8149 | |
| 462 | G | A | -1.4061 | |
| 463 | R | A | -2.0514 | |
| 464 | Q | A | -1.2292 | |
| 465 | I | A | 0.7963 | |
| 466 | A | A | 0.2696 | |
| 467 | S | A | -0.0921 | |
| 468 | G | A | -0.0982 | |
| 469 | P | A | 0.3675 | |
| 470 | V | A | 1.5048 | |
| 471 | A | A | 0.6516 | |
| 472 | T | A | -0.0153 | |
| 473 | G | A | -0.3374 | |
| 474 | G | A | -0.3084 | |
| 475 | S | A | 0.5957 | |
| 476 | I | A | 2.3518 | |
| 477 | T | A | 2.0748 | |
| 478 | V | A | 2.9658 | |
| 479 | L | A | 2.4015 | |
| 480 | A | A | 0.7203 | |
| 481 | P | A | -0.5063 | |
| 482 | D | A | -1.6811 | |
| 483 | S | A | -1.0708 | |
| 484 | C | A | -0.4230 | |
| 485 | Q | A | -1.3921 | |
| 486 | P | A | -1.5537 | |
| 487 | R | A | -2.2522 | |
| 488 | A | A | -1.0583 | |
| 489 | S | A | -0.2167 | |
| 490 | S | A | 0.4743 | |
| 491 | F | A | 1.8120 | |
| 492 | S | A | 0.8827 | |
| 493 | C | A | 0.8078 | |
| 494 | G | A | -0.1317 | |
| 495 | S | A | -0.7858 | |
| 496 | S | A | -1.2254 | |
| 497 | R | A | -1.8533 | |
| 498 | S | A | -0.6058 | |
| 499 | V | A | 0.7577 | |
| 500 | R | A | -0.2826 | |
| 501 | F | A | 1.4763 | |
| 502 | A | A | 0.5892 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine