Project name: 429cad74a5beb8b

Chain sequence(s)	A: MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKKEAAAKKTAVSVQLKGPGPGEEQPPRFPFGPGPGPDFPFVALLVSGGHTGPGPGPEFPFVALLVSGGHTGPGPGGGVSANQALRGGLEKKKALSGDPLAFEFPRPMLHQGLDKKAGQHDGLAVTTTKKQRCVEAGDDSEQTAAYMTDRPGLDF
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:59)
[INFO]       Main:     Simulation completed successfully.                                          (00:03:00)

• Minimal score value: -4.4106
• Maximal score value: 5.336
• Average score: -0.5012
• Total score value: -109.7589

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.9795
2	R	A	0.3233
3	I	A	2.1688
4	H	A	1.6945
5	Y	A	2.5631
6	L	A	2.8701
7	L	A	3.3003
8	F	A	4.0611
9	A	A	3.9784
10	L	A	4.4553
11	L	A	4.9487
12	F	A	5.3360
13	L	A	5.2583
14	F	A	5.1482
15	L	A	4.5014
16	V	A	3.5542
17	P	A	1.9956
18	V	A	1.8692
19	P	A	0.2689
20	G	A	-0.4170
21	H	A	-0.5702
22	G	A	-0.2825
23	G	A	0.0740
24	I	A	1.0445
25	I	A	1.1007
26	N	A	0.1933
27	T	A	0.6276
28	L	A	1.1681
29	Q	A	0.2884
30	K	A	-0.3051
31	Y	A	1.1804
32	Y	A	0.8185
33	C	A	0.0000
34	R	A	-1.3804
35	V	A	0.6311
36	R	A	-0.9223
37	G	A	-1.9415
38	G	A	0.0000
39	R	A	-2.4616
40	C	A	-1.1536
41	A	A	0.3898
42	V	A	1.6495
43	L	A	2.1328
44	S	A	1.0072
45	C	A	0.0028
46	L	A	0.5902
47	P	A	-1.1822
48	K	A	-2.8275
49	E	A	-2.9567
50	E	A	-2.4657
51	Q	A	-1.6728
52	I	A	-1.2596
53	G	A	-1.5001
54	K	A	-2.7317
55	C	A	0.0000
56	S	A	-1.9530
57	T	A	-1.7342
58	R	A	-2.4891
59	G	A	-1.7690
60	R	A	-1.5062
61	K	A	-1.7711
62	C	A	0.0000
63	C	A	0.0000
64	R	A	-3.7020
65	R	A	-4.3600
66	K	A	-4.4106
67	K	A	-4.1073
68	E	A	-3.6092
69	A	A	-3.3085
70	A	A	-2.3882
71	A	A	-2.2068
72	K	A	-2.6344
73	K	A	-2.3311
74	T	A	-0.7991
75	A	A	-0.1267
76	V	A	0.5018
77	S	A	-0.0309
78	V	A	0.0000
79	Q	A	-0.7261
80	L	A	-0.7288
81	K	A	-2.1510
82	G	A	-2.0032
83	P	A	-2.3154
84	G	A	-1.9783
85	P	A	-1.5049
86	G	A	-1.9546
87	E	A	-3.2848
88	E	A	-3.4662
89	Q	A	-2.2337
90	P	A	-1.2729
91	P	A	-0.3839
92	R	A	-0.1985
93	F	A	0.8446
94	P	A	0.0000
95	F	A	0.9627
96	G	A	-0.1520
97	P	A	-0.6279
98	G	A	-0.8783
99	P	A	-0.8892
100	G	A	-0.9823
101	P	A	-0.9312
102	D	A	-1.8953
103	F	A	-1.0304
104	P	A	-0.9221
105	F	A	0.0000
106	V	A	0.2983
107	A	A	0.0000
108	L	A	0.2142
109	L	A	0.0000
110	V	A	-0.0518
111	S	A	0.0000
112	G	A	0.0000
113	G	A	-1.3356
114	H	A	-1.4198
115	T	A	-1.2573
116	G	A	-1.2895
117	P	A	-1.0592
118	G	A	-1.1682
119	P	A	-1.0005
120	G	A	-0.9415
121	P	A	-0.8108
122	E	A	-0.5917
123	F	A	-0.2028
124	P	A	-0.2533
125	F	A	0.0000
126	V	A	0.0000
127	A	A	0.0746
128	L	A	0.0000
129	L	A	0.0000
130	V	A	0.4559
131	S	A	-0.1066
132	G	A	-0.8152
133	G	A	0.0000
134	H	A	-1.0366
135	T	A	-0.6964
136	G	A	-0.9109
137	P	A	-1.1283
138	G	A	-0.9547
139	P	A	-1.0243
140	G	A	-1.0606
141	G	A	-1.1667
142	G	A	-0.9492
143	V	A	-0.7244
144	S	A	-0.3829
145	A	A	-0.0891
146	N	A	0.1738
147	Q	A	-0.2112
148	A	A	-0.2022
149	L	A	0.1249
150	R	A	0.0000
151	G	A	0.0000
152	G	A	-1.2400
153	L	A	0.0000
154	E	A	0.0000
155	K	A	-1.3079
156	K	A	-2.0435
157	K	A	-1.4809
158	A	A	-0.5666
159	L	A	0.1675
160	S	A	-0.6508
161	G	A	-0.8715
162	D	A	-1.0126
163	P	A	-0.3033
164	L	A	0.4129
165	A	A	-0.5443
166	F	A	-0.8810
167	E	A	-1.3784
168	F	A	-0.5213
169	P	A	-0.7676
170	R	A	-1.5167
171	P	A	0.0000
172	M	A	-0.3257
173	L	A	-1.0418
174	H	A	-1.2875
175	Q	A	-1.1482
176	G	A	-1.3142
177	L	A	-1.6376
178	D	A	-3.0317
179	K	A	-3.4516
180	K	A	-3.2120
181	A	A	-2.1083
182	G	A	0.0000
183	Q	A	-1.6740
184	H	A	-1.2365
185	D	A	0.0000
186	G	A	0.0000
187	L	A	0.5970
188	A	A	0.0000
189	V	A	0.0000
190	T	A	0.0000
191	T	A	0.2648
192	T	A	0.0000
193	K	A	0.0000
194	K	A	0.0000
195	Q	A	0.0000
196	R	A	-0.3914
197	C	A	0.0000
198	V	A	-0.8318
199	E	A	-0.5317
200	A	A	-0.7557
201	G	A	-1.1942
202	D	A	-2.1920
203	D	A	-2.4368
204	S	A	-2.3851
205	E	A	-2.6197
206	Q	A	-2.0165
207	T	A	0.0000
208	A	A	-0.9285
209	A	A	-1.1047
210	Y	A	-0.8520
211	M	A	0.0000
212	T	A	-0.8890
213	D	A	-1.8214
214	R	A	-1.2418
215	P	A	-1.1773
216	G	A	-0.7497
217	L	A	-0.1869
218	D	A	0.0000
219	F	A	0.4562