| Chain sequence(s) |
A: FNQINDGMLLNEKNDVKNNEDYKNVDYKNVNFLQYHFKELSNYNIANSIDILQEKEGHLDFVIIPHYTFLDYYKHLSYNSIYHKSSTYGKCIAVDAFIKKINETYDKVKSKCNDIKNDLIATIKKLEHPYDINNKNDDSYRYDISEEIDDKSEETDDETEEVEDSIQDTDSNHTPSNKKKNDLMNRTFKKMMDEYNTKKKKLIKCIKNHENDFNKICMDMKNYGTNLFEQLSCYNNNFCNTNGIRYHYDEYIHKLILSVKSKNLNKDLSDMTNILQQSELLLTNLNKKMGSYIYIDTIKFIHKEMKHIFNRIEYHTKIINDKTKIIQDKIKLNIWRTFQKDELLKRILDMSNEYSLFITSDHLRQMLYNTFYSKEKHLNNIFHHLIYVLQMKFNDVPIKMEYFQTYKKNKPLTQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:11:06)
[INFO] Main: Simulation completed successfully. (00:11:09)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | F | A | 1.2149 | |
| 2 | N | A | -0.6320 | |
| 3 | Q | A | -1.0009 | |
| 4 | I | A | 0.0688 | |
| 5 | N | A | -1.4483 | |
| 6 | D | A | -1.8390 | |
| 7 | G | A | -0.1835 | |
| 8 | M | A | 1.2449 | |
| 9 | L | A | 2.2124 | |
| 10 | L | A | 1.5412 | |
| 11 | N | A | -1.2700 | |
| 12 | E | A | -3.2169 | |
| 13 | K | A | -3.7387 | |
| 14 | N | A | -3.0175 | |
| 15 | D | A | -2.3743 | |
| 16 | V | A | -1.1691 | |
| 17 | K | A | -2.3089 | |
| 18 | N | A | -2.6427 | |
| 19 | N | A | -3.4068 | |
| 20 | E | A | -3.5414 | |
| 21 | D | A | -2.9244 | |
| 22 | Y | A | -0.7807 | |
| 23 | K | A | -2.1095 | |
| 24 | N | A | -1.4146 | |
| 25 | V | A | 0.2494 | |
| 26 | D | A | -1.5009 | |
| 27 | Y | A | -0.0572 | |
| 28 | K | A | -1.7045 | |
| 29 | N | A | -1.4354 | |
| 30 | V | A | 0.4277 | |
| 31 | N | A | -0.5721 | |
| 32 | F | A | 0.3270 | |
| 33 | L | A | 0.0000 | |
| 34 | Q | A | 0.0000 | |
| 35 | Y | A | 0.2483 | |
| 36 | H | A | -0.7032 | |
| 37 | F | A | 0.3775 | |
| 38 | K | A | -1.5693 | |
| 39 | E | A | -1.6901 | |
| 40 | L | A | 0.0887 | |
| 41 | S | A | -0.5776 | |
| 42 | N | A | -0.7795 | |
| 43 | Y | A | 0.1835 | |
| 44 | N | A | -0.7358 | |
| 45 | I | A | -0.4415 | |
| 46 | A | A | -0.9046 | |
| 47 | N | A | -0.7720 | |
| 48 | S | A | 0.0000 | |
| 49 | I | A | 0.0000 | |
| 50 | D | A | -0.0460 | |
| 51 | I | A | -0.3826 | |
| 52 | L | A | -0.5831 | |
| 53 | Q | A | -2.0834 | |
| 54 | E | A | -3.7771 | |
| 55 | K | A | -3.7868 | |
| 56 | E | A | -3.4352 | |
| 57 | G | A | -2.2854 | |
| 58 | H | A | -1.8983 | |
| 59 | L | A | 0.0000 | |
| 60 | D | A | -0.3494 | |
| 61 | F | A | 0.0000 | |
| 62 | V | A | 0.2054 | |
| 63 | I | A | 0.0000 | |
| 64 | I | A | 0.0000 | |
| 65 | P | A | 0.2232 | |
| 66 | H | A | -0.0513 | |
| 67 | Y | A | 0.0000 | |
| 68 | T | A | 0.4021 | |
| 69 | F | A | 0.8860 | |
| 70 | L | A | 0.0000 | |
| 71 | D | A | 0.0000 | |
| 72 | Y | A | 0.0439 | |
| 73 | Y | A | 0.0000 | |
| 74 | K | A | -0.1657 | |
| 75 | H | A | 0.0000 | |
| 76 | L | A | 0.0000 | |
| 77 | S | A | 0.0000 | |
| 78 | Y | A | 0.1372 | |
| 79 | N | A | 0.0000 | |
| 80 | S | A | 0.0000 | |
| 81 | I | A | 0.0000 | |
| 82 | Y | A | -0.2046 | |
| 83 | H | A | -0.6848 | |
| 84 | K | A | -1.2870 | |
| 85 | S | A | -0.6852 | |
| 86 | S | A | -0.3891 | |
| 87 | T | A | 0.2570 | |
| 88 | Y | A | 1.3019 | |
| 89 | G | A | 0.4957 | |
| 90 | K | A | -0.1274 | |
| 91 | C | A | 0.6558 | |
| 92 | I | A | 1.2143 | |
| 93 | A | A | 0.2483 | |
| 94 | V | A | 0.0000 | |
| 95 | D | A | -1.0549 | |
| 96 | A | A | -0.9542 | |
| 97 | F | A | -1.2958 | |
| 98 | I | A | 0.0000 | |
| 99 | K | A | -3.2516 | |
| 100 | K | A | -3.4642 | |
| 101 | I | A | 0.0000 | |
| 102 | N | A | -3.0216 | |
| 103 | E | A | -4.1143 | |
| 104 | T | A | -3.0488 | |
| 105 | Y | A | 0.0000 | |
| 106 | D | A | -3.9167 | |
| 107 | K | A | -3.6193 | |
| 108 | V | A | 0.0000 | |
| 109 | K | A | -2.6911 | |
| 110 | S | A | -2.8241 | |
| 111 | K | A | -2.9657 | |
| 112 | C | A | 0.0000 | |
| 113 | N | A | -3.0244 | |
| 114 | D | A | -3.2281 | |
| 115 | I | A | -2.4591 | |
| 116 | K | A | 0.0000 | |
| 117 | N | A | -2.5811 | |
| 118 | D | A | -2.6170 | |
| 119 | L | A | 0.0000 | |
| 120 | I | A | 0.0000 | |
| 121 | A | A | -1.5287 | |
| 122 | T | A | 0.0000 | |
| 123 | I | A | 0.0000 | |
| 124 | K | A | -2.6709 | |
| 125 | K | A | -2.5167 | |
| 126 | L | A | 0.0000 | |
| 127 | E | A | 0.0000 | |
| 128 | H | A | -1.8813 | |
| 129 | P | A | 0.0000 | |
| 130 | Y | A | -0.8903 | |
| 131 | D | A | -2.5521 | |
| 132 | I | A | -1.7181 | |
| 133 | N | A | -2.4330 | |
| 134 | N | A | -3.2692 | |
| 135 | K | A | -3.5911 | |
| 136 | N | A | -3.5337 | |
| 137 | D | A | -3.6477 | |
| 138 | D | A | -3.0687 | |
| 139 | S | A | -2.3923 | |
| 140 | Y | A | -0.7331 | |
| 141 | R | A | -1.5867 | |
| 142 | Y | A | 0.1369 | |
| 143 | D | A | -1.1459 | |
| 144 | I | A | 0.3693 | |
| 145 | S | A | -0.9064 | |
| 146 | E | A | -2.0284 | |
| 147 | E | A | -1.9384 | |
| 148 | I | A | -0.6344 | |
| 149 | D | A | -2.3972 | |
| 150 | D | A | -3.1177 | |
| 151 | K | A | -3.4416 | |
| 152 | S | A | -2.7366 | |
| 153 | E | A | -3.1716 | |
| 154 | E | A | -3.1745 | |
| 155 | T | A | -2.5908 | |
| 156 | D | A | -3.5369 | |
| 157 | D | A | -3.6033 | |
| 158 | E | A | -3.5288 | |
| 159 | T | A | -2.6425 | |
| 160 | E | A | -2.7594 | |
| 161 | E | A | -2.4635 | |
| 162 | V | A | -0.8069 | |
| 163 | E | A | -2.1473 | |
| 164 | D | A | -2.2880 | |
| 165 | S | A | -0.9537 | |
| 166 | I | A | 0.2370 | |
| 167 | Q | A | -1.6097 | |
| 168 | D | A | -2.6191 | |
| 169 | T | A | -2.2055 | |
| 170 | D | A | -3.1441 | |
| 171 | S | A | -2.4395 | |
| 172 | N | A | -2.6541 | |
| 173 | H | A | -2.6035 | |
| 174 | T | A | -1.9440 | |
| 175 | P | A | -2.1718 | |
| 176 | S | A | -2.5159 | |
| 177 | N | A | -3.7629 | |
| 178 | K | A | -4.2707 | |
| 179 | K | A | -3.7998 | |
| 180 | K | A | -3.3822 | |
| 181 | N | A | -3.0227 | |
| 182 | D | A | -2.9286 | |
| 183 | L | A | -1.4324 | |
| 184 | M | A | -1.7012 | |
| 185 | N | A | -2.2819 | |
| 186 | R | A | -2.9884 | |
| 187 | T | A | -2.0584 | |
| 188 | F | A | 0.0000 | |
| 189 | K | A | -3.7134 | |
| 190 | K | A | -4.0275 | |
| 191 | M | A | -2.8363 | |
| 192 | M | A | -2.8062 | |
| 193 | D | A | -3.6492 | |
| 194 | E | A | -3.3472 | |
| 195 | Y | A | 0.0000 | |
| 196 | N | A | -2.5089 | |
| 197 | T | A | -2.3370 | |
| 198 | K | A | -2.5611 | |
| 199 | K | A | -2.5259 | |
| 200 | K | A | -3.4135 | |
| 201 | K | A | -3.1980 | |
| 202 | L | A | 0.0000 | |
| 203 | I | A | -2.6135 | |
| 204 | K | A | -3.6883 | |
| 205 | C | A | 0.0000 | |
| 206 | I | A | 0.0000 | |
| 207 | K | A | -3.7152 | |
| 208 | N | A | -3.2833 | |
| 209 | H | A | -3.1532 | |
| 210 | E | A | -3.6480 | |
| 211 | N | A | -3.4923 | |
| 212 | D | A | -3.0429 | |
| 213 | F | A | 0.0000 | |
| 214 | N | A | -2.7386 | |
| 215 | K | A | -3.1746 | |
| 216 | I | A | 0.0000 | |
| 217 | C | A | 0.0000 | |
| 218 | M | A | -1.5440 | |
| 219 | D | A | -2.5743 | |
| 220 | M | A | 0.0000 | |
| 221 | K | A | -1.9008 | |
| 222 | N | A | -2.3101 | |
| 223 | Y | A | -1.4097 | |
| 224 | G | A | 0.0000 | |
| 225 | T | A | -2.1038 | |
| 226 | N | A | -2.5801 | |
| 227 | L | A | 0.0000 | |
| 228 | F | A | 0.0000 | |
| 229 | E | A | -2.8021 | |
| 230 | Q | A | -2.5216 | |
| 231 | L | A | 0.0000 | |
| 232 | S | A | -0.9820 | |
| 233 | C | A | -0.6198 | |
| 234 | Y | A | 0.3050 | |
| 235 | N | A | -1.4977 | |
| 236 | N | A | -2.0938 | |
| 237 | N | A | -2.3346 | |
| 238 | F | A | -1.0132 | |
| 239 | C | A | 0.0000 | |
| 240 | N | A | -0.3903 | |
| 241 | T | A | 0.0000 | |
| 242 | N | A | -0.5151 | |
| 243 | G | A | 0.0000 | |
| 244 | I | A | 0.0000 | |
| 245 | R | A | -0.5934 | |
| 246 | Y | A | 0.0974 | |
| 247 | H | A | 0.0000 | |
| 248 | Y | A | 0.0000 | |
| 249 | D | A | -1.4346 | |
| 250 | E | A | -1.5193 | |
| 251 | Y | A | -0.5108 | |
| 252 | I | A | 0.0000 | |
| 253 | H | A | -1.0963 | |
| 254 | K | A | -1.5769 | |
| 255 | L | A | -0.6309 | |
| 256 | I | A | 0.0000 | |
| 257 | L | A | -0.3606 | |
| 258 | S | A | -0.9014 | |
| 259 | V | A | 0.0000 | |
| 260 | K | A | -2.3224 | |
| 261 | S | A | -1.8795 | |
| 262 | K | A | -3.2841 | |
| 263 | N | A | -3.4679 | |
| 264 | L | A | -2.9945 | |
| 265 | N | A | -3.2517 | |
| 266 | K | A | -3.4260 | |
| 267 | D | A | -2.4884 | |
| 268 | L | A | -1.9074 | |
| 269 | S | A | -2.1403 | |
| 270 | D | A | -2.5464 | |
| 271 | M | A | 0.0000 | |
| 272 | T | A | -1.7823 | |
| 273 | N | A | -2.4791 | |
| 274 | I | A | -1.4681 | |
| 275 | L | A | 0.0000 | |
| 276 | Q | A | -2.2198 | |
| 277 | Q | A | -1.8514 | |
| 278 | S | A | 0.0000 | |
| 279 | E | A | -1.7095 | |
| 280 | L | A | -0.1484 | |
| 281 | L | A | -0.4591 | |
| 282 | L | A | -1.0948 | |
| 283 | T | A | -1.2239 | |
| 284 | N | A | -1.8662 | |
| 285 | L | A | 0.0000 | |
| 286 | N | A | -2.0916 | |
| 287 | K | A | -3.2178 | |
| 288 | K | A | -3.0743 | |
| 289 | M | A | -1.4545 | |
| 290 | G | A | -1.5915 | |
| 291 | S | A | -1.0531 | |
| 292 | Y | A | -0.2961 | |
| 293 | I | A | 0.0000 | |
| 294 | Y | A | 0.0000 | |
| 295 | I | A | 0.0000 | |
| 296 | D | A | -0.8006 | |
| 297 | T | A | 0.0000 | |
| 298 | I | A | 0.0000 | |
| 299 | K | A | -1.4325 | |
| 300 | F | A | 0.0000 | |
| 301 | I | A | 0.0000 | |
| 302 | H | A | 0.0000 | |
| 303 | K | A | -2.1162 | |
| 304 | E | A | 0.0000 | |
| 305 | M | A | 0.0000 | |
| 306 | K | A | -1.7460 | |
| 307 | H | A | -1.8216 | |
| 308 | I | A | 0.0000 | |
| 309 | F | A | -1.0599 | |
| 310 | N | A | -1.7417 | |
| 311 | R | A | -1.2496 | |
| 312 | I | A | 0.0000 | |
| 313 | E | A | -1.4717 | |
| 314 | Y | A | -0.8079 | |
| 315 | H | A | 0.0000 | |
| 316 | T | A | 0.0000 | |
| 317 | K | A | -2.4322 | |
| 318 | I | A | -1.5937 | |
| 319 | I | A | 0.0000 | |
| 320 | N | A | -2.6538 | |
| 321 | D | A | -2.9397 | |
| 322 | K | A | -2.1263 | |
| 323 | T | A | 0.0000 | |
| 324 | K | A | -2.7667 | |
| 325 | I | A | -1.6131 | |
| 326 | I | A | 0.0000 | |
| 327 | Q | A | -1.9404 | |
| 328 | D | A | -2.5338 | |
| 329 | K | A | -1.5899 | |
| 330 | I | A | 0.0000 | |
| 331 | K | A | -1.7869 | |
| 332 | L | A | -0.8299 | |
| 333 | N | A | 0.0000 | |
| 334 | I | A | -0.5593 | |
| 335 | W | A | -1.3170 | |
| 336 | R | A | -0.6172 | |
| 337 | T | A | -0.4037 | |
| 338 | F | A | 0.0000 | |
| 339 | Q | A | -2.1053 | |
| 340 | K | A | -2.6469 | |
| 341 | D | A | -3.0328 | |
| 342 | E | A | -2.5089 | |
| 343 | L | A | 0.0000 | |
| 344 | L | A | -2.0245 | |
| 345 | K | A | -2.7039 | |
| 346 | R | A | -2.0743 | |
| 347 | I | A | 0.0000 | |
| 348 | L | A | -1.0399 | |
| 349 | D | A | -2.1737 | |
| 350 | M | A | 0.0000 | |
| 351 | S | A | 0.0000 | |
| 352 | N | A | -1.0400 | |
| 353 | E | A | -0.9611 | |
| 354 | Y | A | 0.0000 | |
| 355 | S | A | 0.0000 | |
| 356 | L | A | -0.1513 | |
| 357 | F | A | 0.0000 | |
| 358 | I | A | 0.0000 | |
| 359 | T | A | 0.0000 | |
| 360 | S | A | 0.0000 | |
| 361 | D | A | 0.0000 | |
| 362 | H | A | -0.2705 | |
| 363 | L | A | 0.0000 | |
| 364 | R | A | 0.0000 | |
| 365 | Q | A | -1.2737 | |
| 366 | M | A | -0.6769 | |
| 367 | L | A | 0.0000 | |
| 368 | Y | A | -0.3424 | |
| 369 | N | A | -0.9620 | |
| 370 | T | A | -0.7768 | |
| 371 | F | A | 0.0000 | |
| 372 | Y | A | -0.5180 | |
| 373 | S | A | -0.8202 | |
| 374 | K | A | 0.0000 | |
| 375 | E | A | -1.5152 | |
| 376 | K | A | -2.4460 | |
| 377 | H | A | -1.9827 | |
| 378 | L | A | 0.0000 | |
| 379 | N | A | -2.3651 | |
| 380 | N | A | -2.4959 | |
| 381 | I | A | 0.0000 | |
| 382 | F | A | 0.0000 | |
| 383 | H | A | -1.2313 | |
| 384 | H | A | -0.6513 | |
| 385 | L | A | 0.0000 | |
| 386 | I | A | 0.6207 | |
| 387 | Y | A | 0.9036 | |
| 388 | V | A | 0.3677 | |
| 389 | L | A | 0.0000 | |
| 390 | Q | A | -0.0032 | |
| 391 | M | A | -0.4500 | |
| 392 | K | A | -1.0468 | |
| 393 | F | A | 0.3015 | |
| 394 | N | A | -1.1179 | |
| 395 | D | A | -1.5294 | |
| 396 | V | A | 0.4555 | |
| 397 | P | A | 0.4210 | |
| 398 | I | A | 1.2803 | |
| 399 | K | A | -0.6687 | |
| 400 | M | A | 0.2447 | |
| 401 | E | A | -0.6183 | |
| 402 | Y | A | 1.3442 | |
| 403 | F | A | 1.8791 | |
| 404 | Q | A | -0.0772 | |
| 405 | T | A | -0.1905 | |
| 406 | Y | A | -0.2068 | |
| 407 | K | A | -2.3300 | |
| 408 | K | A | -3.1695 | |
| 409 | N | A | -3.1495 | |
| 410 | K | A | -2.4643 | |
| 411 | P | A | -0.5489 | |
| 412 | L | A | 0.7678 | |
| 413 | T | A | 0.0471 | |
| 414 | Q | A | -0.9022 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine