| Chain sequence(s) |
A: HMGGGGSYKAADMWGPPNDPAGGGGSPGIKADSLDIGGGGSELGGTNVPAEGGGGSRQWVSAGRRVGGGGSPENAKEKPGGGGSRQWVSAGRRVGGGGSPGIKADSLDIGGGGSPENAKEKPGGGGSPGIKADSLDIGGGGSRQWVSAGRRVGGGGSYKAADMWGPPNDPAGGGGSRQWVSAGRRVGGGGSELGGTNVPAEGGGGSYKAADMWGPPNDPAGGGGSRQWVSAGRRVGGGGSYKAADMWGPPNDPAGGGGSPENAKEKPGGGGSYKAADMWGPPNDPAGGGGSPGIKADSLDIGGGGSYKAADMWGPPNDPAGGGGSYKAADMWGPPNDPAGGGGSYKAADMWGPPNDPAGGGGSELGGTNVPAEGGGGSPENAKEKPGGGGSELGGTNVPAEGGGGSRQWVSAGRRV
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:02:18)
[INFO] Main: Simulation completed successfully. (00:02:22)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | H | A | -0.6580 | |
| 2 | M | A | 0.1838 | |
| 3 | G | A | -0.5980 | |
| 4 | G | A | -0.9305 | |
| 5 | G | A | -0.8541 | |
| 6 | G | A | -0.7093 | |
| 7 | S | A | -0.3204 | |
| 8 | Y | A | 0.2512 | |
| 9 | K | A | -1.2625 | |
| 10 | A | A | -0.6722 | |
| 11 | A | A | -0.7136 | |
| 12 | D | A | -1.1328 | |
| 13 | M | A | 0.6506 | |
| 14 | W | A | 0.9299 | |
| 15 | G | A | -0.1955 | |
| 16 | P | A | -0.7837 | |
| 17 | P | A | -1.4415 | |
| 18 | N | A | -2.4515 | |
| 19 | D | A | -2.6601 | |
| 20 | P | A | -1.6376 | |
| 21 | A | A | -1.0683 | |
| 22 | G | A | -1.1149 | |
| 23 | G | A | -1.0510 | |
| 24 | G | A | -1.0836 | |
| 25 | G | A | -1.0752 | |
| 26 | S | A | -0.7646 | |
| 27 | P | A | -0.2696 | |
| 28 | G | A | -0.1124 | |
| 29 | I | A | 0.7154 | |
| 30 | K | A | -1.2222 | |
| 31 | A | A | -1.2790 | |
| 32 | D | A | -1.6568 | |
| 33 | S | A | -0.7057 | |
| 34 | L | A | 0.5996 | |
| 35 | D | A | -0.2499 | |
| 36 | I | A | 1.0922 | |
| 37 | G | A | -0.0614 | |
| 38 | G | A | -0.6256 | |
| 39 | G | A | -1.0216 | |
| 40 | G | A | -1.3686 | |
| 41 | S | A | -1.2086 | |
| 42 | E | A | -1.4399 | |
| 43 | L | A | 0.2743 | |
| 44 | G | A | -0.2746 | |
| 45 | G | A | -0.5046 | |
| 46 | T | A | -0.6125 | |
| 47 | N | A | -0.6165 | |
| 48 | V | A | 0.9765 | |
| 49 | P | A | -0.1320 | |
| 50 | A | A | -0.8849 | |
| 51 | E | A | -2.2019 | |
| 52 | G | A | -1.8597 | |
| 53 | G | A | -1.4502 | |
| 54 | G | A | -1.2783 | |
| 55 | G | A | -1.6272 | |
| 56 | S | A | -1.6980 | |
| 57 | R | A | -2.1924 | |
| 58 | Q | A | -1.2004 | |
| 59 | W | A | 0.9184 | |
| 60 | V | A | 1.4727 | |
| 61 | S | A | 0.4896 | |
| 62 | A | A | -0.3490 | |
| 63 | G | A | -1.5205 | |
| 64 | R | A | -2.4032 | |
| 65 | R | A | -2.1317 | |
| 66 | V | A | 0.0367 | |
| 67 | G | A | -0.5972 | |
| 68 | G | A | -0.8697 | |
| 69 | G | A | -0.9254 | |
| 70 | G | A | -0.9570 | |
| 71 | S | A | -1.0760 | |
| 72 | P | A | -1.6389 | |
| 73 | E | A | -2.5960 | |
| 74 | N | A | -2.5569 | |
| 75 | A | A | -2.5122 | |
| 76 | K | A | -3.1580 | |
| 77 | E | A | -3.5010 | |
| 78 | K | A | -3.2100 | |
| 79 | P | A | -1.9857 | |
| 80 | G | A | -1.3481 | |
| 81 | G | A | -1.2904 | |
| 82 | G | A | -1.3774 | |
| 83 | G | A | -1.5654 | |
| 84 | S | A | -1.7196 | |
| 85 | R | A | -2.2013 | |
| 86 | Q | A | -1.1817 | |
| 87 | W | A | 0.9014 | |
| 88 | V | A | 1.6404 | |
| 89 | S | A | 0.7232 | |
| 90 | A | A | -0.3159 | |
| 91 | G | A | -1.3357 | |
| 92 | R | A | -2.5498 | |
| 93 | R | A | -2.1605 | |
| 94 | V | A | -0.0319 | |
| 95 | G | A | -0.5946 | |
| 96 | G | A | -0.8363 | |
| 97 | G | A | -0.8935 | |
| 98 | G | A | -1.0188 | |
| 99 | S | A | -0.5499 | |
| 100 | P | A | -0.4114 | |
| 101 | G | A | -0.1729 | |
| 102 | I | A | 0.6887 | |
| 103 | K | A | -1.3276 | |
| 104 | A | A | -1.1892 | |
| 105 | D | A | -1.8744 | |
| 106 | S | A | -0.8269 | |
| 107 | L | A | 0.5604 | |
| 108 | D | A | -0.4964 | |
| 109 | I | A | 1.1301 | |
| 110 | G | A | -0.1720 | |
| 111 | G | A | -0.8333 | |
| 112 | G | A | -0.8727 | |
| 113 | G | A | -1.2118 | |
| 114 | S | A | -1.3590 | |
| 115 | P | A | -1.7117 | |
| 116 | E | A | -2.8488 | |
| 117 | N | A | -2.9046 | |
| 118 | A | A | -2.4348 | |
| 119 | K | A | -3.4450 | |
| 120 | E | A | -3.7358 | |
| 121 | K | A | -3.2502 | |
| 122 | P | A | -2.0300 | |
| 123 | G | A | -1.5788 | |
| 124 | G | A | -1.2814 | |
| 125 | G | A | -1.1003 | |
| 126 | G | A | -1.0129 | |
| 127 | S | A | -0.5466 | |
| 128 | P | A | -0.2915 | |
| 129 | G | A | -0.1141 | |
| 130 | I | A | 0.7120 | |
| 131 | K | A | -1.2625 | |
| 132 | A | A | -0.9847 | |
| 133 | D | A | -1.9156 | |
| 134 | S | A | -0.7546 | |
| 135 | L | A | 0.6626 | |
| 136 | D | A | -0.4865 | |
| 137 | I | A | 1.0991 | |
| 138 | G | A | -0.1247 | |
| 139 | G | A | -0.6936 | |
| 140 | G | A | -0.9555 | |
| 141 | G | A | -1.4696 | |
| 142 | S | A | -1.7007 | |
| 143 | R | A | -2.1845 | |
| 144 | Q | A | -1.2383 | |
| 145 | W | A | 0.9351 | |
| 146 | V | A | 1.6850 | |
| 147 | S | A | 0.7540 | |
| 148 | A | A | -0.1429 | |
| 149 | G | A | -1.8307 | |
| 150 | R | A | -2.8624 | |
| 151 | R | A | -2.3026 | |
| 152 | V | A | 0.0092 | |
| 153 | G | A | -0.6702 | |
| 154 | G | A | -0.8210 | |
| 155 | G | A | -0.8141 | |
| 156 | G | A | -0.8622 | |
| 157 | S | A | -0.2948 | |
| 158 | Y | A | 0.2709 | |
| 159 | K | A | -1.1010 | |
| 160 | A | A | -0.8828 | |
| 161 | A | A | -0.9396 | |
| 162 | D | A | -0.9886 | |
| 163 | M | A | 0.6603 | |
| 164 | W | A | 1.0011 | |
| 165 | G | A | -0.0132 | |
| 166 | P | A | -0.6258 | |
| 167 | P | A | -1.5484 | |
| 168 | N | A | -2.3611 | |
| 169 | D | A | -2.9110 | |
| 170 | P | A | -1.9419 | |
| 171 | A | A | -0.9485 | |
| 172 | G | A | -1.0675 | |
| 173 | G | A | -1.0549 | |
| 174 | G | A | -1.8235 | |
| 175 | G | A | -1.8982 | |
| 176 | S | A | -1.7647 | |
| 177 | R | A | -2.2770 | |
| 178 | Q | A | -1.3108 | |
| 179 | W | A | 0.8832 | |
| 180 | V | A | 1.7088 | |
| 181 | S | A | 0.6493 | |
| 182 | A | A | -0.2971 | |
| 183 | G | A | -1.4603 | |
| 184 | R | A | -2.6466 | |
| 185 | R | A | -2.0964 | |
| 186 | V | A | 0.0989 | |
| 187 | G | A | -0.5753 | |
| 188 | G | A | -0.6547 | |
| 189 | G | A | -1.0609 | |
| 190 | G | A | -1.3142 | |
| 191 | S | A | -1.1599 | |
| 192 | E | A | -1.3493 | |
| 193 | L | A | 0.2501 | |
| 194 | G | A | -0.3072 | |
| 195 | G | A | -0.6688 | |
| 196 | T | A | -0.6357 | |
| 197 | N | A | -0.5924 | |
| 198 | V | A | 1.0263 | |
| 199 | P | A | -0.1525 | |
| 200 | A | A | -0.8668 | |
| 201 | E | A | -2.2626 | |
| 202 | G | A | -1.8250 | |
| 203 | G | A | -1.5663 | |
| 204 | G | A | -1.1633 | |
| 205 | G | A | -0.8436 | |
| 206 | S | A | -0.4515 | |
| 207 | Y | A | 0.2219 | |
| 208 | K | A | -1.3289 | |
| 209 | A | A | -0.7632 | |
| 210 | A | A | -0.7949 | |
| 211 | D | A | -1.1716 | |
| 212 | M | A | 0.6497 | |
| 213 | W | A | 1.0038 | |
| 214 | G | A | 0.0195 | |
| 215 | P | A | -0.8609 | |
| 216 | P | A | -1.5123 | |
| 217 | N | A | -2.4652 | |
| 218 | D | A | -2.7000 | |
| 219 | P | A | -1.5326 | |
| 220 | A | A | -1.0688 | |
| 221 | G | A | -1.1366 | |
| 222 | G | A | -1.0975 | |
| 223 | G | A | -1.1093 | |
| 224 | G | A | -1.3827 | |
| 225 | S | A | -1.7897 | |
| 226 | R | A | -2.1721 | |
| 227 | Q | A | -1.1508 | |
| 228 | W | A | 1.0057 | |
| 229 | V | A | 1.7844 | |
| 230 | S | A | 0.4834 | |
| 231 | A | A | -0.5147 | |
| 232 | G | A | -1.6292 | |
| 233 | R | A | -2.6043 | |
| 234 | R | A | -2.0115 | |
| 235 | V | A | -0.1186 | |
| 236 | G | A | -0.6150 | |
| 237 | G | A | -0.8306 | |
| 238 | G | A | -0.8952 | |
| 239 | G | A | -0.8214 | |
| 240 | S | A | -0.3567 | |
| 241 | Y | A | 0.2687 | |
| 242 | K | A | -1.0949 | |
| 243 | A | A | -0.7049 | |
| 244 | A | A | -0.7864 | |
| 245 | D | A | -0.9471 | |
| 246 | M | A | 0.5474 | |
| 247 | W | A | 0.9780 | |
| 248 | G | A | -0.2067 | |
| 249 | P | A | -0.8835 | |
| 250 | P | A | -1.4135 | |
| 251 | N | A | -2.4477 | |
| 252 | D | A | -2.6893 | |
| 253 | P | A | -1.6999 | |
| 254 | A | A | -0.8346 | |
| 255 | G | A | -1.0086 | |
| 256 | G | A | -1.0320 | |
| 257 | G | A | -1.0809 | |
| 258 | G | A | -1.1544 | |
| 259 | S | A | -1.2514 | |
| 260 | P | A | -1.6666 | |
| 261 | E | A | -2.6822 | |
| 262 | N | A | -2.6213 | |
| 263 | A | A | -2.1958 | |
| 264 | K | A | -3.1841 | |
| 265 | E | A | -3.5938 | |
| 266 | K | A | -3.2951 | |
| 267 | P | A | -2.0874 | |
| 268 | G | A | -1.7062 | |
| 269 | G | A | -1.3316 | |
| 270 | G | A | -1.0979 | |
| 271 | G | A | -0.6247 | |
| 272 | S | A | -0.2143 | |
| 273 | Y | A | 0.2739 | |
| 274 | K | A | -1.0459 | |
| 275 | A | A | -0.8377 | |
| 276 | A | A | -0.9177 | |
| 277 | D | A | -0.9490 | |
| 278 | M | A | 0.5921 | |
| 279 | W | A | 0.9642 | |
| 280 | G | A | -0.1855 | |
| 281 | P | A | -0.7623 | |
| 282 | P | A | -1.4578 | |
| 283 | N | A | -2.4502 | |
| 284 | D | A | -2.6973 | |
| 285 | P | A | -1.7073 | |
| 286 | A | A | -0.9634 | |
| 287 | G | A | -1.0022 | |
| 288 | G | A | -1.0857 | |
| 289 | G | A | -1.1064 | |
| 290 | G | A | -1.0237 | |
| 291 | S | A | -0.8382 | |
| 292 | P | A | -0.3265 | |
| 293 | G | A | -0.0316 | |
| 294 | I | A | 0.6719 | |
| 295 | K | A | -1.3213 | |
| 296 | A | A | -0.8911 | |
| 297 | D | A | -1.9343 | |
| 298 | S | A | -0.6982 | |
| 299 | L | A | 0.6561 | |
| 300 | D | A | -0.4836 | |
| 301 | I | A | 1.1835 | |
| 302 | G | A | -0.0325 | |
| 303 | G | A | -0.8192 | |
| 304 | G | A | -1.0721 | |
| 305 | G | A | -0.6061 | |
| 306 | S | A | -0.2917 | |
| 307 | Y | A | 0.2772 | |
| 308 | K | A | -1.2668 | |
| 309 | A | A | -0.8604 | |
| 310 | A | A | -0.8693 | |
| 311 | D | A | -1.1773 | |
| 312 | M | A | 0.6738 | |
| 313 | W | A | 1.0806 | |
| 314 | G | A | 0.1318 | |
| 315 | P | A | -0.8797 | |
| 316 | P | A | -1.6492 | |
| 317 | N | A | -2.3823 | |
| 318 | D | A | -2.6831 | |
| 319 | P | A | -1.5688 | |
| 320 | A | A | -1.0651 | |
| 321 | G | A | -1.1429 | |
| 322 | G | A | -1.0739 | |
| 323 | G | A | -1.0651 | |
| 324 | G | A | -0.6598 | |
| 325 | S | A | -0.3707 | |
| 326 | Y | A | 0.2983 | |
| 327 | K | A | -1.2732 | |
| 328 | A | A | -0.8359 | |
| 329 | A | A | -0.9833 | |
| 330 | D | A | -1.1729 | |
| 331 | M | A | 0.7088 | |
| 332 | W | A | 1.0807 | |
| 333 | G | A | 0.1712 | |
| 334 | P | A | -0.6330 | |
| 335 | P | A | -1.4420 | |
| 336 | N | A | -2.3756 | |
| 337 | D | A | -2.6423 | |
| 338 | P | A | -1.6484 | |
| 339 | A | A | -0.8865 | |
| 340 | G | A | -0.9941 | |
| 341 | G | A | -1.0153 | |
| 342 | G | A | -1.0976 | |
| 343 | G | A | -0.8310 | |
| 344 | S | A | -0.3419 | |
| 345 | Y | A | 0.1989 | |
| 346 | K | A | -1.0398 | |
| 347 | A | A | -0.8585 | |
| 348 | A | A | -0.8104 | |
| 349 | D | A | -1.0262 | |
| 350 | M | A | 0.3886 | |
| 351 | W | A | 0.4027 | |
| 352 | G | A | -0.6821 | |
| 353 | P | A | -1.0243 | |
| 354 | P | A | -1.8266 | |
| 355 | N | A | -2.7164 | |
| 356 | D | A | -2.7613 | |
| 357 | P | A | -1.7605 | |
| 358 | A | A | -1.3165 | |
| 359 | G | A | -1.5555 | |
| 360 | G | A | -1.2463 | |
| 361 | G | A | -0.6562 | |
| 362 | G | A | -0.5228 | |
| 363 | S | A | -0.4267 | |
| 364 | E | A | -1.1194 | |
| 365 | L | A | 0.2276 | |
| 366 | G | A | -0.3326 | |
| 367 | G | A | -0.6747 | |
| 368 | T | A | -0.6704 | |
| 369 | N | A | -0.5885 | |
| 370 | V | A | 0.8074 | |
| 371 | P | A | 0.0193 | |
| 372 | A | A | -0.8464 | |
| 373 | E | A | -2.0794 | |
| 374 | G | A | -1.9339 | |
| 375 | G | A | -1.4197 | |
| 376 | G | A | -1.2805 | |
| 377 | G | A | -1.2134 | |
| 378 | S | A | -1.2821 | |
| 379 | P | A | -1.7334 | |
| 380 | E | A | -2.8404 | |
| 381 | N | A | -2.8288 | |
| 382 | A | A | -2.5331 | |
| 383 | K | A | -3.5657 | |
| 384 | E | A | -3.7400 | |
| 385 | K | A | -3.3071 | |
| 386 | P | A | -2.2103 | |
| 387 | G | A | -1.5937 | |
| 388 | G | A | -1.3070 | |
| 389 | G | A | -1.0864 | |
| 390 | G | A | -1.3821 | |
| 391 | S | A | -1.1450 | |
| 392 | E | A | -1.4078 | |
| 393 | L | A | 0.2400 | |
| 394 | G | A | -0.4822 | |
| 395 | G | A | -0.7045 | |
| 396 | T | A | -0.4898 | |
| 397 | N | A | -0.6092 | |
| 398 | V | A | 0.7309 | |
| 399 | P | A | -0.0049 | |
| 400 | A | A | -0.9216 | |
| 401 | E | A | -1.9966 | |
| 402 | G | A | -1.7785 | |
| 403 | G | A | -1.4533 | |
| 404 | G | A | -1.2936 | |
| 405 | G | A | -1.6112 | |
| 406 | S | A | -1.6760 | |
| 407 | R | A | -2.1625 | |
| 408 | Q | A | -1.1808 | |
| 409 | W | A | 0.8924 | |
| 410 | V | A | 1.2046 | |
| 411 | S | A | 0.4553 | |
| 412 | A | A | -0.3490 | |
| 413 | G | A | -1.3121 | |
| 414 | R | A | -2.3052 | |
| 415 | R | A | -1.7875 | |
| 416 | V | A | 0.3669 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine