Chain sequence(s) |
A: MKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDAALHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFG
input PDB |
Selected Chain(s) | A |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | Yes |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:00) [INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00) [INFO] runJob: Creating pdb object from: input.pdb (00:00:00) [INFO] FoldX: Starting FoldX energy minimalization (00:00:00) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:08:02) [INFO] Auto_mut: Residue number 213 from chain A and a score of 0.712 (isoleucine) selected for automated muatation (00:08:04) [INFO] Auto_mut: Residue number 93 from chain A and a score of 0.332 (phenylalanine) selected for automated muatation (00:08:04) [INFO] Auto_mut: Residue number 212 from chain A and a score of 0.236 (serine) selected for automated muatation (00:08:04) [INFO] Auto_mut: Residue number 375 from chain A and a score of 0.127 omitted from automated muatation (excluded by the user). (00:08:04) [INFO] Auto_mut: Residue number 330 from chain A and a score of 0.046 (isoleucine) selected for automated muatation (00:08:04) [INFO] Auto_mut: Residue number 336 from chain A and a score of 0.043 (glutamine) selected for automated muatation (00:08:04) [INFO] Auto_mut: Residue number 182 from chain A and a score of 0.041 (valine) selected for automated muatation (00:08:04) [INFO] Auto_mut: Mutating residue number 213 from chain A (isoleucine) into glutamic acid (00:08:04) [INFO] Auto_mut: Mutating residue number 213 from chain A (isoleucine) into aspartic acid (00:08:04) [INFO] Auto_mut: Mutating residue number 93 from chain A (phenylalanine) into glutamic acid Mutating residue number 93 from chain A (phenylalanine) into glutamic acid (00:08:04) [INFO] Auto_mut: Mutating residue number 213 from chain A (isoleucine) into arginine (00:12:00) [INFO] Auto_mut: Mutating residue number 213 from chain A (isoleucine) into lysine (00:12:09) [INFO] Auto_mut: Mutating residue number 93 from chain A (phenylalanine) into lysine (00:12:10) [INFO] Auto_mut: Mutating residue number 93 from chain A (phenylalanine) into aspartic acid Mutating residue number 93 from chain A (phenylalanine) into aspartic acid (00:16:14) [INFO] Auto_mut: Mutating residue number 212 from chain A (serine) into glutamic acid (00:16:35) [INFO] Auto_mut: Mutating residue number 212 from chain A (serine) into aspartic acid (00:16:45) [INFO] Auto_mut: Mutating residue number 93 from chain A (phenylalanine) into arginine (00:20:16) [INFO] Auto_mut: Mutating residue number 212 from chain A (serine) into lysine (00:20:39) [INFO] Auto_mut: Mutating residue number 212 from chain A (serine) into arginine (00:20:45) [INFO] Auto_mut: Mutating residue number 330 from chain A (isoleucine) into glutamic acid (00:24:53) [INFO] Auto_mut: Mutating residue number 330 from chain A (isoleucine) into aspartic acid (00:24:56) [INFO] Auto_mut: Mutating residue number 336 from chain A (glutamine) into glutamic acid (00:25:04) [INFO] Auto_mut: Mutating residue number 330 from chain A (isoleucine) into lysine (00:28:51) [INFO] Auto_mut: Mutating residue number 330 from chain A (isoleucine) into arginine (00:28:53) [INFO] Auto_mut: Mutating residue number 336 from chain A (glutamine) into lysine (00:29:03) [INFO] Auto_mut: Mutating residue number 336 from chain A (glutamine) into aspartic acid (00:33:03) [INFO] Auto_mut: Mutating residue number 182 from chain A (valine) into glutamic acid (00:33:04) [INFO] Auto_mut: Mutating residue number 182 from chain A (valine) into aspartic acid (00:33:05) [INFO] Auto_mut: Mutating residue number 336 from chain A (glutamine) into arginine (00:37:01) [INFO] Auto_mut: Mutating residue number 182 from chain A (valine) into arginine (00:37:07) [INFO] Auto_mut: Mutating residue number 182 from chain A (valine) into lysine (00:37:09) [INFO] Auto_mut: Effect of mutation residue number 213 from chain A (isoleucine) into glutamic acid: Energy difference: 0.4664 kcal/mol, Difference in average score from the base case: -0.0094 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 213 from chain A (isoleucine) into lysine: Energy difference: -1.2157 kcal/mol, Difference in average score from the base case: 0.0022 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 213 from chain A (isoleucine) into aspartic acid: Energy difference: 1.2251 kcal/mol, Difference in average score from the base case: -0.0089 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 213 from chain A (isoleucine) into arginine: Energy difference: -1.0886 kcal/mol, Difference in average score from the base case: -0.0025 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 93 from chain A (phenylalanine) into glutamic acid: Energy difference: 0.7380 kcal/mol, Difference in average score from the base case: -0.0004 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 93 from chain A (phenylalanine) into lysine: Energy difference: 1.0992 kcal/mol, Difference in average score from the base case: 0.0035 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 93 from chain A (phenylalanine) into aspartic acid: Energy difference: 2.2201 kcal/mol, Difference in average score from the base case: 0.0006 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 93 from chain A (phenylalanine) into arginine: Energy difference: -0.1701 kcal/mol, Difference in average score from the base case: -0.0042 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 212 from chain A (serine) into glutamic acid: Energy difference: 0.6942 kcal/mol, Difference in average score from the base case: 0.0017 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 212 from chain A (serine) into lysine: Energy difference: -0.1568 kcal/mol, Difference in average score from the base case: 0.0083 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 212 from chain A (serine) into aspartic acid: Energy difference: 0.7258 kcal/mol, Difference in average score from the base case: 0.0010 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 212 from chain A (serine) into arginine: Energy difference: -0.5635 kcal/mol, Difference in average score from the base case: 0.0102 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 330 from chain A (isoleucine) into glutamic acid: Energy difference: 0.8338 kcal/mol, Difference in average score from the base case: -0.0037 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 330 from chain A (isoleucine) into lysine: Energy difference: 0.8124 kcal/mol, Difference in average score from the base case: 0.0062 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 330 from chain A (isoleucine) into aspartic acid: Energy difference: 2.1057 kcal/mol, Difference in average score from the base case: -0.0027 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 330 from chain A (isoleucine) into arginine: Energy difference: -0.0409 kcal/mol, Difference in average score from the base case: 0.0070 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 336 from chain A (glutamine) into glutamic acid: Energy difference: 0.5008 kcal/mol, Difference in average score from the base case: 0.0101 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 336 from chain A (glutamine) into lysine: Energy difference: -0.0576 kcal/mol, Difference in average score from the base case: 0.0074 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 336 from chain A (glutamine) into aspartic acid: Energy difference: 1.6143 kcal/mol, Difference in average score from the base case: 0.0133 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 336 from chain A (glutamine) into arginine: Energy difference: -0.1658 kcal/mol, Difference in average score from the base case: 0.0047 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 182 from chain A (valine) into glutamic acid: Energy difference: 1.1355 kcal/mol, Difference in average score from the base case: -0.0025 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 182 from chain A (valine) into lysine: Energy difference: 0.1704 kcal/mol, Difference in average score from the base case: 0.0019 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 182 from chain A (valine) into aspartic acid: Energy difference: 1.4596 kcal/mol, Difference in average score from the base case: -0.0028 (00:41:52) [INFO] Auto_mut: Effect of mutation residue number 182 from chain A (valine) into arginine: Energy difference: -0.2550 kcal/mol, Difference in average score from the base case: -0.0025 (00:41:52) [INFO] Main: Simulation completed successfully. (00:42:01) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | M | A | -0.0851 | |
2 | K | A | -1.9896 | |
3 | I | A | 0.0000 | |
4 | E | A | -3.0916 | |
5 | E | A | -3.1157 | |
6 | G | A | -2.0382 | |
7 | K | A | -2.1191 | |
8 | L | A | 0.0000 | |
9 | V | A | 0.0000 | |
10 | I | A | 0.0000 | |
11 | W | A | 0.0000 | |
12 | I | A | 0.0000 | |
13 | N | A | -1.5998 | |
14 | G | A | -1.7999 | |
15 | D | A | -1.1348 | |
16 | K | A | -0.9896 | |
17 | G | A | 0.0000 | |
18 | Y | A | -0.8855 | |
19 | N | A | -1.5717 | |
20 | G | A | 0.0000 | |
21 | L | A | 0.0000 | |
22 | A | A | -1.6118 | |
23 | E | A | -2.8621 | |
24 | V | A | 0.0000 | |
25 | G | A | 0.0000 | |
26 | K | A | -3.9821 | |
27 | K | A | -3.5213 | |
28 | F | A | 0.0000 | |
29 | E | A | -3.8318 | |
30 | K | A | -3.9915 | |
31 | D | A | -3.3820 | |
32 | T | A | -2.2571 | |
33 | G | A | -2.3632 | |
34 | I | A | -2.2031 | |
35 | K | A | -2.6219 | |
36 | V | A | -1.6061 | |
37 | T | A | -0.6828 | |
38 | V | A | -0.3856 | |
39 | E | A | -1.0233 | |
40 | H | A | -1.7644 | |
41 | P | A | -2.0373 | |
42 | D | A | -3.2248 | |
43 | K | A | -3.2544 | |
44 | L | A | 0.0000 | |
45 | E | A | -1.8136 | |
46 | E | A | -2.2138 | |
47 | K | A | -2.2361 | |
48 | F | A | 0.0000 | |
49 | P | A | -1.2449 | |
50 | Q | A | -1.8563 | |
51 | V | A | -0.7865 | |
52 | A | A | 0.0000 | |
53 | A | A | -0.6058 | |
54 | T | A | -0.6167 | |
55 | G | A | -0.6986 | |
56 | D | A | -1.1218 | |
57 | G | A | 0.0000 | |
58 | P | A | 0.0000 | |
59 | D | A | 0.0000 | |
60 | I | A | 0.0000 | |
61 | I | A | 0.0000 | |
62 | F | A | 0.0000 | |
63 | W | A | -0.0079 | |
64 | A | A | -0.0460 | |
65 | H | A | 0.0000 | |
66 | D | A | 0.0000 | |
67 | R | A | -0.4186 | |
68 | F | A | 0.0000 | |
69 | G | A | 0.0000 | |
70 | G | A | -0.7365 | |
71 | Y | A | 0.0000 | |
72 | A | A | -1.4018 | |
73 | Q | A | -1.3848 | |
74 | S | A | -1.0887 | |
75 | G | A | -1.0361 | |
76 | L | A | 0.0000 | |
77 | L | A | 0.0000 | |
78 | A | A | -1.1449 | |
79 | E | A | -2.2698 | |
80 | I | A | 0.0000 | |
81 | T | A | -1.4186 | |
82 | P | A | 0.0000 | |
83 | D | A | -2.9103 | |
84 | K | A | -3.2302 | |
85 | A | A | -2.1934 | |
86 | F | A | 0.0000 | |
87 | Q | A | -2.4566 | |
88 | D | A | -2.9371 | |
89 | K | A | -2.2387 | |
90 | L | A | 0.0000 | |
91 | Y | A | -0.2855 | |
92 | P | A | -0.3996 | |
93 | F | A | 0.3324 | |
94 | T | A | 0.0000 | |
95 | W | A | 0.0000 | |
96 | D | A | -1.9910 | |
97 | A | A | 0.0000 | |
98 | V | A | 0.0000 | |
99 | R | A | -2.8481 | |
100 | Y | A | -2.2512 | |
101 | N | A | -2.1628 | |
102 | G | A | -2.0957 | |
103 | K | A | -2.5911 | |
104 | L | A | -1.9616 | |
105 | I | A | 0.0000 | |
106 | A | A | 0.0000 | |
107 | Y | A | 0.0000 | |
108 | P | A | 0.0000 | |
109 | I | A | 0.0000 | |
110 | A | A | 0.0000 | |
111 | V | A | 0.0000 | |
112 | E | A | 0.0000 | |
113 | A | A | 0.0000 | |
114 | L | A | 0.0000 | |
115 | S | A | 0.0000 | |
116 | L | A | 0.0000 | |
117 | I | A | 0.0000 | |
118 | Y | A | -0.6457 | |
119 | N | A | 0.0000 | |
120 | K | A | -2.5256 | |
121 | D | A | -2.5936 | |
122 | L | A | -1.4232 | |
123 | L | A | 0.0000 | |
124 | P | A | -1.6334 | |
125 | N | A | -1.9549 | |
126 | P | A | 0.0000 | |
127 | P | A | 0.0000 | |
128 | K | A | -2.2328 | |
129 | T | A | -1.9995 | |
130 | W | A | 0.0000 | |
131 | E | A | -2.0151 | |
132 | E | A | -1.9150 | |
133 | I | A | 0.0000 | |
134 | P | A | -1.7169 | |
135 | A | A | -1.3865 | |
136 | L | A | -1.5390 | |
137 | D | A | 0.0000 | |
138 | K | A | -3.4702 | |
139 | E | A | -3.4433 | |
140 | L | A | 0.0000 | |
141 | K | A | -3.5717 | |
142 | A | A | -2.6511 | |
143 | K | A | -3.1249 | |
144 | G | A | -2.7182 | |
145 | K | A | -2.7704 | |
146 | S | A | -1.9202 | |
147 | A | A | 0.0000 | |
148 | L | A | 0.0000 | |
149 | M | A | -0.1683 | |
150 | F | A | 0.0000 | |
151 | N | A | 0.0000 | |
152 | L | A | 0.0000 | |
153 | Q | A | -1.3103 | |
154 | E | A | -1.3042 | |
155 | P | A | 0.0000 | |
156 | Y | A | -0.3461 | |
157 | F | A | 0.0000 | |
158 | T | A | 0.0000 | |
159 | W | A | 0.0000 | |
160 | P | A | 0.0000 | |
161 | L | A | 0.0000 | |
162 | I | A | 0.0000 | |
163 | A | A | 0.0000 | |
164 | A | A | 0.0000 | |
165 | D | A | -1.6557 | |
166 | G | A | -0.8682 | |
167 | G | A | 0.0000 | |
168 | Y | A | 0.0150 | |
169 | A | A | 0.0000 | |
170 | F | A | 0.0000 | |
171 | K | A | -1.1233 | |
172 | Y | A | -0.8178 | |
173 | E | A | -2.7092 | |
174 | N | A | -2.7088 | |
175 | G | A | -2.1548 | |
176 | K | A | -2.4464 | |
177 | Y | A | -1.2492 | |
178 | D | A | -1.6120 | |
179 | I | A | -0.3232 | |
180 | K | A | -1.5133 | |
181 | D | A | -0.9237 | |
182 | V | A | 0.0407 | |
183 | G | A | 0.0000 | |
184 | V | A | -0.1303 | |
185 | D | A | -1.0386 | |
186 | N | A | -0.9283 | |
187 | A | A | -0.7250 | |
188 | G | A | 0.0000 | |
189 | A | A | 0.0000 | |
190 | K | A | -1.2563 | |
191 | A | A | -0.8181 | |
192 | G | A | 0.0000 | |
193 | L | A | 0.0000 | |
194 | T | A | -0.5079 | |
195 | F | A | -0.4411 | |
196 | L | A | 0.0000 | |
197 | V | A | -1.2260 | |
198 | D | A | -2.0698 | |
199 | L | A | 0.0000 | |
200 | I | A | -2.6060 | |
201 | K | A | -3.3855 | |
202 | N | A | -3.3215 | |
203 | K | A | -3.4539 | |
204 | H | A | -2.3748 | |
205 | M | A | 0.0000 | |
206 | N | A | -2.6526 | |
207 | A | A | -2.0475 | |
208 | D | A | -2.1736 | |
209 | T | A | 0.0000 | |
210 | D | A | -1.0253 | |
211 | Y | A | -0.1616 | |
212 | S | A | 0.2357 | |
213 | I | A | 0.7122 | |
214 | A | A | 0.0000 | |
215 | E | A | -0.4255 | |
216 | A | A | -0.6240 | |
217 | A | A | 0.0000 | |
218 | F | A | 0.0000 | |
219 | N | A | -2.0740 | |
220 | K | A | -2.5734 | |
221 | G | A | -2.2881 | |
222 | E | A | -2.5987 | |
223 | T | A | 0.0000 | |
224 | A | A | 0.0000 | |
225 | M | A | 0.0000 | |
226 | T | A | 0.0000 | |
227 | I | A | 0.0000 | |
228 | N | A | 0.0000 | |
229 | G | A | 0.0000 | |
230 | P | A | 0.0000 | |
231 | W | A | 0.0000 | |
232 | A | A | 0.0000 | |
233 | W | A | 0.0000 | |
234 | S | A | -1.2227 | |
235 | N | A | -1.3560 | |
236 | I | A | 0.0000 | |
237 | D | A | -2.2595 | |
238 | T | A | -1.4889 | |
239 | S | A | -1.9795 | |
240 | K | A | -2.6997 | |
241 | V | A | -2.3711 | |
242 | N | A | -2.5031 | |
243 | Y | A | -1.4447 | |
244 | G | A | -0.6509 | |
245 | V | A | 0.0054 | |
246 | T | A | -0.1555 | |
247 | V | A | -0.1268 | |
248 | L | A | 0.0000 | |
249 | P | A | 0.0000 | |
250 | T | A | -1.6174 | |
251 | F | A | 0.0000 | |
252 | K | A | -2.4830 | |
253 | G | A | -2.0556 | |
254 | Q | A | -1.8663 | |
255 | P | A | -1.3058 | |
256 | S | A | 0.0000 | |
257 | K | A | -1.0725 | |
258 | P | A | 0.0000 | |
259 | F | A | 0.0000 | |
260 | V | A | 0.0000 | |
261 | G | A | 0.0000 | |
262 | V | A | 0.0000 | |
263 | L | A | 0.0000 | |
264 | S | A | 0.0000 | |
265 | A | A | 0.0000 | |
266 | G | A | 0.0000 | |
267 | I | A | 0.0000 | |
268 | N | A | 0.0000 | |
269 | A | A | -0.5525 | |
270 | A | A | -0.2921 | |
271 | S | A | 0.0000 | |
272 | P | A | -1.4566 | |
273 | N | A | 0.0000 | |
274 | K | A | -2.1255 | |
275 | E | A | -2.5120 | |
276 | L | A | -1.6839 | |
277 | A | A | 0.0000 | |
278 | K | A | -2.2560 | |
279 | E | A | -2.2262 | |
280 | F | A | 0.0000 | |
281 | L | A | 0.0000 | |
282 | E | A | -1.3648 | |
283 | N | A | -1.7593 | |
284 | Y | A | -1.4041 | |
285 | L | A | 0.0000 | |
286 | L | A | 0.0000 | |
287 | T | A | -1.7581 | |
288 | D | A | -2.4595 | |
289 | E | A | -2.6134 | |
290 | G | A | 0.0000 | |
291 | L | A | 0.0000 | |
292 | E | A | -2.4026 | |
293 | A | A | -2.2374 | |
294 | V | A | 0.0000 | |
295 | N | A | -1.7285 | |
296 | K | A | -2.4208 | |
297 | D | A | -1.9176 | |
298 | K | A | -1.5075 | |
299 | P | A | -0.9188 | |
300 | L | A | 0.0000 | |
301 | G | A | 0.0000 | |
302 | A | A | 0.0000 | |
303 | V | A | 0.0000 | |
304 | A | A | 0.0000 | |
305 | L | A | 0.0000 | |
306 | K | A | -1.9654 | |
307 | S | A | -1.8500 | |
308 | Y | A | 0.0000 | |
309 | E | A | 0.0000 | |
310 | E | A | -3.2771 | |
311 | E | A | -3.4049 | |
312 | L | A | -2.2278 | |
313 | A | A | -2.0757 | |
314 | K | A | -2.8013 | |
315 | D | A | -1.8973 | |
316 | P | A | -0.9965 | |
317 | R | A | -0.9201 | |
318 | I | A | 0.0000 | |
319 | A | A | -0.7395 | |
320 | A | A | 0.0000 | |
321 | T | A | 0.0000 | |
322 | M | A | -0.7962 | |
323 | E | A | -1.7099 | |
324 | N | A | 0.0000 | |
325 | A | A | -1.1607 | |
326 | Q | A | -2.0207 | |
327 | K | A | -1.8268 | |
328 | G | A | -1.2648 | |
329 | E | A | -0.6611 | |
330 | I | A | 0.0460 | |
331 | M | A | 0.0000 | |
332 | P | A | 0.0000 | |
333 | N | A | -0.4256 | |
334 | I | A | -0.2404 | |
335 | P | A | -0.2377 | |
336 | Q | A | 0.0428 | |
337 | M | A | 0.0000 | |
338 | S | A | -0.1177 | |
339 | A | A | 0.0000 | |
340 | F | A | 0.0000 | |
341 | W | A | 0.0000 | |
342 | Y | A | -0.1910 | |
343 | A | A | -0.4234 | |
344 | V | A | 0.0000 | |
345 | R | A | -1.2761 | |
346 | T | A | -0.6071 | |
347 | A | A | 0.0000 | |
348 | V | A | 0.0000 | |
349 | I | A | -0.9718 | |
350 | N | A | -1.2738 | |
351 | A | A | 0.0000 | |
352 | A | A | 0.0000 | |
353 | S | A | -1.7078 | |
354 | G | A | -1.8565 | |
355 | R | A | -2.4385 | |
356 | Q | A | -1.9977 | |
357 | T | A | -1.5818 | |
358 | V | A | 0.0000 | |
359 | D | A | -2.4224 | |
360 | A | A | -1.7253 | |
361 | A | A | -1.6475 | |
362 | L | A | 0.0000 | |
363 | H | A | -1.8751 | |
364 | P | A | -0.8895 | |
365 | D | A | -0.8894 | |
366 | V | A | -0.1693 | |
367 | A | A | 0.0000 | |
368 | K | A | -1.4417 | |
369 | Q | A | -0.7489 | |
370 | L | A | 0.0000 | |
371 | N | A | -0.9393 | |
372 | N | A | -0.3374 | |
373 | L | A | 0.0174 | |
374 | A | A | 0.0000 | |
375 | L | A | 0.1267 | |
376 | L | A | -0.2612 | |
377 | C | A | -1.0354 | |
378 | Q | A | -1.4935 | |
379 | N | A | -1.7309 | |
380 | Q | A | -1.7883 | |
381 | G | A | -1.8293 | |
382 | K | A | -1.6621 | |
383 | Y | A | -1.7677 | |
384 | E | A | -2.2778 | |
385 | E | A | -1.5641 | |
386 | V | A | 0.0000 | |
387 | E | A | -1.3057 | |
388 | Y | A | -0.4767 | |
389 | Y | A | 0.0000 | |
390 | Y | A | 0.0000 | |
391 | Q | A | -1.2331 | |
392 | R | A | -1.1987 | |
393 | A | A | 0.0000 | |
394 | L | A | 0.0000 | |
395 | G | A | -1.1400 | |
396 | I | A | -0.7314 | |
397 | Y | A | 0.0000 | |
398 | Q | A | -1.1797 | |
399 | T | A | -0.9152 | |
400 | K | A | -1.4991 | |
401 | L | A | -0.4253 | |
402 | G | A | -0.8651 | |
403 | P | A | -1.2393 | |
404 | D | A | -1.5880 | |
405 | D | A | -1.2539 | |
406 | P | A | -1.1183 | |
407 | N | A | -1.4327 | |
408 | V | A | 0.0000 | |
409 | A | A | -1.6238 | |
410 | K | A | -2.2442 | |
411 | T | A | 0.0000 | |
412 | K | A | -1.4140 | |
413 | N | A | -1.5054 | |
414 | N | A | -1.1023 | |
415 | L | A | 0.0000 | |
416 | A | A | 0.0000 | |
417 | S | A | -0.7181 | |
418 | C | A | 0.0000 | |
419 | Y | A | 0.0000 | |
420 | L | A | -0.8393 | |
421 | K | A | -1.8378 | |
422 | Q | A | -1.8902 | |
423 | G | A | -1.3835 | |
424 | K | A | -1.6682 | |
425 | F | A | -0.3193 | |
426 | K | A | -1.8126 | |
427 | Q | A | -1.4627 | |
428 | A | A | 0.0000 | |
429 | E | A | -2.3064 | |
430 | T | A | -1.8878 | |
431 | L | A | -1.5617 | |
432 | Y | A | -1.4546 | |
433 | K | A | -2.1921 | |
434 | E | A | -2.4022 | |
435 | I | A | -1.3308 | |
436 | L | A | -0.4745 | |
437 | T | A | -1.7227 | |
438 | R | A | -2.7314 | |
439 | A | A | -2.2112 | |
440 | H | A | -2.4904 | |
441 | E | A | -2.9795 | |
442 | R | A | -3.5105 | |
443 | E | A | -2.7654 | |
444 | F | A | -0.5380 | |
445 | G | A | -1.3344 |
Automated mutations analysis
In the automated mutations mode, the server selects aggregation prone resides
and each selected residue is mutated to glutamic acid, lysine, aspartic acid and arginine.
The table below shows 2 best scored mutants for each mutated residue. Protein variants
are ordered according to the mutation effect they had on protein stability
(energetic effect) together with the difference in the average per-residue aggregation score
between the wild type and the mutant (in the table green values indicate a positive change,
grey are neutral, and orange/red mean destabilizing or more aggregation prone mutants).
Summary for all the mutants can be found in this
CSV file.
Mutant |
Energetic effect |
Score comparison |
|||
IR213A | -1.0886 | -0.0025 | View | CSV | PDB |
FR93A | -0.1701 | -0.0042 | View | CSV | PDB |
VR182A | -0.255 | -0.0025 | View | CSV | PDB |
IE213A | 0.4664 | -0.0094 | View | CSV | PDB |
IE330A | 0.8338 | -0.0037 | View | CSV | PDB |
VE182A | 1.1355 | -0.0025 | View | CSV | PDB |
ID330A | 2.1057 | -0.0027 | View | CSV | PDB |
FE93A | 0.738 | -0.0004 | View | CSV | PDB |
SR212A | -0.5635 | 0.0102 | View | CSV | PDB |
QR336A | -0.1658 | 0.0047 | View | CSV | PDB |
SK212A | -0.1568 | 0.0083 | View | CSV | PDB |
QK336A | -0.0576 | 0.0074 | View | CSV | PDB |