| Chain sequence(s) |
A: GPLALNPEPPLRSTREYVTPTDILYIAETDLITEEGHPEKDIIVNGKVLVPKVSATQFRLFLLTLPDPNKMPLPSEDAFDPATEIRIWRLRAYEIKVFGPLGKGTYGHKNFNALGDVDNPTKPLHETEDDTVDYSFTPKLLQLYIIGDRPPLGKYTAPAAPAPGLPPGAKPPTEVKTTYIDHGDNADIGFGAKDYAALEPEKNDVPDIIKDTTTKVPDLEGMLAEPLGDRLFDHDRREKSKDVKKLVRSGPDLEPLPDSSPPSPLYVKPPASSPTAILPPYDYFTIPDAGEITEEDELFNRPIFLEETPGLNHGVLWGNRLYVLVVDNRRGEIETIRTQISTPAINVYDDSNYITSKRYRREYQLALIVQLCTVPLTPETLALLARRDPRLLVDANLPFIPPVERPDPLAGRTFRELDLTNKLSSDLSKSELGRLYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.1588 | |
| 2 | P | A | 0.4931 | |
| 3 | L | A | 1.6167 | |
| 4 | A | A | 1.0073 | |
| 5 | L | A | 1.0315 | |
| 6 | N | A | -0.9596 | |
| 7 | P | A | -1.4448 | |
| 8 | E | A | -2.1579 | |
| 9 | P | A | -1.4637 | |
| 10 | P | A | -0.8130 | |
| 11 | L | A | -0.3569 | |
| 12 | R | A | -1.2689 | |
| 13 | S | A | -1.3435 | |
| 14 | T | A | 0.0000 | |
| 15 | R | A | -2.7903 | |
| 16 | E | A | -2.8544 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.8399 | |
| 20 | P | A | -0.8659 | |
| 21 | T | A | -0.8809 | |
| 22 | D | A | -1.6318 | |
| 23 | I | A | -0.4726 | |
| 24 | L | A | -0.2380 | |
| 25 | Y | A | 0.0205 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.9676 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.3562 | |
| 31 | L | A | 0.2988 | |
| 32 | I | A | 0.0000 | |
| 33 | T | A | -0.6455 | |
| 34 | E | A | 0.0000 | |
| 35 | E | A | -2.1574 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.7811 | |
| 38 | P | A | 0.0000 | |
| 39 | E | A | -1.6631 | |
| 40 | K | A | -1.9782 | |
| 41 | D | A | -0.6079 | |
| 42 | I | A | 1.4081 | |
| 43 | I | A | 2.5631 | |
| 44 | V | A | 1.7743 | |
| 45 | N | A | -0.4829 | |
| 46 | G | A | -0.3072 | |
| 47 | K | A | -0.0435 | |
| 48 | V | A | 2.1119 | |
| 49 | L | A | 2.6169 | |
| 50 | V | A | 1.0995 | |
| 51 | P | A | -0.1474 | |
| 52 | K | A | -1.2611 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | T | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | L | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.4210 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4274 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.5544 | |
| 70 | K | A | -1.9666 | |
| 71 | M | A | -0.9352 | |
| 72 | P | A | -0.7558 | |
| 73 | L | A | -0.7171 | |
| 74 | P | A | -0.7301 | |
| 75 | S | A | -1.5414 | |
| 76 | E | A | -2.8589 | |
| 77 | D | A | -2.8255 | |
| 78 | A | A | -1.5579 | |
| 79 | F | A | -1.4774 | |
| 80 | D | A | -1.9223 | |
| 81 | P | A | -0.9485 | |
| 82 | A | A | -0.5802 | |
| 83 | T | A | -0.6173 | |
| 84 | E | A | -0.8732 | |
| 85 | I | A | 0.0000 | |
| 86 | R | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3962 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.7551 | |
| 92 | A | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | E | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | K | A | -0.4229 | |
| 97 | V | A | 0.0000 | |
| 98 | F | A | 0.1872 | |
| 99 | G | A | -0.6286 | |
| 100 | P | A | -0.4608 | |
| 101 | L | A | -0.4668 | |
| 102 | G | A | -1.1719 | |
| 103 | K | A | -1.6482 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.6288 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -1.1712 | |
| 108 | H | A | 0.0000 | |
| 109 | K | A | -3.0063 | |
| 110 | N | A | -2.9144 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.4112 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | -0.5406 | |
| 115 | G | A | -0.9885 | |
| 116 | D | A | -1.8827 | |
| 117 | V | A | -1.6681 | |
| 118 | D | A | -2.9633 | |
| 119 | N | A | -2.8244 | |
| 120 | P | A | -1.9120 | |
| 121 | T | A | -1.5976 | |
| 122 | K | A | -2.1672 | |
| 123 | P | A | -0.9540 | |
| 124 | L | A | -0.7770 | |
| 125 | H | A | -1.2669 | |
| 126 | E | A | -2.2117 | |
| 127 | T | A | -2.4307 | |
| 128 | E | A | -3.0856 | |
| 129 | D | A | -3.0955 | |
| 130 | D | A | -1.9809 | |
| 131 | T | A | -1.6550 | |
| 132 | V | A | -1.1931 | |
| 133 | D | A | -2.5270 | |
| 134 | Y | A | -1.2829 | |
| 135 | S | A | -0.7588 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.4602 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | -1.5638 | |
| 140 | L | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | R | A | -0.5850 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | 0.0493 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.0700 | |
| 155 | Y | A | -0.2081 | |
| 156 | T | A | -0.1742 | |
| 157 | A | A | 0.0000 | |
| 158 | P | A | -0.5520 | |
| 159 | A | A | -0.3271 | |
| 160 | A | A | -0.2902 | |
| 161 | P | A | -0.4354 | |
| 162 | A | A | -0.1349 | |
| 163 | P | A | -0.3192 | |
| 164 | G | A | -0.3153 | |
| 165 | L | A | -0.0515 | |
| 166 | P | A | -0.4642 | |
| 167 | P | A | -0.7020 | |
| 168 | G | A | -0.7202 | |
| 169 | A | A | -0.7689 | |
| 170 | K | A | -1.6057 | |
| 171 | P | A | -1.1609 | |
| 172 | P | A | -0.8257 | |
| 173 | T | A | -0.6876 | |
| 174 | E | A | -0.5164 | |
| 175 | V | A | 0.7048 | |
| 176 | K | A | -0.3661 | |
| 177 | T | A | -0.0889 | |
| 178 | T | A | 0.1279 | |
| 179 | Y | A | 0.2646 | |
| 180 | I | A | 0.0000 | |
| 181 | D | A | -0.5693 | |
| 182 | H | A | -0.7011 | |
| 183 | G | A | -0.6042 | |
| 184 | D | A | -0.5036 | |
| 185 | N | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.2475 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.8505 | |
| 190 | F | A | -0.0799 | |
| 191 | G | A | -0.2584 | |
| 192 | A | A | -0.2296 | |
| 193 | K | A | -0.7796 | |
| 194 | D | A | -0.8986 | |
| 195 | Y | A | 0.0000 | |
| 196 | A | A | -1.1962 | |
| 197 | A | A | -0.6244 | |
| 198 | L | A | -0.8187 | |
| 199 | E | A | -1.5813 | |
| 200 | P | A | -1.7943 | |
| 201 | E | A | -2.7996 | |
| 202 | K | A | -2.8563 | |
| 203 | N | A | -2.2062 | |
| 204 | D | A | -1.3686 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.6534 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | K | A | -1.8446 | |
| 211 | D | A | -1.7460 | |
| 212 | T | A | -0.8997 | |
| 213 | T | A | -0.7135 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.1884 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | L | A | -0.7503 | |
| 220 | E | A | -1.5273 | |
| 221 | G | A | -0.8590 | |
| 222 | M | A | 0.0000 | |
| 223 | L | A | -0.1133 | |
| 224 | A | A | -0.3721 | |
| 225 | E | A | -0.5547 | |
| 226 | P | A | -0.1866 | |
| 227 | L | A | 0.0133 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | -0.3431 | |
| 230 | R | A | -0.3910 | |
| 231 | L | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.9758 | |
| 234 | H | A | -0.8762 | |
| 235 | D | A | -1.4474 | |
| 236 | R | A | -2.0443 | |
| 237 | R | A | -2.4164 | |
| 238 | E | A | -2.3175 | |
| 239 | K | A | -2.7924 | |
| 240 | S | A | -2.6041 | |
| 241 | K | A | -3.1097 | |
| 242 | D | A | -2.5826 | |
| 243 | V | A | -0.9212 | |
| 244 | K | A | -2.1880 | |
| 245 | K | A | -2.2979 | |
| 246 | L | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | 0.0000 | |
| 249 | S | A | -1.2493 | |
| 250 | G | A | -1.0844 | |
| 251 | P | A | -0.7715 | |
| 252 | D | A | -0.7241 | |
| 253 | L | A | -0.2011 | |
| 254 | E | A | -1.2174 | |
| 255 | P | A | -0.8508 | |
| 256 | L | A | -0.0039 | |
| 257 | P | A | -0.8789 | |
| 258 | D | A | -1.9495 | |
| 259 | S | A | -1.1581 | |
| 260 | S | A | -1.1589 | |
| 261 | P | A | -0.8113 | |
| 262 | P | A | -0.3838 | |
| 263 | S | A | -0.0661 | |
| 264 | P | A | 0.4870 | |
| 265 | L | A | 1.5423 | |
| 266 | Y | A | 1.1494 | |
| 267 | V | A | 1.1710 | |
| 268 | K | A | -0.6935 | |
| 269 | P | A | -0.2104 | |
| 270 | P | A | -0.3671 | |
| 271 | A | A | -0.1842 | |
| 272 | S | A | -0.1539 | |
| 273 | S | A | -0.0496 | |
| 274 | P | A | -0.1650 | |
| 275 | T | A | 0.2924 | |
| 276 | A | A | 0.6192 | |
| 277 | I | A | 1.7551 | |
| 278 | L | A | 1.2494 | |
| 279 | P | A | 0.1315 | |
| 280 | P | A | 0.0000 | |
| 281 | Y | A | -0.1873 | |
| 282 | D | A | -0.8530 | |
| 283 | Y | A | 0.4092 | |
| 284 | F | A | -0.1648 | |
| 285 | T | A | -1.0429 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.8582 | |
| 289 | A | A | 0.0000 | |
| 290 | G | A | -1.9337 | |
| 291 | E | A | -2.2358 | |
| 292 | I | A | -1.7144 | |
| 293 | T | A | -2.1570 | |
| 294 | E | A | -3.1291 | |
| 295 | E | A | -3.4901 | |
| 296 | D | A | -3.1273 | |
| 297 | E | A | -2.3414 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.0825 | |
| 301 | R | A | -0.9482 | |
| 302 | P | A | -0.3606 | |
| 303 | I | A | -0.0738 | |
| 304 | F | A | -0.4584 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -2.6645 | |
| 307 | E | A | -2.7871 | |
| 308 | T | A | -1.4123 | |
| 309 | P | A | -0.6078 | |
| 310 | G | A | -0.2781 | |
| 311 | L | A | -0.5474 | |
| 312 | N | A | 0.0000 | |
| 313 | H | A | -1.2380 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | G | A | -1.0545 | |
| 319 | N | A | -1.0495 | |
| 320 | R | A | -1.2517 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | L | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | R | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | G | A | 0.0000 | |
| 332 | E | A | -2.7971 | |
| 333 | I | A | -2.1824 | |
| 334 | E | A | -2.7491 | |
| 335 | T | A | -1.3904 | |
| 336 | I | A | -0.2287 | |
| 337 | R | A | -0.6611 | |
| 338 | T | A | 0.3851 | |
| 339 | Q | A | 0.5582 | |
| 340 | I | A | 1.9710 | |
| 341 | S | A | 0.6610 | |
| 342 | T | A | 0.1091 | |
| 343 | P | A | -0.1828 | |
| 344 | A | A | -0.0425 | |
| 345 | I | A | 0.3540 | |
| 346 | N | A | -0.0467 | |
| 347 | V | A | 1.4382 | |
| 348 | Y | A | 0.9454 | |
| 349 | D | A | -1.2312 | |
| 350 | D | A | -1.7355 | |
| 351 | S | A | -0.7255 | |
| 352 | N | A | 0.0287 | |
| 353 | Y | A | 0.6087 | |
| 354 | I | A | 1.7927 | |
| 355 | T | A | 0.4035 | |
| 356 | S | A | -0.4371 | |
| 357 | K | A | -1.5214 | |
| 358 | R | A | -2.1714 | |
| 359 | Y | A | 0.0000 | |
| 360 | R | A | -3.0160 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.5276 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.4407 | |
| 365 | L | A | 0.0000 | |
| 366 | A | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.4369 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | T | A | 0.0000 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -0.5615 | |
| 376 | L | A | -0.3201 | |
| 377 | T | A | -0.6446 | |
| 378 | P | A | -0.9478 | |
| 379 | E | A | -1.6576 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.3983 | |
| 382 | A | A | -0.6323 | |
| 383 | L | A | -0.6756 | |
| 384 | L | A | 0.0000 | |
| 385 | A | A | -0.5973 | |
| 386 | R | A | -0.9567 | |
| 387 | R | A | -0.6622 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -0.6671 | |
| 390 | R | A | -0.9858 | |
| 391 | L | A | 0.0000 | |
| 392 | L | A | -0.5680 | |
| 393 | V | A | -0.9315 | |
| 394 | D | A | -2.0329 | |
| 395 | A | A | -1.4928 | |
| 396 | N | A | -1.5291 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.4873 | |
| 399 | F | A | 1.8152 | |
| 400 | I | A | 1.0710 | |
| 401 | P | A | 0.3570 | |
| 402 | P | A | -0.3901 | |
| 403 | V | A | -0.2053 | |
| 404 | E | A | -2.3190 | |
| 405 | R | A | -2.9547 | |
| 406 | P | A | -2.2283 | |
| 407 | D | A | -2.5841 | |
| 408 | P | A | -1.4018 | |
| 409 | L | A | -0.7114 | |
| 410 | A | A | -0.8644 | |
| 411 | G | A | -0.8064 | |
| 412 | R | A | -0.6737 | |
| 413 | T | A | -0.8203 | |
| 414 | F | A | -1.1319 | |
| 415 | R | A | -2.1956 | |
| 416 | E | A | -2.6954 | |
| 417 | L | A | -2.1834 | |
| 418 | D | A | -2.6961 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.3848 | |
| 421 | N | A | -1.8100 | |
| 422 | K | A | -1.6850 | |
| 423 | L | A | -0.6270 | |
| 424 | S | A | -0.8651 | |
| 425 | S | A | -0.6141 | |
| 426 | D | A | -1.5154 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.9521 | |
| 429 | K | A | -2.7020 | |
| 430 | S | A | 0.0000 | |
| 431 | E | A | -2.2160 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.4738 | |
| 435 | L | A | -0.9189 | |
| 436 | Y | A | -0.5090 | |
| 437 | L | A | -0.0543 | |
| 438 | N | A | -1.6593 | |
| 439 | R | A | -1.9543 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine