| Chain sequence(s) |
A: EEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:06:46)
[INFO] Main: Simulation completed successfully. (00:06:49)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | E | A | -2.8926 | |
| 2 | E | A | -3.1372 | |
| 3 | P | A | -2.3475 | |
| 4 | Q | A | -2.4847 | |
| 5 | S | A | -1.9964 | |
| 6 | D | A | -2.1301 | |
| 7 | P | A | -1.2106 | |
| 8 | S | A | -0.3944 | |
| 9 | V | A | 0.3930 | |
| 10 | E | A | -1.0238 | |
| 11 | P | A | -0.3975 | |
| 12 | P | A | 0.1748 | |
| 13 | L | A | 0.7843 | |
| 14 | S | A | -0.6456 | |
| 15 | Q | A | -1.2425 | |
| 16 | E | A | -1.7705 | |
| 17 | T | A | -0.1277 | |
| 18 | F | A | 1.2259 | |
| 19 | S | A | -0.0695 | |
| 20 | D | A | -0.5241 | |
| 21 | L | A | 1.8874 | |
| 22 | W | A | 1.8025 | |
| 23 | K | A | -0.2070 | |
| 24 | L | A | 1.4489 | |
| 25 | L | A | 0.9977 | |
| 26 | P | A | -0.9690 | |
| 27 | E | A | -2.3561 | |
| 28 | N | A | -1.9978 | |
| 29 | N | A | -0.9266 | |
| 30 | V | A | 1.2296 | |
| 31 | L | A | 1.9066 | |
| 32 | S | A | 1.1577 | |
| 33 | P | A | 0.9267 | |
| 34 | L | A | 1.2581 | |
| 35 | P | A | -0.0363 | |
| 36 | S | A | -0.4577 | |
| 37 | Q | A | -1.0996 | |
| 38 | A | A | -0.7685 | |
| 39 | M | A | -0.4063 | |
| 40 | D | A | -1.8266 | |
| 41 | D | A | -1.3864 | |
| 42 | L | A | 1.3768 | |
| 43 | M | A | 1.9786 | |
| 44 | L | A | 2.0857 | |
| 45 | S | A | -0.0672 | |
| 46 | P | A | -1.0234 | |
| 47 | D | A | -2.3351 | |
| 48 | D | A | -2.4133 | |
| 49 | I | A | -0.3455 | |
| 50 | E | A | -1.5048 | |
| 51 | Q | A | -0.8456 | |
| 52 | W | A | 1.1556 | |
| 53 | F | A | 1.4692 | |
| 54 | T | A | -0.2382 | |
| 55 | E | A | -2.2549 | |
| 56 | D | A | -2.9284 | |
| 57 | P | A | -1.9355 | |
| 58 | G | A | -1.4472 | |
| 59 | P | A | -1.7808 | |
| 60 | D | A | -2.8658 | |
| 61 | E | A | -2.7496 | |
| 62 | A | A | -1.7625 | |
| 63 | P | A | -1.2575 | |
| 64 | R | A | -1.5080 | |
| 65 | M | A | -0.3819 | |
| 66 | P | A | -0.9498 | |
| 67 | E | A | -1.6902 | |
| 68 | A | A | -0.9074 | |
| 69 | A | A | -0.2446 | |
| 70 | P | A | 0.0447 | |
| 71 | P | A | 0.4674 | |
| 72 | V | A | 1.5776 | |
| 73 | A | A | 0.6895 | |
| 74 | P | A | 0.1518 | |
| 75 | A | A | 0.1144 | |
| 76 | P | A | -0.2710 | |
| 77 | A | A | -0.1288 | |
| 78 | A | A | -0.1434 | |
| 79 | P | A | -0.3321 | |
| 80 | T | A | -0.2711 | |
| 81 | P | A | -0.3374 | |
| 82 | A | A | -0.1483 | |
| 83 | A | A | -0.1302 | |
| 84 | P | A | -0.2778 | |
| 85 | A | A | -0.1871 | |
| 86 | P | A | -0.3587 | |
| 87 | A | A | -0.2659 | |
| 88 | P | A | -0.3203 | |
| 89 | S | A | -0.0249 | |
| 90 | W | A | 0.4897 | |
| 91 | P | A | 0.6370 | |
| 92 | L | A | 1.4124 | |
| 93 | S | A | 0.0000 | |
| 94 | S | A | 0.0138 | |
| 95 | S | A | 0.0622 | |
| 96 | V | A | 0.2397 | |
| 97 | P | A | -0.1735 | |
| 98 | S | A | -0.8077 | |
| 99 | Q | A | -1.2782 | |
| 100 | K | A | -1.8602 | |
| 101 | T | A | -0.9697 | |
| 102 | Y | A | -0.1220 | |
| 103 | Q | A | -0.8484 | |
| 104 | G | A | -0.1262 | |
| 105 | S | A | -0.3955 | |
| 106 | Y | A | -0.7018 | |
| 107 | G | A | -0.9373 | |
| 108 | F | A | 0.0000 | |
| 109 | R | A | -1.1859 | |
| 110 | L | A | -0.4097 | |
| 111 | G | A | 0.0625 | |
| 112 | F | A | 0.5558 | |
| 113 | L | A | 0.9878 | |
| 114 | H | A | -0.3713 | |
| 115 | S | A | -0.2259 | |
| 116 | G | A | -0.7184 | |
| 117 | T | A | -1.2434 | |
| 118 | A | A | -1.2415 | |
| 119 | K | A | -2.0113 | |
| 120 | S | A | -0.9286 | |
| 121 | V | A | -0.6030 | |
| 122 | T | A | -0.3907 | |
| 123 | C | A | 0.0272 | |
| 124 | T | A | 0.0000 | |
| 125 | Y | A | 0.0012 | |
| 126 | S | A | 0.0000 | |
| 127 | P | A | -0.5020 | |
| 128 | A | A | -0.2390 | |
| 129 | L | A | -0.1284 | |
| 130 | N | A | -0.7237 | |
| 131 | K | A | 0.0000 | |
| 132 | M | A | 0.0000 | |
| 133 | F | A | 0.0000 | |
| 134 | C | A | 0.0000 | |
| 135 | Q | A | -0.4339 | |
| 136 | L | A | -0.1635 | |
| 137 | A | A | -0.4560 | |
| 138 | K | A | -0.9798 | |
| 139 | T | A | -0.7786 | |
| 140 | C | A | 0.0000 | |
| 141 | P | A | -0.1671 | |
| 142 | V | A | 0.0000 | |
| 143 | Q | A | -0.2476 | |
| 144 | L | A | 0.0000 | |
| 145 | W | A | -0.8916 | |
| 146 | V | A | -1.1812 | |
| 147 | D | A | -2.1224 | |
| 148 | S | A | -1.0040 | |
| 149 | T | A | -0.7031 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | -0.4838 | |
| 152 | P | A | -0.8399 | |
| 153 | G | A | -1.0042 | |
| 154 | T | A | 0.0000 | |
| 155 | R | A | -0.9679 | |
| 156 | V | A | 0.0000 | |
| 157 | R | A | -0.4784 | |
| 158 | A | A | 0.0000 | |
| 159 | M | A | 0.1193 | |
| 160 | A | A | -0.0767 | |
| 161 | I | A | 0.0000 | |
| 162 | Y | A | 0.0000 | |
| 163 | K | A | -1.7409 | |
| 164 | Q | A | -1.7735 | |
| 165 | S | A | -1.3543 | |
| 166 | Q | A | -1.7546 | |
| 167 | H | A | -1.0910 | |
| 168 | M | A | -0.5740 | |
| 169 | T | A | 0.0260 | |
| 170 | E | A | 0.1749 | |
| 171 | V | A | 0.0000 | |
| 172 | V | A | 0.0000 | |
| 173 | R | A | -0.4802 | |
| 174 | R | A | 0.0000 | |
| 175 | C | A | 0.0000 | |
| 176 | P | A | -1.2239 | |
| 177 | H | A | -1.6469 | |
| 178 | H | A | -1.6666 | |
| 179 | E | A | -2.0924 | |
| 180 | R | A | -2.5398 | |
| 181 | C | A | -1.3566 | |
| 182 | S | A | -1.4377 | |
| 183 | D | A | -1.9510 | |
| 184 | S | A | -1.8132 | |
| 185 | D | A | -2.1393 | |
| 186 | G | A | -1.1929 | |
| 187 | L | A | -0.0466 | |
| 188 | A | A | 0.0000 | |
| 189 | P | A | -0.4019 | |
| 190 | P | A | -1.2232 | |
| 191 | Q | A | -0.8979 | |
| 192 | H | A | 0.0000 | |
| 193 | L | A | 0.0000 | |
| 194 | I | A | 0.0000 | |
| 195 | R | A | 0.0000 | |
| 196 | V | A | -0.9286 | |
| 197 | E | A | -1.5117 | |
| 198 | G | A | -1.1074 | |
| 199 | N | A | -0.8745 | |
| 200 | L | A | 0.1632 | |
| 201 | R | A | -1.5753 | |
| 202 | V | A | 0.0000 | |
| 203 | E | A | -1.4741 | |
| 204 | Y | A | -0.6678 | |
| 205 | L | A | -0.5800 | |
| 206 | D | A | -1.1878 | |
| 207 | D | A | -2.0484 | |
| 208 | R | A | -2.7465 | |
| 209 | N | A | -2.3456 | |
| 210 | T | A | -0.9676 | |
| 211 | F | A | -0.4586 | |
| 212 | R | A | 0.0000 | |
| 213 | H | A | 0.0000 | |
| 214 | S | A | -0.2645 | |
| 215 | V | A | 0.0000 | |
| 216 | V | A | 0.0000 | |
| 217 | V | A | 0.0000 | |
| 218 | P | A | -1.3433 | |
| 219 | Y | A | -0.9732 | |
| 220 | E | A | -1.8889 | |
| 221 | P | A | -1.3964 | |
| 222 | P | A | -1.5480 | |
| 223 | E | A | -1.7286 | |
| 224 | V | A | 0.3302 | |
| 225 | G | A | -0.5483 | |
| 226 | S | A | -1.2801 | |
| 227 | D | A | -2.1908 | |
| 228 | C | A | 0.0000 | |
| 229 | T | A | -1.1168 | |
| 230 | T | A | -0.5838 | |
| 231 | I | A | 0.0000 | |
| 232 | H | A | -1.1024 | |
| 233 | Y | A | 0.0000 | |
| 234 | N | A | -0.6594 | |
| 235 | Y | A | 0.0000 | |
| 236 | M | A | 0.0000 | |
| 237 | C | A | 0.0000 | |
| 238 | N | A | -0.6241 | |
| 239 | S | A | -1.1617 | |
| 240 | S | A | -1.2783 | |
| 241 | C | A | -0.5908 | |
| 242 | M | A | 0.0237 | |
| 243 | G | A | -0.2941 | |
| 244 | G | A | 0.0000 | |
| 245 | M | A | 0.0000 | |
| 246 | N | A | -1.6862 | |
| 247 | R | A | -2.4504 | |
| 248 | R | A | -1.9556 | |
| 249 | P | A | -1.4551 | |
| 250 | I | A | 0.0000 | |
| 251 | L | A | -0.5170 | |
| 252 | T | A | 0.0000 | |
| 253 | I | A | 0.0000 | |
| 254 | I | A | 0.0000 | |
| 255 | T | A | 0.0000 | |
| 256 | L | A | 0.0000 | |
| 257 | E | A | 0.0000 | |
| 258 | D | A | -1.0511 | |
| 259 | S | A | -1.0774 | |
| 260 | S | A | -0.9480 | |
| 261 | G | A | -1.0496 | |
| 262 | N | A | -1.2677 | |
| 263 | L | A | 0.0071 | |
| 264 | L | A | 0.0344 | |
| 265 | G | A | 0.0000 | |
| 266 | R | A | -0.6065 | |
| 267 | N | A | -0.8468 | |
| 268 | S | A | -0.6343 | |
| 269 | F | A | 0.0000 | |
| 270 | E | A | -0.5908 | |
| 271 | V | A | 0.0000 | |
| 272 | R | A | -1.0000 | |
| 273 | V | A | 0.0000 | |
| 274 | C | A | 0.0000 | |
| 275 | A | A | -0.3734 | |
| 276 | C | A | -0.7551 | |
| 277 | P | A | 0.0000 | |
| 278 | G | A | 0.0000 | |
| 279 | R | A | -2.0995 | |
| 280 | D | A | 0.0000 | |
| 281 | R | A | -1.6980 | |
| 282 | R | A | -2.3661 | |
| 283 | T | A | -1.9101 | |
| 284 | E | A | -1.6412 | |
| 285 | E | A | -1.9990 | |
| 286 | E | A | -3.0346 | |
| 287 | N | A | -2.1500 | |
| 288 | L | A | -1.5288 | |
| 289 | R | A | -2.8111 | |
| 290 | K | A | -3.1525 | |
| 291 | K | A | -2.6065 | |
| 292 | G | A | -2.5561 | |
| 293 | E | A | -2.9918 | |
| 294 | P | A | -2.7858 | |
| 295 | H | A | -2.6356 | |
| 296 | H | A | -2.2990 | |
| 297 | E | A | -1.9338 | |
| 298 | L | A | 0.0395 | |
| 299 | P | A | -0.4189 | |
| 300 | P | A | -0.5419 | |
| 301 | G | A | -0.7848 | |
| 302 | S | A | -0.9439 | |
| 303 | T | A | -1.5573 | |
| 304 | K | A | -2.7187 | |
| 305 | R | A | -2.3153 | |
| 306 | A | A | -0.6123 | |
| 307 | L | A | 0.7617 | |
| 308 | P | A | -0.4470 | |
| 309 | N | A | -1.6824 | |
| 310 | N | A | -2.0656 | |
| 311 | T | A | -1.1661 | |
| 312 | S | A | -0.7082 | |
| 313 | S | A | -0.6309 | |
| 314 | S | A | -0.8165 | |
| 315 | P | A | -1.2699 | |
| 316 | Q | A | -2.1673 | |
| 317 | P | A | -2.4824 | |
| 318 | K | A | -3.5086 | |
| 319 | K | A | -3.4182 | |
| 320 | K | A | -3.0309 | |
| 321 | P | A | -1.7811 | |
| 322 | L | A | -0.6832 | |
| 323 | D | A | -2.0254 | |
| 324 | G | A | -1.9107 | |
| 325 | E | A | -1.2307 | |
| 326 | Y | A | 1.2884 | |
| 327 | F | A | 2.3210 | |
| 328 | T | A | 1.4788 | |
| 329 | L | A | 1.6492 | |
| 330 | Q | A | -0.4443 | |
| 331 | I | A | -1.4415 | |
| 332 | R | A | -2.8466 | |
| 333 | G | A | -3.1476 | |
| 334 | R | A | -3.5006 | |
| 335 | E | A | -3.5631 | |
| 336 | R | A | -3.1280 | |
| 337 | F | A | -1.6406 | |
| 338 | E | A | -1.8689 | |
| 339 | M | A | -1.2194 | |
| 340 | F | A | -0.5854 | |
| 341 | R | A | -1.8703 | |
| 342 | E | A | -2.0777 | |
| 343 | L | A | -0.6686 | |
| 344 | N | A | -2.1376 | |
| 345 | E | A | -2.5086 | |
| 346 | A | A | -1.3849 | |
| 347 | L | A | -1.2078 | |
| 348 | E | A | -2.3588 | |
| 349 | L | A | -0.9655 | |
| 350 | K | A | -2.6492 | |
| 351 | D | A | -3.0999 | |
| 352 | A | A | -2.5643 | |
| 353 | Q | A | -3.0614 | |
| 354 | A | A | -2.8601 | |
| 355 | G | A | -3.0893 | |
| 356 | K | A | -3.6542 | |
| 357 | E | A | -3.3370 | |
| 358 | P | A | -2.0207 | |
| 359 | G | A | -1.7748 | |
| 360 | G | A | -1.6215 | |
| 361 | S | A | -1.8653 | |
| 362 | R | A | -2.3745 | |
| 363 | A | A | -1.5219 | |
| 364 | H | A | -1.7649 | |
| 365 | S | A | -1.0907 | |
| 366 | S | A | -0.8623 | |
| 367 | H | A | -1.0103 | |
| 368 | L | A | -0.0716 | |
| 369 | K | A | -1.7664 | |
| 370 | S | A | -1.9850 | |
| 371 | K | A | -2.9790 | |
| 372 | K | A | -3.0610 | |
| 373 | G | A | -2.3604 | |
| 374 | Q | A | -1.9434 | |
| 375 | S | A | -0.9675 | |
| 376 | T | A | -0.9086 | |
| 377 | S | A | -1.4590 | |
| 378 | R | A | -2.8045 | |
| 379 | H | A | -3.1951 | |
| 380 | K | A | -3.0928 | |
| 381 | K | A | -1.7627 | |
| 382 | L | A | 1.2381 | |
| 383 | M | A | 2.0898 | |
| 384 | F | A | 1.9384 | |
| 385 | K | A | -0.7840 | |
| 386 | T | A | -1.4051 | |
| 387 | E | A | -2.4971 | |
| 388 | G | A | -1.8468 | |
| 389 | P | A | -1.7945 | |
| 390 | D | A | -2.4752 | |
| 391 | S | A | -2.0744 | |
| 392 | D | A | -2.2688 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine