| Chain sequence(s) |
A: MAAGQNGHEEWVGSAYLFVESSLDKVVLSDAYAHPQQKVAVYRALQAALAESGGSPDVLQMLKIHRSDPQLIVQLRFCGRQPCGRFLRAYREGALRAALQRSLAAALAQHSVPLQLELRAGAERLDALLADEERCLSCILAQQPDRLRDEELAELEDALRNLKCGSGARGGDGEVASAPLQPPVPSLSEVKPPPPPPPAQTFLFQGQPVVNRPLSLKDQQTFARSVGLKWRKVGRSLQRGCRALRDPALDSLAYEYEREGLYEQAFQLLRRFVQAEGRRATLQRLVEALEENELTSLAEDLLGLTDPNGGLA
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:03)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 1.0445 | |
| 2 | A | A | 0.3411 | |
| 3 | A | A | -0.3329 | |
| 4 | G | A | -1.2572 | |
| 5 | Q | A | -2.3410 | |
| 6 | N | A | -2.7058 | |
| 7 | G | A | -2.8152 | |
| 8 | H | A | -3.1865 | |
| 9 | E | A | -3.4418 | |
| 10 | E | A | -3.1365 | |
| 11 | W | A | -1.8696 | |
| 12 | V | A | -0.9935 | |
| 13 | G | A | 0.0000 | |
| 14 | S | A | 0.0000 | |
| 15 | A | A | 0.0000 | |
| 16 | Y | A | -0.1953 | |
| 17 | L | A | 0.0000 | |
| 18 | F | A | -0.3667 | |
| 19 | V | A | 0.0000 | |
| 20 | E | A | -0.9958 | |
| 21 | S | A | -0.9302 | |
| 22 | S | A | -0.8350 | |
| 23 | L | A | -0.7901 | |
| 24 | D | A | -2.1855 | |
| 25 | K | A | -2.1509 | |
| 26 | V | A | -1.1714 | |
| 27 | V | A | -1.1610 | |
| 28 | L | A | 0.0000 | |
| 29 | S | A | 0.0000 | |
| 30 | D | A | -2.4831 | |
| 31 | A | A | 0.0000 | |
| 32 | Y | A | 0.0000 | |
| 33 | A | A | -1.5712 | |
| 34 | H | A | -1.7535 | |
| 35 | P | A | -1.3287 | |
| 36 | Q | A | -1.7702 | |
| 37 | Q | A | -1.7601 | |
| 38 | K | A | -1.4620 | |
| 39 | V | A | -1.0584 | |
| 40 | A | A | -0.8963 | |
| 41 | V | A | 0.0000 | |
| 42 | Y | A | 0.0000 | |
| 43 | R | A | -1.5893 | |
| 44 | A | A | 0.0000 | |
| 45 | L | A | 0.0000 | |
| 46 | Q | A | -1.1903 | |
| 47 | A | A | -1.0376 | |
| 48 | A | A | 0.0000 | |
| 49 | L | A | 0.0000 | |
| 50 | A | A | -1.2590 | |
| 51 | E | A | -1.9048 | |
| 52 | S | A | -1.4958 | |
| 53 | G | A | 0.0000 | |
| 54 | G | A | -1.2794 | |
| 55 | S | A | -1.1739 | |
| 56 | P | A | -1.2784 | |
| 57 | D | A | -1.9118 | |
| 58 | V | A | -1.0738 | |
| 59 | L | A | 0.0000 | |
| 60 | Q | A | -1.1249 | |
| 61 | M | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | K | A | -1.0603 | |
| 64 | I | A | 0.0000 | |
| 65 | H | A | -1.2764 | |
| 66 | R | A | -2.6364 | |
| 67 | S | A | -2.1584 | |
| 68 | D | A | -2.7314 | |
| 69 | P | A | -2.0847 | |
| 70 | Q | A | -1.7710 | |
| 71 | L | A | 0.0000 | |
| 72 | I | A | -0.5088 | |
| 73 | V | A | 0.0000 | |
| 74 | Q | A | 0.0000 | |
| 75 | L | A | 0.0000 | |
| 76 | R | A | -0.9943 | |
| 77 | F | A | 0.0000 | |
| 78 | C | A | -1.0087 | |
| 79 | G | A | -1.7051 | |
| 80 | R | A | -2.5241 | |
| 81 | Q | A | -2.3314 | |
| 82 | P | A | -1.6664 | |
| 83 | C | A | 0.0000 | |
| 84 | G | A | 0.0000 | |
| 85 | R | A | -2.8406 | |
| 86 | F | A | 0.0000 | |
| 87 | L | A | 0.0000 | |
| 88 | R | A | -2.4698 | |
| 89 | A | A | -2.2936 | |
| 90 | Y | A | 0.0000 | |
| 91 | R | A | -2.9245 | |
| 92 | E | A | -2.8697 | |
| 93 | G | A | -1.9057 | |
| 94 | A | A | -1.5533 | |
| 95 | L | A | 0.0000 | |
| 96 | R | A | -2.0178 | |
| 97 | A | A | -1.2977 | |
| 98 | A | A | 0.0000 | |
| 99 | L | A | 0.0000 | |
| 100 | Q | A | -1.7772 | |
| 101 | R | A | -2.3989 | |
| 102 | S | A | -1.3444 | |
| 103 | L | A | 0.0000 | |
| 104 | A | A | 0.0000 | |
| 105 | A | A | -0.7991 | |
| 106 | A | A | -0.6242 | |
| 107 | L | A | -0.3034 | |
| 108 | A | A | -0.4567 | |
| 109 | Q | A | -1.3804 | |
| 110 | H | A | -1.6814 | |
| 111 | S | A | -1.2821 | |
| 112 | V | A | 0.0000 | |
| 113 | P | A | -0.7782 | |
| 114 | L | A | 0.0000 | |
| 115 | Q | A | -1.6502 | |
| 116 | L | A | 0.0000 | |
| 117 | E | A | -0.9663 | |
| 118 | L | A | 0.0000 | |
| 119 | R | A | -1.7541 | |
| 120 | A | A | 0.0000 | |
| 121 | G | A | -1.1402 | |
| 122 | A | A | -1.0897 | |
| 123 | E | A | -1.9805 | |
| 124 | R | A | -2.3609 | |
| 125 | L | A | 0.0000 | |
| 126 | D | A | -1.2828 | |
| 127 | A | A | -0.7622 | |
| 128 | L | A | -1.1919 | |
| 129 | L | A | -1.5293 | |
| 130 | A | A | -1.2024 | |
| 131 | D | A | -2.2401 | |
| 132 | E | A | -2.6813 | |
| 133 | E | A | -3.2696 | |
| 134 | R | A | -2.8419 | |
| 135 | C | A | 0.0000 | |
| 136 | L | A | 0.0000 | |
| 137 | S | A | -1.2274 | |
| 138 | C | A | -1.0938 | |
| 139 | I | A | 0.0000 | |
| 140 | L | A | -0.1346 | |
| 141 | A | A | -0.2066 | |
| 142 | Q | A | -1.1406 | |
| 143 | Q | A | -1.8329 | |
| 144 | P | A | -1.5573 | |
| 145 | D | A | -2.3762 | |
| 146 | R | A | -1.3853 | |
| 147 | L | A | 0.0876 | |
| 148 | R | A | -1.0621 | |
| 149 | D | A | -1.7227 | |
| 150 | E | A | -2.2720 | |
| 151 | E | A | -2.3247 | |
| 152 | L | A | 0.0000 | |
| 153 | A | A | -2.1248 | |
| 154 | E | A | -3.0849 | |
| 155 | L | A | 0.0000 | |
| 156 | E | A | -2.4226 | |
| 157 | D | A | -3.0946 | |
| 158 | A | A | -1.9887 | |
| 159 | L | A | 0.0000 | |
| 160 | R | A | -3.1669 | |
| 161 | N | A | -2.2520 | |
| 162 | L | A | -0.6879 | |
| 163 | K | A | -2.0569 | |
| 164 | C | A | -0.9253 | |
| 165 | G | A | -1.1546 | |
| 166 | S | A | -1.0662 | |
| 167 | G | A | -1.1834 | |
| 168 | A | A | -1.2828 | |
| 169 | R | A | -2.5615 | |
| 170 | G | A | -2.0271 | |
| 171 | G | A | -2.0832 | |
| 172 | D | A | -2.9775 | |
| 173 | G | A | -2.1265 | |
| 174 | E | A | -1.6319 | |
| 175 | V | A | 0.7793 | |
| 176 | A | A | 0.4462 | |
| 177 | S | A | 0.1433 | |
| 178 | A | A | 0.1478 | |
| 179 | P | A | 0.2097 | |
| 180 | L | A | 0.8129 | |
| 181 | Q | A | -0.6855 | |
| 182 | P | A | -0.3038 | |
| 183 | P | A | 0.1406 | |
| 184 | V | A | 1.4290 | |
| 185 | P | A | 0.7457 | |
| 186 | S | A | 0.7617 | |
| 187 | L | A | 1.0903 | |
| 188 | S | A | -0.1245 | |
| 189 | E | A | -1.1429 | |
| 190 | V | A | 0.0733 | |
| 191 | K | A | -1.5101 | |
| 192 | P | A | -0.8475 | |
| 193 | P | A | -0.7995 | |
| 194 | P | A | -0.8855 | |
| 195 | P | A | -0.6916 | |
| 196 | P | A | -0.6654 | |
| 197 | P | A | -1.0020 | |
| 198 | P | A | -1.5552 | |
| 199 | A | A | -0.6894 | |
| 200 | Q | A | -1.0121 | |
| 201 | T | A | 0.1012 | |
| 202 | F | A | 0.0000 | |
| 203 | L | A | 0.7453 | |
| 204 | F | A | 0.0000 | |
| 205 | Q | A | -1.5800 | |
| 206 | G | A | -1.1740 | |
| 207 | Q | A | -1.1972 | |
| 208 | P | A | -0.1738 | |
| 209 | V | A | 0.6997 | |
| 210 | V | A | 1.2851 | |
| 211 | N | A | -0.0346 | |
| 212 | R | A | -1.3070 | |
| 213 | P | A | -1.6126 | |
| 214 | L | A | 0.0000 | |
| 215 | S | A | -0.0884 | |
| 216 | L | A | 0.4094 | |
| 217 | K | A | -1.1644 | |
| 218 | D | A | 0.0000 | |
| 219 | Q | A | 0.0000 | |
| 220 | Q | A | -1.1008 | |
| 221 | T | A | -1.2314 | |
| 222 | F | A | 0.0000 | |
| 223 | A | A | 0.0000 | |
| 224 | R | A | -1.7883 | |
| 225 | S | A | -0.9958 | |
| 226 | V | A | 0.0000 | |
| 227 | G | A | 0.1446 | |
| 228 | L | A | 0.8635 | |
| 229 | K | A | -1.1713 | |
| 230 | W | A | 0.0000 | |
| 231 | R | A | -2.4844 | |
| 232 | K | A | -2.9977 | |
| 233 | V | A | 0.0000 | |
| 234 | G | A | 0.0000 | |
| 235 | R | A | -3.1731 | |
| 236 | S | A | 0.0000 | |
| 237 | L | A | 0.0000 | |
| 238 | Q | A | -3.0556 | |
| 239 | R | A | -2.9865 | |
| 240 | G | A | -2.2067 | |
| 241 | C | A | 0.0000 | |
| 242 | R | A | -3.1107 | |
| 243 | A | A | -1.7802 | |
| 244 | L | A | 0.0000 | |
| 245 | R | A | -3.8910 | |
| 246 | D | A | -3.4121 | |
| 247 | P | A | -2.2004 | |
| 248 | A | A | 0.0000 | |
| 249 | L | A | 0.0000 | |
| 250 | D | A | -2.0683 | |
| 251 | S | A | -1.2541 | |
| 252 | L | A | 0.0000 | |
| 253 | A | A | 0.0000 | |
| 254 | Y | A | -0.7594 | |
| 255 | E | A | -2.4402 | |
| 256 | Y | A | -2.2392 | |
| 257 | E | A | -3.1458 | |
| 258 | R | A | -3.6527 | |
| 259 | E | A | -3.3278 | |
| 260 | G | A | -1.6624 | |
| 261 | L | A | 0.0310 | |
| 262 | Y | A | 0.0164 | |
| 263 | E | A | -1.1319 | |
| 264 | Q | A | 0.0000 | |
| 265 | A | A | 0.0000 | |
| 266 | F | A | -0.1736 | |
| 267 | Q | A | -0.6036 | |
| 268 | L | A | 0.0000 | |
| 269 | L | A | 0.0000 | |
| 270 | R | A | -1.3019 | |
| 271 | R | A | -1.4013 | |
| 272 | F | A | 0.0000 | |
| 273 | V | A | -1.4682 | |
| 274 | Q | A | -1.8620 | |
| 275 | A | A | -1.6718 | |
| 276 | E | A | -2.2108 | |
| 277 | G | A | -2.4962 | |
| 278 | R | A | -3.1670 | |
| 279 | R | A | -3.2082 | |
| 280 | A | A | 0.0000 | |
| 281 | T | A | 0.0000 | |
| 282 | L | A | 0.0000 | |
| 283 | Q | A | -0.7417 | |
| 284 | R | A | -1.2640 | |
| 285 | L | A | 0.0000 | |
| 286 | V | A | 0.0000 | |
| 287 | E | A | -1.8734 | |
| 288 | A | A | 0.0000 | |
| 289 | L | A | 0.0000 | |
| 290 | E | A | -2.9494 | |
| 291 | E | A | -3.3248 | |
| 292 | N | A | -2.9128 | |
| 293 | E | A | -2.7386 | |
| 294 | L | A | -1.6902 | |
| 295 | T | A | -1.6148 | |
| 296 | S | A | -0.6779 | |
| 297 | L | A | 0.0000 | |
| 298 | A | A | 0.0000 | |
| 299 | E | A | -0.8381 | |
| 300 | D | A | -1.2075 | |
| 301 | L | A | 0.0000 | |
| 302 | L | A | 0.1598 | |
| 303 | G | A | -0.4857 | |
| 304 | L | A | 0.2913 | |
| 305 | T | A | -1.2292 | |
| 306 | D | A | -2.4904 | |
| 307 | P | A | -1.7731 | |
| 308 | N | A | -2.1319 | |
| 309 | G | A | -1.6713 | |
| 310 | G | A | -0.5290 | |
| 311 | L | A | 1.0576 | |
| 312 | A | A | 0.6090 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine