| Chain sequence(s) |
A: MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Mutated residues | RH175A |
| Energy difference between WT (input) and mutated protein (by FoldX) | 11.24 kcal/mol
CAUTION: Your mutation/s can destabilize the protein structure |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] FoldX: Building mutant model (00:07:26)
[INFO] FoldX: Starting FoldX energy minimalization (00:08:11)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:12:17)
[INFO] Main: Simulation completed successfully. (00:12:22)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | -0.2144 | |
| 2 | E | A | -2.3888 | |
| 3 | E | A | -2.8998 | |
| 4 | P | A | -2.3795 | |
| 5 | Q | A | -2.5080 | |
| 6 | S | A | -2.0007 | |
| 7 | D | A | -2.1312 | |
| 8 | P | A | -1.1781 | |
| 9 | S | A | -0.4564 | |
| 10 | V | A | 0.3705 | |
| 11 | E | A | -1.0179 | |
| 12 | P | A | -0.4547 | |
| 13 | P | A | -0.0068 | |
| 14 | L | A | 0.6566 | |
| 15 | S | A | -0.4874 | |
| 16 | Q | A | -1.5634 | |
| 17 | E | A | -2.1573 | |
| 18 | T | A | -0.7920 | |
| 19 | F | A | -0.0532 | |
| 20 | S | A | -0.8026 | |
| 21 | D | A | -1.1950 | |
| 22 | L | A | 0.7707 | |
| 23 | W | A | 1.2278 | |
| 24 | K | A | -0.5115 | |
| 25 | L | A | 1.3311 | |
| 26 | L | A | 1.1623 | |
| 27 | P | A | -0.5810 | |
| 28 | E | A | -2.1637 | |
| 29 | N | A | -1.9661 | |
| 30 | N | A | -1.0158 | |
| 31 | V | A | 1.1728 | |
| 32 | L | A | 1.7678 | |
| 33 | S | A | 0.9120 | |
| 34 | P | A | 0.6930 | |
| 35 | L | A | 1.0430 | |
| 36 | P | A | 0.1927 | |
| 37 | S | A | -0.3919 | |
| 38 | Q | A | -1.0949 | |
| 39 | A | A | -0.8669 | |
| 40 | M | A | -0.3315 | |
| 41 | D | A | -1.8151 | |
| 42 | D | A | -1.2498 | |
| 43 | L | A | 1.3857 | |
| 44 | M | A | 1.7613 | |
| 45 | L | A | 1.7088 | |
| 46 | S | A | 0.0764 | |
| 47 | P | A | -1.0196 | |
| 48 | D | A | -2.5330 | |
| 49 | D | A | -2.2347 | |
| 50 | I | A | -0.1506 | |
| 51 | E | A | -1.6403 | |
| 52 | Q | A | -0.9851 | |
| 53 | W | A | 1.0404 | |
| 54 | F | A | 1.4456 | |
| 55 | T | A | -0.4773 | |
| 56 | E | A | -2.2429 | |
| 57 | D | A | -2.7103 | |
| 58 | P | A | -1.7825 | |
| 59 | G | A | -1.4105 | |
| 60 | P | A | -1.7764 | |
| 61 | D | A | -2.8745 | |
| 62 | E | A | -2.7627 | |
| 63 | A | A | -1.6864 | |
| 64 | P | A | -1.2572 | |
| 65 | R | A | -1.5058 | |
| 66 | M | A | -0.3967 | |
| 67 | P | A | -0.9483 | |
| 68 | E | A | -1.6876 | |
| 69 | A | A | -0.8895 | |
| 70 | A | A | -0.2878 | |
| 71 | P | A | 0.0741 | |
| 72 | P | A | 0.4911 | |
| 73 | V | A | 1.5732 | |
| 74 | A | A | 0.6849 | |
| 75 | P | A | 0.1555 | |
| 76 | A | A | 0.0559 | |
| 77 | P | A | -0.2741 | |
| 78 | A | A | -0.1270 | |
| 79 | A | A | -0.1434 | |
| 80 | P | A | -0.3375 | |
| 81 | T | A | -0.2711 | |
| 82 | P | A | -0.3406 | |
| 83 | A | A | -0.1527 | |
| 84 | A | A | -0.1295 | |
| 85 | P | A | -0.2774 | |
| 86 | A | A | -0.1878 | |
| 87 | P | A | -0.3563 | |
| 88 | A | A | -0.1404 | |
| 89 | P | A | -0.1389 | |
| 90 | S | A | 0.2657 | |
| 91 | W | A | 1.0855 | |
| 92 | P | A | 0.9529 | |
| 93 | L | A | 1.5952 | |
| 94 | S | A | 0.0000 | |
| 95 | S | A | 0.0399 | |
| 96 | S | A | 0.0348 | |
| 97 | V | A | 0.1335 | |
| 98 | P | A | -0.3384 | |
| 99 | S | A | -1.0460 | |
| 100 | Q | A | -1.9351 | |
| 101 | K | A | -2.2583 | |
| 102 | T | A | -1.3402 | |
| 103 | Y | A | -0.6900 | |
| 104 | Q | A | -1.4525 | |
| 105 | G | A | -0.4515 | |
| 106 | S | A | -0.5602 | |
| 107 | Y | A | -0.7932 | |
| 108 | G | A | -1.1028 | |
| 109 | F | A | 0.0000 | |
| 110 | R | A | -1.0321 | |
| 111 | L | A | -0.2751 | |
| 112 | G | A | 0.1383 | |
| 113 | F | A | 0.5171 | |
| 114 | L | A | 0.8393 | |
| 115 | H | A | -0.4427 | |
| 116 | S | A | -0.2654 | |
| 117 | G | A | -0.7299 | |
| 118 | T | A | -1.3176 | |
| 119 | A | A | -1.3150 | |
| 120 | K | A | -2.1198 | |
| 121 | S | A | -1.0920 | |
| 122 | V | A | -0.6374 | |
| 123 | T | A | -0.3836 | |
| 124 | C | A | -0.0098 | |
| 125 | T | A | 0.0000 | |
| 126 | Y | A | -0.0117 | |
| 127 | S | A | 0.0000 | |
| 128 | P | A | -0.4960 | |
| 129 | A | A | -0.2668 | |
| 130 | L | A | -0.0959 | |
| 131 | N | A | -0.6711 | |
| 132 | K | A | 0.0000 | |
| 133 | M | A | 0.0000 | |
| 134 | F | A | 0.0000 | |
| 135 | C | A | 0.0000 | |
| 136 | Q | A | -0.3944 | |
| 137 | L | A | -0.0389 | |
| 138 | A | A | -0.4630 | |
| 139 | K | A | -0.9876 | |
| 140 | T | A | -0.7952 | |
| 141 | C | A | 0.0000 | |
| 142 | P | A | -0.2025 | |
| 143 | V | A | 0.0000 | |
| 144 | Q | A | -0.1807 | |
| 145 | L | A | 0.0000 | |
| 146 | W | A | -0.8056 | |
| 147 | V | A | -1.2006 | |
| 148 | D | A | -2.1457 | |
| 149 | S | A | -1.0149 | |
| 150 | T | A | -0.7280 | |
| 151 | P | A | 0.0000 | |
| 152 | P | A | -0.4419 | |
| 153 | P | A | -0.8172 | |
| 154 | G | A | -1.0119 | |
| 155 | T | A | 0.0000 | |
| 156 | R | A | -0.9565 | |
| 157 | V | A | 0.0000 | |
| 158 | R | A | -0.4459 | |
| 159 | A | A | 0.0000 | |
| 160 | M | A | 0.1007 | |
| 161 | A | A | -0.1046 | |
| 162 | I | A | 0.0000 | |
| 163 | Y | A | 0.0000 | |
| 164 | K | A | -2.1149 | |
| 165 | Q | A | -1.9298 | |
| 166 | S | A | -1.4336 | |
| 167 | Q | A | -1.7540 | |
| 168 | H | A | -1.1167 | |
| 169 | M | A | -0.5045 | |
| 170 | T | A | 0.0731 | |
| 171 | E | A | 0.2624 | |
| 172 | V | A | 0.0000 | |
| 173 | V | A | 0.0000 | |
| 174 | R | A | -0.5485 | |
| 175 | H | A | 0.0000 | mutated: RH175A |
| 176 | C | A | 0.0000 | |
| 177 | P | A | -1.3216 | |
| 178 | H | A | -1.7001 | |
| 179 | H | A | -1.8914 | |
| 180 | E | A | -2.3755 | |
| 181 | R | A | -2.6677 | |
| 182 | C | A | -1.4533 | |
| 183 | S | A | -1.7356 | |
| 184 | D | A | -2.6330 | |
| 185 | S | A | -2.1062 | |
| 186 | D | A | -2.2770 | |
| 187 | G | A | -1.2511 | |
| 188 | L | A | 0.1103 | |
| 189 | A | A | 0.0000 | |
| 190 | P | A | -0.5436 | |
| 191 | P | A | -1.4202 | |
| 192 | Q | A | -1.1420 | |
| 193 | H | A | 0.0000 | |
| 194 | L | A | 0.0000 | |
| 195 | I | A | 0.0000 | |
| 196 | R | A | 0.0000 | |
| 197 | V | A | -0.8734 | |
| 198 | E | A | -1.4928 | |
| 199 | G | A | -1.0784 | |
| 200 | N | A | -0.8068 | |
| 201 | L | A | 0.2499 | |
| 202 | R | A | -1.4888 | |
| 203 | V | A | 0.0000 | |
| 204 | E | A | -1.2502 | |
| 205 | Y | A | -0.6614 | |
| 206 | L | A | -0.8692 | |
| 207 | D | A | -2.4117 | |
| 208 | D | A | -2.6436 | |
| 209 | R | A | -3.0666 | |
| 210 | N | A | -2.5229 | |
| 211 | T | A | -1.2097 | |
| 212 | F | A | -0.7620 | |
| 213 | R | A | 0.0000 | |
| 214 | H | A | -0.8310 | |
| 215 | S | A | -0.4845 | |
| 216 | V | A | 0.0000 | |
| 217 | V | A | 0.0000 | |
| 218 | V | A | 0.0000 | |
| 219 | P | A | -1.3191 | |
| 220 | Y | A | -1.0348 | |
| 221 | E | A | -2.0620 | |
| 222 | P | A | -1.4573 | |
| 223 | P | A | -1.5711 | |
| 224 | E | A | -1.7444 | |
| 225 | V | A | 0.3326 | |
| 226 | G | A | -0.5431 | |
| 227 | S | A | -1.2529 | |
| 228 | D | A | -2.1559 | |
| 229 | C | A | -1.4256 | |
| 230 | T | A | 0.0000 | |
| 231 | T | A | -0.5785 | |
| 232 | I | A | 0.0000 | |
| 233 | H | A | -1.1092 | |
| 234 | Y | A | 0.0000 | |
| 235 | N | A | -0.6298 | |
| 236 | Y | A | 0.0000 | |
| 237 | M | A | -0.4362 | |
| 238 | C | A | 0.0000 | |
| 239 | N | A | -0.6323 | |
| 240 | S | A | -1.1742 | |
| 241 | S | A | -1.3276 | |
| 242 | C | A | 0.0000 | |
| 243 | M | A | -0.0057 | |
| 244 | G | A | -0.2822 | |
| 245 | G | A | 0.0000 | |
| 246 | M | A | 0.0000 | |
| 247 | N | A | -1.7789 | |
| 248 | R | A | -2.5014 | |
| 249 | R | A | -2.0544 | |
| 250 | P | A | -1.5871 | |
| 251 | I | A | 0.0000 | |
| 252 | L | A | -0.6975 | |
| 253 | T | A | 0.0000 | |
| 254 | I | A | 0.0000 | |
| 255 | I | A | 0.0000 | |
| 256 | T | A | 0.0000 | |
| 257 | L | A | 0.0000 | |
| 258 | E | A | 0.0000 | |
| 259 | D | A | -1.0596 | |
| 260 | S | A | -1.0445 | |
| 261 | S | A | -1.0049 | |
| 262 | G | A | -1.1752 | |
| 263 | N | A | -1.3230 | |
| 264 | L | A | -0.0767 | |
| 265 | L | A | -0.1147 | |
| 266 | G | A | 0.0000 | |
| 267 | R | A | -0.9053 | |
| 268 | N | A | -1.0754 | |
| 269 | S | A | -0.7765 | |
| 270 | F | A | 0.0000 | |
| 271 | E | A | -0.6351 | |
| 272 | V | A | 0.0000 | |
| 273 | R | A | -0.9987 | |
| 274 | V | A | 0.0000 | |
| 275 | C | A | 0.0000 | |
| 276 | A | A | -0.3716 | |
| 277 | C | A | -0.8730 | |
| 278 | P | A | 0.0000 | |
| 279 | G | A | 0.0000 | |
| 280 | R | A | -2.5386 | |
| 281 | D | A | 0.0000 | |
| 282 | R | A | -1.6206 | |
| 283 | R | A | -2.1032 | |
| 284 | T | A | -1.6085 | |
| 285 | E | A | -1.3181 | |
| 286 | E | A | -1.5835 | |
| 287 | E | A | -1.7004 | |
| 288 | N | A | -1.5391 | |
| 289 | L | A | -1.1919 | |
| 290 | R | A | -2.6680 | |
| 291 | K | A | -2.9079 | |
| 292 | K | A | -2.5122 | |
| 293 | G | A | -2.6003 | |
| 294 | E | A | -3.3085 | |
| 295 | P | A | -3.0265 | |
| 296 | H | A | -2.7918 | |
| 297 | H | A | -2.5067 | |
| 298 | E | A | -2.1429 | |
| 299 | L | A | 0.0513 | |
| 300 | P | A | -0.3748 | |
| 301 | P | A | -0.5506 | |
| 302 | G | A | -0.8341 | |
| 303 | S | A | -1.2002 | |
| 304 | T | A | -1.6173 | |
| 305 | K | A | -2.7841 | |
| 306 | R | A | -2.3945 | |
| 307 | A | A | -0.3943 | |
| 308 | L | A | 0.7867 | |
| 309 | P | A | -0.4300 | |
| 310 | N | A | -1.6885 | |
| 311 | N | A | -2.0300 | |
| 312 | T | A | -1.1900 | |
| 313 | S | A | -0.6684 | |
| 314 | S | A | -0.4986 | |
| 315 | S | A | -0.8315 | |
| 316 | P | A | -1.2614 | |
| 317 | Q | A | -2.1734 | |
| 318 | P | A | -2.5185 | |
| 319 | K | A | -3.5023 | |
| 320 | K | A | -3.4918 | |
| 321 | K | A | -3.1684 | |
| 322 | P | A | -2.1216 | |
| 323 | L | A | -1.2603 | |
| 324 | D | A | -2.8515 | |
| 325 | G | A | -2.0942 | |
| 326 | E | A | -1.2223 | |
| 327 | Y | A | 1.2263 | |
| 328 | F | A | 2.2701 | |
| 329 | T | A | 1.3828 | |
| 330 | L | A | 1.4896 | |
| 331 | Q | A | -0.4519 | |
| 332 | I | A | -1.2294 | |
| 333 | R | A | -2.7521 | |
| 334 | G | A | -3.0756 | |
| 335 | R | A | -3.4174 | |
| 336 | E | A | -3.4746 | |
| 337 | R | A | -3.0219 | |
| 338 | F | A | -1.4075 | |
| 339 | E | A | -1.6948 | |
| 340 | M | A | -1.1846 | |
| 341 | F | A | -0.4060 | |
| 342 | R | A | -1.6840 | |
| 343 | E | A | -1.9029 | |
| 344 | L | A | -0.4381 | |
| 345 | N | A | -1.8982 | |
| 346 | E | A | -2.3606 | |
| 347 | A | A | -1.1173 | |
| 348 | L | A | -0.8442 | |
| 349 | E | A | -2.0959 | |
| 350 | L | A | -0.7783 | |
| 351 | K | A | -2.4712 | |
| 352 | D | A | -3.0160 | |
| 353 | A | A | -2.2328 | |
| 354 | Q | A | -3.0225 | |
| 355 | A | A | -2.8216 | |
| 356 | G | A | -2.9304 | |
| 357 | K | A | -3.4952 | |
| 358 | E | A | -3.3607 | |
| 359 | P | A | -2.0330 | |
| 360 | G | A | -1.8570 | |
| 361 | G | A | -1.6528 | |
| 362 | S | A | -1.9053 | |
| 363 | R | A | -2.4010 | |
| 364 | A | A | -1.5379 | |
| 365 | H | A | -1.8045 | |
| 366 | S | A | -1.1096 | |
| 367 | S | A | -0.8929 | |
| 368 | H | A | -1.0494 | |
| 369 | L | A | -0.0833 | |
| 370 | K | A | -1.9714 | |
| 371 | S | A | -1.9446 | |
| 372 | K | A | -3.1002 | |
| 373 | K | A | -3.2300 | |
| 374 | G | A | -2.3660 | |
| 375 | Q | A | -2.1056 | |
| 376 | S | A | -0.9744 | |
| 377 | T | A | -0.9067 | |
| 378 | S | A | -1.3969 | |
| 379 | R | A | -2.8271 | |
| 380 | H | A | -3.2481 | |
| 381 | K | A | -2.9919 | |
| 382 | K | A | -1.5882 | |
| 383 | L | A | 1.1829 | |
| 384 | M | A | 1.7434 | |
| 385 | F | A | 1.6336 | |
| 386 | K | A | -0.8668 | |
| 387 | T | A | -1.2735 | |
| 388 | E | A | -2.3536 | |
| 389 | G | A | -2.0033 | |
| 390 | P | A | -1.8130 | |
| 391 | D | A | -2.5010 | |
| 392 | S | A | -2.0962 | |
| 393 | D | A | -2.2883 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine