| Chain sequence(s) |
A: GPLPLNPEPEIRSTSEYVTPTDLLYYAETDLLTRTGHPFADIVVDGKVLIPKVSAWQYRLFKLTLPDPNKLPLPSEDFVDPSTEILIWRLLAFKIGKFGPLGKGTVGHKNFNRLGNVDNPTTYVHEGADDTVDYSFRPKRLQEYVIGDLPPIGKYTDIAEPAPDLPPGAKPPLKTVHAIIEDGDNADIGFGAKDYAKLLPEKNDVPDLIKDTTTKRLDYEGMRAEPYGRRMFDYDRKESSYDKEKYVRDGPMLDPLPDDPPPSPLYVPPPASSPYAVRPSYDYFTIPDEGEITEADLLFNKPYFFEKAPGKNDFILWHNQLYVLILDNTRAEIETIRTRTSTPAPDVYDPSNYVTSLRYTEQYKLELIVQLCKIPLTPEILAELERLDPSILVDANLPFVPKVERPDPYAGKKFIEIDLTDKLSSDLSKSELGRLYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2116 | |
| 2 | P | A | 0.4554 | |
| 3 | L | A | 1.3669 | |
| 4 | P | A | 0.4706 | |
| 5 | L | A | 0.9080 | |
| 6 | N | A | -1.0545 | |
| 7 | P | A | -1.6601 | |
| 8 | E | A | -2.6829 | |
| 9 | P | A | -2.3010 | |
| 10 | E | A | -2.5448 | |
| 11 | I | A | -1.5987 | |
| 12 | R | A | -1.8917 | |
| 13 | S | A | -1.5942 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -1.6801 | |
| 16 | E | A | -2.2498 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.6148 | |
| 20 | P | A | -0.7203 | |
| 21 | T | A | -0.8881 | |
| 22 | D | A | -1.6072 | |
| 23 | L | A | -0.4457 | |
| 24 | L | A | -0.1458 | |
| 25 | Y | A | -0.1114 | |
| 26 | Y | A | -0.5022 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.3565 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.3798 | |
| 31 | L | A | 0.1771 | |
| 32 | L | A | 0.1227 | |
| 33 | T | A | -0.2545 | |
| 34 | R | A | -0.6335 | |
| 35 | T | A | -0.5346 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.3982 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.0600 | |
| 40 | A | A | -0.1158 | |
| 41 | D | A | 0.0469 | |
| 42 | I | A | 1.8421 | |
| 43 | V | A | 2.4446 | |
| 44 | V | A | 1.4371 | |
| 45 | D | A | -1.0501 | |
| 46 | G | A | -0.6064 | |
| 47 | K | A | -0.2661 | |
| 48 | V | A | 2.1203 | |
| 49 | L | A | 2.5274 | |
| 50 | I | A | 1.5657 | |
| 51 | P | A | 0.4148 | |
| 52 | K | A | -0.3255 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | Y | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | L | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | -1.0970 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.3440 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.2682 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.8477 | |
| 70 | K | A | -1.9861 | |
| 71 | L | A | -0.8347 | |
| 72 | P | A | -0.6124 | |
| 73 | L | A | -0.5202 | |
| 74 | P | A | -0.6023 | |
| 75 | S | A | -1.4945 | |
| 76 | E | A | -2.8054 | |
| 77 | D | A | -2.8431 | |
| 78 | F | A | -1.5052 | |
| 79 | V | A | 0.0000 | |
| 80 | D | A | -2.1932 | |
| 81 | P | A | -1.5428 | |
| 82 | S | A | -0.7025 | |
| 83 | T | A | -0.8557 | |
| 84 | E | A | -1.1129 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3786 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | 0.0000 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | -0.6084 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | 0.0000 | |
| 97 | K | A | 0.0000 | |
| 98 | F | A | 0.6766 | |
| 99 | G | A | -0.2459 | |
| 100 | P | A | -0.5513 | |
| 101 | L | A | -0.3561 | |
| 102 | G | A | -0.9726 | |
| 103 | K | A | -1.6111 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.6719 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | -1.2032 | |
| 108 | H | A | 0.0000 | |
| 109 | K | A | -2.9648 | |
| 110 | N | A | -2.6980 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | R | A | -1.0831 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | -0.6049 | |
| 116 | N | A | -1.1636 | |
| 117 | V | A | -0.6414 | |
| 118 | D | A | -2.2556 | |
| 119 | N | A | -2.0911 | |
| 120 | P | A | -0.9453 | |
| 121 | T | A | -0.5495 | |
| 122 | T | A | -0.0534 | |
| 123 | Y | A | 0.6993 | |
| 124 | V | A | 0.2574 | |
| 125 | H | A | -0.3624 | |
| 126 | E | A | -1.5357 | |
| 127 | G | A | -1.4904 | |
| 128 | A | A | -1.4259 | |
| 129 | D | A | -2.2941 | |
| 130 | D | A | -1.4800 | |
| 131 | T | A | -1.6025 | |
| 132 | V | A | -1.4564 | |
| 133 | D | A | -2.6205 | |
| 134 | Y | A | -1.3662 | |
| 135 | S | A | -0.8886 | |
| 136 | F | A | 0.0000 | |
| 137 | R | A | -0.7799 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | R | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | L | A | 0.1358 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | I | A | -0.0245 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.9218 | |
| 155 | Y | A | -0.8100 | |
| 156 | T | A | -0.3646 | |
| 157 | D | A | 0.0000 | |
| 158 | I | A | -0.4632 | |
| 159 | A | A | -0.6961 | |
| 160 | E | A | -1.8286 | |
| 161 | P | A | -1.2855 | |
| 162 | A | A | -0.9975 | |
| 163 | P | A | -1.2398 | |
| 164 | D | A | -1.7125 | |
| 165 | L | A | -0.8576 | |
| 166 | P | A | -0.9476 | |
| 167 | P | A | -0.9109 | |
| 168 | G | A | -0.7196 | |
| 169 | A | A | -0.8257 | |
| 170 | K | A | -1.5984 | |
| 171 | P | A | -0.9556 | |
| 172 | P | A | -0.4374 | |
| 173 | L | A | 0.2740 | |
| 174 | K | A | -0.7560 | |
| 175 | T | A | -0.5650 | |
| 176 | V | A | -0.5009 | |
| 177 | H | A | -1.1036 | |
| 178 | A | A | -0.3796 | |
| 179 | I | A | -0.2739 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.1736 | |
| 182 | D | A | -1.0152 | |
| 183 | G | A | -0.6795 | |
| 184 | D | A | -0.7591 | |
| 185 | N | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.4527 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.1320 | |
| 190 | F | A | -0.0579 | |
| 191 | G | A | -0.3420 | |
| 192 | A | A | -0.5956 | |
| 193 | K | A | -0.8276 | |
| 194 | D | A | 0.0000 | |
| 195 | Y | A | 0.0000 | |
| 196 | A | A | -1.7565 | |
| 197 | K | A | -1.9934 | |
| 198 | L | A | -0.7734 | |
| 199 | L | A | -1.1843 | |
| 200 | P | A | -1.6935 | |
| 201 | E | A | -2.1052 | |
| 202 | K | A | -2.3578 | |
| 203 | N | A | -1.7059 | |
| 204 | D | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.4407 | |
| 208 | L | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | K | A | -1.7730 | |
| 211 | D | A | -2.0260 | |
| 212 | T | A | -1.1489 | |
| 213 | T | A | -0.7601 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | R | A | -0.8210 | |
| 217 | L | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | Y | A | -1.4267 | |
| 220 | E | A | -2.5359 | |
| 221 | G | A | -1.8627 | |
| 222 | M | A | 0.0000 | |
| 223 | R | A | -2.7187 | |
| 224 | A | A | -1.6383 | |
| 225 | E | A | -1.4434 | |
| 226 | P | A | -1.0139 | |
| 227 | Y | A | -0.6952 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.4500 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.5368 | |
| 234 | Y | A | -0.1575 | |
| 235 | D | A | -0.9499 | |
| 236 | R | A | -1.3936 | |
| 237 | K | A | -1.5156 | |
| 238 | E | A | -1.1410 | |
| 239 | S | A | -0.6094 | |
| 240 | S | A | -0.4326 | |
| 241 | Y | A | -0.4857 | |
| 242 | D | A | -2.2717 | |
| 243 | K | A | -2.7989 | |
| 244 | E | A | -2.4711 | |
| 245 | K | A | -2.0997 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.5744 | |
| 249 | D | A | -1.2462 | |
| 250 | G | A | -0.7172 | |
| 251 | P | A | -0.3471 | |
| 252 | M | A | 0.3244 | |
| 253 | L | A | 0.3940 | |
| 254 | D | A | -1.3527 | |
| 255 | P | A | -1.0333 | |
| 256 | L | A | -0.4134 | |
| 257 | P | A | -0.6150 | |
| 258 | D | A | -0.2281 | |
| 259 | D | A | -1.6016 | |
| 260 | P | A | -1.2110 | |
| 261 | P | A | -0.4473 | |
| 262 | P | A | -0.1019 | |
| 263 | S | A | 0.2485 | |
| 264 | P | A | 0.7986 | |
| 265 | L | A | 1.6970 | |
| 266 | Y | A | 1.5313 | |
| 267 | V | A | 2.0254 | |
| 268 | P | A | 1.0948 | |
| 269 | P | A | 0.5648 | |
| 270 | P | A | -0.0044 | |
| 271 | A | A | 0.1738 | |
| 272 | S | A | 0.0008 | |
| 273 | S | A | 0.3411 | |
| 274 | P | A | 0.5726 | |
| 275 | Y | A | 1.4427 | |
| 276 | A | A | 0.9187 | |
| 277 | V | A | 1.3309 | |
| 278 | R | A | 0.0751 | |
| 279 | P | A | -0.1523 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | 0.3755 | |
| 282 | D | A | 0.1547 | |
| 283 | Y | A | 0.9603 | |
| 284 | F | A | 0.2137 | |
| 285 | T | A | -0.8616 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | 0.0000 | |
| 289 | E | A | 0.0000 | |
| 290 | G | A | -1.2061 | |
| 291 | E | A | -1.7072 | |
| 292 | I | A | -1.2386 | |
| 293 | T | A | -1.3544 | |
| 294 | E | A | -1.9023 | |
| 295 | A | A | -1.1379 | |
| 296 | D | A | -1.3138 | |
| 297 | L | A | -1.0438 | |
| 298 | L | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.0127 | |
| 301 | K | A | -0.9484 | |
| 302 | P | A | -0.4407 | |
| 303 | Y | A | 0.1263 | |
| 304 | F | A | 0.1179 | |
| 305 | F | A | 0.0000 | |
| 306 | E | A | -2.5314 | |
| 307 | K | A | -2.7970 | |
| 308 | A | A | 0.0000 | |
| 309 | P | A | -1.2297 | |
| 310 | G | A | -1.4114 | |
| 311 | K | A | -1.5828 | |
| 312 | N | A | 0.0000 | |
| 313 | D | A | 0.0000 | |
| 314 | F | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.4720 | |
| 319 | N | A | -0.5651 | |
| 320 | Q | A | -0.4821 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | L | A | 0.0000 | |
| 325 | I | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.3802 | |
| 333 | I | A | -1.3227 | |
| 334 | E | A | -1.5998 | |
| 335 | T | A | -0.6952 | |
| 336 | I | A | 0.2679 | |
| 337 | R | A | -1.3165 | |
| 338 | T | A | -1.0411 | |
| 339 | R | A | -2.0277 | |
| 340 | T | A | -0.9533 | |
| 341 | S | A | -0.8378 | |
| 342 | T | A | -0.6318 | |
| 343 | P | A | -0.7894 | |
| 344 | A | A | -0.5878 | |
| 345 | P | A | -0.5605 | |
| 346 | D | A | -0.8134 | |
| 347 | V | A | 1.2758 | |
| 348 | Y | A | 1.2563 | |
| 349 | D | A | -0.2390 | |
| 350 | P | A | -0.4162 | |
| 351 | S | A | -0.3924 | |
| 352 | N | A | -0.6011 | |
| 353 | Y | A | -0.3479 | |
| 354 | V | A | 0.8432 | |
| 355 | T | A | 0.2594 | |
| 356 | S | A | 0.1272 | |
| 357 | L | A | -0.1055 | |
| 358 | R | A | -0.5903 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.7998 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | 0.0129 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -0.5862 | |
| 365 | L | A | 0.0000 | |
| 366 | E | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.3521 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.4791 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.6681 | |
| 376 | L | A | -0.4361 | |
| 377 | T | A | -0.6872 | |
| 378 | P | A | -1.0231 | |
| 379 | E | A | -1.8310 | |
| 380 | I | A | 0.0000 | |
| 381 | L | A | -0.8517 | |
| 382 | A | A | -1.2309 | |
| 383 | E | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | E | A | -1.8334 | |
| 386 | R | A | -1.7998 | |
| 387 | L | A | -0.9573 | |
| 388 | D | A | -1.0676 | |
| 389 | P | A | -1.1411 | |
| 390 | S | A | -0.5993 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -0.7789 | |
| 394 | D | A | -1.5442 | |
| 395 | A | A | -1.3368 | |
| 396 | N | A | -1.4441 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.1692 | |
| 399 | F | A | 1.5002 | |
| 400 | V | A | 0.5497 | |
| 401 | P | A | -0.3250 | |
| 402 | K | A | -1.4311 | |
| 403 | V | A | -0.3017 | |
| 404 | E | A | -1.9197 | |
| 405 | R | A | -1.7597 | |
| 406 | P | A | -1.5330 | |
| 407 | D | A | -2.1778 | |
| 408 | P | A | -1.2121 | |
| 409 | Y | A | -1.0587 | |
| 410 | A | A | -1.2416 | |
| 411 | G | A | -1.4737 | |
| 412 | K | A | -2.0654 | |
| 413 | K | A | -2.4676 | |
| 414 | F | A | -1.3577 | |
| 415 | I | A | -0.9677 | |
| 416 | E | A | -2.1611 | |
| 417 | I | A | -1.6677 | |
| 418 | D | A | -2.6941 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.9073 | |
| 421 | D | A | -2.8264 | |
| 422 | K | A | -2.7363 | |
| 423 | L | A | -1.2033 | |
| 424 | S | A | -1.0907 | |
| 425 | S | A | -0.5312 | |
| 426 | D | A | -1.4195 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.6987 | |
| 429 | K | A | -2.6461 | |
| 430 | S | A | 0.0000 | |
| 431 | E | A | -2.1571 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.1010 | |
| 435 | L | A | -0.6176 | |
| 436 | Y | A | -0.2322 | |
| 437 | L | A | -0.0156 | |
| 438 | N | A | -1.4917 | |
| 439 | R | A | -1.9181 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine