Project name: 47cdad2b584c1c3

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSYISSSSSTIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARGGHGYFDLWGRGTLVTVSS; L: EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYHHSPLTFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:07)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:08)

• Minimal score value: -3.5783
• Maximal score value: 1.7275
• Average score: -0.5714
• Total score value: -128.5557

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.8818
2	V	H	-0.7961
3	Q	H	-1.1401
4	L	H	0.0000
5	V	H	0.0994
6	E	H	0.0000
7	S	H	-0.3910
8	G	H	-0.5599
9	G	H	0.2501
11	G	H	0.8367
12	L	H	1.4127
13	V	H	-0.0213
14	Q	H	-1.3110
15	P	H	-1.5709
16	G	H	-1.3897
17	G	H	-0.9572
18	S	H	-1.1095
19	L	H	-0.7019
20	R	H	-1.5206
21	L	H	0.0000
22	S	H	-0.3556
23	C	H	0.0000
24	A	H	-0.3653
25	A	H	0.0000
26	S	H	-0.7935
27	G	H	-1.0026
28	F	H	-0.3585
29	T	H	-0.1904
30	F	H	0.0000
35	S	H	-0.7033
36	S	H	-0.2086
37	Y	H	-0.0499
38	S	H	-0.1977
39	M	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.5899
45	A	H	-1.0106
46	P	H	-0.7884
47	G	H	-1.4574
48	K	H	-2.2725
49	G	H	-1.3664
50	L	H	0.0000
51	E	H	-0.8862
52	W	H	0.0000
53	V	H	0.0000
54	S	H	0.0000
55	Y	H	0.6279
56	I	H	0.0000
57	S	H	-0.0182
58	S	H	-0.4218
59	S	H	-0.4324
62	S	H	-0.3161
63	S	H	-0.1681
64	T	H	0.4472
65	I	H	1.3021
66	Y	H	1.0216
67	Y	H	-0.3210
68	A	H	0.0000
69	D	H	-2.4413
70	S	H	-1.8266
71	V	H	0.0000
72	K	H	-2.5316
74	G	H	-1.7822
75	R	H	-1.6858
76	F	H	0.0000
77	T	H	-0.5596
78	I	H	0.0000
79	S	H	-0.2255
80	R	H	-0.9203
81	D	H	-1.4265
82	N	H	-1.5818
83	A	H	-1.3411
84	K	H	-2.2578
85	N	H	-1.7497
86	S	H	-1.0635
87	L	H	0.0000
88	Y	H	-0.4124
89	L	H	0.0000
90	Q	H	-1.0351
91	M	H	0.0000
92	N	H	-1.2878
93	S	H	-1.2112
94	L	H	0.0000
95	R	H	-2.2420
96	A	H	-1.6849
97	E	H	-2.2146
98	D	H	0.0000
99	T	H	-0.3513
100	A	H	0.0000
101	V	H	0.7926
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.4130
107	G	H	0.0000
108	G	H	0.0000
109	H	H	-0.9386
113	G	H	0.0000
114	Y	H	-0.0583
115	F	H	0.0000
116	D	H	-0.7360
117	L	H	-0.3600
118	W	H	0.0000
119	G	H	0.0000
120	R	H	-2.0163
121	G	H	-0.6043
122	T	H	0.3725
123	L	H	1.7275
124	V	H	0.0000
125	T	H	0.3397
126	V	H	0.0000
127	S	H	-0.7348
128	S	H	-0.5581
1	E	L	-1.7694
2	I	L	0.0000
3	V	L	0.7078
4	L	L	0.0000
5	T	L	-0.6235
6	Q	L	0.0000
7	S	L	-0.8777
8	P	L	-0.5985
9	G	L	-0.8781
10	T	L	-0.6913
11	L	L	-0.1989
12	S	L	-0.1770
13	L	L	-0.5456
14	S	L	-1.0874
15	P	L	-1.5286
16	G	L	-2.3176
17	E	L	-3.0207
18	R	L	-3.3342
19	A	L	0.0000
20	T	L	-0.6732
21	L	L	0.0000
22	S	L	-0.8866
23	C	L	0.0000
24	R	L	-2.2876
25	A	L	0.0000
26	S	L	-1.0326
27	Q	L	-1.8253
28	S	L	-1.4875
29	V	L	0.0000
30	S	L	-0.5749
36	S	L	-0.2533
37	S	L	-0.2293
38	Y	L	0.2528
39	L	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.3163
46	P	L	-0.9850
47	G	L	-1.5001
48	Q	L	-2.1186
49	A	L	-1.4151
50	P	L	0.0000
51	R	L	-0.9911
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.1472
56	G	L	0.0083
57	A	L	0.0000
65	S	L	-0.4914
66	S	L	-0.5591
67	R	L	-1.2947
68	A	L	-0.7280
69	T	L	-0.6002
70	G	L	-0.8707
71	I	L	0.0000
72	P	L	-1.3122
74	D	L	-2.4035
75	R	L	-2.0211
76	F	L	0.0000
77	S	L	-0.8978
78	G	L	0.0000
79	S	L	-0.6218
80	G	L	-1.0062
83	S	L	-0.9574
84	G	L	-1.1412
85	T	L	-1.7027
86	D	L	-2.0141
87	F	L	0.0000
88	T	L	-0.7152
89	L	L	0.0000
90	T	L	-0.8325
91	I	L	0.0000
92	S	L	-2.5526
93	R	L	-3.5783
94	L	L	0.0000
95	E	L	-1.9572
96	P	L	-1.1053
97	E	L	-1.6711
98	D	L	0.0000
99	F	L	-0.1850
100	A	L	0.0000
101	V	L	-0.2094
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	0.0000
108	H	L	-0.7281
109	H	L	-1.4170
114	S	L	-0.8590
115	P	L	-0.9634
116	L	L	-0.1768
117	T	L	-0.1292
118	F	L	0.2278
119	G	L	0.0000
120	G	L	-0.6919
121	G	L	-0.8107
122	T	L	0.0000
123	K	L	-0.9494
124	V	L	0.0000
125	E	L	0.0164
126	I	L	0.9114
127	K	L	-0.8008