Project name: 48932e5a823282

Chain sequence(s)	H: EVQLQQSGPEVEKTGASVKISCKASGYSFTAYYIQWLKQSHGKSLEWIGYINCYNGGTGYNPKFRGKATFSVDSSSNTAYMHFNSLTSDDSAVYFCARSDYDTMDYWGQGTSVTVSS; L: DVLMTQTPLSLPVSLGGQASISCRSTQTILHSNGKTYLEWYFLRPGQSPKLLIYQVSNRFSGVPDRFSGSGSGTDFTLKISRVESEDLGLYYCFQGSHFPYTFGGGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:03:26)
[INFO]       Main:     Simulation completed successfully.                                          (00:03:27)

• Minimal score value: -2.7718
• Maximal score value: 1.5231
• Average score: -0.5843
• Total score value: -133.8104

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.1641
2	V	H	-1.3412
3	Q	H	-2.1677
4	L	H	0.0000
5	Q	H	-2.2511
6	Q	H	0.0000
7	S	H	-1.1984
8	G	H	-1.0141
9	P	H	-0.3924
10	E	H	-0.3219
11	V	H	0.7599
12	E	H	-0.8286
13	K	H	-1.9317
14	T	H	-1.6887
15	G	H	-1.2887
16	A	H	-0.9401
17	S	H	-1.2754
18	V	H	0.0000
19	K	H	-1.8854
20	I	H	0.0000
21	S	H	-0.8665
22	C	H	0.0000
23	K	H	-2.1133
24	A	H	0.0000
25	S	H	-1.5763
26	G	H	-1.3479
27	Y	H	-0.6269
28	S	H	-0.2331
29	F	H	0.0000
30	T	H	0.1908
31	A	H	0.3324
32	Y	H	0.4855
33	Y	H	0.2976
34	I	H	0.0000
35	Q	H	-0.0346
36	W	H	0.0000
37	L	H	0.0000
38	K	H	0.0000
39	Q	H	-0.8279
40	S	H	-1.3313
41	H	H	-1.5796
42	G	H	-1.4705
43	K	H	-1.9659
44	S	H	-1.3395
45	L	H	0.0000
46	E	H	-0.7764
47	W	H	0.0000
48	I	H	0.0000
49	G	H	0.0000
50	Y	H	0.1910
51	I	H	0.0000
52	N	H	-0.1502
53	C	H	0.0000
54	Y	H	0.5615
55	N	H	-0.8189
56	G	H	-0.6361
57	G	H	-0.5040
58	T	H	-0.3502
59	G	H	-0.1082
60	Y	H	0.0000
61	N	H	0.0000
62	P	H	-1.6434
63	K	H	-2.5273
64	F	H	0.0000
65	R	H	-2.7718
66	G	H	-1.8795
67	K	H	-1.6320
68	A	H	0.0000
69	T	H	-0.8011
70	F	H	0.0000
71	S	H	-0.0935
72	V	H	-0.2836
73	D	H	-0.8799
74	S	H	-0.7253
75	S	H	-0.6719
76	S	H	-0.8979
77	N	H	-1.1469
78	T	H	0.0000
79	A	H	0.0000
80	Y	H	-0.2973
81	M	H	0.0000
82	H	H	-1.0986
83	F	H	0.0000
84	N	H	-1.1438
85	S	H	-0.9762
86	L	H	0.0000
87	T	H	-1.4220
88	S	H	-1.5543
89	D	H	-1.9502
90	D	H	0.0000
91	S	H	-0.7489
92	A	H	-0.5258
93	V	H	-0.1048
94	Y	H	0.0000
95	F	H	0.0000
96	C	H	0.0000
97	A	H	0.0000
98	R	H	0.0000
99	S	H	0.0000
100	D	H	-0.3972
101	Y	H	0.4720
102	D	H	-0.7880
103	T	H	0.0000
104	M	H	0.0000
105	D	H	0.0000
106	Y	H	-0.0189
107	W	H	0.0000
108	G	H	0.0000
109	Q	H	-1.6571
110	G	H	-0.9086
111	T	H	0.0000
112	S	H	-0.1373
113	V	H	0.0000
114	T	H	-0.2518
115	V	H	0.0000
116	S	H	-0.8467
117	S	H	-1.0260
1	D	L	-1.0578
2	V	L	0.0299
3	L	L	0.6049
4	M	L	0.0000
5	T	L	-0.3780
6	Q	L	0.0000
7	T	L	-0.0675
8	P	L	0.4221
9	L	L	1.1957
10	S	L	0.2707
11	L	L	0.0127
12	P	L	-0.5154
13	V	L	0.0000
14	S	L	-0.5284
15	L	L	-0.2916
16	G	L	-1.1601
17	G	L	-1.3683
18	Q	L	-2.3010
19	A	L	0.0000
20	S	L	-1.1182
21	I	L	0.0000
22	S	L	-0.9191
23	C	L	0.0000
24	R	L	-2.2991
25	S	L	0.0000
26	T	L	-0.8987
27	Q	L	-1.4125
28	T	L	-0.7529
29	I	L	0.0000
30	L	L	0.0189
31	H	L	-0.8557
32	S	L	-1.1302
33	N	L	-1.8886
34	G	L	-1.5421
35	K	L	-1.7524
36	T	L	-0.6443
37	Y	L	-0.1658
38	L	L	0.0000
39	E	L	0.0000
40	W	L	0.0000
41	Y	L	0.0000
42	F	L	0.0000
43	L	L	0.0000
44	R	L	-1.7029
45	P	L	-1.3397
46	G	L	-1.5406
47	Q	L	-2.1515
48	S	L	-1.6189
49	P	L	0.0000
50	K	L	-1.2425
51	L	L	0.0000
52	L	L	0.0000
53	I	L	0.0000
54	Y	L	-0.2406
55	Q	L	-0.5663
56	V	L	-0.4688
57	S	L	-0.7476
58	N	L	-1.0415
59	R	L	-1.6153
60	F	L	-0.6403
61	S	L	-0.6151
62	G	L	-0.8991
63	V	L	0.0000
64	P	L	-1.3580
65	D	L	-2.2748
66	R	L	-2.3806
67	F	L	0.0000
68	S	L	-1.6001
69	G	L	0.0000
70	S	L	-0.9574
71	G	L	-1.0676
72	S	L	-0.8000
73	G	L	-0.7790
74	T	L	-1.4712
75	D	L	-2.1143
76	F	L	0.0000
77	T	L	-1.1732
78	L	L	0.0000
79	K	L	-2.3507
80	I	L	0.0000
81	S	L	-2.4303
82	R	L	-2.7023
83	V	L	0.0000
84	E	L	-2.1075
85	S	L	-1.1787
86	E	L	-2.1719
87	D	L	0.0000
88	L	L	-0.6282
89	G	L	-0.6813
90	L	L	-0.5686
91	Y	L	0.0000
92	Y	L	0.0000
93	C	L	0.0000
94	F	L	0.0000
95	Q	L	0.0000
96	G	L	0.3641
97	S	L	0.0000
98	H	L	0.4200
99	F	L	1.5231
100	P	L	0.5155
101	Y	L	0.6848
102	T	L	0.2447
103	F	L	0.0000
104	G	L	0.0000
105	G	L	-0.3010
106	G	L	0.0000
107	T	L	0.0000
108	K	L	-0.4879
109	L	L	0.0000
110	E	L	-0.3753
111	I	L	0.3085
112	K	L	-1.1240