| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFRDIVKNGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTIGHPLFNKFGDTENPTEYQHEGADDRVAFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRSGPVGHPLPDAPPPSPLYVPPPPTSPYAVRPPYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPAINVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9462 | |
| 2 | L | A | 1.9692 | |
| 3 | P | A | 0.6513 | |
| 4 | P | A | 0.3718 | |
| 5 | T | A | 0.1173 | |
| 6 | T | A | 0.1269 | |
| 7 | P | A | 0.1666 | |
| 8 | V | A | 1.2144 | |
| 9 | A | A | 0.0205 | |
| 10 | K | A | -1.1759 | |
| 11 | V | A | -0.4434 | |
| 12 | Q | A | -1.5545 | |
| 13 | S | A | -1.6137 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4153 | |
| 16 | E | A | -2.4386 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4572 | |
| 20 | P | A | 0.1085 | |
| 21 | T | A | 0.1181 | |
| 22 | S | A | -0.1684 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.0891 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2639 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8722 | |
| 31 | R | A | -2.6453 | |
| 32 | L | A | -0.7699 | |
| 33 | L | A | 1.2186 | |
| 34 | T | A | 1.4651 | |
| 35 | V | A | 1.9977 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2434 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6623 | |
| 40 | R | A | -1.7230 | |
| 41 | D | A | -0.8683 | |
| 42 | I | A | 0.6810 | |
| 43 | V | A | 0.8552 | |
| 44 | K | A | -1.2673 | |
| 45 | N | A | -1.9599 | |
| 46 | G | A | -1.2878 | |
| 47 | K | A | -0.9851 | |
| 48 | V | A | 1.4460 | |
| 49 | V | A | 2.0185 | |
| 50 | V | A | 1.2505 | |
| 51 | P | A | 0.4891 | |
| 52 | K | A | -0.6155 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1007 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4372 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2603 | |
| 70 | K | A | -1.8040 | |
| 71 | F | A | -0.6568 | |
| 72 | A | A | -0.5754 | |
| 73 | L | A | -0.8693 | |
| 74 | P | A | -1.2641 | |
| 75 | Q | A | -2.4822 | |
| 76 | K | A | -3.0970 | |
| 77 | D | A | -2.9910 | |
| 78 | F | A | -1.6480 | |
| 79 | Y | A | -1.9189 | |
| 80 | D | A | -2.7590 | |
| 81 | P | A | -2.3533 | |
| 82 | E | A | -3.0737 | |
| 83 | K | A | -3.4431 | |
| 84 | E | A | -2.5104 | |
| 85 | R | A | -1.3172 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6329 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9529 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3182 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7290 | |
| 99 | G | A | -0.5131 | |
| 100 | P | A | -0.3761 | |
| 101 | L | A | 0.0961 | |
| 102 | G | A | -0.2175 | |
| 103 | K | A | -0.6673 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4494 | |
| 106 | I | A | 0.0000 | |
| 107 | G | A | 0.1403 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4115 | |
| 110 | L | A | 0.2923 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1643 | |
| 113 | K | A | -0.3519 | |
| 114 | F | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.5407 | |
| 117 | T | A | -1.0216 | |
| 118 | E | A | -1.8278 | |
| 119 | N | A | -2.2301 | |
| 120 | P | A | -1.9671 | |
| 121 | T | A | -1.6495 | |
| 122 | E | A | -2.3283 | |
| 123 | Y | A | -1.0375 | |
| 124 | Q | A | -2.0587 | |
| 125 | H | A | -2.1837 | |
| 126 | E | A | -2.6639 | |
| 127 | G | A | -2.2277 | |
| 128 | A | A | -1.5299 | |
| 129 | D | A | -2.4101 | |
| 130 | D | A | -2.0566 | |
| 131 | R | A | -1.1549 | |
| 132 | V | A | 0.2176 | |
| 133 | A | A | 0.4366 | |
| 134 | F | A | 0.2677 | |
| 135 | S | A | -0.0735 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.6862 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5536 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2202 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1598 | |
| 157 | D | A | 0.3390 | |
| 158 | L | A | 0.8315 | |
| 159 | A | A | 0.1869 | |
| 160 | E | A | -1.4472 | |
| 161 | P | A | -0.2366 | |
| 162 | C | A | 0.1685 | |
| 163 | P | A | -0.1859 | |
| 164 | G | A | -0.0986 | |
| 165 | L | A | 0.5475 | |
| 166 | P | A | -0.1383 | |
| 167 | P | A | -0.3535 | |
| 168 | G | A | -0.4268 | |
| 169 | A | A | -0.0274 | |
| 170 | C | A | 0.6625 | |
| 171 | P | A | 0.5261 | |
| 172 | P | A | 0.7012 | |
| 173 | I | A | 2.0166 | |
| 174 | Q | A | 0.8742 | |
| 175 | L | A | 1.5151 | |
| 176 | V | A | 0.8614 | |
| 177 | N | A | -0.3071 | |
| 178 | S | A | 0.0388 | |
| 179 | V | A | 0.4362 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3717 | |
| 182 | D | A | 0.0773 | |
| 183 | G | A | -0.1654 | |
| 184 | D | A | -0.5617 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1365 | |
| 190 | F | A | 0.0520 | |
| 191 | G | A | -0.1120 | |
| 192 | N | A | -0.2750 | |
| 193 | M | A | -0.1311 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4191 | |
| 197 | E | A | -2.5991 | |
| 198 | L | A | -1.2190 | |
| 199 | Q | A | -2.5552 | |
| 200 | Q | A | -3.3451 | |
| 201 | D | A | -3.6103 | |
| 202 | R | A | -3.3513 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1385 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3976 | |
| 211 | S | A | -1.9310 | |
| 212 | T | A | -1.4682 | |
| 213 | R | A | -2.1440 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1747 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3280 | |
| 220 | L | A | 0.5291 | |
| 221 | K | A | -1.2499 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8748 | |
| 224 | N | A | -1.5582 | |
| 225 | E | A | -1.3128 | |
| 226 | A | A | -0.6808 | |
| 227 | Y | A | -0.4053 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6904 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0920 | |
| 234 | F | A | 0.2741 | |
| 235 | G | A | -0.8432 | |
| 236 | R | A | -2.6677 | |
| 237 | R | A | -3.0038 | |
| 238 | E | A | -2.1606 | |
| 239 | Q | A | -0.1617 | |
| 240 | V | A | 1.5260 | |
| 241 | Y | A | 1.2338 | |
| 242 | A | A | 0.1587 | |
| 243 | R | A | -1.2541 | |
| 244 | H | A | -1.0127 | |
| 245 | F | A | 0.0686 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.5402 | |
| 249 | S | A | -1.2404 | |
| 250 | G | A | -0.9315 | |
| 251 | P | A | -0.7107 | |
| 252 | V | A | -0.6626 | |
| 253 | G | A | -0.9241 | |
| 254 | H | A | -1.1572 | |
| 255 | P | A | -0.9478 | |
| 256 | L | A | -0.2572 | |
| 257 | P | A | -0.8675 | |
| 258 | D | A | -1.8959 | |
| 259 | A | A | -0.6081 | |
| 260 | P | A | -0.6792 | |
| 261 | P | A | -0.1981 | |
| 262 | P | A | 0.0674 | |
| 263 | S | A | 0.2784 | |
| 264 | P | A | 0.7041 | |
| 265 | L | A | 1.8591 | |
| 266 | Y | A | 1.5005 | |
| 267 | V | A | 1.9112 | |
| 268 | P | A | 0.6798 | |
| 269 | P | A | 0.5572 | |
| 270 | P | A | -0.0844 | |
| 271 | P | A | -0.0593 | |
| 272 | T | A | 0.0375 | |
| 273 | S | A | 0.3812 | |
| 274 | P | A | 0.4638 | |
| 275 | Y | A | 1.4775 | |
| 276 | A | A | 1.0146 | |
| 277 | V | A | 1.5509 | |
| 278 | R | A | 0.3220 | |
| 279 | P | A | -0.3629 | |
| 280 | P | A | 0.0000 | |
| 281 | Y | A | 0.0783 | |
| 282 | D | A | -0.2985 | |
| 283 | Y | A | 1.0895 | |
| 284 | F | A | 0.8200 | |
| 285 | G | A | 0.2264 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9358 | |
| 291 | L | A | 1.6192 | |
| 292 | V | A | 0.6320 | |
| 293 | S | A | -0.1523 | |
| 294 | S | A | -0.9562 | |
| 295 | D | A | -1.8444 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1448 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6325 | |
| 301 | R | A | -1.8640 | |
| 302 | P | A | -0.9586 | |
| 303 | F | A | -0.1540 | |
| 304 | W | A | -0.5168 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0797 | |
| 307 | R | A | -2.8312 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2587 | |
| 310 | G | A | -1.2244 | |
| 311 | N | A | -1.3176 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8444 | |
| 319 | N | A | -0.8568 | |
| 320 | E | A | -1.0317 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3227 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.1366 | |
| 333 | N | A | 0.4246 | |
| 334 | F | A | 1.4850 | |
| 335 | T | A | 0.7469 | |
| 336 | I | A | 0.4199 | |
| 337 | S | A | -0.8381 | |
| 338 | Q | A | -1.4795 | |
| 339 | Q | A | -0.8755 | |
| 340 | L | A | 0.8435 | |
| 341 | C | A | 0.5301 | |
| 342 | T | A | 0.2749 | |
| 343 | P | A | -0.1046 | |
| 344 | A | A | 0.2371 | |
| 345 | I | A | 0.7392 | |
| 346 | N | A | 0.0351 | |
| 347 | V | A | 1.7636 | |
| 348 | Y | A | 1.5990 | |
| 349 | D | A | 0.0832 | |
| 350 | P | A | -0.3424 | |
| 351 | S | A | -0.2774 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.5720 | |
| 354 | K | A | -1.6247 | |
| 355 | N | A | -1.6789 | |
| 356 | Y | A | -0.1004 | |
| 357 | L | A | 0.5588 | |
| 358 | R | A | 0.9009 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.4845 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0023 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9368 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6653 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2769 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3282 | |
| 376 | L | A | -1.7598 | |
| 377 | D | A | -2.0320 | |
| 378 | P | A | -1.0621 | |
| 379 | G | A | -1.0208 | |
| 380 | V | A | -0.9299 | |
| 381 | L | A | -0.5422 | |
| 382 | A | A | -0.6621 | |
| 383 | H | A | -0.8538 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3960 | |
| 386 | T | A | -0.5781 | |
| 387 | M | A | -0.3322 | |
| 388 | N | A | -0.8662 | |
| 389 | P | A | -1.2510 | |
| 390 | T | A | -1.4744 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4801 | |
| 393 | E | A | -2.8383 | |
| 394 | N | A | -2.4952 | |
| 395 | W | A | -1.4536 | |
| 396 | N | A | -1.3499 | |
| 397 | L | A | -0.2066 | |
| 398 | G | A | 0.5347 | |
| 399 | F | A | 2.4165 | |
| 400 | V | A | 1.8294 | |
| 401 | P | A | 0.0406 | |
| 402 | P | A | -1.8595 | |
| 403 | K | A | -3.4496 | |
| 404 | E | A | -3.7605 | |
| 405 | R | A | -3.9197 | |
| 406 | E | A | -3.7546 | |
| 407 | D | A | -2.8399 | |
| 408 | P | A | -1.7455 | |
| 409 | Y | A | -0.9841 | |
| 410 | K | A | -2.0893 | |
| 411 | G | A | -0.6399 | |
| 412 | L | A | 0.6654 | |
| 413 | I | A | 1.5876 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3801 | |
| 416 | E | A | -1.6335 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9139 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0391 | |
| 421 | E | A | -2.7617 | |
| 422 | R | A | -2.6012 | |
| 423 | F | A | -1.2756 | |
| 424 | S | A | -1.4416 | |
| 425 | Q | A | -1.8742 | |
| 426 | D | A | -2.8738 | |
| 427 | L | A | -1.9830 | |
| 428 | D | A | -2.7679 | |
| 429 | Q | A | -2.6013 | |
| 430 | F | A | -1.4412 | |
| 431 | A | A | -0.9094 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.6101 | |
| 435 | K | A | -0.7563 | |
| 436 | F | A | 0.1384 | |
| 437 | L | A | 1.0206 | |
| 438 | Y | A | 0.8140 | |
| 439 | Q | A | -0.2757 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine