| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFADIVVNGKVVVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTAPVHPGADDRVNFSFDPKQTQLFIVGCEPPTGEHWDLAAPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFFVRCGPDGVPLPSAPPPSPLYVPPPPTSPYAVPPPTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPADNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9462 | |
| 2 | L | A | 1.9710 | |
| 3 | P | A | 0.6533 | |
| 4 | P | A | 0.3610 | |
| 5 | T | A | 0.1147 | |
| 6 | T | A | 0.1321 | |
| 7 | P | A | 0.1835 | |
| 8 | V | A | 1.2138 | |
| 9 | A | A | 0.0410 | |
| 10 | K | A | -1.1376 | |
| 11 | V | A | -0.3766 | |
| 12 | Q | A | -1.4860 | |
| 13 | S | A | -1.5727 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.3849 | |
| 16 | E | A | -2.4165 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4645 | |
| 20 | P | A | 0.1114 | |
| 21 | T | A | 0.1150 | |
| 22 | S | A | -0.1687 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.0972 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.1799 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.7752 | |
| 31 | R | A | -2.6659 | |
| 32 | L | A | -0.8024 | |
| 33 | L | A | 1.1287 | |
| 34 | T | A | 1.3759 | |
| 35 | V | A | 1.9068 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | 0.2016 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | 0.2030 | |
| 40 | A | A | 0.0110 | |
| 41 | D | A | 0.0927 | |
| 42 | I | A | 1.8388 | |
| 43 | V | A | 2.6083 | |
| 44 | V | A | 1.9101 | |
| 45 | N | A | -0.3487 | |
| 46 | G | A | -0.2435 | |
| 47 | K | A | 0.0169 | |
| 48 | V | A | 2.3822 | |
| 49 | V | A | 2.8283 | |
| 50 | V | A | 1.9079 | |
| 51 | P | A | 0.7675 | |
| 52 | K | A | -0.0294 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1444 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4595 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2684 | |
| 70 | K | A | -1.8135 | |
| 71 | F | A | -0.6684 | |
| 72 | A | A | -0.5850 | |
| 73 | L | A | -0.8800 | |
| 74 | P | A | -1.2735 | |
| 75 | Q | A | -2.4788 | |
| 76 | K | A | -3.0945 | |
| 77 | D | A | -2.9900 | |
| 78 | F | A | -1.6529 | |
| 79 | Y | A | -1.9157 | |
| 80 | D | A | -2.7586 | |
| 81 | P | A | -2.3527 | |
| 82 | E | A | -3.0707 | |
| 83 | K | A | -3.4430 | |
| 84 | E | A | -2.5054 | |
| 85 | R | A | -1.3164 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6399 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9693 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3626 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.8088 | |
| 99 | G | A | -0.6258 | |
| 100 | P | A | -0.4380 | |
| 101 | L | A | -0.0031 | |
| 102 | G | A | -0.2446 | |
| 103 | K | A | -0.6861 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4499 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | -0.0873 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -0.1512 | |
| 110 | L | A | -0.0993 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.2784 | |
| 113 | K | A | -0.6867 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | -0.6758 | |
| 116 | D | A | -1.3132 | |
| 117 | T | A | -1.1411 | |
| 118 | E | A | -2.5970 | |
| 119 | N | A | -2.3567 | |
| 120 | P | A | -1.4293 | |
| 121 | T | A | -0.6845 | |
| 122 | A | A | -0.2409 | |
| 123 | P | A | 0.1341 | |
| 124 | V | A | 0.2754 | |
| 125 | H | A | -0.5391 | |
| 126 | P | A | -1.1332 | |
| 127 | G | A | -1.4265 | |
| 128 | A | A | -1.2733 | |
| 129 | D | A | -2.2797 | |
| 130 | D | A | -1.8695 | |
| 131 | R | A | -1.4710 | |
| 132 | V | A | -0.4986 | |
| 133 | N | A | -0.8794 | |
| 134 | F | A | -0.3476 | |
| 135 | S | A | -0.3500 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.7061 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | -0.2329 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5532 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2379 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1368 | |
| 157 | D | A | 0.5295 | |
| 158 | L | A | 1.2729 | |
| 159 | A | A | 1.0792 | |
| 160 | A | A | 0.3927 | |
| 161 | P | A | 0.5823 | |
| 162 | C | A | 0.5607 | |
| 163 | P | A | 0.0356 | |
| 164 | G | A | -0.1062 | |
| 165 | L | A | 0.5379 | |
| 166 | P | A | -0.1338 | |
| 167 | P | A | -0.3500 | |
| 168 | G | A | -0.4272 | |
| 169 | A | A | 0.2877 | |
| 170 | C | A | 1.0048 | |
| 171 | P | A | 0.7800 | |
| 172 | P | A | 1.0777 | |
| 173 | I | A | 2.2767 | |
| 174 | Q | A | 1.1072 | |
| 175 | L | A | 1.4695 | |
| 176 | V | A | 0.8403 | |
| 177 | N | A | -0.3173 | |
| 178 | S | A | 0.0368 | |
| 179 | V | A | 0.4412 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3746 | |
| 182 | D | A | 0.0773 | |
| 183 | G | A | -0.1652 | |
| 184 | D | A | -0.5745 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1365 | |
| 190 | F | A | 0.0539 | |
| 191 | G | A | -0.1077 | |
| 192 | N | A | -0.2922 | |
| 193 | M | A | -0.1532 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4535 | |
| 197 | E | A | -2.6503 | |
| 198 | L | A | -1.2360 | |
| 199 | Q | A | -2.5608 | |
| 200 | Q | A | -3.3455 | |
| 201 | D | A | -3.5881 | |
| 202 | R | A | -3.3435 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.4850 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3815 | |
| 211 | S | A | -1.7217 | |
| 212 | T | A | -1.4846 | |
| 213 | R | A | -2.2001 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1817 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.2997 | |
| 220 | L | A | 0.5150 | |
| 221 | K | A | -1.2809 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9624 | |
| 224 | N | A | -1.6937 | |
| 225 | E | A | -1.3277 | |
| 226 | A | A | -0.6691 | |
| 227 | Y | A | -0.4542 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.7057 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1418 | |
| 234 | F | A | 0.0265 | |
| 235 | G | A | -0.9600 | |
| 236 | R | A | -2.7666 | |
| 237 | R | A | -3.1382 | |
| 238 | E | A | -2.2733 | |
| 239 | Q | A | -0.2162 | |
| 240 | V | A | 1.5267 | |
| 241 | Y | A | 1.2357 | |
| 242 | A | A | 0.1448 | |
| 243 | R | A | -1.3779 | |
| 244 | H | A | -1.2159 | |
| 245 | F | A | -0.2061 | |
| 246 | F | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.7530 | |
| 249 | C | A | -1.0978 | |
| 250 | G | A | -0.9767 | |
| 251 | P | A | -0.5904 | |
| 252 | D | A | -0.4016 | |
| 253 | G | A | 0.0619 | |
| 254 | V | A | 1.3017 | |
| 255 | P | A | 0.4639 | |
| 256 | L | A | 0.7478 | |
| 257 | P | A | 0.3434 | |
| 258 | S | A | -0.1243 | |
| 259 | A | A | 0.1806 | |
| 260 | P | A | -0.3553 | |
| 261 | P | A | -0.1914 | |
| 262 | P | A | 0.0919 | |
| 263 | S | A | 0.5572 | |
| 264 | P | A | 0.7075 | |
| 265 | L | A | 1.9182 | |
| 266 | Y | A | 1.8159 | |
| 267 | V | A | 1.9713 | |
| 268 | P | A | 1.0482 | |
| 269 | P | A | 0.5579 | |
| 270 | P | A | -0.1746 | |
| 271 | P | A | -0.1049 | |
| 272 | T | A | -0.2323 | |
| 273 | S | A | 0.1527 | |
| 274 | P | A | 0.3016 | |
| 275 | Y | A | 1.0924 | |
| 276 | A | A | 0.9427 | |
| 277 | V | A | 1.7567 | |
| 278 | P | A | 0.8555 | |
| 279 | P | A | 0.1331 | |
| 280 | P | A | -0.3196 | |
| 281 | T | A | -0.1805 | |
| 282 | D | A | -0.6956 | |
| 283 | Y | A | 0.7965 | |
| 284 | F | A | 0.6850 | |
| 285 | G | A | 0.1290 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9214 | |
| 291 | L | A | 1.6288 | |
| 292 | V | A | 0.6439 | |
| 293 | S | A | -0.1511 | |
| 294 | S | A | -0.9711 | |
| 295 | D | A | -1.8393 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1669 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6526 | |
| 301 | R | A | -1.8772 | |
| 302 | P | A | -0.9666 | |
| 303 | F | A | -0.1792 | |
| 304 | W | A | -0.5161 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0822 | |
| 307 | R | A | -2.9211 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.7817 | |
| 310 | G | A | -1.4250 | |
| 311 | N | A | -1.3838 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8702 | |
| 319 | N | A | -0.8795 | |
| 320 | E | A | -1.0518 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.4009 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.2056 | |
| 333 | N | A | 0.3447 | |
| 334 | F | A | 1.3758 | |
| 335 | T | A | 0.7273 | |
| 336 | I | A | 0.4173 | |
| 337 | S | A | -0.9642 | |
| 338 | Q | A | -1.7135 | |
| 339 | Q | A | -1.2786 | |
| 340 | L | A | 0.6879 | |
| 341 | C | A | 0.5410 | |
| 342 | T | A | 0.1207 | |
| 343 | P | A | -0.0838 | |
| 344 | A | A | -0.6295 | |
| 345 | D | A | -1.6576 | |
| 346 | N | A | -1.0557 | |
| 347 | V | A | 0.9944 | |
| 348 | Y | A | 1.2334 | |
| 349 | D | A | 0.1488 | |
| 350 | P | A | -0.3572 | |
| 351 | S | A | -0.2872 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.7241 | |
| 354 | K | A | -1.7485 | |
| 355 | N | A | -1.7380 | |
| 356 | Y | A | -0.1039 | |
| 357 | L | A | 0.5525 | |
| 358 | R | A | 0.8322 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.1937 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.2033 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9860 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6885 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2801 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3250 | |
| 376 | L | A | -1.7577 | |
| 377 | D | A | -2.0318 | |
| 378 | P | A | -1.0605 | |
| 379 | G | A | -1.0218 | |
| 380 | V | A | -0.9308 | |
| 381 | L | A | -0.5450 | |
| 382 | A | A | -0.6647 | |
| 383 | H | A | -0.8464 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4165 | |
| 386 | T | A | -0.5819 | |
| 387 | M | A | -0.3351 | |
| 388 | N | A | -0.8727 | |
| 389 | P | A | -1.2656 | |
| 390 | T | A | -1.4847 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4879 | |
| 393 | E | A | -2.8441 | |
| 394 | N | A | -2.7020 | |
| 395 | W | A | -1.4450 | |
| 396 | N | A | -1.2945 | |
| 397 | L | A | -0.2009 | |
| 398 | G | A | 0.5624 | |
| 399 | F | A | 2.4291 | |
| 400 | V | A | 1.8533 | |
| 401 | P | A | 0.0679 | |
| 402 | P | A | -1.7890 | |
| 403 | K | A | -3.4506 | |
| 404 | E | A | -3.8598 | |
| 405 | R | A | -3.9311 | |
| 406 | E | A | -3.7512 | |
| 407 | D | A | -2.8295 | |
| 408 | P | A | -1.7399 | |
| 409 | Y | A | -0.9786 | |
| 410 | K | A | -2.0892 | |
| 411 | G | A | -0.6344 | |
| 412 | L | A | 0.6679 | |
| 413 | I | A | 1.5821 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3958 | |
| 416 | E | A | -1.6738 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.8470 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8802 | |
| 421 | E | A | -2.4776 | |
| 422 | R | A | -2.0354 | |
| 423 | F | A | -1.0070 | |
| 424 | S | A | -1.3180 | |
| 425 | Q | A | -1.8622 | |
| 426 | D | A | -2.9143 | |
| 427 | L | A | -2.0304 | |
| 428 | D | A | -2.8441 | |
| 429 | Q | A | -2.6419 | |
| 430 | F | A | -1.4714 | |
| 431 | A | A | -0.9281 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.6570 | |
| 435 | K | A | -0.7729 | |
| 436 | F | A | 0.1238 | |
| 437 | L | A | 1.0079 | |
| 438 | Y | A | 0.8044 | |
| 439 | Q | A | -0.2834 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine