Project name: huEgA1

Chain sequence(s)	A: EVQLVESGGGLVQPGGSLKLSCAASGRTFSSYAMGWFRQAPGKGRELVAAIRWSGGYAYYTDSVKGRFTISRDNAKRMVYLQMNSLRAEDTAVYYCAATYLSSDYSRYALPQRPLDYDYWGQGTQVTVSS
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:50)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:51)

• Minimal score value: -2.7358
• Maximal score value: 1.2197
• Average score: -0.7432
• Total score value: -96.6128

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	A	-2.4859
2	V	A	0.0000
3	Q	A	-1.3593
4	L	A	0.0000
5	V	A	1.2197
6	E	A	0.0000
7	S	A	-0.4914
8	G	A	-1.0994
9	G	A	-0.8415
10	G	A	-0.1060
11	L	A	0.9164
12	V	A	0.0000
13	Q	A	-1.4007
14	P	A	-1.6004
15	G	A	-1.4012
16	G	A	-0.9696
17	S	A	-1.2860
18	L	A	-1.0182
19	K	A	-1.9995
20	L	A	0.0000
21	S	A	-0.2673
22	C	A	0.0000
23	A	A	-0.1001
24	A	A	0.0000
25	S	A	-1.3865
26	G	A	-2.1175
27	R	A	-2.4344
28	T	A	-1.2393
29	F	A	0.0000
30	S	A	-0.7702
31	S	A	-0.1081
32	Y	A	0.0000
33	A	A	0.0000
34	M	A	0.0000
35	G	A	0.0000
36	W	A	0.0000
37	F	A	0.0000
38	R	A	0.0000
39	Q	A	-1.8170
40	A	A	-1.7666
41	P	A	-1.2073
42	G	A	-1.6502
43	K	A	-2.7358
44	G	A	-2.3336
45	R	A	-2.6311
46	E	A	-2.7311
47	L	A	0.0000
48	V	A	0.0000
49	A	A	0.0000
50	A	A	0.0000
51	I	A	0.0000
52	R	A	0.0000
53	W	A	-0.0528
54	S	A	-0.5213
55	G	A	-0.6300
56	G	A	-0.5532
57	Y	A	0.0737
58	A	A	0.4356
59	Y	A	0.1703
60	Y	A	-0.8001
61	T	A	-1.4691
62	D	A	-2.4453
63	S	A	-1.7617
64	V	A	0.0000
65	K	A	-2.5688
66	G	A	-1.7525
67	R	A	-1.5381
68	F	A	0.0000
69	T	A	-0.7858
70	I	A	0.0000
71	S	A	-0.3693
72	R	A	-0.9604
73	D	A	-1.5636
74	N	A	-1.7790
75	A	A	-1.4957
76	K	A	-2.4377
77	R	A	-2.3499
78	M	A	-0.9755
79	V	A	0.0000
80	Y	A	-0.3453
81	L	A	0.0000
82	Q	A	-1.2664
83	M	A	0.0000
84	N	A	-1.3999
85	S	A	-1.1807
86	L	A	0.0000
87	R	A	-2.2093
88	A	A	-1.6959
89	E	A	-2.2130
90	D	A	0.0000
91	T	A	-0.8975
92	A	A	0.0000
93	V	A	-0.6467
94	Y	A	0.0000
95	Y	A	-0.3116
96	C	A	0.0000
97	A	A	0.0000
98	A	A	0.0000
99	T	A	0.0000
100	Y	A	0.9077
101	L	A	0.0000
102	S	A	-0.3680
103	S	A	-1.1672
104	D	A	-2.0536
105	Y	A	-0.8271
106	S	A	-0.9366
107	R	A	-1.5068
108	Y	A	0.5161
109	A	A	0.1621
110	L	A	0.0000
111	P	A	-0.6720
112	Q	A	-1.7396
113	R	A	-2.2894
114	P	A	-1.2950
115	L	A	0.2787
116	D	A	-0.6593
117	Y	A	0.0000
118	D	A	-1.1997
119	Y	A	-0.9174
120	W	A	-0.2738
121	G	A	-0.1206
122	Q	A	-0.8765
123	G	A	-0.5360
124	T	A	-0.7382
125	Q	A	-1.0837
126	V	A	0.0000
127	T	A	-0.3741
128	V	A	0.0000
129	S	A	-0.7513
130	S	A	-0.5759