| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVINGKVLVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTAPVHEAADVRVAFSFDPKQTQLFIVGCEPPTGEHWDLADPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYRRAGPDGHPLPDAPPPSPLYVRPPPSSPFAVLPSTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPEPNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9419 | |
| 2 | L | A | 1.9608 | |
| 3 | P | A | 0.8344 | |
| 4 | P | A | 0.3837 | |
| 5 | T | A | 0.1291 | |
| 6 | T | A | 0.1298 | |
| 7 | P | A | 0.1902 | |
| 8 | V | A | 1.2102 | |
| 9 | A | A | 0.0831 | |
| 10 | K | A | -1.0336 | |
| 11 | V | A | -0.1869 | |
| 12 | Q | A | -1.4203 | |
| 13 | S | A | -1.5589 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4095 | |
| 16 | E | A | -2.4361 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4630 | |
| 20 | P | A | 0.1309 | |
| 21 | T | A | 0.1618 | |
| 22 | S | A | -0.0938 | |
| 23 | L | A | 0.1004 | |
| 24 | F | A | -0.0264 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2815 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8953 | |
| 31 | R | A | -2.6833 | |
| 32 | L | A | -0.7973 | |
| 33 | L | A | 1.1611 | |
| 34 | T | A | 1.3694 | |
| 35 | V | A | 1.8273 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2638 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6372 | |
| 40 | K | A | -1.6940 | |
| 41 | D | A | -0.7204 | |
| 42 | I | A | 1.2976 | |
| 43 | V | A | 2.3689 | |
| 44 | I | A | 2.0715 | |
| 45 | N | A | -0.3219 | |
| 46 | G | A | -0.2313 | |
| 47 | K | A | -0.0040 | |
| 48 | V | A | 2.1095 | |
| 49 | L | A | 2.5902 | |
| 50 | V | A | 1.4658 | |
| 51 | P | A | 0.3058 | |
| 52 | K | A | -0.6991 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1471 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3887 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2625 | |
| 70 | K | A | -1.7831 | |
| 71 | F | A | -0.6285 | |
| 72 | A | A | -0.5772 | |
| 73 | L | A | -0.8652 | |
| 74 | P | A | -1.2704 | |
| 75 | Q | A | -2.5064 | |
| 76 | K | A | -3.1051 | |
| 77 | D | A | -2.9874 | |
| 78 | F | A | -1.6598 | |
| 79 | Y | A | -1.8905 | |
| 80 | D | A | -2.6933 | |
| 81 | P | A | -2.3073 | |
| 82 | E | A | -3.0516 | |
| 83 | K | A | -3.3999 | |
| 84 | E | A | -2.4658 | |
| 85 | R | A | -1.2932 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6781 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9578 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3517 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6918 | |
| 99 | G | A | -0.5354 | |
| 100 | P | A | -0.4026 | |
| 101 | L | A | 0.0480 | |
| 102 | G | A | -0.1889 | |
| 103 | K | A | -0.5359 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.3453 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1770 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4276 | |
| 110 | L | A | 0.4046 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -0.9872 | |
| 113 | K | A | -0.5277 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.2694 | |
| 117 | T | A | -0.8834 | |
| 118 | E | A | -1.8375 | |
| 119 | N | A | -2.0157 | |
| 120 | P | A | -1.3272 | |
| 121 | T | A | -0.6478 | |
| 122 | A | A | -0.2822 | |
| 123 | P | A | -0.0065 | |
| 124 | V | A | -0.3259 | |
| 125 | H | A | -1.3093 | |
| 126 | E | A | -2.3834 | |
| 127 | A | A | -1.5197 | |
| 128 | A | A | -1.2202 | |
| 129 | D | A | -2.0272 | |
| 130 | V | A | -1.3358 | |
| 131 | R | A | -0.7086 | |
| 132 | V | A | 0.4102 | |
| 133 | A | A | 0.4466 | |
| 134 | F | A | 0.2781 | |
| 135 | S | A | -0.0281 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | 0.0000 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5582 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.1945 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1521 | |
| 157 | D | A | 0.3205 | |
| 158 | L | A | 0.7970 | |
| 159 | A | A | 0.1854 | |
| 160 | D | A | -1.4478 | |
| 161 | P | A | -0.2474 | |
| 162 | C | A | 0.1706 | |
| 163 | P | A | -0.1853 | |
| 164 | G | A | -0.0831 | |
| 165 | L | A | 0.5813 | |
| 166 | P | A | -0.1148 | |
| 167 | P | A | -0.3399 | |
| 168 | G | A | -0.4465 | |
| 169 | A | A | -0.0194 | |
| 170 | C | A | 0.6562 | |
| 171 | P | A | 0.5205 | |
| 172 | P | A | 0.8531 | |
| 173 | I | A | 2.0191 | |
| 174 | Q | A | 0.8825 | |
| 175 | L | A | 1.5068 | |
| 176 | V | A | 0.8763 | |
| 177 | N | A | -0.2769 | |
| 178 | S | A | 0.0335 | |
| 179 | V | A | 0.4294 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3827 | |
| 182 | D | A | 0.0784 | |
| 183 | G | A | -0.1604 | |
| 184 | D | A | -0.5502 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1336 | |
| 190 | F | A | 0.0673 | |
| 191 | G | A | -0.0992 | |
| 192 | N | A | -0.2676 | |
| 193 | M | A | -0.1343 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4335 | |
| 197 | E | A | -2.6642 | |
| 198 | L | A | -1.2608 | |
| 199 | Q | A | -2.5737 | |
| 200 | Q | A | -3.3151 | |
| 201 | D | A | -3.5637 | |
| 202 | R | A | -3.3282 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2202 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3516 | |
| 211 | S | A | -1.8990 | |
| 212 | T | A | -1.4548 | |
| 213 | R | A | -2.1425 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1661 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3568 | |
| 220 | L | A | 0.6277 | |
| 221 | K | A | -1.0673 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.7983 | |
| 224 | N | A | -1.4742 | |
| 225 | E | A | -1.2125 | |
| 226 | A | A | -0.6001 | |
| 227 | Y | A | -0.3685 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6455 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0735 | |
| 234 | F | A | 0.2526 | |
| 235 | G | A | -0.8121 | |
| 236 | R | A | -2.5747 | |
| 237 | R | A | -2.8038 | |
| 238 | E | A | -2.0744 | |
| 239 | Q | A | -0.1667 | |
| 240 | V | A | 1.4244 | |
| 241 | Y | A | 1.1236 | |
| 242 | A | A | 0.2659 | |
| 243 | R | A | -0.7988 | |
| 244 | H | A | -0.9125 | |
| 245 | F | A | 0.0324 | |
| 246 | Y | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.5320 | |
| 249 | A | A | -1.3810 | |
| 250 | G | A | -1.0796 | |
| 251 | P | A | -1.1927 | |
| 252 | D | A | -1.2838 | |
| 253 | G | A | -1.2659 | |
| 254 | H | A | -1.4357 | |
| 255 | P | A | -1.1654 | |
| 256 | L | A | -0.1763 | |
| 257 | P | A | -0.8440 | |
| 258 | D | A | -1.9289 | |
| 259 | A | A | -0.8932 | |
| 260 | P | A | -0.9929 | |
| 261 | P | A | -0.5831 | |
| 262 | P | A | -0.1937 | |
| 263 | S | A | -0.0212 | |
| 264 | P | A | 0.7066 | |
| 265 | L | A | 1.4919 | |
| 266 | Y | A | 1.0808 | |
| 267 | V | A | 1.0485 | |
| 268 | R | A | -0.9244 | |
| 269 | P | A | 0.0321 | |
| 270 | P | A | -0.4574 | |
| 271 | P | A | -0.2689 | |
| 272 | S | A | -0.2185 | |
| 273 | S | A | 0.2663 | |
| 274 | P | A | 0.8036 | |
| 275 | F | A | 1.9320 | |
| 276 | A | A | 1.2511 | |
| 277 | V | A | 2.3866 | |
| 278 | L | A | 1.3850 | |
| 279 | P | A | 0.3615 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.3476 | |
| 282 | D | A | -0.7415 | |
| 283 | Y | A | 0.9433 | |
| 284 | F | A | 0.7276 | |
| 285 | G | A | 0.2643 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9732 | |
| 291 | L | A | 1.6271 | |
| 292 | V | A | 0.6463 | |
| 293 | S | A | -0.1560 | |
| 294 | S | A | -0.9583 | |
| 295 | D | A | -1.8418 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.0978 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6216 | |
| 301 | R | A | -1.8330 | |
| 302 | P | A | -0.9382 | |
| 303 | F | A | -0.1914 | |
| 304 | W | A | -0.5649 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0871 | |
| 307 | R | A | -2.8343 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2638 | |
| 310 | G | A | -1.2231 | |
| 311 | N | A | -1.2750 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8250 | |
| 319 | N | A | -0.9336 | |
| 320 | E | A | -1.0371 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3266 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0504 | |
| 333 | N | A | 0.5757 | |
| 334 | F | A | 1.7500 | |
| 335 | T | A | 0.8693 | |
| 336 | I | A | 0.4627 | |
| 337 | S | A | -0.7777 | |
| 338 | Q | A | -1.3893 | |
| 339 | Q | A | -1.0064 | |
| 340 | L | A | 0.6213 | |
| 341 | C | A | -0.0392 | |
| 342 | T | A | -0.4515 | |
| 343 | P | A | -1.1904 | |
| 344 | E | A | -1.7444 | |
| 345 | P | A | -0.7407 | |
| 346 | N | A | -0.7591 | |
| 347 | V | A | 1.2925 | |
| 348 | Y | A | 1.2373 | |
| 349 | D | A | 0.0469 | |
| 350 | P | A | -0.3189 | |
| 351 | S | A | -0.2463 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.4854 | |
| 354 | K | A | -1.5954 | |
| 355 | N | A | -1.6650 | |
| 356 | Y | A | -0.0861 | |
| 357 | L | A | 0.6382 | |
| 358 | R | A | 0.9656 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3930 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0752 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0409 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6852 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3044 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3150 | |
| 376 | L | A | -1.7122 | |
| 377 | D | A | -1.9895 | |
| 378 | P | A | -1.0376 | |
| 379 | G | A | -1.0147 | |
| 380 | V | A | -0.9360 | |
| 381 | L | A | -0.5367 | |
| 382 | A | A | -0.6596 | |
| 383 | H | A | -0.8146 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4263 | |
| 386 | T | A | -0.5582 | |
| 387 | M | A | -0.3037 | |
| 388 | N | A | -0.8666 | |
| 389 | P | A | -1.2553 | |
| 390 | T | A | -1.4468 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4373 | |
| 393 | E | A | -2.7622 | |
| 394 | N | A | -2.3806 | |
| 395 | W | A | -1.3500 | |
| 396 | N | A | -1.0513 | |
| 397 | L | A | -0.1577 | |
| 398 | G | A | 0.5473 | |
| 399 | F | A | 2.4253 | |
| 400 | V | A | 1.8476 | |
| 401 | P | A | 0.0578 | |
| 402 | P | A | -1.8518 | |
| 403 | K | A | -3.3223 | |
| 404 | E | A | -3.7853 | |
| 405 | R | A | -3.9351 | |
| 406 | E | A | -3.8044 | |
| 407 | D | A | -2.8836 | |
| 408 | P | A | -1.7713 | |
| 409 | Y | A | -0.9929 | |
| 410 | K | A | -2.1268 | |
| 411 | G | A | -0.6407 | |
| 412 | L | A | 0.6701 | |
| 413 | I | A | 1.5826 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.4014 | |
| 416 | E | A | -1.7027 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9473 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0399 | |
| 421 | E | A | -2.7668 | |
| 422 | R | A | -2.6037 | |
| 423 | F | A | -1.2616 | |
| 424 | S | A | -1.4530 | |
| 425 | Q | A | -1.8597 | |
| 426 | D | A | -2.8825 | |
| 427 | L | A | -1.9646 | |
| 428 | D | A | -2.7400 | |
| 429 | Q | A | -2.6006 | |
| 430 | F | A | -1.4053 | |
| 431 | A | A | -0.8775 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5294 | |
| 435 | K | A | -0.6782 | |
| 436 | F | A | 0.1556 | |
| 437 | L | A | 1.0444 | |
| 438 | Y | A | 0.8408 | |
| 439 | Q | A | -0.2661 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine