| Chain sequence(s) |
A: ETHVTGGSAGRTTAGLVGLLTPGAKQNIQLINTNGSWHINSTALNCNESLNTGWLAGLFYQHKFNSSGCPERLASCRRLTDFAQGWGPISYANGSGLDERPYCWHYPPRPCGIVPAKSVCGPVYCFTPSPVVVGTTDRSGAPTYSWGANDTDVFVLNNTRPPLGNWFGCTWMNSTGFTKVCGAPPCVIGGVGNNTLLCPTDCFRKHPEATYSRCGSGPWITPRCMVDYPYRLWHYPCTINYTIFKVRMYVGGVEHRLEAACNWTRGERCDLEDRDRSELSPLLLSTTQWQVLPCSFTTLPALSTGLIHLHQNIVDVQYLYGVGSSIASWAIKWEYVVLLFLLLADARVCSCLWMMLLISQAEA
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:05:49)
[INFO] Main: Simulation completed successfully. (00:05:55)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | E | A | -1.8989 | |
| 2 | T | A | -0.9618 | |
| 3 | H | A | -0.7410 | |
| 4 | V | A | 0.8002 | |
| 5 | T | A | 0.1318 | |
| 6 | G | A | -0.5246 | |
| 7 | G | A | -0.7295 | |
| 8 | S | A | -0.9079 | |
| 9 | A | A | -1.0250 | |
| 10 | G | A | -1.5733 | |
| 11 | R | A | -2.1191 | |
| 12 | T | A | -1.2576 | |
| 13 | T | A | -0.4566 | |
| 14 | A | A | -0.3080 | |
| 15 | G | A | -0.3698 | |
| 16 | L | A | 0.7194 | |
| 17 | V | A | 1.5425 | |
| 18 | G | A | 0.6530 | |
| 19 | L | A | 1.2456 | |
| 20 | L | A | 1.1839 | |
| 21 | T | A | 0.4527 | |
| 22 | P | A | -0.9003 | |
| 23 | G | A | -1.4703 | |
| 24 | A | A | -1.5294 | |
| 25 | K | A | -2.6599 | |
| 26 | Q | A | -2.6852 | |
| 27 | N | A | -2.2777 | |
| 28 | I | A | -0.5943 | |
| 29 | Q | A | -0.9844 | |
| 30 | L | A | 0.1726 | |
| 31 | I | A | 0.7456 | |
| 32 | N | A | -0.6040 | |
| 33 | T | A | -0.3510 | |
| 34 | N | A | -0.8369 | |
| 35 | G | A | -1.0733 | |
| 36 | S | A | -0.7335 | |
| 37 | W | A | -0.5937 | |
| 38 | H | A | -0.6094 | |
| 39 | I | A | 0.3008 | |
| 40 | N | A | 0.4250 | |
| 41 | S | A | 0.0000 | |
| 42 | T | A | 0.0000 | |
| 43 | A | A | 0.0000 | |
| 44 | L | A | -0.2381 | |
| 45 | N | A | -1.0253 | |
| 46 | C | A | -0.8659 | |
| 47 | N | A | -1.2423 | |
| 48 | E | A | -0.9427 | |
| 49 | S | A | -0.3539 | |
| 50 | L | A | 0.4904 | |
| 51 | N | A | -0.9443 | |
| 52 | T | A | -0.4404 | |
| 53 | G | A | -0.7646 | |
| 54 | W | A | 0.2072 | |
| 55 | L | A | -0.1758 | |
| 56 | A | A | -0.0548 | |
| 57 | G | A | -0.2595 | |
| 58 | L | A | 0.0000 | |
| 59 | F | A | 0.4097 | |
| 60 | Y | A | 0.0371 | |
| 61 | Q | A | -0.5628 | |
| 62 | H | A | -1.5483 | |
| 63 | K | A | -2.0572 | |
| 64 | F | A | -0.9187 | |
| 65 | N | A | -1.6236 | |
| 66 | S | A | -0.9081 | |
| 67 | S | A | -1.0641 | |
| 68 | G | A | -1.4264 | |
| 69 | C | A | 0.0000 | |
| 70 | P | A | -1.6081 | |
| 71 | E | A | -2.7095 | |
| 72 | R | A | -2.6482 | |
| 73 | L | A | -1.2293 | |
| 74 | A | A | -1.3477 | |
| 75 | S | A | -1.3373 | |
| 76 | C | A | -1.2185 | |
| 77 | R | A | -1.6242 | |
| 78 | R | A | -2.3909 | |
| 79 | L | A | 0.0000 | |
| 80 | T | A | -1.6650 | |
| 81 | D | A | -1.4938 | |
| 82 | F | A | -1.3641 | |
| 83 | A | A | -0.8400 | |
| 84 | Q | A | -1.1062 | |
| 85 | G | A | 0.0000 | |
| 86 | W | A | 0.9346 | |
| 87 | G | A | 0.2059 | |
| 88 | P | A | -0.1160 | |
| 89 | I | A | 0.1793 | |
| 90 | S | A | 0.5577 | |
| 91 | Y | A | 0.7793 | |
| 92 | A | A | -0.2832 | |
| 93 | N | A | -1.5874 | |
| 94 | G | A | 0.0000 | |
| 95 | S | A | -0.9672 | |
| 96 | G | A | 0.0000 | |
| 97 | L | A | -1.3456 | |
| 98 | D | A | -2.4159 | |
| 99 | E | A | -2.7294 | |
| 100 | R | A | -2.4708 | |
| 101 | P | A | -0.9802 | |
| 102 | Y | A | -0.7286 | |
| 103 | C | A | 0.0000 | |
| 104 | W | A | 0.0000 | |
| 105 | H | A | -0.5045 | |
| 106 | Y | A | -0.6290 | |
| 107 | P | A | -0.6382 | |
| 108 | P | A | 0.0000 | |
| 109 | R | A | -2.2924 | |
| 110 | P | A | -1.6890 | |
| 111 | C | A | 0.0000 | |
| 112 | G | A | -0.3660 | |
| 113 | I | A | 0.6027 | |
| 114 | V | A | 0.2291 | |
| 115 | P | A | -0.8497 | |
| 116 | A | A | 0.0000 | |
| 117 | K | A | -1.8905 | |
| 118 | S | A | -0.8634 | |
| 119 | V | A | 0.0000 | |
| 120 | C | A | 0.0000 | |
| 121 | G | A | 0.0000 | |
| 122 | P | A | 0.0000 | |
| 123 | V | A | 0.0000 | |
| 124 | Y | A | 0.0000 | |
| 125 | C | A | 0.0000 | |
| 126 | F | A | 0.0000 | |
| 127 | T | A | -0.0781 | |
| 128 | P | A | 0.0000 | |
| 129 | S | A | -0.6540 | |
| 130 | P | A | 0.0744 | |
| 131 | V | A | 0.6395 | |
| 132 | V | A | 0.4103 | |
| 133 | V | A | 0.5020 | |
| 134 | G | A | 0.3010 | |
| 135 | T | A | 0.0000 | |
| 136 | T | A | -0.6867 | |
| 137 | D | A | -2.0121 | |
| 138 | R | A | -2.0819 | |
| 139 | S | A | -1.3689 | |
| 140 | G | A | -1.0736 | |
| 141 | A | A | -0.8102 | |
| 142 | P | A | -0.4863 | |
| 143 | T | A | 0.0956 | |
| 144 | Y | A | 1.0623 | |
| 145 | S | A | 0.4977 | |
| 146 | W | A | 0.4104 | |
| 147 | G | A | 0.0000 | |
| 148 | A | A | -1.0553 | |
| 149 | N | A | -2.2275 | |
| 150 | D | A | -2.7521 | |
| 151 | T | A | -2.0660 | |
| 152 | D | A | 0.0000 | |
| 153 | V | A | 0.0000 | |
| 154 | F | A | 0.0000 | |
| 155 | V | A | 0.0021 | |
| 156 | L | A | 0.0000 | |
| 157 | N | A | -1.1353 | |
| 158 | N | A | -0.8198 | |
| 159 | T | A | -0.3143 | |
| 160 | R | A | 0.0000 | |
| 161 | P | A | 0.0000 | |
| 162 | P | A | 0.4846 | |
| 163 | L | A | 1.1551 | |
| 164 | G | A | 0.0734 | |
| 165 | N | A | -0.5784 | |
| 166 | W | A | -0.2040 | |
| 167 | F | A | 0.0000 | |
| 168 | G | A | 0.0000 | |
| 169 | C | A | 0.0000 | |
| 170 | T | A | 0.0000 | |
| 171 | W | A | 0.0000 | |
| 172 | M | A | 0.0000 | |
| 173 | N | A | -0.0653 | |
| 174 | S | A | -0.5132 | |
| 175 | T | A | 0.1186 | |
| 176 | G | A | 0.6355 | |
| 177 | F | A | 1.2491 | |
| 178 | T | A | 0.1032 | |
| 179 | K | A | -0.5467 | |
| 180 | V | A | -0.4439 | |
| 181 | C | A | 0.0000 | |
| 182 | G | A | 0.0000 | |
| 183 | A | A | 0.0000 | |
| 184 | P | A | -0.7057 | |
| 185 | P | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | V | A | 0.7747 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.3423 | |
| 190 | G | A | 0.0023 | |
| 191 | V | A | 0.8530 | |
| 192 | G | A | -0.6429 | |
| 193 | N | A | -1.6819 | |
| 194 | N | A | -1.7067 | |
| 195 | T | A | -0.8205 | |
| 196 | L | A | 0.0000 | |
| 197 | L | A | 0.2748 | |
| 198 | C | A | 0.0000 | |
| 199 | P | A | 0.0000 | |
| 200 | T | A | 0.0000 | |
| 201 | D | A | 0.0000 | |
| 202 | C | A | 0.0000 | |
| 203 | F | A | -0.8586 | |
| 204 | R | A | -1.4762 | |
| 205 | K | A | -0.9667 | |
| 206 | H | A | 0.0000 | |
| 207 | P | A | -1.0101 | |
| 208 | E | A | -1.9581 | |
| 209 | A | A | 0.0000 | |
| 210 | T | A | 0.0000 | |
| 211 | Y | A | 0.0000 | |
| 212 | S | A | -0.8614 | |
| 213 | R | A | -1.1865 | |
| 214 | C | A | 0.0000 | |
| 215 | G | A | 0.0000 | |
| 216 | S | A | 0.0000 | |
| 217 | G | A | 0.0000 | |
| 218 | P | A | 0.0000 | |
| 219 | W | A | 0.0000 | |
| 220 | I | A | 0.0000 | |
| 221 | T | A | 0.0000 | |
| 222 | P | A | 0.0000 | |
| 223 | R | A | -0.8448 | |
| 224 | C | A | 0.0000 | |
| 225 | M | A | 0.0000 | |
| 226 | V | A | 0.0000 | |
| 227 | D | A | -0.6583 | |
| 228 | Y | A | 0.0000 | |
| 229 | P | A | -0.0016 | |
| 230 | Y | A | 0.0000 | |
| 231 | R | A | 0.0000 | |
| 232 | L | A | 0.1226 | |
| 233 | W | A | 0.0000 | |
| 234 | H | A | 0.0000 | |
| 235 | Y | A | 0.0000 | |
| 236 | P | A | -0.0373 | |
| 237 | C | A | -0.2485 | |
| 238 | T | A | 0.0000 | |
| 239 | I | A | -0.0494 | |
| 240 | N | A | -0.9291 | |
| 241 | Y | A | -0.3688 | |
| 242 | T | A | -0.1316 | |
| 243 | I | A | 0.4087 | |
| 244 | F | A | -0.1428 | |
| 245 | K | A | -1.3933 | |
| 246 | V | A | 0.0000 | |
| 247 | R | A | -1.4280 | |
| 248 | M | A | 0.0000 | |
| 249 | Y | A | 0.5638 | |
| 250 | V | A | 0.0000 | |
| 251 | G | A | 0.1628 | |
| 252 | G | A | 0.2776 | |
| 253 | V | A | 1.1547 | |
| 254 | E | A | -0.2319 | |
| 255 | H | A | -0.9499 | |
| 256 | R | A | -2.3945 | |
| 257 | L | A | 0.0000 | |
| 258 | E | A | -1.9812 | |
| 259 | A | A | 0.0000 | |
| 260 | A | A | 0.0000 | |
| 261 | C | A | 0.0000 | |
| 262 | N | A | -0.9412 | |
| 263 | W | A | 0.0000 | |
| 264 | T | A | -1.9844 | |
| 265 | R | A | -2.7149 | |
| 266 | G | A | -2.5623 | |
| 267 | E | A | -3.0281 | |
| 268 | R | A | -3.2033 | |
| 269 | C | A | -2.1990 | |
| 270 | D | A | -2.0790 | |
| 271 | L | A | -0.5835 | |
| 272 | E | A | -1.8434 | |
| 273 | D | A | -1.9921 | |
| 274 | R | A | -1.2724 | |
| 275 | D | A | 0.0000 | |
| 276 | R | A | -1.0587 | |
| 277 | S | A | 0.0000 | |
| 278 | E | A | -0.9225 | |
| 279 | L | A | 0.0000 | |
| 280 | S | A | -0.3066 | |
| 281 | P | A | 0.0000 | |
| 282 | L | A | 0.0000 | |
| 283 | L | A | 1.5546 | |
| 284 | L | A | 1.5991 | |
| 285 | S | A | 0.6025 | |
| 286 | T | A | 0.3077 | |
| 287 | T | A | 0.0103 | |
| 288 | Q | A | -0.2312 | |
| 289 | W | A | 0.5371 | |
| 290 | Q | A | 0.2618 | |
| 291 | V | A | 0.1787 | |
| 292 | L | A | 0.0000 | |
| 293 | P | A | 0.0000 | |
| 294 | C | A | 0.0000 | |
| 295 | S | A | 0.0000 | |
| 296 | F | A | -0.3287 | |
| 297 | T | A | 0.0000 | |
| 298 | T | A | -0.2535 | |
| 299 | L | A | 0.0000 | |
| 300 | P | A | 0.9841 | |
| 301 | A | A | 1.6611 | |
| 302 | L | A | 1.9524 | |
| 303 | S | A | 0.8582 | |
| 304 | T | A | 0.5969 | |
| 305 | G | A | 0.4656 | |
| 306 | L | A | 1.1794 | |
| 307 | I | A | 0.3195 | |
| 308 | H | A | -0.7351 | |
| 309 | L | A | -0.6791 | |
| 310 | H | A | -1.6581 | |
| 311 | Q | A | -2.2001 | |
| 312 | N | A | -2.3991 | |
| 313 | I | A | 0.0000 | |
| 314 | V | A | -0.6527 | |
| 315 | D | A | -1.0881 | |
| 316 | V | A | -0.1979 | |
| 317 | Q | A | -0.1832 | |
| 318 | Y | A | 1.1241 | |
| 319 | L | A | 1.9192 | |
| 320 | Y | A | 2.1473 | |
| 321 | G | A | 1.6345 | |
| 322 | V | A | 2.3481 | |
| 323 | G | A | 1.1462 | |
| 324 | S | A | 0.6449 | |
| 325 | S | A | 1.0229 | |
| 326 | I | A | 2.7142 | |
| 327 | A | A | 1.9435 | |
| 328 | S | A | 1.6107 | |
| 329 | W | A | 2.1819 | |
| 330 | A | A | 2.2405 | |
| 331 | I | A | 2.7332 | |
| 332 | K | A | 1.1924 | |
| 333 | W | A | 1.7813 | |
| 334 | E | A | 1.0115 | |
| 335 | Y | A | 2.4558 | |
| 336 | V | A | 2.5731 | |
| 337 | V | A | 2.3498 | |
| 338 | L | A | 2.9628 | |
| 339 | L | A | 3.4770 | |
| 340 | F | A | 3.7376 | |
| 341 | L | A | 2.6186 | |
| 342 | L | A | 2.7753 | |
| 343 | L | A | 2.6311 | |
| 344 | A | A | 0.9842 | |
| 345 | D | A | -0.5797 | |
| 346 | A | A | 0.0574 | |
| 347 | R | A | -0.4525 | |
| 348 | V | A | 1.6410 | |
| 349 | C | A | 1.6345 | |
| 350 | S | A | 0.0000 | |
| 351 | C | A | 2.4748 | |
| 352 | L | A | 2.9801 | |
| 353 | W | A | 2.3968 | |
| 354 | M | A | 2.2727 | |
| 355 | M | A | 2.5963 | |
| 356 | L | A | 1.8979 | |
| 357 | L | A | 1.1941 | |
| 358 | I | A | 0.9491 | |
| 359 | S | A | -0.1290 | |
| 360 | Q | A | -1.0315 | |
| 361 | A | A | -0.9204 | |
| 362 | E | A | -1.9114 | |
| 363 | A | A | -1.0893 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine