| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFEDIVENGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKFGDTENPTEYQHCGADDRVAFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRCGPDGVPLPSGPPPSPLYVPPPPSSPYAVPPPTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPLLNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9436 | |
| 2 | L | A | 1.9642 | |
| 3 | P | A | 0.8321 | |
| 4 | P | A | 0.3755 | |
| 5 | T | A | 0.1242 | |
| 6 | T | A | 0.1270 | |
| 7 | P | A | 0.1851 | |
| 8 | V | A | 1.2127 | |
| 9 | A | A | 0.0927 | |
| 10 | K | A | -1.0163 | |
| 11 | V | A | -0.1520 | |
| 12 | Q | A | -1.3929 | |
| 13 | S | A | -1.5472 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4138 | |
| 16 | E | A | -2.4360 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4623 | |
| 20 | P | A | 0.1285 | |
| 21 | T | A | 0.1782 | |
| 22 | S | A | -0.0976 | |
| 23 | L | A | 0.1112 | |
| 24 | F | A | -0.0383 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2901 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.9027 | |
| 31 | R | A | -2.6882 | |
| 32 | L | A | -0.8041 | |
| 33 | L | A | 1.1614 | |
| 34 | T | A | 1.3724 | |
| 35 | V | A | 1.8390 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2573 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6760 | |
| 40 | E | A | -1.8062 | |
| 41 | D | A | -1.1262 | |
| 42 | I | A | 0.5222 | |
| 43 | V | A | 0.6588 | |
| 44 | E | A | -1.4574 | |
| 45 | N | A | -2.0489 | |
| 46 | G | A | -1.3510 | |
| 47 | K | A | -1.1295 | |
| 48 | V | A | 1.2081 | |
| 49 | V | A | 1.7289 | |
| 50 | V | A | 1.0436 | |
| 51 | P | A | 0.3064 | |
| 52 | K | A | -0.7355 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1354 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3829 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2693 | |
| 70 | K | A | -1.7899 | |
| 71 | F | A | -0.6397 | |
| 72 | A | A | -0.5787 | |
| 73 | L | A | -0.8677 | |
| 74 | P | A | -1.2107 | |
| 75 | Q | A | -2.5024 | |
| 76 | K | A | -3.1063 | |
| 77 | D | A | -2.9879 | |
| 78 | F | A | -1.6547 | |
| 79 | Y | A | -1.8812 | |
| 80 | D | A | -2.6801 | |
| 81 | P | A | -2.3021 | |
| 82 | E | A | -3.0470 | |
| 83 | K | A | -3.3940 | |
| 84 | E | A | -2.4525 | |
| 85 | R | A | -1.2853 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6726 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9694 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3676 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7000 | |
| 99 | G | A | -0.5396 | |
| 100 | P | A | -0.4122 | |
| 101 | L | A | 0.0268 | |
| 102 | G | A | -0.2229 | |
| 103 | K | A | -0.5986 | |
| 104 | G | A | -0.3939 | |
| 105 | T | A | -0.3770 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1708 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4380 | |
| 110 | L | A | 0.3325 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.0875 | |
| 113 | K | A | -0.2809 | |
| 114 | F | A | -1.0453 | |
| 115 | G | A | -1.1582 | |
| 116 | D | A | -1.7629 | |
| 117 | T | A | -1.2224 | |
| 118 | E | A | -1.8536 | |
| 119 | N | A | -2.2310 | |
| 120 | P | A | -2.0468 | |
| 121 | T | A | -1.6617 | |
| 122 | E | A | -2.3207 | |
| 123 | Y | A | -0.9542 | |
| 124 | Q | A | -1.4221 | |
| 125 | H | A | -1.1779 | |
| 126 | C | A | -1.1146 | |
| 127 | G | A | -1.4425 | |
| 128 | A | A | -1.2935 | |
| 129 | D | A | -2.1558 | |
| 130 | D | A | -1.7329 | |
| 131 | R | A | -1.0793 | |
| 132 | V | A | 0.2660 | |
| 133 | A | A | 0.4618 | |
| 134 | F | A | 0.2847 | |
| 135 | S | A | -0.0305 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | 0.0000 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | -0.2101 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5698 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.1920 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1641 | |
| 157 | D | A | 0.3394 | |
| 158 | L | A | 0.8046 | |
| 159 | A | A | 0.1736 | |
| 160 | E | A | -1.4545 | |
| 161 | P | A | -0.2114 | |
| 162 | C | A | 0.1944 | |
| 163 | P | A | -0.1589 | |
| 164 | G | A | -0.0608 | |
| 165 | L | A | 0.6293 | |
| 166 | P | A | -0.1023 | |
| 167 | P | A | -0.3344 | |
| 168 | G | A | -0.4222 | |
| 169 | A | A | 0.3018 | |
| 170 | C | A | 1.0194 | |
| 171 | P | A | 0.5284 | |
| 172 | P | A | 0.7549 | |
| 173 | I | A | 2.0012 | |
| 174 | Q | A | 0.8537 | |
| 175 | L | A | 1.4824 | |
| 176 | V | A | 0.8607 | |
| 177 | N | A | -0.2956 | |
| 178 | S | A | 0.0301 | |
| 179 | V | A | 0.4289 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3842 | |
| 182 | D | A | 0.0844 | |
| 183 | G | A | -0.1588 | |
| 184 | D | A | -0.5327 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1352 | |
| 190 | F | A | 0.0678 | |
| 191 | G | A | -0.0978 | |
| 192 | N | A | -0.2503 | |
| 193 | M | A | -0.1077 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4025 | |
| 197 | E | A | -2.6258 | |
| 198 | L | A | -1.2445 | |
| 199 | Q | A | -2.5763 | |
| 200 | Q | A | -3.3250 | |
| 201 | D | A | -3.5875 | |
| 202 | R | A | -3.3356 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1794 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3517 | |
| 211 | S | A | -1.9011 | |
| 212 | T | A | -1.4283 | |
| 213 | R | A | -2.0577 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1493 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3636 | |
| 220 | L | A | 0.5882 | |
| 221 | K | A | -1.1466 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8260 | |
| 224 | N | A | -1.5061 | |
| 225 | E | A | -1.2430 | |
| 226 | A | A | -0.5969 | |
| 227 | Y | A | -0.3532 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6888 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0815 | |
| 234 | F | A | 0.2670 | |
| 235 | G | A | -0.8150 | |
| 236 | R | A | -2.5997 | |
| 237 | R | A | -2.8878 | |
| 238 | E | A | -2.1700 | |
| 239 | Q | A | -0.2116 | |
| 240 | V | A | 1.4877 | |
| 241 | Y | A | 1.2315 | |
| 242 | A | A | 0.4034 | |
| 243 | R | A | -0.5866 | |
| 244 | H | A | -0.6719 | |
| 245 | F | A | 0.1012 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.7241 | |
| 249 | C | A | -0.9557 | |
| 250 | G | A | -0.9760 | |
| 251 | P | A | -0.5583 | |
| 252 | D | A | -0.4403 | |
| 253 | G | A | 0.0363 | |
| 254 | V | A | 1.2987 | |
| 255 | P | A | 0.4802 | |
| 256 | L | A | 0.8027 | |
| 257 | P | A | 0.3280 | |
| 258 | S | A | -0.2428 | |
| 259 | G | A | -0.5090 | |
| 260 | P | A | -0.7033 | |
| 261 | P | A | -0.1606 | |
| 262 | P | A | 0.0148 | |
| 263 | S | A | 0.5036 | |
| 264 | P | A | 0.6636 | |
| 265 | L | A | 1.8786 | |
| 266 | Y | A | 1.8372 | |
| 267 | V | A | 1.9980 | |
| 268 | P | A | 1.0286 | |
| 269 | P | A | 0.5928 | |
| 270 | P | A | -0.1745 | |
| 271 | P | A | -0.1583 | |
| 272 | S | A | -0.3209 | |
| 273 | S | A | 0.2085 | |
| 274 | P | A | 0.3697 | |
| 275 | Y | A | 1.2736 | |
| 276 | A | A | 1.0635 | |
| 277 | V | A | 1.7362 | |
| 278 | P | A | 0.8605 | |
| 279 | P | A | -0.0831 | |
| 280 | P | A | -0.4713 | |
| 281 | T | A | -0.2575 | |
| 282 | D | A | -0.7606 | |
| 283 | Y | A | 0.7264 | |
| 284 | F | A | 0.6753 | |
| 285 | G | A | 0.3542 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9894 | |
| 291 | L | A | 1.6124 | |
| 292 | V | A | 0.6202 | |
| 293 | S | A | -0.1623 | |
| 294 | S | A | -0.9649 | |
| 295 | D | A | -1.8437 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1114 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6541 | |
| 301 | R | A | -1.8673 | |
| 302 | P | A | -0.9785 | |
| 303 | F | A | -0.1924 | |
| 304 | W | A | -0.5671 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0858 | |
| 307 | R | A | -2.8326 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2500 | |
| 310 | G | A | -1.2239 | |
| 311 | N | A | -1.2675 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7690 | |
| 319 | N | A | -0.8338 | |
| 320 | E | A | -1.0252 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3475 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0698 | |
| 333 | N | A | 0.5789 | |
| 334 | F | A | 1.8188 | |
| 335 | T | A | 0.9090 | |
| 336 | I | A | 0.4728 | |
| 337 | S | A | -0.7718 | |
| 338 | Q | A | -1.3802 | |
| 339 | Q | A | -0.3414 | |
| 340 | L | A | 1.1776 | |
| 341 | C | A | 1.0811 | |
| 342 | T | A | 0.7840 | |
| 343 | P | A | 0.6470 | |
| 344 | L | A | 1.9235 | |
| 345 | L | A | 1.5811 | |
| 346 | N | A | 0.3875 | |
| 347 | V | A | 1.9754 | |
| 348 | Y | A | 1.7927 | |
| 349 | D | A | 0.1711 | |
| 350 | P | A | -0.2854 | |
| 351 | S | A | -0.2344 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.4951 | |
| 354 | K | A | -1.6455 | |
| 355 | N | A | -1.6712 | |
| 356 | Y | A | -0.0729 | |
| 357 | L | A | 0.6715 | |
| 358 | R | A | 1.0168 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.4033 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0772 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0602 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6881 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2977 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3131 | |
| 376 | L | A | -1.7075 | |
| 377 | D | A | -2.0019 | |
| 378 | P | A | -1.0438 | |
| 379 | G | A | -1.0184 | |
| 380 | V | A | -0.9373 | |
| 381 | L | A | -0.5347 | |
| 382 | A | A | -0.6588 | |
| 383 | H | A | -0.8084 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4133 | |
| 386 | T | A | -0.5514 | |
| 387 | M | A | -0.2979 | |
| 388 | N | A | -0.8672 | |
| 389 | P | A | -1.2363 | |
| 390 | T | A | -1.4119 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.3986 | |
| 393 | E | A | -2.7222 | |
| 394 | N | A | -2.4447 | |
| 395 | W | A | -1.3099 | |
| 396 | N | A | -1.0465 | |
| 397 | L | A | -0.1569 | |
| 398 | G | A | 0.5478 | |
| 399 | F | A | 2.4203 | |
| 400 | V | A | 1.8250 | |
| 401 | P | A | 0.0548 | |
| 402 | P | A | -1.8107 | |
| 403 | K | A | -3.2968 | |
| 404 | E | A | -3.8098 | |
| 405 | R | A | -3.8220 | |
| 406 | E | A | -3.7507 | |
| 407 | D | A | -2.8578 | |
| 408 | P | A | -1.7556 | |
| 409 | Y | A | -0.9868 | |
| 410 | K | A | -2.1119 | |
| 411 | G | A | -0.6386 | |
| 412 | L | A | 0.6790 | |
| 413 | I | A | 1.5920 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3878 | |
| 416 | E | A | -1.6785 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9493 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0581 | |
| 421 | E | A | -2.7940 | |
| 422 | R | A | -2.6562 | |
| 423 | F | A | -1.2885 | |
| 424 | S | A | -1.4732 | |
| 425 | Q | A | -1.8583 | |
| 426 | D | A | -2.8954 | |
| 427 | L | A | -1.9755 | |
| 428 | D | A | -2.7585 | |
| 429 | Q | A | -2.6078 | |
| 430 | F | A | -1.4062 | |
| 431 | A | A | -0.8780 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5359 | |
| 435 | K | A | -0.6788 | |
| 436 | F | A | 0.1559 | |
| 437 | L | A | 1.0396 | |
| 438 | Y | A | 0.8400 | |
| 439 | Q | A | -0.2655 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine