| Chain sequence(s) |
A: GGFGNQGGFANSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSG
C: GGFGNQGGFANSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSG B: GGFGNQGGFANSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSG E: GGFGNQGGFANSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSG D: GGFGNQGGFANSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSG input PDB |
| Selected Chain(s) | A,C,B,E,D |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with all chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:01:28)
[INFO] Main: Simulation completed successfully. (00:01:30)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 281 | G | A | -1.2635 | |
| 282 | G | A | -1.0307 | |
| 283 | F | A | 0.0000 | |
| 284 | G | A | -1.0621 | |
| 285 | N | A | 0.0000 | |
| 286 | Q | A | -1.6804 | |
| 287 | G | A | 0.0000 | |
| 288 | G | A | -0.7608 | |
| 289 | F | A | 0.0000 | |
| 290 | A | A | -1.0417 | |
| 291 | N | A | 0.0000 | |
| 292 | S | A | 0.0000 | |
| 293 | R | A | -3.3034 | |
| 294 | G | A | -2.3892 | |
| 295 | G | A | -1.6317 | |
| 296 | G | A | 0.0000 | |
| 297 | A | A | 0.1286 | |
| 298 | G | A | 0.6632 | |
| 299 | L | A | 1.4089 | |
| 300 | G | A | 0.0000 | |
| 301 | N | A | 0.0000 | |
| 302 | N | A | 0.0000 | |
| 303 | Q | A | 0.0000 | |
| 304 | G | A | 0.0000 | |
| 305 | S | A | 0.0000 | |
| 306 | N | A | 0.0000 | |
| 307 | M | A | 0.0000 | |
| 308 | G | A | 0.0000 | |
| 309 | G | A | 0.0000 | |
| 310 | G | A | 0.0000 | |
| 311 | M | A | 0.0000 | |
| 312 | N | A | 0.0000 | |
| 313 | F | A | 1.5387 | |
| 314 | G | A | 0.9748 | |
| 315 | A | A | 0.4780 | |
| 316 | F | A | 0.0000 | |
| 317 | S | A | -0.3006 | |
| 318 | I | A | 0.0000 | |
| 319 | N | A | -1.1366 | |
| 320 | P | A | 0.0000 | |
| 321 | A | A | -0.0741 | |
| 322 | M | A | 0.0000 | |
| 323 | M | A | 0.6974 | |
| 324 | A | A | 0.0000 | |
| 325 | A | A | 0.1380 | |
| 326 | A | A | -0.1705 | |
| 327 | Q | A | -0.4837 | |
| 328 | A | A | 0.0000 | |
| 329 | A | A | 0.0000 | |
| 330 | L | A | 0.0000 | |
| 331 | Q | A | 0.0000 | |
| 332 | S | A | 0.0000 | |
| 333 | S | A | 0.0000 | |
| 334 | W | A | 0.0000 | |
| 335 | G | A | 0.0000 | |
| 336 | M | A | 0.0000 | |
| 337 | M | A | 0.0000 | |
| 338 | G | A | 0.0000 | |
| 339 | M | A | 0.0000 | |
| 340 | L | A | 0.0000 | |
| 341 | A | A | 0.0000 | |
| 342 | S | A | 0.0000 | |
| 343 | Q | A | 0.0000 | |
| 344 | Q | A | -1.6214 | |
| 345 | N | A | 0.0000 | |
| 346 | Q | A | -2.0514 | |
| 347 | S | A | -1.5438 | |
| 348 | G | A | -1.2051 | |
| 349 | P | A | 0.0000 | |
| 350 | S | A | -1.0004 | |
| 351 | G | A | -1.0754 | |
| 281 | G | B | -1.2954 | |
| 282 | G | B | -1.0454 | |
| 283 | F | B | -0.2990 | |
| 284 | G | B | 0.0000 | |
| 285 | N | B | 0.0000 | |
| 286 | Q | B | -1.6268 | |
| 287 | G | B | 0.0000 | |
| 288 | G | B | -0.8040 | |
| 289 | F | B | 0.0000 | |
| 290 | A | B | 0.0000 | |
| 291 | N | B | 0.0000 | |
| 292 | S | B | 0.0000 | |
| 293 | R | B | -3.0610 | |
| 294 | G | B | -2.2314 | |
| 295 | G | B | -1.4150 | |
| 296 | G | B | 0.0000 | |
| 297 | A | B | 0.1921 | |
| 298 | G | B | 0.6432 | |
| 299 | L | B | 1.2836 | |
| 300 | G | B | 0.0000 | |
| 301 | N | B | 0.0000 | |
| 302 | N | B | 0.0000 | |
| 303 | Q | B | 0.0000 | |
| 304 | G | B | 0.0000 | |
| 305 | S | B | -0.1056 | |
| 306 | N | B | 0.0000 | |
| 307 | M | B | 0.0000 | |
| 308 | G | B | 0.0000 | |
| 309 | G | B | 0.0000 | |
| 310 | G | B | 0.0000 | |
| 311 | M | B | 0.0000 | |
| 312 | N | B | 0.0000 | |
| 313 | F | B | 2.0558 | |
| 314 | G | B | 1.0465 | |
| 315 | A | B | 0.4233 | |
| 316 | F | B | 0.0000 | |
| 317 | S | B | -0.3995 | |
| 318 | I | B | 0.0000 | |
| 319 | N | B | -1.2732 | |
| 320 | P | B | 0.0000 | |
| 321 | A | B | -0.0993 | |
| 322 | M | B | 0.0000 | |
| 323 | M | B | 0.6322 | |
| 324 | A | B | 0.0000 | |
| 325 | A | B | 0.0483 | |
| 326 | A | B | -0.2225 | |
| 327 | Q | B | -0.6988 | |
| 328 | A | B | 0.0000 | |
| 329 | A | B | 0.0000 | |
| 330 | L | B | 0.0000 | |
| 331 | Q | B | 0.0000 | |
| 332 | S | B | 0.0000 | |
| 333 | S | B | 0.0000 | |
| 334 | W | B | 0.0000 | |
| 335 | G | B | 0.0000 | |
| 336 | M | B | 0.0000 | |
| 337 | M | B | 0.0000 | |
| 338 | G | B | 0.0000 | |
| 339 | M | B | 0.0000 | |
| 340 | L | B | 0.0000 | |
| 341 | A | B | 0.0000 | |
| 342 | S | B | 0.0000 | |
| 343 | Q | B | 0.0000 | |
| 344 | Q | B | -1.0311 | |
| 345 | N | B | 0.0000 | |
| 346 | Q | B | -1.7441 | |
| 347 | S | B | 0.0000 | |
| 348 | G | B | -1.0347 | |
| 349 | P | B | 0.0000 | |
| 350 | S | B | -0.9460 | |
| 351 | G | B | -1.1113 | |
| 281 | G | C | -1.0941 | |
| 282 | G | C | -0.8667 | |
| 283 | F | C | -0.3984 | |
| 284 | G | C | -0.9180 | |
| 285 | N | C | -1.3253 | |
| 286 | Q | C | -1.8737 | |
| 287 | G | C | -1.1042 | |
| 288 | G | C | -0.8233 | |
| 289 | F | C | -0.1759 | |
| 290 | A | C | -0.8706 | |
| 291 | N | C | -1.2463 | |
| 292 | S | C | -2.0798 | |
| 293 | R | C | -2.9690 | |
| 294 | G | C | -2.3546 | |
| 295 | G | C | -1.5557 | |
| 296 | G | C | -1.3677 | |
| 297 | A | C | -0.0759 | |
| 298 | G | C | 0.5221 | |
| 299 | L | C | 1.5556 | |
| 300 | G | C | 0.0000 | |
| 301 | N | C | -0.2167 | |
| 302 | N | C | -0.8325 | |
| 303 | Q | C | -0.4851 | |
| 304 | G | C | 0.0000 | |
| 305 | S | C | 0.0751 | |
| 306 | N | C | 0.0000 | |
| 307 | M | C | 0.3173 | |
| 308 | G | C | 0.0028 | |
| 309 | G | C | -0.3883 | |
| 310 | G | C | -0.5131 | |
| 311 | M | C | 0.2995 | |
| 312 | N | C | 0.3725 | |
| 313 | F | C | 1.9110 | |
| 314 | G | C | 0.8763 | |
| 315 | A | C | 0.5303 | |
| 316 | F | C | 0.5304 | |
| 317 | S | C | -0.1231 | |
| 318 | I | C | -0.4026 | |
| 319 | N | C | -1.2917 | |
| 320 | P | C | -0.6194 | |
| 321 | A | C | 0.0298 | |
| 322 | M | C | 0.7445 | |
| 323 | M | C | 0.8492 | |
| 324 | A | C | 0.4682 | |
| 325 | A | C | 0.1675 | |
| 326 | A | C | -0.1230 | |
| 327 | Q | C | -0.4446 | |
| 328 | A | C | 0.0588 | |
| 329 | A | C | 0.1686 | |
| 330 | L | C | 0.0139 | |
| 331 | Q | C | -0.7148 | |
| 332 | S | C | -0.0761 | |
| 333 | S | C | 0.1055 | |
| 334 | W | C | 0.3591 | |
| 335 | G | C | 0.0000 | |
| 336 | M | C | 0.3918 | |
| 337 | M | C | 0.4076 | |
| 338 | G | C | 0.2992 | |
| 339 | M | C | 0.4220 | |
| 340 | L | C | 0.1214 | |
| 341 | A | C | -0.0009 | |
| 342 | S | C | -0.4944 | |
| 343 | Q | C | -1.2847 | |
| 344 | Q | C | -2.2256 | |
| 345 | N | C | -2.3092 | |
| 346 | Q | C | -2.3874 | |
| 347 | S | C | -1.4496 | |
| 348 | G | C | -1.2805 | |
| 349 | P | C | -0.7871 | |
| 350 | S | C | -0.8935 | |
| 351 | G | C | -0.8775 | |
| 281 | G | D | -1.1886 | |
| 282 | G | D | -0.7919 | |
| 283 | F | D | 0.0000 | |
| 284 | G | D | -1.0394 | |
| 285 | N | D | 0.0000 | |
| 286 | Q | D | -1.9016 | |
| 287 | G | D | 0.0000 | |
| 288 | G | D | -0.8318 | |
| 289 | F | D | 0.0000 | |
| 290 | A | D | -1.1193 | |
| 291 | N | D | 0.0000 | |
| 292 | S | D | 0.0000 | |
| 293 | R | D | -3.3231 | |
| 294 | G | D | -2.2599 | |
| 295 | G | D | -1.5677 | |
| 296 | G | D | 0.0000 | |
| 297 | A | D | 0.1696 | |
| 298 | G | D | 0.5055 | |
| 299 | L | D | 1.2740 | |
| 300 | G | D | 0.0000 | |
| 301 | N | D | 0.0000 | |
| 302 | N | D | 0.0000 | |
| 303 | Q | D | 0.0000 | |
| 304 | G | D | 0.0000 | |
| 305 | S | D | 0.0000 | |
| 306 | N | D | 0.0000 | |
| 307 | M | D | 0.0000 | |
| 308 | G | D | 0.0000 | |
| 309 | G | D | 0.0000 | |
| 310 | G | D | 0.0000 | |
| 311 | M | D | 0.0000 | |
| 312 | N | D | 0.0000 | |
| 313 | F | D | 2.0853 | |
| 314 | G | D | 1.2990 | |
| 315 | A | D | 0.6266 | |
| 316 | F | D | 0.0000 | |
| 317 | S | D | -0.3616 | |
| 318 | I | D | 0.0000 | |
| 319 | N | D | -1.2254 | |
| 320 | P | D | 0.0000 | |
| 321 | A | D | -0.1010 | |
| 322 | M | D | 0.0000 | |
| 323 | M | D | 0.7773 | |
| 324 | A | D | 0.0000 | |
| 325 | A | D | 0.0423 | |
| 326 | A | D | -0.4996 | |
| 327 | Q | D | -0.9294 | |
| 328 | A | D | 0.0000 | |
| 329 | A | D | 0.0000 | |
| 330 | L | D | 0.0000 | |
| 331 | Q | D | 0.0000 | |
| 332 | S | D | 0.0000 | |
| 333 | S | D | 0.0000 | |
| 334 | W | D | 0.0000 | |
| 335 | G | D | 0.0000 | |
| 336 | M | D | 0.0000 | |
| 337 | M | D | 0.0000 | |
| 338 | G | D | 0.0000 | |
| 339 | M | D | 0.0000 | |
| 340 | L | D | 0.0000 | |
| 341 | A | D | 0.0000 | |
| 342 | S | D | 0.0000 | |
| 343 | Q | D | 0.0000 | |
| 344 | Q | D | -1.1579 | |
| 345 | N | D | 0.0000 | |
| 346 | Q | D | -1.8793 | |
| 347 | S | D | 0.0000 | |
| 348 | G | D | -1.1310 | |
| 349 | P | D | 0.0000 | |
| 350 | S | D | -0.9152 | |
| 351 | G | D | -1.0998 | |
| 281 | G | E | -1.0508 | |
| 282 | G | E | -0.5172 | |
| 283 | F | E | 0.2232 | |
| 284 | G | E | -0.8481 | |
| 285 | N | E | -1.0051 | |
| 286 | Q | E | -1.8965 | |
| 287 | G | E | -1.0059 | |
| 288 | G | E | -0.8109 | |
| 289 | F | E | -0.3918 | |
| 290 | A | E | -0.9436 | |
| 291 | N | E | -1.3798 | |
| 292 | S | E | -1.9533 | |
| 293 | R | E | -3.0630 | |
| 294 | G | E | -2.1564 | |
| 295 | G | E | -1.7044 | |
| 296 | G | E | -1.0425 | |
| 297 | A | E | -0.0716 | |
| 298 | G | E | 0.2551 | |
| 299 | L | E | 1.4194 | |
| 300 | G | E | 0.0886 | |
| 301 | N | E | -0.5158 | |
| 302 | N | E | -1.4654 | |
| 303 | Q | E | -1.1908 | |
| 304 | G | E | -0.8251 | |
| 305 | S | E | -0.5575 | |
| 306 | N | E | -0.7742 | |
| 307 | M | E | 0.0000 | |
| 308 | G | E | -0.2583 | |
| 309 | G | E | -0.3741 | |
| 310 | G | E | 0.0000 | |
| 311 | M | E | 0.8795 | |
| 312 | N | E | 1.2209 | |
| 313 | F | E | 2.3440 | |
| 314 | G | E | 0.9964 | |
| 315 | A | E | 0.5907 | |
| 316 | F | E | 0.3971 | |
| 317 | S | E | -0.2210 | |
| 318 | I | E | -0.2640 | |
| 319 | N | E | -1.3196 | |
| 320 | P | E | -0.4509 | |
| 321 | A | E | 0.1546 | |
| 322 | M | E | 0.8246 | |
| 323 | M | E | 1.2706 | |
| 324 | A | E | 0.0000 | |
| 325 | A | E | -0.0221 | |
| 326 | A | E | -0.6119 | |
| 327 | Q | E | -1.2387 | |
| 328 | A | E | -0.4976 | |
| 329 | A | E | 0.0000 | |
| 330 | L | E | -0.4742 | |
| 331 | Q | E | -1.3147 | |
| 332 | S | E | -0.5567 | |
| 333 | S | E | -0.2390 | |
| 334 | W | E | 0.1889 | |
| 335 | G | E | 0.0781 | |
| 336 | M | E | 0.3282 | |
| 337 | M | E | 0.0453 | |
| 338 | G | E | -0.1921 | |
| 339 | M | E | 0.1550 | |
| 340 | L | E | -0.2015 | |
| 341 | A | E | 0.0029 | |
| 342 | S | E | -0.1262 | |
| 343 | Q | E | -0.7145 | |
| 344 | Q | E | -1.4306 | |
| 345 | N | E | -1.8779 | |
| 346 | Q | E | -2.1109 | |
| 347 | S | E | -1.5256 | |
| 348 | G | E | -1.0926 | |
| 349 | P | E | -0.7688 | |
| 350 | S | E | -0.8501 | |
| 351 | G | E | -1.0641 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine