| Chain sequence(s) |
A: GPLSLDPEPEPRSTDEYVTPTDLLYVAETDLITETGNPTADVVVDGKVAEPRVSAYQWKVFKLTLPDPNTLPLPSSDFIDKSTEILIWRLLAFKIEVFGPLGKGSYGLANFNALGDVDNPTAPQHPGADDRVAYSFEPIYRQEYVIGDEPPLGVYETPAPPAPGLPPGALPPLTRVTDIIQDGDMADIGFGARDFAALEPRKDDVPDIILNTTTKRLDIEGMKAEKYGRRMFTYDRFEKSSDSKKLVLSGPDPVPPPAAPPPSPLYVPPPPTSPLAVPPPRRLFTLPDSGEITEEDLLFNKPIFLEKTEGLNNGVLWHNKLYITVLDNSRSEIETKTTQVSTPAIPVYDPANYVTSKTYKREYKISLILQLCKIPLTPETLEYLERLDPRILVDANLPFIPPVEREDPYAGKKFHEIDLKDKLSTDLSKTELGQAYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.1945 | |
| 2 | P | A | 0.4294 | |
| 3 | L | A | 1.3936 | |
| 4 | S | A | 0.5146 | |
| 5 | L | A | 0.5600 | |
| 6 | D | A | -1.5119 | |
| 7 | P | A | -1.9342 | |
| 8 | E | A | -2.8530 | |
| 9 | P | A | -2.4762 | |
| 10 | E | A | -2.7432 | |
| 11 | P | A | -1.7802 | |
| 12 | R | A | -1.8629 | |
| 13 | S | A | -1.5586 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.7703 | |
| 16 | E | A | -2.8237 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.9520 | |
| 20 | P | A | -0.9383 | |
| 21 | T | A | -0.9162 | |
| 22 | D | A | -1.6626 | |
| 23 | L | A | -0.5412 | |
| 24 | L | A | -0.2433 | |
| 25 | Y | A | 0.0000 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.9725 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.3531 | |
| 31 | L | A | 0.4177 | |
| 32 | I | A | 0.1499 | |
| 33 | T | A | -0.3065 | |
| 34 | E | A | -0.8496 | |
| 35 | T | A | -1.0070 | |
| 36 | G | A | 0.0000 | |
| 37 | N | A | -1.5029 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -0.6664 | |
| 40 | A | A | -0.5335 | |
| 41 | D | A | -0.7007 | |
| 42 | V | A | 0.9348 | |
| 43 | V | A | 1.8912 | |
| 44 | V | A | 1.3099 | |
| 45 | D | A | -1.0203 | |
| 46 | G | A | -0.6551 | |
| 47 | K | A | -0.6979 | |
| 48 | V | A | 1.1269 | |
| 49 | A | A | 0.5610 | |
| 50 | E | A | -0.3444 | |
| 51 | P | A | -0.7206 | |
| 52 | R | A | -0.9547 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | -0.3630 | |
| 58 | W | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | -1.3908 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.5847 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -0.8749 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.8636 | |
| 70 | T | A | -0.2355 | |
| 71 | L | A | -0.0342 | |
| 72 | P | A | -0.1132 | |
| 73 | L | A | -0.0730 | |
| 74 | P | A | -0.3549 | |
| 75 | S | A | -0.7305 | |
| 76 | S | A | -1.2415 | |
| 77 | D | A | -2.3075 | |
| 78 | F | A | -1.1694 | |
| 79 | I | A | 0.0000 | |
| 80 | D | A | -2.9585 | |
| 81 | K | A | -2.8938 | |
| 82 | S | A | -1.6995 | |
| 83 | T | A | -1.3761 | |
| 84 | E | A | -1.6215 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3343 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | 0.0000 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | E | A | -0.6154 | |
| 97 | V | A | 0.0000 | |
| 98 | F | A | 0.3116 | |
| 99 | G | A | -0.5530 | |
| 100 | P | A | -0.4303 | |
| 101 | L | A | -0.3499 | |
| 102 | G | A | -0.9143 | |
| 103 | K | A | -1.5518 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.7721 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.4101 | |
| 108 | L | A | -0.3365 | |
| 109 | A | A | -0.0078 | |
| 110 | N | A | -0.8819 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | -0.4891 | |
| 115 | G | A | -0.6823 | |
| 116 | D | A | -1.3633 | |
| 117 | V | A | -1.0194 | |
| 118 | D | A | -2.5677 | |
| 119 | N | A | -2.0452 | |
| 120 | P | A | -1.3142 | |
| 121 | T | A | -0.8858 | |
| 122 | A | A | -1.0410 | |
| 123 | P | A | -1.0856 | |
| 124 | Q | A | -1.5573 | |
| 125 | H | A | -1.8875 | |
| 126 | P | A | -1.7031 | |
| 127 | G | A | -1.6598 | |
| 128 | A | A | -1.3353 | |
| 129 | D | A | -2.3247 | |
| 130 | D | A | -1.8181 | |
| 131 | R | A | -1.1116 | |
| 132 | V | A | 0.2729 | |
| 133 | A | A | 0.3804 | |
| 134 | Y | A | 0.2848 | |
| 135 | S | A | -0.1613 | |
| 136 | F | A | 0.0000 | |
| 137 | E | A | -0.8338 | |
| 138 | P | A | 0.0000 | |
| 139 | I | A | 0.0000 | |
| 140 | Y | A | 0.0000 | |
| 141 | R | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | E | A | -0.3478 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.4013 | |
| 153 | G | A | 0.0000 | |
| 154 | V | A | -0.6688 | |
| 155 | Y | A | -1.0689 | |
| 156 | E | A | -1.4408 | |
| 157 | T | A | -0.8334 | |
| 158 | P | A | -0.2562 | |
| 159 | A | A | -0.2946 | |
| 160 | P | A | -0.3827 | |
| 161 | P | A | -0.2501 | |
| 162 | A | A | -0.2537 | |
| 163 | P | A | -0.3839 | |
| 164 | G | A | -0.3489 | |
| 165 | L | A | 0.3908 | |
| 166 | P | A | -0.0900 | |
| 167 | P | A | -0.2891 | |
| 168 | G | A | -0.0710 | |
| 169 | A | A | 0.6639 | |
| 170 | L | A | 1.4487 | |
| 171 | P | A | 0.6925 | |
| 172 | P | A | 0.2249 | |
| 173 | L | A | -0.0402 | |
| 174 | T | A | -0.9495 | |
| 175 | R | A | -1.8072 | |
| 176 | V | A | -0.8129 | |
| 177 | T | A | -0.6924 | |
| 178 | D | A | -0.6387 | |
| 179 | I | A | 0.0000 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -1.2768 | |
| 182 | D | A | -1.3102 | |
| 183 | G | A | -0.8000 | |
| 184 | D | A | -0.7658 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.3168 | |
| 190 | F | A | 0.0000 | |
| 191 | G | A | -0.5519 | |
| 192 | A | A | -0.9515 | |
| 193 | R | A | -1.2485 | |
| 194 | D | A | -0.8442 | |
| 195 | F | A | 0.0000 | |
| 196 | A | A | -0.9900 | |
| 197 | A | A | -0.3885 | |
| 198 | L | A | -0.4859 | |
| 199 | E | A | -1.5384 | |
| 200 | P | A | -1.5729 | |
| 201 | R | A | -2.1737 | |
| 202 | K | A | -2.7902 | |
| 203 | D | A | 0.0000 | |
| 204 | D | A | -1.2687 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.1544 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.1267 | |
| 211 | N | A | -1.6230 | |
| 212 | T | A | -0.8375 | |
| 213 | T | A | -0.6794 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | R | A | -0.6856 | |
| 217 | L | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | I | A | -1.2379 | |
| 220 | E | A | -2.3935 | |
| 221 | G | A | -1.5858 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.9779 | |
| 224 | A | A | -1.6883 | |
| 225 | E | A | -1.5618 | |
| 226 | K | A | -1.3844 | |
| 227 | Y | A | -0.5806 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.5852 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.9044 | |
| 234 | Y | A | -0.4097 | |
| 235 | D | A | -0.8172 | |
| 236 | R | A | -0.9097 | |
| 237 | F | A | -0.5283 | |
| 238 | E | A | -1.4534 | |
| 239 | K | A | -1.6819 | |
| 240 | S | A | -1.7117 | |
| 241 | S | A | -1.7853 | |
| 242 | D | A | -2.3909 | |
| 243 | S | A | -1.8251 | |
| 244 | K | A | -2.2012 | |
| 245 | K | A | -1.5233 | |
| 246 | L | A | 0.0000 | |
| 247 | V | A | 0.0837 | |
| 248 | L | A | 0.1482 | |
| 249 | S | A | -0.6127 | |
| 250 | G | A | -0.6117 | |
| 251 | P | A | -0.7791 | |
| 252 | D | A | -0.9499 | |
| 253 | P | A | -0.0425 | |
| 254 | V | A | 1.1239 | |
| 255 | P | A | 0.1735 | |
| 256 | P | A | -0.1995 | |
| 257 | P | A | -0.2197 | |
| 258 | A | A | -0.1931 | |
| 259 | A | A | -0.2123 | |
| 260 | P | A | -0.4544 | |
| 261 | P | A | -0.5402 | |
| 262 | P | A | 0.1299 | |
| 263 | S | A | 0.5866 | |
| 264 | P | A | 0.7997 | |
| 265 | L | A | 1.9235 | |
| 266 | Y | A | 1.8850 | |
| 267 | V | A | 2.0410 | |
| 268 | P | A | 1.0773 | |
| 269 | P | A | 0.6262 | |
| 270 | P | A | -0.1142 | |
| 271 | P | A | -0.0995 | |
| 272 | T | A | -0.1266 | |
| 273 | S | A | 0.4273 | |
| 274 | P | A | 0.7243 | |
| 275 | L | A | 1.8223 | |
| 276 | A | A | 1.2436 | |
| 277 | V | A | 2.0617 | |
| 278 | P | A | 0.6087 | |
| 279 | P | A | -0.1646 | |
| 280 | P | A | -0.8439 | |
| 281 | R | A | -1.7180 | |
| 282 | R | A | -0.3809 | |
| 283 | L | A | 1.1577 | |
| 284 | F | A | 0.6785 | |
| 285 | T | A | -0.4182 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.6374 | |
| 289 | S | A | 0.0000 | |
| 290 | G | A | -1.6623 | |
| 291 | E | A | -2.0252 | |
| 292 | I | A | -1.5361 | |
| 293 | T | A | -1.8173 | |
| 294 | E | A | -2.5884 | |
| 295 | E | A | -2.7257 | |
| 296 | D | A | -1.9297 | |
| 297 | L | A | -1.0405 | |
| 298 | L | A | -0.7683 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.2869 | |
| 301 | K | A | -1.8263 | |
| 302 | P | A | -0.9765 | |
| 303 | I | A | -0.0902 | |
| 304 | F | A | -0.3151 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -2.4786 | |
| 307 | K | A | -2.9219 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -2.5059 | |
| 310 | G | A | -1.6586 | |
| 311 | L | A | -0.9975 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.6353 | |
| 319 | N | A | -0.7901 | |
| 320 | K | A | -0.7327 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | -0.7779 | |
| 331 | S | A | 0.0000 | |
| 332 | E | A | -2.5468 | |
| 333 | I | A | -2.3827 | |
| 334 | E | A | -3.1912 | |
| 335 | T | A | -2.3567 | |
| 336 | K | A | -2.2797 | |
| 337 | T | A | -0.5904 | |
| 338 | T | A | 0.0283 | |
| 339 | Q | A | 0.2334 | |
| 340 | V | A | 1.5770 | |
| 341 | S | A | 0.2704 | |
| 342 | T | A | -0.1020 | |
| 343 | P | A | -0.3274 | |
| 344 | A | A | 0.1732 | |
| 345 | I | A | 0.8682 | |
| 346 | P | A | 1.0242 | |
| 347 | V | A | 2.1830 | |
| 348 | Y | A | 1.7630 | |
| 349 | D | A | 0.0990 | |
| 350 | P | A | -0.0102 | |
| 351 | A | A | 0.2090 | |
| 352 | N | A | 0.5422 | |
| 353 | Y | A | 0.8541 | |
| 354 | V | A | 1.5395 | |
| 355 | T | A | -0.2483 | |
| 356 | S | A | -1.2983 | |
| 357 | K | A | -2.4498 | |
| 358 | T | A | -2.3123 | |
| 359 | Y | A | 0.0000 | |
| 360 | K | A | -1.8821 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.2190 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -0.5208 | |
| 365 | I | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | L | A | 0.0000 | |
| 370 | Q | A | -0.4530 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.6597 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.8552 | |
| 376 | L | A | -0.7615 | |
| 377 | T | A | -0.9085 | |
| 378 | P | A | -1.4475 | |
| 379 | E | A | -2.3522 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -1.6006 | |
| 382 | E | A | -2.7234 | |
| 383 | Y | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | E | A | -2.3381 | |
| 386 | R | A | -2.3360 | |
| 387 | L | A | 0.0000 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -1.4364 | |
| 390 | R | A | -1.6988 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -0.7341 | |
| 394 | D | A | -1.0888 | |
| 395 | A | A | -0.9655 | |
| 396 | N | A | -1.1579 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.3936 | |
| 399 | F | A | 1.7147 | |
| 400 | I | A | 0.9951 | |
| 401 | P | A | 0.3581 | |
| 402 | P | A | -0.1354 | |
| 403 | V | A | -0.0257 | |
| 404 | E | A | -2.5688 | |
| 405 | R | A | -3.6540 | |
| 406 | E | A | -3.6448 | |
| 407 | D | A | -2.9741 | |
| 408 | P | A | -1.5861 | |
| 409 | Y | A | -1.1620 | |
| 410 | A | A | -1.3390 | |
| 411 | G | A | -1.2765 | |
| 412 | K | A | -1.8071 | |
| 413 | K | A | -2.4971 | |
| 414 | F | A | -1.6280 | |
| 415 | H | A | -1.6214 | |
| 416 | E | A | -2.5059 | |
| 417 | I | A | -2.0633 | |
| 418 | D | A | -3.1147 | |
| 419 | L | A | 0.0000 | |
| 420 | K | A | -3.2029 | |
| 421 | D | A | -3.2386 | |
| 422 | K | A | -2.7657 | |
| 423 | L | A | -1.2398 | |
| 424 | S | A | -0.9282 | |
| 425 | T | A | -0.4930 | |
| 426 | D | A | -1.2926 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.6026 | |
| 429 | K | A | -2.5746 | |
| 430 | T | A | -2.1975 | |
| 431 | E | A | -2.5274 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | Q | A | -2.0172 | |
| 435 | A | A | -1.3161 | |
| 436 | Y | A | -0.4491 | |
| 437 | L | A | 0.0933 | |
| 438 | N | A | -1.6101 | |
| 439 | R | A | -1.9627 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine